|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PGPEP1-C10orf76 (FusionGDB2 ID:64240) |
Fusion Gene Summary for PGPEP1-C10orf76 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PGPEP1-C10orf76 | Fusion gene ID: 64240 | Hgene | Tgene | Gene symbol | PGPEP1 | C10orf76 | Gene ID | 54858 | 79591 |
Gene name | pyroglutamyl-peptidase I | armadillo like helical domain containing 3 | |
Synonyms | PAP-I|PGI|PGP|PGP-I|PGPI|Pcp | C10orf76 | |
Cytomap | 19p13.11 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | pyroglutamyl-peptidase 15-oxoprolyl-peptidasepGlu-peptidase Ipyroglutamyl aminopeptidase Ipyrrolidone-carboxylate peptidase | armadillo-like helical domain-containing protein 3UPF0668 protein C10orf76 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000269919, ENST00000604499, ENST00000595066, ENST00000252813, ENST00000597431, | ENST00000370033, ENST00000311122, ENST00000495001, | |
Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 8 X 6 X 5=240 |
# samples | 8 | 9 | |
** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PGPEP1 [Title/Abstract] AND C10orf76 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PGPEP1(18453721)-C10orf76(103773781), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across PGPEP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across C10orf76 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KIRC | TCGA-A3-3323-01A | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
Top |
Fusion Gene ORF analysis for PGPEP1-C10orf76 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000269919 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000269919 | ENST00000311122 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000269919 | ENST00000495001 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
In-frame | ENST00000604499 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000604499 | ENST00000311122 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000604499 | ENST00000495001 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
In-frame | ENST00000595066 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000595066 | ENST00000311122 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000595066 | ENST00000495001 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
intron-3CDS | ENST00000252813 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
intron-intron | ENST00000252813 | ENST00000311122 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
intron-intron | ENST00000252813 | ENST00000495001 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
In-frame | ENST00000597431 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000597431 | ENST00000311122 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
5CDS-intron | ENST00000597431 | ENST00000495001 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000269919 | PGPEP1 | chr19 | 18453721 | + | ENST00000370033 | C10orf76 | chr10 | 103773781 | - | 3512 | 182 | 95 | 1582 | 495 |
ENST00000604499 | PGPEP1 | chr19 | 18453721 | + | ENST00000370033 | C10orf76 | chr10 | 103773781 | - | 3501 | 171 | 84 | 1571 | 495 |
ENST00000595066 | PGPEP1 | chr19 | 18453721 | + | ENST00000370033 | C10orf76 | chr10 | 103773781 | - | 3500 | 170 | 83 | 1570 | 495 |
ENST00000597431 | PGPEP1 | chr19 | 18453721 | + | ENST00000370033 | C10orf76 | chr10 | 103773781 | - | 3460 | 130 | 43 | 1530 | 495 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000269919 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - | 0.003398865 | 0.9966011 |
ENST00000604499 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - | 0.003447215 | 0.9965528 |
ENST00000595066 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - | 0.003434324 | 0.99656576 |
ENST00000597431 | ENST00000370033 | PGPEP1 | chr19 | 18453721 | + | C10orf76 | chr10 | 103773781 | - | 0.003116629 | 0.99688333 |
Top |
Fusion Genomic Features for PGPEP1-C10orf76 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for PGPEP1-C10orf76 |
Go to FGviewer for the breakpoints of chr19:18453721-chr10:103773781 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | C10orf76 | chr19:18453721 | chr10:103773781 | ENST00000370033 | 7 | 26 | 520_538 | 223.0 | 690.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for PGPEP1-C10orf76 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000269919_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(transcript)=3512nt_BP=182nt AGGGGCGTGGCCTCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATC CCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTC AGTCTGTGAATCCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTAT CTGAGTACAACAGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCA TAGCAGATGCCCATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCA TCACAGTATTAGCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGA CCACACCGCCTTCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAA AGTATAGCTCAATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAG AGGATCAATATGCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGG CAGCAGACAAGAATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGT TTCCTATGGATCTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCT GGCGGGAGCTCTGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACAT TAGCCCTTATGATTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACT ATGAGATTATCCGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAG CTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACA TATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGT ATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCT TCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTAC CCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTG AAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTG GGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCT ACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAG ATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACT GGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGT CTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTC AGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTAC CCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGC CAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCC TTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCT TAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACT TTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACG TGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGC CTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGC TCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACT ATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGG AGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAAC CTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCAC TAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTT AGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGGTGGCAAGTTGAAATTATTAAAAATTGATTTGTGTGGGACTG >In-frame_ENST00000269919_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(amino acids)=495AA_start in transcript=95_stop in transcript=1582 MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE -------------------------------------------------------------- >In-frame_ENST00000604499_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(transcript)=3501nt_BP=171nt CTCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAG CAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAAT CCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAAC AGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCC CATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTA GCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCT TCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCA ATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATAT GCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAG AATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGAT CTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTC TGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATG ATTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATC CGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTG ACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTG TCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTAC TCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTC AGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATC ATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACT TCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCT CCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATT TTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCA GATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTC CAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTC GCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAG TAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTC TCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTA TTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTT AGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAAT TTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCC CTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCC CTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAG AGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGG GTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCC CAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCA CTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCT TTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGC CATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCC >In-frame_ENST00000604499_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(amino acids)=495AA_start in transcript=84_stop in transcript=1571 MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE -------------------------------------------------------------- >In-frame_ENST00000595066_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(transcript)=3500nt_BP=170nt TCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAGC AGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAATC CTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAACA GGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCCC ATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTAG CTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCTT CCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCAA TTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATATG CCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAGA ATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGATC TCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTCT GGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATGA TTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATCC GCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGA CCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGT CAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACT CAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCA GCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCA TGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTT CAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTC CAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTT TCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAG ATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCC AGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCG CCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGT AGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCT CAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTAT TTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTA GTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATT TCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCC TTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCC TTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGA GAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGG TGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCC AACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCAC TGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTT TGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCC ATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCT >In-frame_ENST00000595066_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(amino acids)=495AA_start in transcript=83_stop in transcript=1570 MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE -------------------------------------------------------------- >In-frame_ENST00000597431_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(transcript)=3460nt_BP=130nt CAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTT TGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAATCCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCAC ACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAACAGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTT TTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCCCATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCT GGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTAGCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGT CAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCTTCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGC AGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCAATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAG TGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATATGCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGT AAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAGAATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCT GATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGATCTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTG CTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTCTGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAA TGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATGATTGTGAACCTATTTAATATGTTTATCACATATGGCGACAC ATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATCCGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCT GAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTT TAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGA CACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGT TCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTG AGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCG AGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAG GGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGC CCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCAC CCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGG CTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGG AATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGC AGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTT TTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCA AAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGA TGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCT GGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAA ACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTC TGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTT CCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGC CAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGC TTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCC CTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAG AGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCT AACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTC ATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGGTGG >In-frame_ENST00000597431_ENST00000370033_TCGA-A3-3323-01A_PGPEP1_chr19_18453721_+_C10orf76_chr10_103773781_length(amino acids)=495AA_start in transcript=43_stop in transcript=1530 MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for PGPEP1-C10orf76 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for PGPEP1-C10orf76 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for PGPEP1-C10orf76 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |