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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF21A-CNP (FusionGDB2 ID:64447)

Fusion Gene Summary for PHF21A-CNP

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21A-CNP
Fusion gene ID: 64447
HgeneTgene
Gene symbol

PHF21A

CNP

Gene ID

51317

4880

Gene namePHD finger protein 21Anatriuretic peptide C
SynonymsBHC80|BM-006|IDDBCS|NEDMSCNP|CNP2
Cytomap

11p11.2

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)C-type natriuretic peptidenatriuretic peptide precursor type C
Modification date2020032720200313
UniProtAcc.

Q8N129

Ensembl transtripts involved in fusion geneENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
ENST00000393892, ENST00000472031, 
ENST00000591072, ENST00000592446, 
ENST00000393888, 
Fusion gene scores* DoF score19 X 13 X 12=29646 X 6 X 3=108
# samples 226
** MAII scorelog2(22/2964*10)=-3.75197001878117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF21A [Title/Abstract] AND CNP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF21A(46098305)-CNP(40120086), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNP

GO:0006182

cGMP biosynthetic process

1672777

TgeneCNP

GO:0006457

protein folding

16870210

TgeneCNP

GO:0007168

receptor guanylyl cyclase signaling pathway

1672777

TgeneCNP

GO:0051447

negative regulation of meiotic cell cycle

20947764

TgeneCNP

GO:1900194

negative regulation of oocyte maturation

20947764


check buttonFusion gene breakpoints across PHF21A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CNP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-QR-A70G-01BPHF21Achr11

46098305

-CNPchr17

40120086

+
ChimerDB4PCPGTCGA-QR-A70G-01BPHF21Achr11

46098305

-CNPchr17

40120086

+


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Fusion Gene ORF analysis for PHF21A-CNP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257821ENST00000393892PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000257821ENST00000472031PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000257821ENST00000591072PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-3UTRENST00000257821ENST00000592446PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-5UTRENST00000257821ENST00000393888PHF21Achr11

46098305

-CNPchr17

40120086

+
In-frameENST00000323180ENST00000393892PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000323180ENST00000472031PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000323180ENST00000591072PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-3UTRENST00000323180ENST00000592446PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-5UTRENST00000323180ENST00000393888PHF21Achr11

46098305

-CNPchr17

40120086

+
In-frameENST00000418153ENST00000393892PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000418153ENST00000472031PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-intronENST00000418153ENST00000591072PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-3UTRENST00000418153ENST00000592446PHF21Achr11

46098305

-CNPchr17

40120086

+
5CDS-5UTRENST00000418153ENST00000393888PHF21Achr11

46098305

-CNPchr17

40120086

+
intron-3CDSENST00000527753ENST00000393892PHF21Achr11

46098305

-CNPchr17

40120086

+
intron-intronENST00000527753ENST00000472031PHF21Achr11

46098305

-CNPchr17

40120086

+
intron-intronENST00000527753ENST00000591072PHF21Achr11

46098305

-CNPchr17

40120086

+
intron-3UTRENST00000527753ENST00000592446PHF21Achr11

46098305

-CNPchr17

40120086

+
intron-5UTRENST00000527753ENST00000393888PHF21Achr11

46098305

-CNPchr17

40120086

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257821PHF21Achr1146098305-ENST00000393892CNPchr1740120086+58477776242039471
ENST00000323180PHF21Achr1146098305-ENST00000393892CNPchr1740120086+55915213681783471
ENST00000418153PHF21Achr1146098305-ENST00000393892CNPchr1740120086+54233532001615471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257821ENST00000393892PHF21Achr1146098305-CNPchr1740120086+0.0054093620.99459064
ENST00000323180ENST00000393892PHF21Achr1146098305-CNPchr1740120086+0.0063367420.9936633
ENST00000418153ENST00000393892PHF21Achr1146098305-CNPchr1740120086+0.0058545460.9941454

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Fusion Genomic Features for PHF21A-CNP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHF21Achr1146098304-CNPchr1740120090+8.44E-080.9999999
PHF21Achr1146098304-CNPchr1740120090+8.44E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF21A-CNP


check button Go to

FGviewer for the breakpoints of chr11:46098305-chr17:40120086

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNP

Q8N129

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF21Achr11:46098305chr17:40120086ENST00000257821-518558_60351.0682.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr17:40120086ENST00000323180-518558_60351.0635.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr17:40120086ENST00000418153-518558_60351.0681.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr17:40120086ENST00000257821-5184_10851.0682.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr17:40120086ENST00000323180-5184_10851.0635.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr17:40120086ENST00000418153-5184_10851.0681.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr17:40120086ENST00000257821-518425_43751.0682.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr17:40120086ENST00000323180-518425_43751.0635.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr17:40120086ENST00000418153-518425_43751.0681.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr17:40120086ENST00000257821-518486_68051.0682.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr17:40120086ENST00000323180-518486_68051.0635.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr17:40120086ENST00000418153-518486_68051.0681.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr17:40120086ENST00000257821-518488_53551.0682.0Zinc fingerPHD-type
HgenePHF21Achr11:46098305chr17:40120086ENST00000323180-518488_53551.0635.0Zinc fingerPHD-type
HgenePHF21Achr11:46098305chr17:40120086ENST00000418153-518488_53551.0681.0Zinc fingerPHD-type


