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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF3-RHAG (FusionGDB2 ID:6411)

Fusion Gene Summary for ARHGEF3-RHAG

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF3-RHAG
Fusion gene ID: 6411
HgeneTgene
Gene symbol

ARHGEF3

RHAG

Gene ID

50650

6005

Gene nameRho guanine nucleotide exchange factor 3Rh associated glycoprotein
SynonymsGEF3|STA3|XPLNCD241|OHS|OHST|RH2|RH50A|RHNR|Rh50|Rh50GP|SLC42A1
Cytomap

3p14.3

6p12.3

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLNammonium transporter Rh type ARh 50 glycoproteinRhesus associated polypeptide, 50-KDRhesus blood group-associated glycoproteinerythrocyte membrane glycoprotein Rh50erythrocyte plasma membrane 50 kDa glycoproteinmutant Rh associated glycoproteinrh f
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000338458, ENST00000496106, 
ENST00000498517, ENST00000296315, 
ENST00000413728, ENST00000497267, 
ENST00000495373, 		ENST00000371175, 
ENST00000229810, 
Fusion gene scores* DoF score19 X 17 X 8=25844 X 3 X 4=48
# samples 234
** MAII scorelog2(23/2584*10)=-3.48990030374955
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF3 [Title/Abstract] AND RHAG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF3(56916320)-RHAG(49587075), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGEF3-RHAG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF3-RHAG seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRHAG

GO:0006873

cellular ion homeostasis

15856280

TgeneRHAG

GO:0015670

carbon dioxide transport

16574458|17712059|19273840

TgeneRHAG

GO:0015672

monovalent inorganic cation transport

18931342

TgeneRHAG

GO:0015696

ammonium transport

15856280|15929723|16574458|16866382|17712059|19273840


check buttonFusion gene breakpoints across ARHGEF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RHAG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-7953-01AARHGEF3chr3

56916320

-RHAGchr6

49587075

-
ChimerDB4LUADTCGA-86-7953-01AARHGEF3chr3

56916320

-RHAGchr6

49587075

-
ChimerDB4LUADTCGA-86-7953-01AARHGEF3chr3

56916320

-RHAGchr6

49587075

-


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Fusion Gene ORF analysis for ARHGEF3-RHAG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000338458ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
In-frameENST00000338458ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
Frame-shiftENST00000496106ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
In-frameENST00000496106ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
5UTR-3CDSENST00000498517ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
5UTR-3CDSENST00000498517ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000296315ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000296315ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000413728ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000413728ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000497267ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000497267ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000495373ENST00000371175ARHGEF3chr3

56916320

-RHAGchr6

49587075

-
intron-3CDSENST00000495373ENST00000229810ARHGEF3chr3

56916320

-RHAGchr6

49587075

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338458ARHGEF3chr356916320-ENST00000229810RHAGchr649587075-13433022831200305
ENST00000496106ARHGEF3chr356916320-ENST00000229810RHAGchr649587075-12672262071124305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338458ENST00000229810ARHGEF3chr356916320-RHAGchr649587075-0.0011472580.9988527
ENST00000496106ENST00000229810ARHGEF3chr356916320-RHAGchr649587075-0.0016821150.99831796

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Fusion Genomic Features for ARHGEF3-RHAG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF3-RHAG


check button Go to

FGviewer for the breakpoints of chr3:56916320-chr6:49587075

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009101_11352.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009135_14252.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009164_16752.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009189_20852.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009230_23952.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009261_26852.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009292_29552.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009319_33252.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009354_36252.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009384_40952.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST000002298100973_7952.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010101_11352.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010135_14252.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010164_16752.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010189_20852.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010230_23952.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010261_26852.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010292_29552.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010319_33252.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010354_36252.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010384_40952.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000037117501073_7952.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009114_13452.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009143_16352.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009168_18852.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009209_22952.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009240_26052.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009269_29152.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009296_31852.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009333_35352.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000022981009363_38352.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST000002298100952_7252.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST000002298100980_10052.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010114_13452.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010143_16352.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010168_18852.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010209_22952.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010240_26052.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010269_29152.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010296_31852.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010333_35352.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST00000371175010363_38352.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000037117501052_7252.333333333333336410.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST0000037117501080_10052.333333333333336410.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000296315-110122_3040527.0DomainDH
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000296315-110291_4490527.0DomainPH
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000338458-413122_30464.0559.0DomainDH
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000338458-413291_44964.0559.0DomainPH
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000413728-110122_3040533.0DomainDH
HgeneARHGEF3chr3:56916320chr6:49587075ENST00000413728-110291_4490533.0DomainPH
TgeneRHAGchr3:56916320chr6:49587075ENST00000229810091_252.333333333333336290.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST000002298100924_5152.333333333333336290.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST000003711750101_252.333333333333336410.0Topological domainCytoplasmic
TgeneRHAGchr3:56916320chr6:49587075ENST0000037117501024_5152.333333333333336410.0Topological domainExtracellular
TgeneRHAGchr3:56916320chr6:49587075ENST00000229810093_2352.333333333333336290.0TransmembraneHelical
TgeneRHAGchr3:56916320chr6:49587075ENST000003711750103_2352.333333333333336410.0TransmembraneHelical


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Fusion Gene Sequence for ARHGEF3-RHAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000338458_ENST00000229810_TCGA-86-7953-01A_ARHGEF3_chr3_56916320_-_RHAG_chr6_49587075_length(transcript)=1343nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGTTCCAAGATGTACATGTTATGATATTTGTTGGGTTTGGCTTCCTCATGACCTTCCT
GAAGAAATATGGCTTCAGCAGTGTGGGTATCAACCTACTCGTTGCTGCTTTGGGCCTCCAGTGGGGCACTATTGTACAGGGAATCCTGCA
AAGCCAGGGACAGAAATTTAACATTGGAATCAAAAACATGATAAATGCAGACTTCAGTGCAGCCACAGTTCTGATATCTTTTGGAGCTGT
CCTGGGAAAAACGAGCCCCACCCAAATGCTGATCATGACAATTTTAGAAATTGTTTTCTTTGCCCACAATGAATACCTGGTTAGTGAAAT
ATTTAAGGCCTCTGACATTGGAGCATCAATGACGATCCATGCCTTTGGGGCCTACTTTGGCTTGGCTGTAGCAGGCATCTTGTATCGATC
TGGACTGAGAAAGGGGCATGAAAATGAAGAGTCCGCATACTACTCAGACTTGTTTGCAATGATTGGGACTCTCTTTCTGTGGATGTTTTG
GCCCAGCTTTAACTCGGCCATTGCTGAACCTGGAGACAAACAGTGCAGGGCCATTGTAAACACGTACTTCTCTCTCGCTGCCTGTGTGCT
CACAGCCTTTGCCTTCTCCAGCCTAGTGGAGCACCGAGGCAAGCTCAACATGGTTCACATTCAGAATGCCACCCTTGCTGGAGGAGTTGC
TGTGGGCACTTGTGCGGATATGGCAATTCACCCATTTGGTTCTATGATTATTGGGAGCATTGCAGGAATGGTCTCTGTGCTTGGATACAA
GTTCCTGACTGTCTATGGCCATGCAGGCAGCTGCACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGTCTGATGACAGGTTTAATTC
TAAAGTTGCCTCTCTGGGGACAGCCATCTGACCAGAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCTAAGACGAGATAACTTGACA

>In-frame_ENST00000338458_ENST00000229810_TCGA-86-7953-01A_ARHGEF3_chr3_56916320_-_RHAG_chr6_49587075_length(amino acids)=305AA_start in transcript=283_stop in transcript=1200
MQSRHKLFQDVHVMIFVGFGFLMTFLKKYGFSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFSAATVLISFGAVLGKT
SPTQMLIMTILEIVFFAHNEYLVSEIFKASDIGASMTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMFWPSFN
SAIAEPGDKQCRAIVNTYFSLAACVLTAFAFSSLVEHRGKLNMVHIQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTV

--------------------------------------------------------------
>In-frame_ENST00000496106_ENST00000229810_TCGA-86-7953-01A_ARHGEF3_chr3_56916320_-_RHAG_chr6_49587075_length(transcript)=1267nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGTTCCAAGATGTACATGTTATGATATTTGTTGGGTTTGGCTTC
CTCATGACCTTCCTGAAGAAATATGGCTTCAGCAGTGTGGGTATCAACCTACTCGTTGCTGCTTTGGGCCTCCAGTGGGGCACTATTGTA
CAGGGAATCCTGCAAAGCCAGGGACAGAAATTTAACATTGGAATCAAAAACATGATAAATGCAGACTTCAGTGCAGCCACAGTTCTGATA
TCTTTTGGAGCTGTCCTGGGAAAAACGAGCCCCACCCAAATGCTGATCATGACAATTTTAGAAATTGTTTTCTTTGCCCACAATGAATAC
CTGGTTAGTGAAATATTTAAGGCCTCTGACATTGGAGCATCAATGACGATCCATGCCTTTGGGGCCTACTTTGGCTTGGCTGTAGCAGGC
ATCTTGTATCGATCTGGACTGAGAAAGGGGCATGAAAATGAAGAGTCCGCATACTACTCAGACTTGTTTGCAATGATTGGGACTCTCTTT
CTGTGGATGTTTTGGCCCAGCTTTAACTCGGCCATTGCTGAACCTGGAGACAAACAGTGCAGGGCCATTGTAAACACGTACTTCTCTCTC
GCTGCCTGTGTGCTCACAGCCTTTGCCTTCTCCAGCCTAGTGGAGCACCGAGGCAAGCTCAACATGGTTCACATTCAGAATGCCACCCTT
GCTGGAGGAGTTGCTGTGGGCACTTGTGCGGATATGGCAATTCACCCATTTGGTTCTATGATTATTGGGAGCATTGCAGGAATGGTCTCT
GTGCTTGGATACAAGTTCCTGACTGTCTATGGCCATGCAGGCAGCTGCACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGTCTGAT
GACAGGTTTAATTCTAAAGTTGCCTCTCTGGGGACAGCCATCTGACCAGAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCTAAGAC
GAGATAACTTGACAATCAGTTCCATGGACATGGTGACCACAGCCAGCTGGAACCTGAAGTCTAAACACCATTCCTGCTCTCCAGCTTCCT

>In-frame_ENST00000496106_ENST00000229810_TCGA-86-7953-01A_ARHGEF3_chr3_56916320_-_RHAG_chr6_49587075_length(amino acids)=305AA_start in transcript=207_stop in transcript=1124
MQSRHKLFQDVHVMIFVGFGFLMTFLKKYGFSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFSAATVLISFGAVLGKT
SPTQMLIMTILEIVFFAHNEYLVSEIFKASDIGASMTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMFWPSFN
SAIAEPGDKQCRAIVNTYFSLAACVLTAFAFSSLVEHRGKLNMVHIQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF3-RHAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF3-RHAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF3-RHAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRHAGC1849387Rh-Null, Regulator Type5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRHAGC1861455STOMATOCYTOSIS I5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRHAGC0272048stomatocytic anemia2GENOMICS_ENGLAND
TgeneRHAGC0272052Rh Deficiency Syndrome2ORPHANET
TgeneRHAGC0677598Stomatocytosis Result2GENOMICS_ENGLAND