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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF12-MYO18A (FusionGDB2 ID:64373)

Fusion Gene Summary for PHF12-MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF12-MYO18A
Fusion gene ID: 64373
HgeneTgene
Gene symbol

PHF12

MYO18A

Gene ID

57649

399687

Gene namePHD finger protein 12myosin XVIIIA
SynonymsPF1MAJN|MYSPDZ|SP-R210|SPR210
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 12PHD factor 1PHD zinc finger transcription factorunconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2020031320200313
UniProtAcc.

Q92614

Ensembl transtripts involved in fusion geneENST00000332830, ENST00000577226, 
ENST00000268756, ENST00000582655, 
ENST00000354329, ENST00000529578, 
ENST00000533112, ENST00000531253, 
ENST00000527372, 
Fusion gene scores* DoF score17 X 13 X 7=154720 X 17 X 12=4080
# samples 2034
** MAII scorelog2(20/1547*10)=-2.95140129167431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/4080*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF12 [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF12(27248705)-MYO18A(27401932), # samples:1
PHF12(27248706)-MYO18A(27401932), # samples:1
PHF12(27254009)-MYO18A(27449271), # samples:1
Anticipated loss of major functional domain due to fusion event.PHF12-MYO18A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PHF12-MYO18A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PHF12-MYO18A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF12

GO:0000122

negative regulation of transcription by RNA polymerase II

22048773

HgenePHF12

GO:0045892

negative regulation of transcription, DNA-templated

11390640


check buttonFusion gene breakpoints across PHF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYO18A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1847PHF12chr17

27248705

-MYO18Achr17

27401932

-
ChimerDB4OVTCGA-24-1847-01APHF12chr17

27248706

-MYO18Achr17

27401932

-
ChimerDB4OVTCGA-04-1348-01APHF12chr17

27254009

-MYO18Achr17

27449271

-


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Fusion Gene ORF analysis for PHF12-MYO18A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000332830ENST00000354329PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000529578PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000533112PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000531253PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000527372PHF12chr17

27248705

-MYO18Achr17

27401932

-
Frame-shiftENST00000577226ENST00000354329PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000529578PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000533112PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000531253PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000527372PHF12chr17

27248705

-MYO18Achr17

27401932

-
Frame-shiftENST00000268756ENST00000354329PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000529578PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000533112PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000531253PHF12chr17

27248705

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000527372PHF12chr17

27248705

-MYO18Achr17

27401932

-
5UTR-3CDSENST00000582655ENST00000354329PHF12chr17

27248705

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000529578PHF12chr17

27248705

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000533112PHF12chr17

27248705

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000531253PHF12chr17

27248705

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000527372PHF12chr17

27248705

-MYO18Achr17

27401932

-
Frame-shiftENST00000332830ENST00000354329PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000529578PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000533112PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000531253PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000332830ENST00000527372PHF12chr17

27248706

-MYO18Achr17

27401932

-
Frame-shiftENST00000577226ENST00000354329PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000529578PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000533112PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000531253PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000577226ENST00000527372PHF12chr17

27248706

-MYO18Achr17

27401932

-
Frame-shiftENST00000268756ENST00000354329PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000529578PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000533112PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000531253PHF12chr17

27248706

-MYO18Achr17

27401932

-
5CDS-5UTRENST00000268756ENST00000527372PHF12chr17

27248706

-MYO18Achr17

27401932

-
5UTR-3CDSENST00000582655ENST00000354329PHF12chr17

27248706

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000529578PHF12chr17

27248706

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000533112PHF12chr17

27248706

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000531253PHF12chr17

27248706

-MYO18Achr17

27401932

-
5UTR-5UTRENST00000582655ENST00000527372PHF12chr17

27248706

-MYO18Achr17

27401932

-
In-frameENST00000332830ENST00000354329PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000332830ENST00000529578PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000332830ENST00000533112PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000332830ENST00000531253PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000332830ENST00000527372PHF12chr17

27254009

-MYO18Achr17

27449271

-
In-frameENST00000577226ENST00000354329PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000577226ENST00000529578PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000577226ENST00000533112PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000577226ENST00000531253PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000577226ENST00000527372PHF12chr17

27254009

-MYO18Achr17

27449271

-
In-frameENST00000268756ENST00000354329PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000268756ENST00000529578PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000268756ENST00000533112PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000268756ENST00000531253PHF12chr17

27254009

-MYO18Achr17

27449271

-
5CDS-intronENST00000268756ENST00000527372PHF12chr17

27254009

-MYO18Achr17

27449271

-
intron-3CDSENST00000582655ENST00000354329PHF12chr17

27254009

-MYO18Achr17

27449271

-
intron-intronENST00000582655ENST00000529578PHF12chr17

27254009

-MYO18Achr17

27449271

-
intron-intronENST00000582655ENST00000533112PHF12chr17

27254009

-MYO18Achr17

27449271

-
intron-intronENST00000582655ENST00000531253PHF12chr17

27254009

-MYO18Achr17

27449271

-
intron-intronENST00000582655ENST00000527372PHF12chr17

27254009

-MYO18Achr17

27449271

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332830PHF12chr1727254009-ENST00000354329MYO18Achr1727449271-7558113281162971828
ENST00000577226PHF12chr1727254009-ENST00000354329MYO18Achr1727449271-709466834758331828
ENST00000268756PHF12chr1727254009-ENST00000354329MYO18Achr1727449271-727785153060161828

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332830ENST00000354329PHF12chr1727254009-MYO18Achr1727449271-0.010709520.98929054
ENST00000577226ENST00000354329PHF12chr1727254009-MYO18Achr1727449271-0.0085238270.9914761
ENST00000268756ENST00000354329PHF12chr1727254009-MYO18Achr1727449271-0.0091396090.99086034

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Fusion Genomic Features for PHF12-MYO18A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF12-MYO18A


check button Go to

FGviewer for the breakpoints of chr17:27254009-chr17:27449271

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO18A

Q92614

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-3956_105107.0705.0Zinc fingerPHD-type 1
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-31556_105107.01005.0Zinc fingerPHD-type 1
TgeneMYO18Achr17:27254009chr17:27449271ENST000005273721421246_1971333.02055.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:27254009chr17:27449271ENST000005312531411246_1971333.02040.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:27254009chr17:27449271ENST000005331121401246_1971333.02003.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:27254009chr17:27449271ENST000005273721421188_1217333.02055.0DomainIQ
TgeneMYO18Achr17:27254009chr17:27449271ENST00000527372142349_401333.02055.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:27254009chr17:27449271ENST00000527372142405_1185333.02055.0DomainMyosin motor
TgeneMYO18Achr17:27254009chr17:27449271ENST000005312531411188_1217333.02040.0DomainIQ
TgeneMYO18Achr17:27254009chr17:27449271ENST00000531253141349_401333.02040.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:27254009chr17:27449271ENST00000531253141405_1185333.02040.0DomainMyosin motor
TgeneMYO18Achr17:27254009chr17:27449271ENST000005331121401188_1217333.02003.0DomainIQ
TgeneMYO18Achr17:27254009chr17:27449271ENST00000533112140349_401333.02003.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:27254009chr17:27449271ENST00000533112140405_1185333.02003.0DomainMyosin motor
TgeneMYO18Achr17:27254009chr17:27449271ENST00000527372142498_505333.02055.0Nucleotide bindingATP
TgeneMYO18Achr17:27254009chr17:27449271ENST00000531253141498_505333.02040.0Nucleotide bindingATP
TgeneMYO18Achr17:27254009chr17:27449271ENST00000533112140498_505333.02003.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39894_897107.0705.0Compositional biasPoly-Arg
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39929_932107.0705.0Compositional biasPoly-Ser
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315894_897107.01005.0Compositional biasPoly-Arg
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315929_932107.01005.0Compositional biasPoly-Ser
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39815_869107.0705.0DomainFHA
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315815_869107.01005.0DomainFHA
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39105_128107.0705.0RegionNote=PBR
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315105_128107.01005.0RegionNote=PBR
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39271_321107.0705.0Zinc fingerPHD-type 2%3B atypical
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315271_321107.01005.0Zinc fingerPHD-type 2%3B atypical
TgeneMYO18Achr17:27254009chr17:27449271ENST000005273721426_25333.02055.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:27254009chr17:27449271ENST000005312531416_25333.02040.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:27254009chr17:27449271ENST000005331121406_25333.02003.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:27254009chr17:27449271ENST00000527372142220_311333.02055.0DomainPDZ
TgeneMYO18Achr17:27254009chr17:27449271ENST00000531253141220_311333.02040.0DomainPDZ
TgeneMYO18Achr17:27254009chr17:27449271ENST00000533112140220_311333.02003.0DomainPDZ


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Fusion Gene Sequence for PHF12-MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000332830_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(transcript)=7558nt_BP=1132nt
CTTAGTTTGCACACAAACACCAATGGATGAACAGTCCCTAGCTTCCTGCGGCTGCGCCTTGACCCCTACAAGCTTTCTCAAGCGCCTGCG
CGAGACCTCAGGTCCCGCCCTTTTGTCTCAGTGCGCTGGCGCAGGGCAGAAAGGTGGGGCTTCGGTCCTCCAGACGAATGCCAGCGCGGC
TGCGCGCTGGGGGGTACTCCCTCACCGCGGCTGCGCGGGAGCCAGGCCGCCGGCTGTCACTGCGGTTGCGCGCGGCGAGCGCCGATCCCG
GGGCGCCTGCGCGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGA
GGCGGAGCCCGGGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATAC
CCCCAGCCCCGGGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGC
CGAGGCCTGACCCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGA
GGACGCTGTCGTCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCC
GGGGTCAGGAGCGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATG
AATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCC
CCCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGA
TAGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGTAACCCTCCACTGAGTGAAGA
AATGTTGCCTCCTGGAGAGTGGATGTGTCACCGGTGCACTGTTCGCCGAAAGGCGAAAACAGAAGAACAGATTGCAGCAGAAGAGGCCTG
GAATGAGACGGAGAAGGTGTGGCTGGTCCATAGGGACGGCTTCTCACTGGCCAGTCAACTCAAATCTGAGGAGCTCAACTTGCCTGAGGG
GAAGGTGCGTGTGAAGCTGGACCACGATGGGGCCATCCTGGATGTGGATGAGGATGACGTTGAGAAGGCTAATGCTCCCTCCTGCGACCG
TCTGGAGGATCTGGCCTCACTGGTGTACCTCAATGAGTCCAGCGTCCTGCACACCTTGCGCCAGCGCTATGGCGCTAGCCTGCTGCACAC
GTATGCTGGCCCCAGCCTGCTGGTTCTTGGCCCCCGTGGGGCCCCTGCTGTGTACTCTGAGAAGGTGATGCACATGTTCAAGGGTTGTCG
GCGGGAGGACATGGCACCCCACATCTATGCAGTGGCCCAGACCGCATACAGGGCGATGCTGATGAGCCGTCAGGATCAGTCAATCATCCT
CCTGGGCAGTAGTGGCAGTGGCAAGACCACCAGCTGCCAGCATCTGGTGCAGTACCTGGCCACCATCGCGGGCATCAGCGGGAACAAGGT
GTTTTCTGTGGAGAAGTGGCAGGCTCTGTACACCCTCCTGGAAGCCTTTGGGAACAGCCCCACCATCATTAATGGCAATGCCACCCGCTT
CTCCCAGATCCTCTCCCTGGACTTTGACCAAGCTGGCCAGGTGGCCTCAGCCTCCATTCAGACAATGCTTCTGGAGAAGCTGCGTGTGGC
TCGGCGCCCAGCCAGTGAAGCCACATTCAACGTCTTCTACTACCTGCTGGCCTGTGGGGATGGCACCCTCAGGACAGAGCTCCACCTCAA
CCACTTGGCAGAGAACAATGTGTTTGGGATTGTGCCACTGGCCAAGCCTGAGGAAAAGCAGAAGGCAGCTCAGCAGTTTAGTAAGCTGCA
GGCGGCCATGAAGGTGCTGGGCATCTCCCCCGATGAACAGAAGGCCTGCTGGTTCATTCTGGCTGCCATCTACCACCTGGGGGCTGCGGG
AGCCACCAAAGTCCACTCCACAGCTGGGCGCAAGCAGTTTGCCCGCCATGAGTGGGCCCAGAAGGCTGCGTACCTACTGGGCTGCAGCCT
GGAGGAGCTGTCCTCAGCCATCTTCAAGCACCAGCACAAGGGTGGCACCCTGCAGCGCTCCACCTCCTTCCGCCAGGGCCCCGAGGAGAG
TGGCCTGGGAGATGGGACAGGCCCGAAACTGAGTGCACTGGAGTGCCTTGAGGGCATGGCGGCCGGCCTCTACAGCGAGCTCTTCACCCT
TCTCGTCTCCCTGGTGAATAGGGCTCTCAAGTCCAGCCAGCACTCACTCTGCTCCATGATGATTGTCGACACCCCGGGCTTCCAGAACCC
TGAGCAGGGTGGGTCAGCCCGCGGAGCCTCCTTTGAGGAGCTGTGCCACAACTACACCCAAGACCGGCTGCAGAGGCTCTTCCACGAGCG
CACCTTCGTGCAGGAGTTGGAAAGATACAAGGAGGAGAACATCGAGCTGGCGTTTGACGACTTGGAACCCCCGACGGATGACTCTGTGGC
TGCTGTGGACCAGGCCTCCCATCAGTCCCTGGTCCGCTCGCTGGCCCGCACAGACGAGGCGAGGGGCCTGCTCTGGCTATTGGAAGAGGA
GGCTCTGGTGCCAGGGGCCAGTGAGGACACCCTCCTGGAGCGCCTTTTCTCCTATTATGGCCCCCAGGAAGGTGACAAAAAAGGCCAAAG
CCCCCTTCTGCACAGCAGCAAACCACACCACTTTCTCCTGGGCCACAGCCATGGCACCAACTGGGTAGAGTACAATGTGACTGGCTGGCT
GAACTACACCAAGCAGAACCCAGCCACCCAGAATGCCCCCCGGCTCCTGCAGGACTCCCAGAAAAAAATCATCAGCAACCTGTTTCTGGG
CCGCGCAGGCAGTGCCACGGTGCTCTCTGGCTCCATCGCGGGCCTGGAGGGCGGCTCGCAGCTGGCACTGCGCCGGGCCACCAGCATGCG
GAAAACCTTTACCACAGGCATGGCGGCTGTCAAAAAGAAGTCACTGTGCATCCAGATGAAGCTACAGGTGGACGCCCTCATCGACACCAT
CAAGAAGTCAAAGCTGCATTTTGTGCACTGCTTCCTGCCTGTAGCTGAGGGCTGGGCTGGGGAGCCCCGTTCCGCCTCCTCCCGCCGAGT
CAGCAGCAGCAGTGAGCTGGACCTGCCCTCGGGAGACCACTGCGAGGCTGGGCTCCTGCAGCTCGACGTGCCCCTGCTCCGCACCCAGCT
CCGCGGCTCCCGCCTGCTCGATGCCATGCGCATGTACCGCCAAGGTTACCCTGACCACATGGTGTTTTCCGAGTTCCGCCGCCGCTTTGA
TGTCCTGGCCCCGCACCTGACCAAGAAACACGGGCGTAACTACATCGTGGTGGATGAAAGGCGGGCAGTGGAGGAGCTGCTGGAGTGCTT
GGATCTGGAGAAGAGCAGCTGCTGCATGGGCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGAGGAGCAGCGGGATGA
ACAAACCAGCAGGAACCTAACCCTGTTCCAAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAGGACCT
GGCCATTCGCTGTGTACAGAAGAACATCAAGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCT
CATCGAAGTACAGCTGTCAGAGGAGCAGATCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGA
GAGGAACGAGCTGCGGCTCAACAGTGACCGGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGA
GTCCGCCTCCCAGCTGCTGGACGCGGAGACAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACT
GAAGAAGCAGATGGAGGTTATGGAAATGGAGGTGATGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGA
TGCAGGTGGCGAGTGGCGGCTGAAGTATGAGCGGGCTGTGCGGGAGGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAA
GCTGGAGGTGGAGCAGCAGAACAAGAGGCAGCTGGAACGGCGGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCA
GCAGCTCAAGAAGAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACT
GGAGAAGAAGCAGAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCG
GGAGAAGGACATGCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGT
TGTGTCTCTAGAGGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGA
CCTGGAGGCCAAAGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGA
GATGGAGATGGAGCGGATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAA
GAAGTTAAAACAGATGGAGGTGCAGCTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCT
CGCCACCCTCAGCGACCAGGTGAACCGGCGGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGC
AGATGCCCAGCTCATGCTGGACCACCTGAAGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGA
GTTCACCTGTGCGGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGC
CAAGACAGCGCTGGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAA
CGAATTGATGAAGAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGC
CAACAAAGAGAAGCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCT
GGTGAGCAGGCAGGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAG
CCGTCTCAAGGAAAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCT
ACAGAGGCAGCTCCGGGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGAT
GGATCTAGAAAGCCTGGAGGCTGCTAACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCAT
TGAGGATGAGATGGAGAGTGATGAGAATGAGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACT
TGAGGGAGACTCTGATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGC
AGCTTCTGATGATGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCC
TCTCGACAACACCTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCC
CAGGGGAGTGGTTGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCAC
CCGACTGCTGATCTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAG
AGGTGGGGGAAAGAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGG
GCAGTGGCAGGTGGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACT
GGGACACTCTAGGTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCT
TGGTGCCTGCTGTCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGT
AGCTGGGGCTCCCAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGG
TGAGGAGAGCCGGGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAA
GTGTGTGTGTGGACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCC
ATTCCAACTACAGCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGG
GAAGGCTTGGGGTTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTC
CTGAGCCCGTGTCATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCC
TAAAAAGGTTATCCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCT

>In-frame_ENST00000332830_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(amino acids)=1828AA_start in transcript=811_stop in transcript=6297
MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEE
MLPPGEWMCHRCTVRRKAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDR
LEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIIL
LGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVA
RRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAG
ATKVHSTAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTL
LVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVA
AVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWL
NYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTI
KKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFD
VLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDL
AIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE
SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDK
LEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQR
EKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE
MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA
DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN
ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLAS
RLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAI
EDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDP

--------------------------------------------------------------
>In-frame_ENST00000577226_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(transcript)=7094nt_BP=668nt
TGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGACCCC
CGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCGTCC
CGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAGCGC
CCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGAAAA
TGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGGACG
AGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGGAAG
GTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGTAACCCTCCACTGAGTGAAGAAATGTTGCCTCCTG
GAGAGTGGATGTGTCACCGGTGCACTGTTCGCCGAAAGGCGAAAACAGAAGAACAGATTGCAGCAGAAGAGGCCTGGAATGAGACGGAGA
AGGTGTGGCTGGTCCATAGGGACGGCTTCTCACTGGCCAGTCAACTCAAATCTGAGGAGCTCAACTTGCCTGAGGGGAAGGTGCGTGTGA
AGCTGGACCACGATGGGGCCATCCTGGATGTGGATGAGGATGACGTTGAGAAGGCTAATGCTCCCTCCTGCGACCGTCTGGAGGATCTGG
CCTCACTGGTGTACCTCAATGAGTCCAGCGTCCTGCACACCTTGCGCCAGCGCTATGGCGCTAGCCTGCTGCACACGTATGCTGGCCCCA
GCCTGCTGGTTCTTGGCCCCCGTGGGGCCCCTGCTGTGTACTCTGAGAAGGTGATGCACATGTTCAAGGGTTGTCGGCGGGAGGACATGG
CACCCCACATCTATGCAGTGGCCCAGACCGCATACAGGGCGATGCTGATGAGCCGTCAGGATCAGTCAATCATCCTCCTGGGCAGTAGTG
GCAGTGGCAAGACCACCAGCTGCCAGCATCTGGTGCAGTACCTGGCCACCATCGCGGGCATCAGCGGGAACAAGGTGTTTTCTGTGGAGA
AGTGGCAGGCTCTGTACACCCTCCTGGAAGCCTTTGGGAACAGCCCCACCATCATTAATGGCAATGCCACCCGCTTCTCCCAGATCCTCT
CCCTGGACTTTGACCAAGCTGGCCAGGTGGCCTCAGCCTCCATTCAGACAATGCTTCTGGAGAAGCTGCGTGTGGCTCGGCGCCCAGCCA
GTGAAGCCACATTCAACGTCTTCTACTACCTGCTGGCCTGTGGGGATGGCACCCTCAGGACAGAGCTCCACCTCAACCACTTGGCAGAGA
ACAATGTGTTTGGGATTGTGCCACTGGCCAAGCCTGAGGAAAAGCAGAAGGCAGCTCAGCAGTTTAGTAAGCTGCAGGCGGCCATGAAGG
TGCTGGGCATCTCCCCCGATGAACAGAAGGCCTGCTGGTTCATTCTGGCTGCCATCTACCACCTGGGGGCTGCGGGAGCCACCAAAGTCC
ACTCCACAGCTGGGCGCAAGCAGTTTGCCCGCCATGAGTGGGCCCAGAAGGCTGCGTACCTACTGGGCTGCAGCCTGGAGGAGCTGTCCT
CAGCCATCTTCAAGCACCAGCACAAGGGTGGCACCCTGCAGCGCTCCACCTCCTTCCGCCAGGGCCCCGAGGAGAGTGGCCTGGGAGATG
GGACAGGCCCGAAACTGAGTGCACTGGAGTGCCTTGAGGGCATGGCGGCCGGCCTCTACAGCGAGCTCTTCACCCTTCTCGTCTCCCTGG
TGAATAGGGCTCTCAAGTCCAGCCAGCACTCACTCTGCTCCATGATGATTGTCGACACCCCGGGCTTCCAGAACCCTGAGCAGGGTGGGT
CAGCCCGCGGAGCCTCCTTTGAGGAGCTGTGCCACAACTACACCCAAGACCGGCTGCAGAGGCTCTTCCACGAGCGCACCTTCGTGCAGG
AGTTGGAAAGATACAAGGAGGAGAACATCGAGCTGGCGTTTGACGACTTGGAACCCCCGACGGATGACTCTGTGGCTGCTGTGGACCAGG
CCTCCCATCAGTCCCTGGTCCGCTCGCTGGCCCGCACAGACGAGGCGAGGGGCCTGCTCTGGCTATTGGAAGAGGAGGCTCTGGTGCCAG
GGGCCAGTGAGGACACCCTCCTGGAGCGCCTTTTCTCCTATTATGGCCCCCAGGAAGGTGACAAAAAAGGCCAAAGCCCCCTTCTGCACA
GCAGCAAACCACACCACTTTCTCCTGGGCCACAGCCATGGCACCAACTGGGTAGAGTACAATGTGACTGGCTGGCTGAACTACACCAAGC
AGAACCCAGCCACCCAGAATGCCCCCCGGCTCCTGCAGGACTCCCAGAAAAAAATCATCAGCAACCTGTTTCTGGGCCGCGCAGGCAGTG
CCACGGTGCTCTCTGGCTCCATCGCGGGCCTGGAGGGCGGCTCGCAGCTGGCACTGCGCCGGGCCACCAGCATGCGGAAAACCTTTACCA
CAGGCATGGCGGCTGTCAAAAAGAAGTCACTGTGCATCCAGATGAAGCTACAGGTGGACGCCCTCATCGACACCATCAAGAAGTCAAAGC
TGCATTTTGTGCACTGCTTCCTGCCTGTAGCTGAGGGCTGGGCTGGGGAGCCCCGTTCCGCCTCCTCCCGCCGAGTCAGCAGCAGCAGTG
AGCTGGACCTGCCCTCGGGAGACCACTGCGAGGCTGGGCTCCTGCAGCTCGACGTGCCCCTGCTCCGCACCCAGCTCCGCGGCTCCCGCC
TGCTCGATGCCATGCGCATGTACCGCCAAGGTTACCCTGACCACATGGTGTTTTCCGAGTTCCGCCGCCGCTTTGATGTCCTGGCCCCGC
ACCTGACCAAGAAACACGGGCGTAACTACATCGTGGTGGATGAAAGGCGGGCAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGAAGA
GCAGCTGCTGCATGGGCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGAGGAGCAGCGGGATGAACAAACCAGCAGGA
ACCTAACCCTGTTCCAAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAGGACCTGGCCATTCGCTGTG
TACAGAAGAACATCAAGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCGAAGTACAGC
TGTCAGAGGAGCAGATCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGCTGC
GGCTCAACAGTGACCGGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCCAGC
TGCTGGACGCGGAGACAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGATGG
AGGTTATGGAAATGGAGGTGATGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCGAGT
GGCGGCTGAAGTATGAGCGGGCTGTGCGGGAGGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGGAGC
AGCAGAACAAGAGGCAGCTGGAACGGCGGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGA
AGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGA
GGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACATGC
TCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGAGG
CAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAAAG
TCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGC
GGATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGA
TGGAGGTGCAGCTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCG
ACCAGGTGAACCGGCGGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCA
TGCTGGACCACCTGAAGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGG
CAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGG
AGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGA
AGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAAGC
AGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCAGG
AAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGAAA
ACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCC
GGGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCC
TGGAGGCTGCTAACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGG
AGAGTGATGAGAATGAGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTCTG
ATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGATG
GCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCT
CCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTG
GCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCT
GCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGA
GGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGG
CCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGT
TGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTC
TTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCA
AGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGG
TCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGAC
CATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGC
AGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTT
GAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCA
TTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCC
CTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTA

>In-frame_ENST00000577226_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(amino acids)=1828AA_start in transcript=347_stop in transcript=5833
MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEE
MLPPGEWMCHRCTVRRKAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDR
LEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIIL
LGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVA
RRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAG
ATKVHSTAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTL
LVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVA
AVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWL
NYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTI
KKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFD
VLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDL
AIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE
SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDK
LEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQR
EKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE
MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA
DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN
ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLAS
RLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAI
EDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDP

--------------------------------------------------------------
>In-frame_ENST00000268756_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(transcript)=7277nt_BP=851nt
CGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGAGGCGGAGCCCG
GGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATACCCCCAGCCCCG
GGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGAC
CCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCG
TCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAG
CGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGA
AAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGG
ACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGG
AAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGTAACCCTCCACTGAGTGAAGAAATGTTGCCTC
CTGGAGAGTGGATGTGTCACCGGTGCACTGTTCGCCGAAAGGCGAAAACAGAAGAACAGATTGCAGCAGAAGAGGCCTGGAATGAGACGG
AGAAGGTGTGGCTGGTCCATAGGGACGGCTTCTCACTGGCCAGTCAACTCAAATCTGAGGAGCTCAACTTGCCTGAGGGGAAGGTGCGTG
TGAAGCTGGACCACGATGGGGCCATCCTGGATGTGGATGAGGATGACGTTGAGAAGGCTAATGCTCCCTCCTGCGACCGTCTGGAGGATC
TGGCCTCACTGGTGTACCTCAATGAGTCCAGCGTCCTGCACACCTTGCGCCAGCGCTATGGCGCTAGCCTGCTGCACACGTATGCTGGCC
CCAGCCTGCTGGTTCTTGGCCCCCGTGGGGCCCCTGCTGTGTACTCTGAGAAGGTGATGCACATGTTCAAGGGTTGTCGGCGGGAGGACA
TGGCACCCCACATCTATGCAGTGGCCCAGACCGCATACAGGGCGATGCTGATGAGCCGTCAGGATCAGTCAATCATCCTCCTGGGCAGTA
GTGGCAGTGGCAAGACCACCAGCTGCCAGCATCTGGTGCAGTACCTGGCCACCATCGCGGGCATCAGCGGGAACAAGGTGTTTTCTGTGG
AGAAGTGGCAGGCTCTGTACACCCTCCTGGAAGCCTTTGGGAACAGCCCCACCATCATTAATGGCAATGCCACCCGCTTCTCCCAGATCC
TCTCCCTGGACTTTGACCAAGCTGGCCAGGTGGCCTCAGCCTCCATTCAGACAATGCTTCTGGAGAAGCTGCGTGTGGCTCGGCGCCCAG
CCAGTGAAGCCACATTCAACGTCTTCTACTACCTGCTGGCCTGTGGGGATGGCACCCTCAGGACAGAGCTCCACCTCAACCACTTGGCAG
AGAACAATGTGTTTGGGATTGTGCCACTGGCCAAGCCTGAGGAAAAGCAGAAGGCAGCTCAGCAGTTTAGTAAGCTGCAGGCGGCCATGA
AGGTGCTGGGCATCTCCCCCGATGAACAGAAGGCCTGCTGGTTCATTCTGGCTGCCATCTACCACCTGGGGGCTGCGGGAGCCACCAAAG
TCCACTCCACAGCTGGGCGCAAGCAGTTTGCCCGCCATGAGTGGGCCCAGAAGGCTGCGTACCTACTGGGCTGCAGCCTGGAGGAGCTGT
CCTCAGCCATCTTCAAGCACCAGCACAAGGGTGGCACCCTGCAGCGCTCCACCTCCTTCCGCCAGGGCCCCGAGGAGAGTGGCCTGGGAG
ATGGGACAGGCCCGAAACTGAGTGCACTGGAGTGCCTTGAGGGCATGGCGGCCGGCCTCTACAGCGAGCTCTTCACCCTTCTCGTCTCCC
TGGTGAATAGGGCTCTCAAGTCCAGCCAGCACTCACTCTGCTCCATGATGATTGTCGACACCCCGGGCTTCCAGAACCCTGAGCAGGGTG
GGTCAGCCCGCGGAGCCTCCTTTGAGGAGCTGTGCCACAACTACACCCAAGACCGGCTGCAGAGGCTCTTCCACGAGCGCACCTTCGTGC
AGGAGTTGGAAAGATACAAGGAGGAGAACATCGAGCTGGCGTTTGACGACTTGGAACCCCCGACGGATGACTCTGTGGCTGCTGTGGACC
AGGCCTCCCATCAGTCCCTGGTCCGCTCGCTGGCCCGCACAGACGAGGCGAGGGGCCTGCTCTGGCTATTGGAAGAGGAGGCTCTGGTGC
CAGGGGCCAGTGAGGACACCCTCCTGGAGCGCCTTTTCTCCTATTATGGCCCCCAGGAAGGTGACAAAAAAGGCCAAAGCCCCCTTCTGC
ACAGCAGCAAACCACACCACTTTCTCCTGGGCCACAGCCATGGCACCAACTGGGTAGAGTACAATGTGACTGGCTGGCTGAACTACACCA
AGCAGAACCCAGCCACCCAGAATGCCCCCCGGCTCCTGCAGGACTCCCAGAAAAAAATCATCAGCAACCTGTTTCTGGGCCGCGCAGGCA
GTGCCACGGTGCTCTCTGGCTCCATCGCGGGCCTGGAGGGCGGCTCGCAGCTGGCACTGCGCCGGGCCACCAGCATGCGGAAAACCTTTA
CCACAGGCATGGCGGCTGTCAAAAAGAAGTCACTGTGCATCCAGATGAAGCTACAGGTGGACGCCCTCATCGACACCATCAAGAAGTCAA
AGCTGCATTTTGTGCACTGCTTCCTGCCTGTAGCTGAGGGCTGGGCTGGGGAGCCCCGTTCCGCCTCCTCCCGCCGAGTCAGCAGCAGCA
GTGAGCTGGACCTGCCCTCGGGAGACCACTGCGAGGCTGGGCTCCTGCAGCTCGACGTGCCCCTGCTCCGCACCCAGCTCCGCGGCTCCC
GCCTGCTCGATGCCATGCGCATGTACCGCCAAGGTTACCCTGACCACATGGTGTTTTCCGAGTTCCGCCGCCGCTTTGATGTCCTGGCCC
CGCACCTGACCAAGAAACACGGGCGTAACTACATCGTGGTGGATGAAAGGCGGGCAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGA
AGAGCAGCTGCTGCATGGGCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGAGGAGCAGCGGGATGAACAAACCAGCA
GGAACCTAACCCTGTTCCAAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAGGACCTGGCCATTCGCT
GTGTACAGAAGAACATCAAGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCGAAGTAC
AGCTGTCAGAGGAGCAGATCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGC
TGCGGCTCAACAGTGACCGGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCC
AGCTGCTGGACGCGGAGACAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGA
TGGAGGTTATGGAAATGGAGGTGATGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCG
AGTGGCGGCTGAAGTATGAGCGGGCTGTGCGGGAGGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGG
AGCAGCAGAACAAGAGGCAGCTGGAACGGCGGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGA
AGAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGC
AGAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACA
TGCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAG
AGGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCA
AAGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGG
AGCGGATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAAC
AGATGGAGGTGCAGCTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCA
GCGACCAGGTGAACCGGCGGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGC
TCATGCTGGACCACCTGAAGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTG
CGGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGC
TGGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGA
AGAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGA
AGCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGC
AGGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGG
AAAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGC
TCCGGGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAA
GCCTGGAGGCTGCTAACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGA
TGGAGAGTGATGAGAATGAGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACT
CTGATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATG
ATGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACA
CCTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGG
TTGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGA
TCTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAA
AGAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGG
TGGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTA
GGTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCT
GTCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTC
CCAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCC
GGGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTG
GACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTAC
AGCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGG
GTTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTG
TCATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTA
TCCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTT

>In-frame_ENST00000268756_ENST00000354329_TCGA-04-1348-01A_PHF12_chr17_27254009_-_MYO18A_chr17_27449271_length(amino acids)=1828AA_start in transcript=530_stop in transcript=6016
MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEE
MLPPGEWMCHRCTVRRKAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDR
LEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIIL
LGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVA
RRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAG
ATKVHSTAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTL
LVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVA
AVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWL
NYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTI
KKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFD
VLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDL
AIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE
SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDK
LEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQR
EKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE
MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA
DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN
ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLAS
RLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAI
EDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PHF12-MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39102_273107.0705.0SIN3A
HgenePHF12chr17:27254009chr17:27449271ENST00000268756-39300_704107.0705.0SIN3A
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315102_273107.01005.0SIN3A
HgenePHF12chr17:27254009chr17:27449271ENST00000332830-315300_704107.01005.0SIN3A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF12-MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF12-MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource