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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGD-CLSTN1 (FusionGDB2 ID:64183)

Fusion Gene Summary for PGD-CLSTN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PGD-CLSTN1
Fusion gene ID: 64183
HgeneTgene
Gene symbol

PGD

CLSTN1

Gene ID

26227

22883

Gene namephosphoglycerate dehydrogenasecalsyntenin 1
Synonyms3-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERAALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2
Cytomap

1p12

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionD-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenasecalsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha
Modification date2020032020200313
UniProtAcc.

O94985

Ensembl transtripts involved in fusion geneENST00000541529, ENST00000270776, 
ENST00000538557, ENST00000498356, 
ENST00000377298, ENST00000361311, 
ENST00000377288, ENST00000477264, 
Fusion gene scores* DoF score11 X 8 X 6=52810 X 10 X 5=500
# samples 1212
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/500*10)=-2.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGD [Title/Abstract] AND CLSTN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGD(10459761)-CLSTN1(9790763), # samples:1
Anticipated loss of major functional domain due to fusion event.PGD-CLSTN1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PGD-CLSTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLSTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6869-01APGDchr1

10459761

+CLSTN1chr1

9790763

-


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Fusion Gene ORF analysis for PGD-CLSTN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000541529ENST00000377298PGDchr1

10459761

+CLSTN1chr1

9790763

-
In-frameENST00000541529ENST00000361311PGDchr1

10459761

+CLSTN1chr1

9790763

-
Frame-shiftENST00000541529ENST00000377288PGDchr1

10459761

+CLSTN1chr1

9790763

-
5CDS-5UTRENST00000541529ENST00000477264PGDchr1

10459761

+CLSTN1chr1

9790763

-
Frame-shiftENST00000270776ENST00000377298PGDchr1

10459761

+CLSTN1chr1

9790763

-
In-frameENST00000270776ENST00000361311PGDchr1

10459761

+CLSTN1chr1

9790763

-
Frame-shiftENST00000270776ENST00000377288PGDchr1

10459761

+CLSTN1chr1

9790763

-
5CDS-5UTRENST00000270776ENST00000477264PGDchr1

10459761

+CLSTN1chr1

9790763

-
Frame-shiftENST00000538557ENST00000377298PGDchr1

10459761

+CLSTN1chr1

9790763

-
In-frameENST00000538557ENST00000361311PGDchr1

10459761

+CLSTN1chr1

9790763

-
Frame-shiftENST00000538557ENST00000377288PGDchr1

10459761

+CLSTN1chr1

9790763

-
5CDS-5UTRENST00000538557ENST00000477264PGDchr1

10459761

+CLSTN1chr1

9790763

-
intron-3CDSENST00000498356ENST00000377298PGDchr1

10459761

+CLSTN1chr1

9790763

-
intron-3CDSENST00000498356ENST00000361311PGDchr1

10459761

+CLSTN1chr1

9790763

-
intron-3CDSENST00000498356ENST00000377288PGDchr1

10459761

+CLSTN1chr1

9790763

-
intron-5UTRENST00000498356ENST00000477264PGDchr1

10459761

+CLSTN1chr1

9790763

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541529PGDchr110459761+ENST00000361311CLSTN1chr19790763-181113315201068150
ENST00000270776PGDchr110459761+ENST00000361311CLSTN1chr19790763-180012215091057150
ENST00000538557PGDchr110459761+ENST00000361311CLSTN1chr19790763-196728916761224150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541529ENST00000361311PGDchr110459761+CLSTN1chr19790763-0.84113420.15886582
ENST00000270776ENST00000361311PGDchr110459761+CLSTN1chr19790763-0.7813260.21867406
ENST00000538557ENST00000361311PGDchr110459761+CLSTN1chr19790763-0.90322780.09677219

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Fusion Genomic Features for PGD-CLSTN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGD-CLSTN1


check button Go to

FGviewer for the breakpoints of chr1:10459761-chr1:9790763

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLSTN1

O94985

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250, ECO:0000269|PubMed:12972431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10459761chr1:9790763ENST00000270776+21310_1528.0484.0Nucleotide bindingNADP
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003613111618916_959906.0972.0Compositional biasNote=Glu-rich (highly acidic)
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003772981719916_959916.0982.0Compositional biasNote=Glu-rich (highly acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10459761chr1:9790763ENST00000270776+21333_3528.0484.0Nucleotide bindingNADP
HgenePGDchr1:10459761chr1:9790763ENST00000270776+213478_48128.0484.0Nucleotide bindingNADP%3B shared with dimeric partner
HgenePGDchr1:10459761chr1:9790763ENST00000270776+21375_7728.0484.0Nucleotide bindingNADP
HgenePGDchr1:10459761chr1:9790763ENST00000270776+213129_13128.0484.0RegionSubstrate binding
HgenePGDchr1:10459761chr1:9790763ENST00000270776+213187_18828.0484.0RegionSubstrate binding
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003613111618165_265906.0972.0DomainCadherin 2
TgeneCLSTN1chr1:10459761chr1:9790763ENST00000361311161838_164906.0972.0DomainCadherin 1
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003772981719165_265916.0982.0DomainCadherin 2
TgeneCLSTN1chr1:10459761chr1:9790763ENST00000377298171938_164916.0982.0DomainCadherin 1
TgeneCLSTN1chr1:10459761chr1:9790763ENST00000361311161829_859906.0972.0Topological domainExtracellular
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003613111618881_981906.0972.0Topological domainCytoplasmic
TgeneCLSTN1chr1:10459761chr1:9790763ENST00000377298171929_859916.0982.0Topological domainExtracellular
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003772981719881_981916.0982.0Topological domainCytoplasmic
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003613111618860_880906.0972.0TransmembraneHelical
TgeneCLSTN1chr1:10459761chr1:9790763ENST000003772981719860_880916.0982.0TransmembraneHelical


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Fusion Gene Sequence for PGD-CLSTN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000541529_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(transcript)=1811nt_BP=133nt
ACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCAT
GGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGACCTATGAGGACCAGCACAGCAGTGAGGAGGAGGAGGAAGAGGAAGA
GGAAGAGGAAAGCGAGGACGGCGAAGAAGAGGATGACATCACCAGCGCCGAGTCGGAGAGCAGCGAGGAGGAGGAGGGGGAGCAGGGCGA
CCCCCAGAACGCAACCCGGCAGCAGCAGCTGGAGTGGGATGACTCCACCCTCAGCTACTGACCCGTGCCCCCGGCCACCTCGGTTTCTGC
TTTCGAAGACTCTGCTGCCATCCGTTCTCCCAGTCCCAAGGGTCCACGATGTACAAAGTCATTTCGGCCAGTAGGTGTGCAGACCCCTCC
CCGCCACGATCGTCGCTGTGCTTGGTGTGTAGGACCCTAGGCTCCCCGCCCACCCTCTGCCTGGTCGCGCTCTTCAGTCCCACGAGGAGC
TGACACGTCCTCTCTGGCCGCCATCCGGCTCGCACAGGGGCCTCCCAGCGCCTCAGGCCCCGCGTTTGTGTCTGGAGTCTCCCCCCGGGG
AGAGGACACTGGCCCCTCGCACTCCAGAAAAGCCATGCCAGCTGGGCTCGTTGACAAAGGGTAAAACATGCTCACTCCCACCCGGTAATC
ATTTTTTTCTTTTTTTAAAAAAAGTTTTTATTTTTTCCAAACTAGTGCATGTATAAATAATGGCAGGATGGGGGGTACTGTGTAGATGAT
TAACTGACTTTTTAATATTTTGTAAATAAATCGGATTCCTTGTGTCCTTTGTGCTAGTGTAACCCGGGACTGGAATGTAAAGTGAAGTTC
GGAGCTCTGAGCACGGGCTCTTCCCGCCGGGTCCTCCCTCCCCAGACCCCAGAGGGAGAGGCCCACCCCGCCCAGCCCCGCCCCAGCCCC
TGCTCAGGTCTGAGTATGGCTGGGAGTCGGGGGCCACAGGCCTCTAGCTGTGCTGCTCAAGAGACTGGATCAGGGTAGCTACAAGTGGCC
GGGCCTTGCCTTTGGGATTCTACCTGTTCCTAATTTGGTGTGGGGTGCGGGGTCCCTGGCCCCTTTTCCACACTCCTCCTCCGACAGCAG
CTCCCTGGGCAGTGGCCTGGTCTCACCGTGTGCAGCCTTGTGGTTTATGCTTAAATGTACATTTTCCTGCTGGTAAAAGGAGAAACTGAG
AGGTGTCCTGCAGACCGGCTGACCACTCCTTTTGGAGACGGCAGGAGGCCTGAGCGATCCGTACTCAGAACGTCCAGGAGAGACGCATGG
CCCGAAGTCAAAGTGCTGGAATTTTCCAAAACAGCCTGTTCTCTCCTCTCTCCTCCCCAGAGCACCCCCTGCCATCAGGGGGGTTGAAAT
CCCTCTCCCCCAGGAGCCCTGCTGCTTTGCTTGGTGGTAGGGCAGGAGAGCAAACAAACAGTCATGGTCTAAAACCCACATAGCACTTTG
CTCTTAGTTACATGTAAAATTTTAGATTTCTAAAACAGGTGGGCAATCATTTTGAATACTGTTCTGTGACCCTGACTGCTAGTTCTGAGG
ACACTGGTGGCTGTGCTATGTGTGGCCATCCTCCATGTCCCGTCCCTGTAGCTGCTCTGTTTAGACAGCGGACAGACGCTCACGCCCAGG
GGATGTCCTCACGCTGTCGCCGCGCGGTTTCCCTTCGCAGATGTGTATACTCATGATAGGTCAGAAAGTGTATCCGCTACAATAAAGTTC

>In-frame_ENST00000541529_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(amino acids)=150AA_start in transcript=1520_stop in transcript=1068
MWVLDHDCLFALLPYHQAKQQGSWGRGISTPLMAGGALGRREERTGCFGKFQHFDFGPCVSPGRSEYGSLRPPAVSKRSGQPVCRTPLSF

--------------------------------------------------------------
>In-frame_ENST00000270776_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(transcript)=1800nt_BP=122nt
GCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACT
TAATTCTGAACATGAATGACCACGGCTTTGTGACCTATGAGGACCAGCACAGCAGTGAGGAGGAGGAGGAAGAGGAAGAGGAAGAGGAAA
GCGAGGACGGCGAAGAAGAGGATGACATCACCAGCGCCGAGTCGGAGAGCAGCGAGGAGGAGGAGGGGGAGCAGGGCGACCCCCAGAACG
CAACCCGGCAGCAGCAGCTGGAGTGGGATGACTCCACCCTCAGCTACTGACCCGTGCCCCCGGCCACCTCGGTTTCTGCTTTCGAAGACT
CTGCTGCCATCCGTTCTCCCAGTCCCAAGGGTCCACGATGTACAAAGTCATTTCGGCCAGTAGGTGTGCAGACCCCTCCCCGCCACGATC
GTCGCTGTGCTTGGTGTGTAGGACCCTAGGCTCCCCGCCCACCCTCTGCCTGGTCGCGCTCTTCAGTCCCACGAGGAGCTGACACGTCCT
CTCTGGCCGCCATCCGGCTCGCACAGGGGCCTCCCAGCGCCTCAGGCCCCGCGTTTGTGTCTGGAGTCTCCCCCCGGGGAGAGGACACTG
GCCCCTCGCACTCCAGAAAAGCCATGCCAGCTGGGCTCGTTGACAAAGGGTAAAACATGCTCACTCCCACCCGGTAATCATTTTTTTCTT
TTTTTAAAAAAAGTTTTTATTTTTTCCAAACTAGTGCATGTATAAATAATGGCAGGATGGGGGGTACTGTGTAGATGATTAACTGACTTT
TTAATATTTTGTAAATAAATCGGATTCCTTGTGTCCTTTGTGCTAGTGTAACCCGGGACTGGAATGTAAAGTGAAGTTCGGAGCTCTGAG
CACGGGCTCTTCCCGCCGGGTCCTCCCTCCCCAGACCCCAGAGGGAGAGGCCCACCCCGCCCAGCCCCGCCCCAGCCCCTGCTCAGGTCT
GAGTATGGCTGGGAGTCGGGGGCCACAGGCCTCTAGCTGTGCTGCTCAAGAGACTGGATCAGGGTAGCTACAAGTGGCCGGGCCTTGCCT
TTGGGATTCTACCTGTTCCTAATTTGGTGTGGGGTGCGGGGTCCCTGGCCCCTTTTCCACACTCCTCCTCCGACAGCAGCTCCCTGGGCA
GTGGCCTGGTCTCACCGTGTGCAGCCTTGTGGTTTATGCTTAAATGTACATTTTCCTGCTGGTAAAAGGAGAAACTGAGAGGTGTCCTGC
AGACCGGCTGACCACTCCTTTTGGAGACGGCAGGAGGCCTGAGCGATCCGTACTCAGAACGTCCAGGAGAGACGCATGGCCCGAAGTCAA
AGTGCTGGAATTTTCCAAAACAGCCTGTTCTCTCCTCTCTCCTCCCCAGAGCACCCCCTGCCATCAGGGGGGTTGAAATCCCTCTCCCCC
AGGAGCCCTGCTGCTTTGCTTGGTGGTAGGGCAGGAGAGCAAACAAACAGTCATGGTCTAAAACCCACATAGCACTTTGCTCTTAGTTAC
ATGTAAAATTTTAGATTTCTAAAACAGGTGGGCAATCATTTTGAATACTGTTCTGTGACCCTGACTGCTAGTTCTGAGGACACTGGTGGC
TGTGCTATGTGTGGCCATCCTCCATGTCCCGTCCCTGTAGCTGCTCTGTTTAGACAGCGGACAGACGCTCACGCCCAGGGGATGTCCTCA
CGCTGTCGCCGCGCGGTTTCCCTTCGCAGATGTGTATACTCATGATAGGTCAGAAAGTGTATCCGCTACAATAAAGTTCTGGTTCTAACT

>In-frame_ENST00000270776_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(amino acids)=150AA_start in transcript=1509_stop in transcript=1057
MWVLDHDCLFALLPYHQAKQQGSWGRGISTPLMAGGALGRREERTGCFGKFQHFDFGPCVSPGRSEYGSLRPPAVSKRSGQPVCRTPLSF

--------------------------------------------------------------
>In-frame_ENST00000538557_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(transcript)=1967nt_BP=289nt
ATGGCCCAGTGAGTGACTCGCCAGGGGCAGCCCGGCTCGGCCTCAGCGGGCGGGGAACTCTTTGGGGGTCGAGATCTCCCTCGTTCTCTC
CGACGCCTCCCACCCTGGGGGTCGCCTGAGCTCACTTGGGGCTCTGTGACCCTGGCCCTACGGCGTCTCGGGCCCAGAGCTCCTTCCCTG
CGGGCCCGGCCCCCTGCCCTCTCGGCCGCGCAGAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACAT
GAATGACCACGGCTTTGTGACCTATGAGGACCAGCACAGCAGTGAGGAGGAGGAGGAAGAGGAAGAGGAAGAGGAAAGCGAGGACGGCGA
AGAAGAGGATGACATCACCAGCGCCGAGTCGGAGAGCAGCGAGGAGGAGGAGGGGGAGCAGGGCGACCCCCAGAACGCAACCCGGCAGCA
GCAGCTGGAGTGGGATGACTCCACCCTCAGCTACTGACCCGTGCCCCCGGCCACCTCGGTTTCTGCTTTCGAAGACTCTGCTGCCATCCG
TTCTCCCAGTCCCAAGGGTCCACGATGTACAAAGTCATTTCGGCCAGTAGGTGTGCAGACCCCTCCCCGCCACGATCGTCGCTGTGCTTG
GTGTGTAGGACCCTAGGCTCCCCGCCCACCCTCTGCCTGGTCGCGCTCTTCAGTCCCACGAGGAGCTGACACGTCCTCTCTGGCCGCCAT
CCGGCTCGCACAGGGGCCTCCCAGCGCCTCAGGCCCCGCGTTTGTGTCTGGAGTCTCCCCCCGGGGAGAGGACACTGGCCCCTCGCACTC
CAGAAAAGCCATGCCAGCTGGGCTCGTTGACAAAGGGTAAAACATGCTCACTCCCACCCGGTAATCATTTTTTTCTTTTTTTAAAAAAAG
TTTTTATTTTTTCCAAACTAGTGCATGTATAAATAATGGCAGGATGGGGGGTACTGTGTAGATGATTAACTGACTTTTTAATATTTTGTA
AATAAATCGGATTCCTTGTGTCCTTTGTGCTAGTGTAACCCGGGACTGGAATGTAAAGTGAAGTTCGGAGCTCTGAGCACGGGCTCTTCC
CGCCGGGTCCTCCCTCCCCAGACCCCAGAGGGAGAGGCCCACCCCGCCCAGCCCCGCCCCAGCCCCTGCTCAGGTCTGAGTATGGCTGGG
AGTCGGGGGCCACAGGCCTCTAGCTGTGCTGCTCAAGAGACTGGATCAGGGTAGCTACAAGTGGCCGGGCCTTGCCTTTGGGATTCTACC
TGTTCCTAATTTGGTGTGGGGTGCGGGGTCCCTGGCCCCTTTTCCACACTCCTCCTCCGACAGCAGCTCCCTGGGCAGTGGCCTGGTCTC
ACCGTGTGCAGCCTTGTGGTTTATGCTTAAATGTACATTTTCCTGCTGGTAAAAGGAGAAACTGAGAGGTGTCCTGCAGACCGGCTGACC
ACTCCTTTTGGAGACGGCAGGAGGCCTGAGCGATCCGTACTCAGAACGTCCAGGAGAGACGCATGGCCCGAAGTCAAAGTGCTGGAATTT
TCCAAAACAGCCTGTTCTCTCCTCTCTCCTCCCCAGAGCACCCCCTGCCATCAGGGGGGTTGAAATCCCTCTCCCCCAGGAGCCCTGCTG
CTTTGCTTGGTGGTAGGGCAGGAGAGCAAACAAACAGTCATGGTCTAAAACCCACATAGCACTTTGCTCTTAGTTACATGTAAAATTTTA
GATTTCTAAAACAGGTGGGCAATCATTTTGAATACTGTTCTGTGACCCTGACTGCTAGTTCTGAGGACACTGGTGGCTGTGCTATGTGTG
GCCATCCTCCATGTCCCGTCCCTGTAGCTGCTCTGTTTAGACAGCGGACAGACGCTCACGCCCAGGGGATGTCCTCACGCTGTCGCCGCG

>In-frame_ENST00000538557_ENST00000361311_TCGA-BA-6869-01A_PGD_chr1_10459761_+_CLSTN1_chr1_9790763_length(amino acids)=150AA_start in transcript=1676_stop in transcript=1224
MWVLDHDCLFALLPYHQAKQQGSWGRGISTPLMAGGALGRREERTGCFGKFQHFDFGPCVSPGRSEYGSLRPPAVSKRSGQPVCRTPLSF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGD-CLSTN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGD-CLSTN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGD-CLSTN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGDC2239176Liver carcinoma1CTD_human