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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGAP3-IFI35 (FusionGDB2 ID:64143)

Fusion Gene Summary for PGAP3-IFI35

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP3-IFI35
Fusion gene ID: 64143
HgeneTgene
Gene symbol

PGAP3

IFI35

Gene ID

93210

3430

Gene namepost-GPI attachment to proteins phospholipase 3interferon induced protein 35
SynonymsAGLA546|CAB2|PERLD1|PP1498|hCOS16IFP35
Cytomap

17q12

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionpost-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1post-GPI attachment to proteins 3interferon-induced 35 kDa proteinIFP 35ifi-35
Modification date2020032720200313
UniProtAcc.

P80217

Ensembl transtripts involved in fusion geneENST00000579146, ENST00000300658, 
ENST00000378011, ENST00000429199, 
ENST00000415816, ENST00000438323, 
ENST00000536969, 
Fusion gene scores* DoF score18 X 8 X 9=12962 X 2 X 2=8
# samples 273
** MAII scorelog2(27/1296*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: PGAP3 [Title/Abstract] AND IFI35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGAP3(37840850)-IFI35(41164196), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IFI35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2FB-01APGAP3chr17

37840850

-IFI35chr17

41164196

+


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Fusion Gene ORF analysis for PGAP3-IFI35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000579146ENST00000415816PGAP3chr17

37840850

-IFI35chr17

41164196

+
In-frameENST00000579146ENST00000438323PGAP3chr17

37840850

-IFI35chr17

41164196

+
5CDS-3UTRENST00000579146ENST00000536969PGAP3chr17

37840850

-IFI35chr17

41164196

+
In-frameENST00000300658ENST00000415816PGAP3chr17

37840850

-IFI35chr17

41164196

+
In-frameENST00000300658ENST00000438323PGAP3chr17

37840850

-IFI35chr17

41164196

+
5CDS-3UTRENST00000300658ENST00000536969PGAP3chr17

37840850

-IFI35chr17

41164196

+
intron-3CDSENST00000378011ENST00000415816PGAP3chr17

37840850

-IFI35chr17

41164196

+
intron-3CDSENST00000378011ENST00000438323PGAP3chr17

37840850

-IFI35chr17

41164196

+
intron-3UTRENST00000378011ENST00000536969PGAP3chr17

37840850

-IFI35chr17

41164196

+
In-frameENST00000429199ENST00000415816PGAP3chr17

37840850

-IFI35chr17

41164196

+
In-frameENST00000429199ENST00000438323PGAP3chr17

37840850

-IFI35chr17

41164196

+
5CDS-3UTRENST00000429199ENST00000536969PGAP3chr17

37840850

-IFI35chr17

41164196

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579146PGAP3chr1737840850-ENST00000415816IFI35chr1741164196+1472475431314423
ENST00000579146PGAP3chr1737840850-ENST00000438323IFI35chr1741164196+1478475431320425
ENST00000300658PGAP3chr1737840850-ENST00000415816IFI35chr1741164196+1522525931364423
ENST00000300658PGAP3chr1737840850-ENST00000438323IFI35chr1741164196+1528525931370425
ENST00000429199PGAP3chr1737840850-ENST00000415816IFI35chr1741164196+1472475431314423
ENST00000429199PGAP3chr1737840850-ENST00000438323IFI35chr1741164196+1478475431320425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579146ENST00000415816PGAP3chr1737840850-IFI35chr1741164196+0.0277586910.97224134
ENST00000579146ENST00000438323PGAP3chr1737840850-IFI35chr1741164196+0.0215666050.97843343
ENST00000300658ENST00000415816PGAP3chr1737840850-IFI35chr1741164196+0.0254458670.9745541
ENST00000300658ENST00000438323PGAP3chr1737840850-IFI35chr1741164196+0.019601490.9803985
ENST00000429199ENST00000415816PGAP3chr1737840850-IFI35chr1741164196+0.0277586910.97224134
ENST00000429199ENST00000438323PGAP3chr1737840850-IFI35chr1741164196+0.0215666050.97843343

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Fusion Genomic Features for PGAP3-IFI35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGAP3chr1737840849-IFI35chr1741164195+1.39E-121
PGAP3chr1737840849-IFI35chr1741164195+1.39E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP3-IFI35


check button Go to

FGviewer for the breakpoints of chr17:37840850-chr17:41164196

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IFI35

P80217

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38120_135144.0321.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-3821_98144.0321.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-3899_119144.0321.0TransmembraneHelical
TgeneIFI35chr17:37840850chr17:41164196ENST0000041581607183_2667.0287.0DomainNID 2
TgeneIFI35chr17:37840850chr17:41164196ENST000004158160781_1707.0287.0DomainNID 1
TgeneIFI35chr17:37840850chr17:41164196ENST0000043832307183_2667.0289.0DomainNID 2
TgeneIFI35chr17:37840850chr17:41164196ENST000004383230781_1707.0289.0DomainNID 1
TgeneIFI35chr17:37840850chr17:41164196ENST00000415816075_267.0287.0RegionNote=Leucine-zipper
TgeneIFI35chr17:37840850chr17:41164196ENST00000438323075_267.0289.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38157_169144.0321.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38191_193144.0321.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38215_224144.0321.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38246_257144.0321.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38279_279144.0321.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38300_320144.0321.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17120_1350270.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17157_1690270.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17191_1930270.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17215_2240270.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-1721_980270.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17246_2570270.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17279_2790270.0Topological domainLumenal
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17300_3200270.0Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38136_156144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38170_190144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38194_214144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38225_245144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38258_278144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000300658-38280_299144.0321.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17136_1560270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17170_1900270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17194_2140270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17225_2450270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17258_2780270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-17280_2990270.0TransmembraneHelical
HgenePGAP3chr17:37840850chr17:41164196ENST00000378011-1799_1190270.0TransmembraneHelical


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Fusion Gene Sequence for PGAP3-IFI35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000579146_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1472nt_BP=475nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTTCAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCT
GAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCATTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGA
CCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATCCACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAA
AGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATCAACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCC
CATGGTCACCACCATCCAGATGTCCAGCCAGTTGAGTGGCCGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAGTGAGGA
GGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGCAAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGGGAGTGT
CATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAGCGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGTCCCTCT
GAGAGTCTCTCCGTATGTGAACGGGGAGATCCAGAAGGCTGAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAACATTCC
TGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAGATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGCCCTGAC
AGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCCCCCGCC
AAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCATATAGGAGGTCTGTATGTTCACCAACAGTGCGGAGGGGTCACACATTGCAAAACAC

>In-frame_ENST00000579146_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=423AA_start in transcript=43_stop in transcript=1314
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGR
RVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAE

--------------------------------------------------------------
>In-frame_ENST00000579146_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1478nt_BP=475nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTTCAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCT
GAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCATTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGA
CCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATCCACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAA
AGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATCAACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCC
CATGGTCACCACCATCCAGGTGATGATGTCCAGCCAGTTGAGTGGCCGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAG
TGAGGAGGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGCAAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGG
GAGTGTCATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAGCGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGT
CCCTCTGAGAGTCTCTCCGTATGTGAACGGGGAGATCCAGAAGGCTGAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAA
CATTCCTGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAGATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGC
CCTGACAGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCC
CCCGCCAAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCATATAGGAGGTCTGTATGTTCACCAACAGTGCGGAGGGGTCACACATTGCA

>In-frame_ENST00000579146_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=425AA_start in transcript=43_stop in transcript=1320
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQVMMSSQLS
GRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQK

--------------------------------------------------------------
>In-frame_ENST00000300658_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1522nt_BP=525nt
GTAGAATAAAGAACACAGGAACTTCCGGTTACTCCGGAAGTGGAAGCTTCATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAA
AGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTAC
CGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTA
GCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAG
TTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTG
GTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTT
CAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCTGAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCA
TTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGACCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATC
CACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAAAGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATC
AACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCCCATGGTCACCACCATCCAGATGTCCAGCCAGTTGAGTGGC
CGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAGTGAGGAGGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGCAAGACT
AGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGGGAGTGTCATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAGCGTCTG
TGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGTCCCTCTGAGAGTCTCTCCGTATGTGAACGGGGAGATCCAGAAGGCT
GAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAACATTCCTGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAG
ATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGCCCTGACAGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACC
TCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCCCCCGCCAAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCATATAGG

>In-frame_ENST00000300658_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=423AA_start in transcript=93_stop in transcript=1364
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGR
RVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAE

--------------------------------------------------------------
>In-frame_ENST00000300658_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1528nt_BP=525nt
GTAGAATAAAGAACACAGGAACTTCCGGTTACTCCGGAAGTGGAAGCTTCATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAA
AGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTAC
CGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTA
GCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAG
TTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTG
GTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTT
CAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCTGAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCA
TTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGACCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATC
CACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAAAGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATC
AACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCCCATGGTCACCACCATCCAGGTGATGATGTCCAGCCAGTTG
AGTGGCCGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAGTGAGGAGGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGC
AAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGGGAGTGTCATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAG
CGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGTCCCTCTGAGAGTCTCTCCGTATGTGAACGGGGAGATCCAG
AAGGCTGAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAACATTCCTGATATCTTGGATGGCCCGGAGCTGCATGACGTC
CTGGAGATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGCCCTGACAGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTC
TTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCCCCCGCCAAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCA

>In-frame_ENST00000300658_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=425AA_start in transcript=93_stop in transcript=1370
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQVMMSSQLS
GRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQK

--------------------------------------------------------------
>In-frame_ENST00000429199_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1472nt_BP=475nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTTCAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCT
GAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCATTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGA
CCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATCCACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAA
AGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATCAACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCC
CATGGTCACCACCATCCAGATGTCCAGCCAGTTGAGTGGCCGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAGTGAGGA
GGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGCAAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGGGAGTGT
CATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAGCGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGTCCCTCT
GAGAGTCTCTCCGTATGTGAACGGGGAGATCCAGAAGGCTGAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAACATTCC
TGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAGATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGCCCTGAC
AGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCCCCCGCC
AAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCATATAGGAGGTCTGTATGTTCACCAACAGTGCGGAGGGGTCACACATTGCAAAACAC

>In-frame_ENST00000429199_ENST00000415816_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=423AA_start in transcript=43_stop in transcript=1314
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGR
RVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAE

--------------------------------------------------------------
>In-frame_ENST00000429199_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(transcript)=1478nt_BP=475nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGGCCCTCCACGCCCTTCAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCT
GAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTCCCATTTTCAGTGCCCAAGATCCCCCTGGTATTCCGAGGACACACCCAGCAGGA
CCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATCCACTGCCCTCTGCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAA
AGTGGCTGAGCAGGTGCTGCAACAAAAGGAGCACACGATCAACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCC
CATGGTCACCACCATCCAGGTGATGATGTCCAGCCAGTTGAGTGGCCGGAGGGTGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAG
TGAGGAGGAGCTGCTGGACAAGCTAGAGATCTTCTTTGGCAAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGG
GAGTGTCATGCTGGGGTTTGCTAGGGATGGAGTGGCTCAGCGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGT
CCCTCTGAGAGTCTCTCCGTATGTGAACGGGGAGATCCAGAAGGCTGAGATCAGGTCGCAGCCAGTTCCCCGCTCGGTACTGGTGCTCAA
CATTCCTGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAGATCCACTTCCAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGC
CCTGACAGTCGTACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCC
CCCGCCAAGGTTCTCACACTGGCCTGGGCTTGGGTGCCCATATAGGAGGTCTGTATGTTCACCAACAGTGCGGAGGGGTCACACATTGCA

>In-frame_ENST00000429199_ENST00000438323_TCGA-AC-A2FB-01A_PGAP3_chr17_37840850_-_IFI35_chr17_41164196_length(amino acids)=425AA_start in transcript=43_stop in transcript=1320
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPF
SVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQVMMSSQLS
GRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGAP3-IFI35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGAP3-IFI35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGAP3-IFI35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGAP3C1855923Hyperphosphatasia with Mental Retardation1CTD_human;ORPHANET
HgenePGAP3C3810354HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 41GENOMICS_ENGLAND;UNIPROT
TgeneIFI35C0000786Spontaneous abortion1CTD_human
TgeneIFI35C0000822Abortion, Tubal1CTD_human
TgeneIFI35C0021400Influenza1CTD_human
TgeneIFI35C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIFI35C3830362Early Pregnancy Loss1CTD_human
TgeneIFI35C4552766Miscarriage1CTD_human