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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGC-PGA4 (FusionGDB2 ID:64173)

Fusion Gene Summary for PGC-PGA4

check button Fusion gene summary
Fusion gene informationFusion gene name: PGC-PGA4
Fusion gene ID: 64173
HgeneTgene
Gene symbol

PGC

PGA4

Gene ID

5225

643847

Gene nameprogastricsinpepsinogen A4
SynonymsPEPC|PGII-
Cytomap

6p21.1

11q12.2

Type of geneprotein-codingprotein-coding
Descriptiongastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsinpepsin A-4pepsinogen 4, group I (pepsinogen A)pepsinogen-4pregnancy-associated glycoprotein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373025, ENST00000425343, 
ENST00000378149, ENST00000422676, 
ENST00000537932, ENST00000544899, 
Fusion gene scores* DoF score18 X 23 X 5=207012 X 27 X 5=1620
# samples 2414
** MAII scorelog2(24/2070*10)=-3.10852445677817
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1620*10)=-3.53249508082702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGC [Title/Abstract] AND PGA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGA4(60990577)-PGC(41712252), # samples:8
PGC(41712134)-PGA4(60993797), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PGA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer115NdPGCchr6

41710027

-PGA4chr11

60996142

+
ChimerDB4Non-Cancer115NdPGCchr6

41712134

-PGA4chr11

60993797

+
ChimerDB4Non-Cancer119NdPGCchr6

41710027

-PGA4chr11

60996142

+
ChimerDB4Non-Cancer139NPGCchr6

41712134

-PGA4chr11

60993797

+
ChimerDB4Non-Cancer169NPGCchr6

41704448

-PGA4chr11

60998853

+
ChimerDB4Non-Cancer5357NPGCchr6

41712134

-PGA4chr11

60993797

+


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Fusion Gene ORF analysis for PGC-PGA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373025ENST00000378149PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000373025ENST00000422676PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000373025ENST00000537932PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000373025ENST00000544899PGCchr6

41710027

-PGA4chr11

60996142

+
In-frameENST00000425343ENST00000378149PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000425343ENST00000422676PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000425343ENST00000537932PGCchr6

41710027

-PGA4chr11

60996142

+
5CDS-intronENST00000425343ENST00000544899PGCchr6

41710027

-PGA4chr11

60996142

+
In-frameENST00000373025ENST00000378149PGCchr6

41712134

-PGA4chr11

60993797

+
In-frameENST00000373025ENST00000422676PGCchr6

41712134

-PGA4chr11

60993797

+
5CDS-intronENST00000373025ENST00000537932PGCchr6

41712134

-PGA4chr11

60993797

+
5CDS-intronENST00000373025ENST00000544899PGCchr6

41712134

-PGA4chr11

60993797

+
In-frameENST00000425343ENST00000378149PGCchr6

41712134

-PGA4chr11

60993797

+
In-frameENST00000425343ENST00000422676PGCchr6

41712134

-PGA4chr11

60993797

+
5CDS-intronENST00000425343ENST00000537932PGCchr6

41712134

-PGA4chr11

60993797

+
5CDS-intronENST00000425343ENST00000544899PGCchr6

41712134

-PGA4chr11

60993797

+
In-frameENST00000373025ENST00000378149PGCchr6

41704448

-PGA4chr11

60998853

+
5CDS-intronENST00000373025ENST00000422676PGCchr6

41704448

-PGA4chr11

60998853

+
5CDS-intronENST00000373025ENST00000537932PGCchr6

41704448

-PGA4chr11

60998853

+
5CDS-intronENST00000373025ENST00000544899PGCchr6

41704448

-PGA4chr11

60998853

+
intron-3CDSENST00000425343ENST00000378149PGCchr6

41704448

-PGA4chr11

60998853

+
intron-intronENST00000425343ENST00000422676PGCchr6

41704448

-PGA4chr11

60998853

+
intron-intronENST00000425343ENST00000537932PGCchr6

41704448

-PGA4chr11

60998853

+
intron-intronENST00000425343ENST00000544899PGCchr6

41704448

-PGA4chr11

60998853

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373025PGCchr641710027-ENST00000378149PGA4chr1160996142+161771061220404
ENST00000425343PGCchr641710027-ENST00000378149PGA4chr1160996142+1621714101224404
ENST00000373025PGCchr641712134-ENST00000378149PGA4chr1160993797+161739161220404
ENST00000373025PGCchr641712134-ENST00000422676PGA4chr1160993797+139739161220404
ENST00000425343PGCchr641712134-ENST00000378149PGA4chr1160993797+1621395101224404
ENST00000425343PGCchr641712134-ENST00000422676PGA4chr1160993797+1401395101224404
ENST00000373025PGCchr641704448-ENST00000378149PGA4chr1160998853+1917137161229407

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373025ENST00000378149PGCchr641710027-PGA4chr1160996142+0.0022265850.99777335
ENST00000425343ENST00000378149PGCchr641710027-PGA4chr1160996142+0.0022471050.99775285
ENST00000373025ENST00000378149PGCchr641712134-PGA4chr1160993797+0.0022003260.9977997
ENST00000373025ENST00000422676PGCchr641712134-PGA4chr1160993797+0.0028382770.99716175
ENST00000425343ENST00000378149PGCchr641712134-PGA4chr1160993797+0.0022444650.9977556
ENST00000425343ENST00000422676PGCchr641712134-PGA4chr1160993797+0.0028553420.99714464
ENST00000373025ENST00000378149PGCchr641704448-PGA4chr1160998853+0.0026838760.99731606

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Fusion Genomic Features for PGC-PGA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGCchr641704448-PGA4chr1160998853+0.093988810.90601116
PGCchr641712134-PGA4chr1160993797+5.66E-050.9999434
PGCchr641710027-PGA4chr1160996142+9.79E-060.9999902
PGCchr641704448-PGA4chr1160998853+0.093988810.90601116
PGCchr641712134-PGA4chr1160993797+5.66E-050.9999434
PGCchr641710027-PGA4chr1160996142+9.79E-060.9999902

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGC-PGA4


check button Go to

FGviewer for the breakpoints of chr6:41710027-chr11:60996142

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGCchr6:41704448chr11:60998853ENST00000373025-9973_385436.0389.0DomainPeptidase A1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGCchr6:41704448chr11:60998853ENST00000425343-1773_3850316.0DomainPeptidase A1
HgenePGCchr6:41710027chr11:60996142ENST00000373025-5973_385215.66666666666666389.0DomainPeptidase A1
HgenePGCchr6:41710027chr11:60996142ENST00000425343-5773_385215.66666666666666316.0DomainPeptidase A1
HgenePGCchr6:41712134chr11:60993797ENST00000373025-3973_385109.33333333333333389.0DomainPeptidase A1
HgenePGCchr6:41712134chr11:60993797ENST00000425343-3773_385109.33333333333333316.0DomainPeptidase A1
TgenePGA4chr6:41704448chr11:60998853ENST000003781497976_385339.0389.0DomainPeptidase A1
TgenePGA4chr6:41710027chr11:60996142ENST000003781494976_385218.66666666666666389.0DomainPeptidase A1
TgenePGA4chr6:41712134chr11:60993797ENST000003781492976_385112.33333333333333389.0DomainPeptidase A1


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Fusion Gene Sequence for PGC-PGA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373025_ENST00000378149_115Nd_PGC_chr6_41710027_-_PGA4_chr11_60996142_length(transcript)=1617nt_BP=710nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACGCCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>In-frame_ENST00000373025_ENST00000378149_115Nd_PGC_chr6_41710027_-_PGA4_chr11_60996142_length(amino acids)=404AA_start in transcript=6_stop in transcript=1220
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000425343_ENST00000378149_115Nd_PGC_chr6_41710027_-_PGA4_chr11_60996142_length(transcript)=1621nt_BP=714nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCA
GACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCA
GGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTC
CGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACGCCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>In-frame_ENST00000425343_ENST00000378149_115Nd_PGC_chr6_41710027_-_PGA4_chr11_60996142_length(amino acids)=404AA_start in transcript=10_stop in transcript=1224
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000373025_ENST00000378149_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(transcript)=1617nt_BP=391nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGAGACA
GTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCAGATC
TTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCC
TCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACGCCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>In-frame_ENST00000373025_ENST00000378149_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(amino acids)=404AA_start in transcript=6_stop in transcript=1220
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000373025_ENST00000422676_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(transcript)=1397nt_BP=391nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGAGACA
GTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCAGATC
TTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCC
TCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACAAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCTGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCCGTCCTATGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGAAGGTCTTGGCCCTGTTCCCTGTCCTAC

>In-frame_ENST00000373025_ENST00000422676_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(amino acids)=404AA_start in transcript=6_stop in transcript=1220
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000425343_ENST00000378149_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(transcript)=1621nt_BP=395nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGA
GACAGTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCA
GATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTC
CTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACGCCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>In-frame_ENST00000425343_ENST00000378149_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(amino acids)=404AA_start in transcript=10_stop in transcript=1224
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000425343_ENST00000422676_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(transcript)=1401nt_BP=395nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGA
GACAGTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCA
GATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTC
CTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGA
CAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCTGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCCGTCCTATGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGAAGGTCTTGGCCCTGTTCCCTGTC

>In-frame_ENST00000425343_ENST00000422676_115Nd_PGC_chr6_41712134_-_PGA4_chr11_60993797_length(amino acids)=404AA_start in transcript=10_stop in transcript=1224
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>In-frame_ENST00000373025_ENST00000378149_169N_PGC_chr6_41704448_-_PGA4_chr11_60998853_length(transcript)=1917nt_BP=1371nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGC
TCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACACGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTAC
TGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCTGGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACC
TCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCACAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAAC
TGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTGTGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAAC
AACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGAACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGG
TCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCACTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTC
TTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACTCTGGATTCAGCCTTCTTTTTCTGGACTCTGGACTTTCTCTA
ATAATAAATAGTTCTTCTTTAAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATC
CTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTC
TCTTCAGCCACCTCCCAGGAAGATCTGGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTG
TGGAGGTCTTGGCCCTGTTCCCTGTCCTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTT
GCTGGTCTTTTTCCTTCACATTACTGGGGTTAGAACGCCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTG
ACCCCAGCAGCTGACACTTCATGATGGAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTC

>In-frame_ENST00000373025_ENST00000378149_169N_PGC_chr6_41704448_-_PGA4_chr11_60998853_length(amino acids)=407AA_start in transcript=6_stop in transcript=1229
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQ
IGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGC-PGA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGC-PGA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGC-PGA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource