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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHC3-SEC62 (FusionGDB2 ID:64343)

Fusion Gene Summary for PHC3-SEC62

check button Fusion gene summary
Fusion gene informationFusion gene name: PHC3-SEC62
Fusion gene ID: 64343
HgeneTgene
Gene symbol

PHC3

SEC62

Gene ID

80012

7095

Gene namepolyhomeotic homolog 3SEC62 homolog, preprotein translocation factor
SynonymsEDR3|HPH3Dtrp1|HTP1|TLOC1|TP-1
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionpolyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3translocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000495893, ENST00000494943, 
ENST00000467570, ENST00000474275, 
ENST00000497658, ENST00000481639, 
ENST00000337002, ENST00000480708, 
ENST00000470355, 
Fusion gene scores* DoF score15 X 15 X 11=247517 X 20 X 8=2720
# samples 2025
** MAII scorelog2(20/2475*10)=-3.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2720*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHC3 [Title/Abstract] AND SEC62 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHC3(169854207)-SEC62(169710382), # samples:1
SEC62(169703653)-PHC3(169840532), # samples:1
Anticipated loss of major functional domain due to fusion event.PHC3-SEC62 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PHC3-SEC62 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PHC3-SEC62 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PHC3-SEC62 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SEC62-PHC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SEC62-PHC3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SEC62-PHC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SEC62-PHC3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SEC62 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09Z-01APHC3chr3

169854207

-SEC62chr3

169710382

+


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Fusion Gene ORF analysis for PHC3-SEC62

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000495893ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
In-frameENST00000495893ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
5CDS-3UTRENST00000495893ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+
Frame-shiftENST00000494943ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
In-frameENST00000494943ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
5CDS-3UTRENST00000494943ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+
Frame-shiftENST00000467570ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
In-frameENST00000467570ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
5CDS-3UTRENST00000467570ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000474275ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000474275ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3UTRENST00000474275ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000497658ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000497658ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3UTRENST00000497658ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000481639ENST00000337002PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3CDSENST00000481639ENST00000480708PHC3chr3

169854207

-SEC62chr3

169710382

+
intron-3UTRENST00000481639ENST00000470355PHC3chr3

169854207

-SEC62chr3

169710382

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000495893PHC3chr3169854207-ENST00000480708SEC62chr3169710382+1636951321420462
ENST00000494943PHC3chr3169854207-ENST00000480708SEC62chr3169710382+1637952691421450
ENST00000467570PHC3chr3169854207-ENST00000480708SEC62chr3169710382+1479794341263409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000495893ENST00000480708PHC3chr3169854207-SEC62chr3169710382+0.0122513580.98774856
ENST00000494943ENST00000480708PHC3chr3169854207-SEC62chr3169710382+0.0169391860.9830608
ENST00000467570ENST00000480708PHC3chr3169854207-SEC62chr3169710382+0.007773920.9922261

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Fusion Genomic Features for PHC3-SEC62


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHC3chr3169854206-SEC62chr3169710381+0.31541010.6845899
PHC3chr3169854206-SEC62chr3169710381+0.31541010.6845899

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHC3-SEC62


check button Go to

FGviewer for the breakpoints of chr3:169854207-chr3:169710382

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-71519_26294.3333333333333984.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-71589_287294.3333333333333984.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-71519_26306.3333333333333996.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-71589_287306.3333333333333996.0Compositional biasNote=Ser-rich
TgeneSEC62chr3:169854207chr3:169710382ENST0000033700268256_399243.33333333333334400.0Topological domainCytoplasmic
TgeneSEC62chr3:169854207chr3:169710382ENST0000048070869256_399243.33333333333334442.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-1519_260187.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-15324_5390187.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-15346_6700187.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-1589_2870187.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-715324_539294.3333333333333984.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-715346_670294.3333333333333984.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-715324_539306.3333333333333996.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-715346_670306.3333333333333996.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-1419_260152.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-14324_5390152.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-14346_6700152.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-1489_2870152.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-15919_9830187.0DomainSAM
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-715919_983294.3333333333333984.0DomainSAM
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-715919_983306.3333333333333996.0DomainSAM
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-14919_9830152.0DomainSAM
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-15691_7200187.0MotifNote=HD1
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-715691_720294.3333333333333984.0MotifNote=HD1
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-715691_720306.3333333333333996.0MotifNote=HD1
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-14691_7200152.0MotifNote=HD1
HgenePHC3chr3:169854207chr3:169710382ENST00000474275-15776_8100187.0Zinc fingerFCS-type
HgenePHC3chr3:169854207chr3:169710382ENST00000494943-715776_810294.3333333333333984.0Zinc fingerFCS-type
HgenePHC3chr3:169854207chr3:169710382ENST00000495893-715776_810306.3333333333333996.0Zinc fingerFCS-type
HgenePHC3chr3:169854207chr3:169710382ENST00000497658-14776_8100152.0Zinc fingerFCS-type
TgeneSEC62chr3:169854207chr3:169710382ENST00000337002681_196243.33333333333334400.0Topological domainCytoplasmic
TgeneSEC62chr3:169854207chr3:169710382ENST0000033700268218_234243.33333333333334400.0Topological domainLumenal
TgeneSEC62chr3:169854207chr3:169710382ENST00000480708691_196243.33333333333334442.0Topological domainCytoplasmic
TgeneSEC62chr3:169854207chr3:169710382ENST0000048070869218_234243.33333333333334442.0Topological domainLumenal
TgeneSEC62chr3:169854207chr3:169710382ENST0000033700268197_217243.33333333333334400.0TransmembraneHelical
TgeneSEC62chr3:169854207chr3:169710382ENST0000033700268235_255243.33333333333334400.0TransmembraneHelical
TgeneSEC62chr3:169854207chr3:169710382ENST0000048070869197_217243.33333333333334442.0TransmembraneHelical
TgeneSEC62chr3:169854207chr3:169710382ENST0000048070869235_255243.33333333333334442.0TransmembraneHelical


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Fusion Gene Sequence for PHC3-SEC62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000495893_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(transcript)=1636nt_BP=951nt
GCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGG
GAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTG
TCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAA
TGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTG
CTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTATCA
ACCTCTCCACTTCTCCTACACCTGCACAGTTAATAAGCCGTTCCCAGGCTTCCAGTTCTACCAGCGGCAGTATTACCCAACAGACTATGT
TACTAGGGAGTACTTCCCCTACCCTAACGGCAAGCCAAGCTCAAATGTATCTCCGAGCTCAAATGCTGATTTTCACACCCGCTACCACTG
TGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGCTACTCAGGTTCAGAATTTAACAT
TACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAACTCAGTCATTGACAATTTGTCATA
ACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGGAGAGAGCCCAAGCCTGGAATCAC
GAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGCTCGATGCATTCTATTTCTCATCATTTGGCTCATAACTG
GAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACACACATGAATACA
AAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAGA
AAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACACGGACAGTGACA
GGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAACAGCAAACAGATG
GGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACTAATTTTGGGACT
GAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCAT
TTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTGTACATAATTTACAAATAAAACAT

>In-frame_ENST00000495893_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(amino acids)=462AA_start in transcript=32_stop in transcript=1420
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKIS
QRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDE
KSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEDEEEEN

--------------------------------------------------------------
>In-frame_ENST00000494943_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(transcript)=1637nt_BP=952nt
AGTGATGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCG
GGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCT
GTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAA
ATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCT
GCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTATC
AACCTCTCCACTTCTCCTACACCTGCACAGTTAATAAGCCGTTCCCAGGCTTCCAGTTCTACCAGCGGCAGTATTACCCAACAGACTATG
TTACTAGGGAGTACTTCCCCTACCCTAACGGCAAGCCAAGCTCAAATGTATCTCCGAGCTCAAATGCTGATTTTCACACCCGCTACCACT
GTGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGCTACTCAGGTTCAGAATTTAACA
TTACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAACTCAGTCATTGACAATTTGTCAT
AACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGGAGAGAGCCCAAGCCTGGAATCA
CGAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGCTCGATGCATTCTATTTCTCATCATTTGGCTCATAACT
GGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACACACATGAATAC
AAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAG
AAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACACGGACAGTGAC
AGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAACAGCAAACAGAT
GGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACTAATTTTGGGAC
TGAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCA
TTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTGTACATAATTTACAAATAAAACA

>In-frame_ENST00000494943_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(amino acids)=450AA_start in transcript=69_stop in transcript=1421
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKG
ESPSLESRSTAVTRTSSIHQLIAPARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDS
EEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEDEEEENDGETPKSSHEKS

--------------------------------------------------------------
>In-frame_ENST00000467570_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(transcript)=1479nt_BP=794nt
ATGCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCC
GGGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTC
TGTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCA
AATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGC
TGCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCT
GATTTTCACACCCGCTACCACTGTGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGC
TACTCAGGTTCAGAATTTAACATTACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAAC
TCAGTCATTGACAATTTGTCATAACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGG
AGAGAGCCCAAGCCTGGAATCACGAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGCTCGATGCATTCTATT
TCTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAG
GCCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAG
TGAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACG
GCATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGA
GGAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATC
ATAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCT
CCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTG

>In-frame_ENST00000467570_ENST00000480708_TCGA-A8-A09Z-01A_PHC3_chr3_169854207_-_SEC62_chr3_169710382_length(amino acids)=409AA_start in transcript=34_stop in transcript=1263
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQ
KLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPARCILFLIIWLITGGRH
HFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRRED

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Fusion Gene PPI Analysis for PHC3-SEC62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHC3-SEC62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHC3-SEC62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource