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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGD-NTSR1 (FusionGDB2 ID:64188)

Fusion Gene Summary for PGD-NTSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: PGD-NTSR1
Fusion gene ID: 64188
HgeneTgene
Gene symbol

PGD

NTSR1

Gene ID

26227

4923

Gene namephosphoglycerate dehydrogenaseneurotensin receptor 1
Synonyms3-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERANTR
Cytomap

1p12

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionD-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenaseneurotensin receptor type 1NT-R-1NTR1NTRHhigh-affinity levocabastine-insensitive neurotensin receptorneurotensin receptor 1 (high affinity)
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000541529, ENST00000270776, 
ENST00000538557, ENST00000498356, 
ENST00000370501, ENST00000482259, 
Fusion gene scores* DoF score11 X 8 X 6=5284 X 3 X 4=48
# samples 125
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PGD [Title/Abstract] AND NTSR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGD(10459761)-NTSR1(61386037), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTSR1

GO:0007218

neuropeptide signaling pathway

21725197


check buttonFusion gene breakpoints across PGD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NTSR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-58-A46K-01APGDchr1

10459761

+NTSR1chr20

61386037

+
ChimerDB4LUSCTCGA-58-A46KPGDchr1

10459761

+NTSR1chr20

61386037

+
ChimerDB4LUSCTCGA-58-A46K-01APGDchr1

10459761

-NTSR1chr20

61386037

+


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Fusion Gene ORF analysis for PGD-NTSR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000541529ENST00000370501PGDchr1

10459761

+NTSR1chr20

61386037

+
5CDS-intronENST00000541529ENST00000482259PGDchr1

10459761

+NTSR1chr20

61386037

+
In-frameENST00000270776ENST00000370501PGDchr1

10459761

+NTSR1chr20

61386037

+
5CDS-intronENST00000270776ENST00000482259PGDchr1

10459761

+NTSR1chr20

61386037

+
In-frameENST00000538557ENST00000370501PGDchr1

10459761

+NTSR1chr20

61386037

+
5CDS-intronENST00000538557ENST00000482259PGDchr1

10459761

+NTSR1chr20

61386037

+
intron-3CDSENST00000498356ENST00000370501PGDchr1

10459761

+NTSR1chr20

61386037

+
intron-intronENST00000498356ENST00000482259PGDchr1

10459761

+NTSR1chr20

61386037

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541529PGDchr110459761+ENST00000370501NTSR1chr2061386037+318013310091728239
ENST00000270776PGDchr110459761+ENST00000370501NTSR1chr2061386037+31691229981717239
ENST00000538557PGDchr110459761+ENST00000370501NTSR1chr2061386037+333628911651884239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541529ENST00000370501PGDchr110459761+NTSR1chr2061386037+0.499773830.5002262
ENST00000270776ENST00000370501PGDchr110459761+NTSR1chr2061386037+0.513622760.4863772
ENST00000538557ENST00000370501PGDchr110459761+NTSR1chr2061386037+0.54324050.45675948

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Fusion Genomic Features for PGD-NTSR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGDchr110459761+NTSR1chr2061386036+1.97E-111
PGDchr110459761+NTSR1chr2061386036+1.97E-111
PGDchr110459761+NTSR1chr2061386036+1.97E-111
PGDchr110459761+NTSR1chr2061386036+1.97E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGD-NTSR1


check button Go to

FGviewer for the breakpoints of chr1:10459761-chr20:61386037

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10459761chr20:61386037ENST00000270776+21310_1528.0484.0Nucleotide bindingNADP
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104321_344238.0419.0RegionNeurotensin binding
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104260_303238.0419.0Topological domainCytoplasmic
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104326_343238.0419.0Topological domainExtracellular
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104365_418238.0419.0Topological domainCytoplasmic
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104235_259238.0419.0TransmembraneHelical%3B Name%3D5
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104304_325238.0419.0TransmembraneHelical%3B Name%3D6
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104344_364238.0419.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10459761chr20:61386037ENST00000270776+21333_3528.0484.0Nucleotide bindingNADP
HgenePGDchr1:10459761chr20:61386037ENST00000270776+213478_48128.0484.0Nucleotide bindingNADP%3B shared with dimeric partner
HgenePGDchr1:10459761chr20:61386037ENST00000270776+21375_7728.0484.0Nucleotide bindingNADP
HgenePGDchr1:10459761chr20:61386037ENST00000270776+213129_13128.0484.0RegionSubstrate binding
HgenePGDchr1:10459761chr20:61386037ENST00000270776+213187_18828.0484.0RegionSubstrate binding
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104123_142238.0419.0Topological domainExtracellular
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104165_184238.0419.0Topological domainCytoplasmic
TgeneNTSR1chr1:10459761chr20:61386037ENST00000370501041_67238.0419.0Topological domainExtracellular
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104206_234238.0419.0Topological domainExtracellular
TgeneNTSR1chr1:10459761chr20:61386037ENST000003705010489_102238.0419.0Topological domainCytoplasmic
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104103_122238.0419.0TransmembraneHelical%3B Name%3D2
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104143_164238.0419.0TransmembraneHelical%3B Name%3D3
TgeneNTSR1chr1:10459761chr20:61386037ENST0000037050104185_205238.0419.0TransmembraneHelical%3B Name%3D4
TgeneNTSR1chr1:10459761chr20:61386037ENST000003705010468_88238.0419.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for PGD-NTSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000541529_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(transcript)=3180nt_BP=133nt
ACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCAT
GGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGT
CCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAG
CACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGT
CTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTA
CTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACAT
CTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAG
CAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGT
CCTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGG
ACCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCT
TTGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTC
TTTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCAT
GTCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGC
AGACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGG
CCCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATG
GGCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCAC
ATGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTC
CAGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGC
CCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAG
GAACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTC
TGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATG
ACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGA
GCCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCT
GCCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGT
CTGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCT
CTCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCAC
AAGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCC
CACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTG
CTCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGC
CTCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCC
CTCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGT
GGATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATG
TCTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACT
AGCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGC
CCCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCA

>In-frame_ENST00000541529_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(amino acids)=239AA_start in transcript=1009_stop in transcript=1728
MVPEKEMKGAGWGRASGGPAAVPMSTSLRPAPPLSSSGSPAPVPQAPWLWASRADPAMQTHAPLPQAAPRKLPDSPLQAWQAGGPSPWGV
PPTTLAAGSCSPQRGPQAQKGQKWAGLEWPRPQPPLLPPILTQAKAQGLCQDTTWEGAQASASRSSAVASRARQKGRRIRGLVSSTCPSG

--------------------------------------------------------------
>In-frame_ENST00000270776_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(transcript)=3169nt_BP=122nt
GCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACT
TAATTCTGAACATGAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCA
TCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCA
TGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGC
CCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGG
TGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCA
CACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCC
TCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCG
ACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTC
CCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAG
AACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAG
ACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTC
TGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCA
TGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGT
GGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGG
AATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGG
CTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCC
CGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGC
TTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCT
TCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCA
GCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGC
CCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAG
CAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGG
CCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGA
GAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACA
GGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCA
TCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCC
CATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGG
GCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTT
CTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGG
ATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCAC
TGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTC
CTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCC
AGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACG
GCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAATAAAGGTGGC

>In-frame_ENST00000270776_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(amino acids)=239AA_start in transcript=998_stop in transcript=1717
MVPEKEMKGAGWGRASGGPAAVPMSTSLRPAPPLSSSGSPAPVPQAPWLWASRADPAMQTHAPLPQAAPRKLPDSPLQAWQAGGPSPWGV
PPTTLAAGSCSPQRGPQAQKGQKWAGLEWPRPQPPLLPPILTQAKAQGLCQDTTWEGAQASASRSSAVASRARQKGRRIRGLVSSTCPSG

--------------------------------------------------------------
>In-frame_ENST00000538557_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(transcript)=3336nt_BP=289nt
ATGGCCCAGTGAGTGACTCGCCAGGGGCAGCCCGGCTCGGCCTCAGCGGGCGGGGAACTCTTTGGGGGTCGAGATCTCCCTCGTTCTCTC
CGACGCCTCCCACCCTGGGGGTCGCCTGAGCTCACTTGGGGCTCTGTGACCCTGGCCCTACGGCGTCTCGGGCCCAGAGCTCCTTCCCTG
CGGGCCCGGCCCCCTGCCCTCTCGGCCGCGCAGAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACAT
GAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAA
GCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCC
TGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCG
GCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACT
CTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCT
CTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGC
CACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAG
CCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACC
CATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGC
TCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGT
TCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACC
CCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGC
CCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCC
CACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACC
CCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGC
CTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGG
CCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGC
CTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGG
AGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGG
CCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGA
AGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCT
TTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCA
GGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTA
CAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCT
CACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGC
CCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCT
GCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAG
CAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCT
GGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCT
GGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCT
CGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACT
TACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTG
GCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCAC
AGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAATAAAGGTGGCCGAAGGGCCTCGA

>In-frame_ENST00000538557_ENST00000370501_TCGA-58-A46K-01A_PGD_chr1_10459761_+_NTSR1_chr20_61386037_length(amino acids)=239AA_start in transcript=1165_stop in transcript=1884
MVPEKEMKGAGWGRASGGPAAVPMSTSLRPAPPLSSSGSPAPVPQAPWLWASRADPAMQTHAPLPQAAPRKLPDSPLQAWQAGGPSPWGV
PPTTLAAGSCSPQRGPQAQKGQKWAGLEWPRPQPPLLPPILTQAKAQGLCQDTTWEGAQASASRSSAVASRARQKGRRIRGLVSSTCPSG

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Fusion Gene PPI Analysis for PGD-NTSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGD-NTSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGD-NTSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGDC2239176Liver carcinoma1CTD_human
TgeneNTSR1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTSR1C0030193Pain1CTD_human
TgeneNTSR1C0036341Schizophrenia1CTD_human
TgeneNTSR1C0234230Pain, Burning1CTD_human
TgeneNTSR1C0234238Ache1CTD_human
TgeneNTSR1C0234254Radiating pain1CTD_human
TgeneNTSR1C0458257Pain, Splitting1CTD_human
TgeneNTSR1C0458259Pain, Crushing1CTD_human
TgeneNTSR1C0525045Mood Disorders1PSYGENET
TgeneNTSR1C0751407Pain, Migratory1CTD_human
TgeneNTSR1C0751408Suffering, Physical1CTD_human
TgeneNTSR1C1510586Autism Spectrum Disorders1CTD_human