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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGD-PEX14 (FusionGDB2 ID:64189)

Fusion Gene Summary for PGD-PEX14

check button Fusion gene summary
Fusion gene informationFusion gene name: PGD-PEX14
Fusion gene ID: 64189
HgeneTgene
Gene symbol

PGD

PEX14

Gene ID

26227

5195

Gene namephosphoglycerate dehydrogenaseperoxisomal biogenesis factor 14
Synonyms3-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERANAPP2|PBD13A|Pex14p|dJ734G22.2
Cytomap

1p12

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionD-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenaseperoxisomal membrane protein PEX14NF-E2 associated polypeptide 2PTS1 receptor docking proteinperoxin-14peroxisomal membrane anchor protein PEX14peroxisomal membrane anchor protein Pex14p
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000541529, ENST00000270776, 
ENST00000538557, ENST00000498356, 
ENST00000356607, ENST00000538836, 
ENST00000492696, 
Fusion gene scores* DoF score11 X 8 X 6=52813 X 10 X 7=910
# samples 1213
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGD [Title/Abstract] AND PEX14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGD(10460629)-PEX14(10596270), # samples:2
PEX14(10535059)-PGD(10459685), # samples:1
PEX14(10535059)-PGD(10459686), # samples:1
Anticipated loss of major functional domain due to fusion event.PEX14-PGD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PEX14-PGD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePEX14

GO:0016561

protein import into peroxisome matrix, translocation

21525035

TgenePEX14

GO:0032091

negative regulation of protein binding

21976670

TgenePEX14

GO:0034453

microtubule anchoring

21525035

TgenePEX14

GO:0036250

peroxisome transport along microtubule

21525035

TgenePEX14

GO:0043433

negative regulation of DNA-binding transcription factor activity

11863372

TgenePEX14

GO:0044721

protein import into peroxisome matrix, substrate release

21976670

TgenePEX14

GO:0045892

negative regulation of transcription, DNA-templated

11863372

TgenePEX14

GO:0065003

protein-containing complex assembly

21525035


check buttonFusion gene breakpoints across PGD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PEX14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1OD-01APGDchr1

10460629

+PEX14chr1

10596270

+
ChimerDB4CESCTCGA-DS-A1OD-01APGDchr1

10460629

+PEX14chr1

10596270

+


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Fusion Gene ORF analysis for PGD-PEX14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000541529ENST00000356607PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-intronENST00000541529ENST00000538836PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-3UTRENST00000541529ENST00000492696PGDchr1

10460629

+PEX14chr1

10596270

+
In-frameENST00000270776ENST00000356607PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-intronENST00000270776ENST00000538836PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-3UTRENST00000270776ENST00000492696PGDchr1

10460629

+PEX14chr1

10596270

+
In-frameENST00000538557ENST00000356607PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-intronENST00000538557ENST00000538836PGDchr1

10460629

+PEX14chr1

10596270

+
5CDS-3UTRENST00000538557ENST00000492696PGDchr1

10460629

+PEX14chr1

10596270

+
intron-3CDSENST00000498356ENST00000356607PGDchr1

10460629

+PEX14chr1

10596270

+
intron-intronENST00000498356ENST00000538836PGDchr1

10460629

+PEX14chr1

10596270

+
intron-3UTRENST00000498356ENST00000492696PGDchr1

10460629

+PEX14chr1

10596270

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541529PGDchr110460629+ENST00000356607PEX14chr110596270+2134313371362441
ENST00000270776PGDchr110460629+ENST00000356607PEX14chr110596270+2123302261351441
ENST00000538557PGDchr110460629+ENST00000356607PEX14chr110596270+22904691931518441

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541529ENST00000356607PGDchr110460629+PEX14chr110596270+0.0035370340.996463
ENST00000270776ENST00000356607PGDchr110460629+PEX14chr110596270+0.0037015650.9962985
ENST00000538557ENST00000356607PGDchr110460629+PEX14chr110596270+0.0044496090.9955504

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Fusion Genomic Features for PGD-PEX14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGDchr110460629+PEX14chr110596269+1.13E-101
PGDchr110460629+PEX14chr110596269+1.13E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGD-PEX14


check button Go to

FGviewer for the breakpoints of chr1:10460629-chr1:10596270

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10460629chr1:10596270ENST00000270776+31310_1588.0484.0Nucleotide bindingNADP
HgenePGDchr1:10460629chr1:10596270ENST00000270776+31333_3588.0484.0Nucleotide bindingNADP
HgenePGDchr1:10460629chr1:10596270ENST00000270776+31375_7788.0484.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGDchr1:10460629chr1:10596270ENST00000270776+313478_48188.0484.0Nucleotide bindingNADP%3B shared with dimeric partner
HgenePGDchr1:10460629chr1:10596270ENST00000270776+313129_13188.0484.0RegionSubstrate binding
HgenePGDchr1:10460629chr1:10596270ENST00000270776+313187_18888.0484.0RegionSubstrate binding


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Fusion Gene Sequence for PGD-PEX14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000541529_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(transcript)=2134nt_BP=313nt
ACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCAT
GGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGATTTCTTGGC
CAATGAGGCAAAGGGAACCAAAGTGGTGGGTGCCCAGTCCCTGAAAGAGATGGTCTCCAAGCTGAAGAAGCCCCGGCGGATCATCCTCCT
GGTGAAGGCTGGGCAAGCTGTGGATGATTTCATCGAGAAATTGATTGCCACGGCAGTGAAGTTTCTACAGAATTCCCGGGTCCGCCAGAG
CCCACTTGCAACCAGGAGAGCATTCCTAAAGAAGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGC
CGATGAGCCTTCGTCCTTGGGCCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTC
CCGATGGCGAGATTACGGCGCCCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCT
CATCCTGGGCGGCCGAGAGGACAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGAC
TCAGTTACAGACGACCCTCGCCTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGC
CAAGGCCACCACATCCACCAACTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTT
AAATCGGAGGCAGTTCCCTCCATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGC
GGCCGTGAACCACCACAGCAGCAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGA
GGGCTCCACGGTCACCTACCACTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCA
AGGCGAGGAGGAGAAGAGGGAGGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGG
GGTGCAGAGGGAGGACCGCCGGGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAG
TGAGCGGGACTAGGGCTGCGCCTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTG
GCCCTGGGAGGGCAGCTTGGAGCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTC
TGTCCACCTGGCCTCCTCTCGCCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAG
GCTGAAGGCAGCGAAGCCTCGGGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTC
TTGACTACCGTGACACCACGCATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTG
TCTGCCATCCCCCTCCCTCCCTGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCC
CAGACAAATGAAACCACGCTGCGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCG
GAGGAGGAGCCAGGCAGCAGGGCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTA

>In-frame_ENST00000541529_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(amino acids)=441AA_start in transcript=37_stop in transcript=1362
MSAAMAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIE
KLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIM
AGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILES
QNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQ

--------------------------------------------------------------
>In-frame_ENST00000270776_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(transcript)=2123nt_BP=302nt
GCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACT
TAATTCTGAACATGAATGACCACGGCTTTGTGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGATTTCTTGGCCAATGAGGCAA
AGGGAACCAAAGTGGTGGGTGCCCAGTCCCTGAAAGAGATGGTCTCCAAGCTGAAGAAGCCCCGGCGGATCATCCTCCTGGTGAAGGCTG
GGCAAGCTGTGGATGATTTCATCGAGAAATTGATTGCCACGGCAGTGAAGTTTCTACAGAATTCCCGGGTCCGCCAGAGCCCACTTGCAA
CCAGGAGAGCATTCCTAAAGAAGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTT
CGTCCTTGGGCCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAG
ATTACGGCGCCCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCG
GCCGAGAGGACAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGA
CGACCCTCGCCTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCA
CATCCACCAACTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGC
AGTTCCCTCCATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACC
ACCACAGCAGCAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGG
TCACCTACCACTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGG
AGAAGAGGGAGGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGG
AGGACCGCCGGGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACT
AGGGCTGCGCCTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGG
GCAGCTTGGAGCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGG
CCTCCTCTCGCCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAG
CGAAGCCTCGGGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGT
GACACCACGCATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCC
CCTCCCTCCCTGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGA
AACCACGCTGCGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCC
AGGCAGCAGGGCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGA

>In-frame_ENST00000270776_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(amino acids)=441AA_start in transcript=26_stop in transcript=1351
MSAAMAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIE
KLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIM
AGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILES
QNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQ

--------------------------------------------------------------
>In-frame_ENST00000538557_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(transcript)=2290nt_BP=469nt
ATGGCCCAGTGAGTGACTCGCCAGGGGCAGCCCGGCTCGGCCTCAGCGGGCGGGGAACTCTTTGGGGGTCGAGATCTCCCTCGTTCTCTC
CGACGCCTCCCACCCTGGGGGTCGCCTGAGCTCACTTGGGGCTCTGTGACCCTGGCCCTACGGCGTCTCGGGCCCAGAGCTCCTTCCCTG
CGGGCCCGGCCCCCTGCCCTCTCGGCCGCGCAGAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACAT
GAATGACCACGGCTTTGTGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGATTTCTTGGCCAATGAGGCAAAGGGAACCAAAGT
GGTGGGTGCCCAGTCCCTGAAAGAGATGGTCTCCAAGCTGAAGAAGCCCCGGCGGATCATCCTCCTGGTGAAGGCTGGGCAAGCTGTGGA
TGATTTCATCGAGAAATTGATTGCCACGGCAGTGAAGTTTCTACAGAATTCCCGGGTCCGCCAGAGCCCACTTGCAACCAGGAGAGCATT
CCTAAAGAAGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGGCCC
AGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGCCCT
GGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGACAG
AAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGCCTC
CGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAACTG
GATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCCATC
CCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAGCAG
CGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCACTT
GCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGAGGA
CAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCGGGG
CGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGCCTG
CTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGAGCC
CAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCGCCT
GGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCGGGG
CCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGCATG
GCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCCTGG
GCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTGCGC
TTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGGGCC
TTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGAACGGAAGATAGGA

>In-frame_ENST00000538557_ENST00000356607_TCGA-DS-A1OD-01A_PGD_chr1_10460629_+_PEX14_chr1_10596270_length(amino acids)=441AA_start in transcript=193_stop in transcript=1518
MPSRPRRADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIE
KLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIM
AGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILES
QNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGD-PEX14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGD-PEX14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGD-PEX14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGDC2239176Liver carcinoma1CTD_human
TgenePEX14C3554004PEROXISOME BIOGENESIS DISORDER 13A (ZELLWEGER)5CTD_human;GENOMICS_ENGLAND
TgenePEX14C1832200Peroxisome biogenesis disorders4CTD_human;GENOMICS_ENGLAND
TgenePEX14C0043459Zellweger Syndrome2CTD_human;GENOMICS_ENGLAND
TgenePEX14C0751594Zellweger-Like Syndrome2CTD_human
TgenePEX14C3658299Zellweger Spectrum2CTD_human
TgenePEX14C0010093Corpus Luteum Cyst1CTD_human
TgenePEX14C0029927Ovarian Cysts1CTD_human