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Fusion Gene Sequence for PHF21A-CNP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000257821_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(transcript)=5847nt_BP=777nt
GGTGAATGGGCTGGTGGTGCTCGCTGCTGCTGCTGAGAGGAGGAGGAGGATGAAGAGTTGGGCTTGTTTGTCTCCTACAGTTTCTCTCCT
GCTGCTCTGATTCCCCCCTCCCGATTCCGGCCCGGGGCCTGTGTGTGTCCCTCCTGGAGGAGGAGGAGGATCCAGTTCCTCCCCCCAACC
CCCTCCTCCCCACCCCCCCTTGCCTGGGGAAGAGGAGGAAAGAAACAGCCCAGAGAGAGAGAGAGAGAGAGAGTGAGTGAGAGAGAGAGG
AGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAGAGGCCCAGAGCAGC
AGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCTGCTTCTCCTGCTCA
GAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCAGTTTCCCCAAAATT
GCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAAGGTAGAGGATGGAG
TTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAATGCTGAC
TTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTC
CTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACA
GTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGAC
AAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGG
CTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAG
CAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAG
GAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGG
TTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAG
CTGCGACAATTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAAAGAGACCCCCAGGCGTGCTGCATTGC
ACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGTTAAAGAAATCTTACTCCAAGGCCTTC
ACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTAAGCGAGCAGCAACTGCAGTTGTGGCCGAGT
GATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCGGCTGTGCAGCTGACGTAGAGGCCGTG
CAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGGTGGGCGAGCTAAGCCGGGGCAAGCTC
TATTCCTTGGGCAATGGGCGCTGGATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACTACGGGAAAGGCAAA
CCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATCATATGAGTGTTCTCACCACCACTTATGCCCCTAGAA
GGGAAGGGGAGAGGGAAACGTGCCCTCTGTTTGATCCTTGTTTTGTGACATTTTTTTTTTTTTTTTTTTTACTCAAAGTTAACCTACCTG
TAACTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAATGCTCACGCTCCCAACACAAGGTGGGC
AGGGAGGCACCATTCAGGAACCTGGACCAAAGCTGACGAGGCTGGGCCAAGCCAGGGATGGGGCCACAGCCAGAACCCCGAGCCCTACTT
CCAGGTTCTGGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGTGAGTGGGGAGACACCTCAGAGCCCCGCAAAACC
CACTGACCGGAGGCAAAAGGCAGTGGGGCTGGGGGTAGTTTTCCATGGTCACAGAGAACTAGTGGTGGCTCTGAGAAGGGGAGGACCTCT
GGGCTTTGATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTATTTCCCAAGCTGGAGTGCAGTGGTGCGATCAT
GGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGCAATCCTCCTGAGTGATCCCATTTCTTAATCAGTGTAGCCCCAAGAAGGCTGGGGCT
ATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCCTCCCCTTCACACCATAACTAGGTAACAGTTT
GATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCGCCACATCCCCGCTGGCTGGGGGCCTCACTCCAGGAAGGGGCTGGACTGGCTGT
CCTTTCCAGTGGCCTGGCTCCGCTGTGTGGATGGGGAGATCGGGGCCAGAGGCAGAACCCTGGTGAGGAAGCTCCAGTCCTGCTCTCTAC
CCAGCCCATCTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACAGGGGCTGGTGGGCACCAAGAGCCAATGGAGTAGACC
CCTGGCTGGTAAGGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTAGTCTGTGTGCTGTGGTTCCTGGGGTGCCCTCC
ACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCGGGTTGTCACTCAACAAAAGTGCTTTGGATTTAAGTTACTATCCTGGCTTTGCCC
AACCTCAGCAACCTGTAAGACTGATAATGAAATAAATCATGTTAATCCTAGCTGTGTGCAGTCTCTCTTACCCTTCTGTGCCCAGCTCAG
TCTTCCCTAGGGCTGGGTGTATTAGGACTGGCTTTGTCCCACAGCTTGGGGCCATCGGTCCTGTCTCCCCTCTGCTGGCCGGGCACAGCT
GTGGTGAGGTTGGGCAGCTGAACAGTGTTGGCTTTCATGAGGAGGCAGAAAGCAGAGGCTGGCCTCAGACTCATACAGAAGGTGGGGGTT
GGCTGGGTACGAGGGATGTGGAGCACAAAAGCCTCTCATCCCCCATTAACCAGGGCACCAAGCCCACAGGTGTCCCCAGCCCACTGGATC
AGAAAGAGTTCAGTAAGACCGGAAGCTCCTGGTATGGGTTTCTCCCAGTTCTCTAGGGAAGGCCACCTGCAGGTCACTGAAACTTCAAGC
ACCAGGGAAGATCTAACATTTGAGTCCCTTCCAGGCCATCAGAGGCCTAGTCAGCCACATGGGAAACTTCCAAGACCTGACTCAGGCATC
ATTCCACCATGGCTAAGGCACCAGCCGGGGAAGACTTGAAAGAAAGGGGCAGGAGCTCAGATGAAGAGAAATCCTAAGTTACCTTTCTAG
GTCAAGGCCTGTCCCTGGCCATCTCTGAACTTCAGCTAGAGCTTCAAGTCTGTGCCTGGAGCTCCTGGGAAGGCTACTCACCTTGAACAC
CACGCTTGACAGGACAGCATGGTGCATGCCGCTGCATCCGTGAGCAGTGTGTCTCCTGCATGCAGAAAGGGAGCAGAGAAGGCCAGGGGC
TTTTGCTAAAAATAGTGGCCAGACCAGAGCTCTGGAGCCACCTGTCCCACCTCAAATGGGTCTGGGGGTCAGGAGGCAGGGTTTTATCTC
TGTCTACCATCTCCCTCGAACCCACACTGCAACAGGAACTGTGAGAGTCTTTGTAAGTAAACTGCCCTGTCTAGGTCAGTACCCACCTGA
GCTTTGGACGCACACAGCTTTTAGTACCCACCTGAGCTTTGGACACACACAGCTTCTAGTGATTTCTGGGGCCCCACCGTAAAGTGAGCA
TGCTTTCTGAACTCGCTTCTCTGTGACTGATGTTAGGCTGGGCCCAGAGGCACAGCCGGGGCCTGCCTAGCACTCACATGCTGGACAGGT
CTGGGAGAGGCAGAGTGCCCCACCTGCCACTAGGCTGGGTGCCCACAGCCCGCATGCAGCAGCTTGCTGCACCCCAAGTCCAGGTCGGGC
TCAGCTCTGGCTCACAGACTGGAGACAATGCAGATGCCAGAGCAAAGGGCCAGGAAGGGTCAAAACATTTTATTCTCTTTTTTTTTTCTT
TTTTAATAAAGTTAAACAGTAAAACAAAAATTCACAAGCTGCCTCCCTGTCCACCCCCGCCTCCCTCCCCTGCCCTCGGTCTTCGGCATT
GGTTCCCTTTGCTCCACCCCACTCACAGAGACACAGGGCATCCAACTGAGAAAACGAAACTGCTCTAAGCACACGGAGACGTGATGAAGG
GAGGAGGTGAACTGTTTCCACATTCAAGATTAAACTGAGTGAATCTGCATTTTCTGGGTTCTGGGTGGTTGCCCTTCATTAGCCAAATTG
AAAAAAGAAATTCCCTGGACCAGATGCTGAAAGAGAAAAGAGGGGTTGGTAGTTGGCTATGGATTTTCTAAGGAAGATCACTTTGCTCTG
ATTATGGAAAAGTCTTCAAGGGCTGCTTCAAACTCAAACACAGAGAGAAACTCTATGGGTATCAAACAGCTCAGGCTGTTTTTGGGTGCA
AGAGGGAGCACGTGACTGTATTATACATGGGTAGCTTCTGACCTCAGCATTATCTATATAGTACCTTTGCTCTTGCAGAGAAGCCTTGGT
ACTAGGCAGTTAGAGATGCCTCCCTGACCCTGCAGAGATGCGGTGGCTAAAGGTCCCAAGGCAAGGGGTGCCTGGGAACCTTCCTGTCTT
CATCCTTAGCAACAGCCGAGTGGATAGATGCCCTGCTAGATGAGAATTCAGCTGCCCCCGCTCATGGGCCCCTCTGACTCCCAAAGAGCT
GCCTAAGAGGCAATGAGTGTGTTGGCTTGTGATCTGGGAACTCCCAAGAACAGCAGGCCCACCTACCTTCAAAGCTGAAGCCGCCAGGAC
CGCCAAAGAATGCCTTGAAGATATTGTTTGGATCAAAATCTGTAGAGCAGGGCAAGTAACATGGAAGGGAAGAAAAGGTGAAAAATTAGA
AATGTTCGAAGAGAACTGATGACACTGAGAACAGATCTCCAAAGCTTTCCTGGAGAGTCTCACTCCCCTCCTTTCCCAACACTTCAGACT
GCAAGTGAGCAAACCTGCCCCATCCCGTGCAAAACATGCTACCTGATCCCACTCCTAGGACATGTTCCCTTCTCCTTCCAACTGCTGCCC
CAAAGGAAGCTTTCTCTGCTTCAGCTTGCTTCATTGGGCTGTTTTCTCAACAAATGGAATGCCATTTGCACTTACACAAGACTTTCCCCA

>In-frame_ENST00000257821_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(amino acids)=471AA_start in transcript=624_stop in transcript=2039
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDE
DTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERER
LEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFK
KELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLW
PSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGK

--------------------------------------------------------------
>In-frame_ENST00000323180_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(transcript)=5591nt_BP=521nt
GTGAGAGAGAGAGGAGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAG
AGGCCCAGAGCAGCAGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCT
GCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCA
GTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAA
GGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATC
CACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAACAGAGGCTTCTCCCGAA
AAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTC
AGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCAC
GGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCG
AGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAAC
GGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACT
GTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGC
TCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGG
CCTTCAAGAAGGAGCTGCGACAATTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAAAGAGACCCCCAG
GCGTGCTGCATTGCACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGTTAAAGAAATCTT
ACTCCAAGGCCTTCACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTAAGCGAGCAGCAACTGC
AGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCGGCTGTGCAGCTG
ACGTAGAGGCCGTGCAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGGTGGGCGAGCTAA
GCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGGATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACT
ACGGGAAAGGCAAACCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATCATATGAGTGTTCTCACCACCAC
TTATGCCCCTAGAAGGGAAGGGGAGAGGGAAACGTGCCCTCTGTTTGATCCTTGTTTTGTGACATTTTTTTTTTTTTTTTTTTTACTCAA
AGTTAACCTACCTGTAACTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAATGCTCACGCTCCC
AACACAAGGTGGGCAGGGAGGCACCATTCAGGAACCTGGACCAAAGCTGACGAGGCTGGGCCAAGCCAGGGATGGGGCCACAGCCAGAAC
CCCGAGCCCTACTTCCAGGTTCTGGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGTGAGTGGGGAGACACCTCAG
AGCCCCGCAAAACCCACTGACCGGAGGCAAAAGGCAGTGGGGCTGGGGGTAGTTTTCCATGGTCACAGAGAACTAGTGGTGGCTCTGAGA
AGGGGAGGACCTCTGGGCTTTGATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTATTTCCCAAGCTGGAGTGC
AGTGGTGCGATCATGGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGCAATCCTCCTGAGTGATCCCATTTCTTAATCAGTGTAGCCCCA
AGAAGGCTGGGGCTATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCCTCCCCTTCACACCATAA
CTAGGTAACAGTTTGATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCGCCACATCCCCGCTGGCTGGGGGCCTCACTCCAGGAAGGG
GCTGGACTGGCTGTCCTTTCCAGTGGCCTGGCTCCGCTGTGTGGATGGGGAGATCGGGGCCAGAGGCAGAACCCTGGTGAGGAAGCTCCA
GTCCTGCTCTCTACCCAGCCCATCTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACAGGGGCTGGTGGGCACCAAGAGC
CAATGGAGTAGACCCCTGGCTGGTAAGGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTAGTCTGTGTGCTGTGGTTC
CTGGGGTGCCCTCCACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCGGGTTGTCACTCAACAAAAGTGCTTTGGATTTAAGTTACTA
TCCTGGCTTTGCCCAACCTCAGCAACCTGTAAGACTGATAATGAAATAAATCATGTTAATCCTAGCTGTGTGCAGTCTCTCTTACCCTTC
TGTGCCCAGCTCAGTCTTCCCTAGGGCTGGGTGTATTAGGACTGGCTTTGTCCCACAGCTTGGGGCCATCGGTCCTGTCTCCCCTCTGCT
GGCCGGGCACAGCTGTGGTGAGGTTGGGCAGCTGAACAGTGTTGGCTTTCATGAGGAGGCAGAAAGCAGAGGCTGGCCTCAGACTCATAC
AGAAGGTGGGGGTTGGCTGGGTACGAGGGATGTGGAGCACAAAAGCCTCTCATCCCCCATTAACCAGGGCACCAAGCCCACAGGTGTCCC
CAGCCCACTGGATCAGAAAGAGTTCAGTAAGACCGGAAGCTCCTGGTATGGGTTTCTCCCAGTTCTCTAGGGAAGGCCACCTGCAGGTCA
CTGAAACTTCAAGCACCAGGGAAGATCTAACATTTGAGTCCCTTCCAGGCCATCAGAGGCCTAGTCAGCCACATGGGAAACTTCCAAGAC
CTGACTCAGGCATCATTCCACCATGGCTAAGGCACCAGCCGGGGAAGACTTGAAAGAAAGGGGCAGGAGCTCAGATGAAGAGAAATCCTA
AGTTACCTTTCTAGGTCAAGGCCTGTCCCTGGCCATCTCTGAACTTCAGCTAGAGCTTCAAGTCTGTGCCTGGAGCTCCTGGGAAGGCTA
CTCACCTTGAACACCACGCTTGACAGGACAGCATGGTGCATGCCGCTGCATCCGTGAGCAGTGTGTCTCCTGCATGCAGAAAGGGAGCAG
AGAAGGCCAGGGGCTTTTGCTAAAAATAGTGGCCAGACCAGAGCTCTGGAGCCACCTGTCCCACCTCAAATGGGTCTGGGGGTCAGGAGG
CAGGGTTTTATCTCTGTCTACCATCTCCCTCGAACCCACACTGCAACAGGAACTGTGAGAGTCTTTGTAAGTAAACTGCCCTGTCTAGGT
CAGTACCCACCTGAGCTTTGGACGCACACAGCTTTTAGTACCCACCTGAGCTTTGGACACACACAGCTTCTAGTGATTTCTGGGGCCCCA
CCGTAAAGTGAGCATGCTTTCTGAACTCGCTTCTCTGTGACTGATGTTAGGCTGGGCCCAGAGGCACAGCCGGGGCCTGCCTAGCACTCA
CATGCTGGACAGGTCTGGGAGAGGCAGAGTGCCCCACCTGCCACTAGGCTGGGTGCCCACAGCCCGCATGCAGCAGCTTGCTGCACCCCA
AGTCCAGGTCGGGCTCAGCTCTGGCTCACAGACTGGAGACAATGCAGATGCCAGAGCAAAGGGCCAGGAAGGGTCAAAACATTTTATTCT
CTTTTTTTTTTCTTTTTTAATAAAGTTAAACAGTAAAACAAAAATTCACAAGCTGCCTCCCTGTCCACCCCCGCCTCCCTCCCCTGCCCT
CGGTCTTCGGCATTGGTTCCCTTTGCTCCACCCCACTCACAGAGACACAGGGCATCCAACTGAGAAAACGAAACTGCTCTAAGCACACGG
AGACGTGATGAAGGGAGGAGGTGAACTGTTTCCACATTCAAGATTAAACTGAGTGAATCTGCATTTTCTGGGTTCTGGGTGGTTGCCCTT
CATTAGCCAAATTGAAAAAAGAAATTCCCTGGACCAGATGCTGAAAGAGAAAAGAGGGGTTGGTAGTTGGCTATGGATTTTCTAAGGAAG
ATCACTTTGCTCTGATTATGGAAAAGTCTTCAAGGGCTGCTTCAAACTCAAACACAGAGAGAAACTCTATGGGTATCAAACAGCTCAGGC
TGTTTTTGGGTGCAAGAGGGAGCACGTGACTGTATTATACATGGGTAGCTTCTGACCTCAGCATTATCTATATAGTACCTTTGCTCTTGC
AGAGAAGCCTTGGTACTAGGCAGTTAGAGATGCCTCCCTGACCCTGCAGAGATGCGGTGGCTAAAGGTCCCAAGGCAAGGGGTGCCTGGG
AACCTTCCTGTCTTCATCCTTAGCAACAGCCGAGTGGATAGATGCCCTGCTAGATGAGAATTCAGCTGCCCCCGCTCATGGGCCCCTCTG
ACTCCCAAAGAGCTGCCTAAGAGGCAATGAGTGTGTTGGCTTGTGATCTGGGAACTCCCAAGAACAGCAGGCCCACCTACCTTCAAAGCT
GAAGCCGCCAGGACCGCCAAAGAATGCCTTGAAGATATTGTTTGGATCAAAATCTGTAGAGCAGGGCAAGTAACATGGAAGGGAAGAAAA
GGTGAAAAATTAGAAATGTTCGAAGAGAACTGATGACACTGAGAACAGATCTCCAAAGCTTTCCTGGAGAGTCTCACTCCCCTCCTTTCC
CAACACTTCAGACTGCAAGTGAGCAAACCTGCCCCATCCCGTGCAAAACATGCTACCTGATCCCACTCCTAGGACATGTTCCCTTCTCCT
TCCAACTGCTGCCCCAAAGGAAGCTTTCTCTGCTTCAGCTTGCTTCATTGGGCTGTTTTCTCAACAAATGGAATGCCATTTGCACTTACA
CAAGACTTTCCCCATACTCTGTCTCCCTATAATGCTGGAGCGGCTACTAAAAAGGATAAAATGTATCACTTAAATGTTACCAAAAATAAA

>In-frame_ENST00000323180_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(amino acids)=471AA_start in transcript=368_stop in transcript=1783
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDE
DTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERER
LEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFK
KELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLW
PSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGK

--------------------------------------------------------------
>In-frame_ENST00000418153_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(transcript)=5423nt_BP=353nt
CCTCCTCCTCCTGCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCT
GAAGGAGAGCCAGTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGA
GAAAGTGGAGAAGGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAA
TGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAACAGAG
GCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGT
TTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGT
CCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAG
GAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACA
CCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGT
GGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGG
ACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGG
GGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAA
AGAGACCCCCAGGCGTGCTGCATTGCACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGT
TAAAGAAATCTTACTCCAAGGCCTTCACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTAAGCG
AGCAGCAACTGCAGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCG
GCTGTGCAGCTGACGTAGAGGCCGTGCAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGG
TGGGCGAGCTAAGCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGGATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCT
TCACGGGGTACTACGGGAAAGGCAAACCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATCATATGAGTGT
TCTCACCACCACTTATGCCCCTAGAAGGGAAGGGGAGAGGGAAACGTGCCCTCTGTTTGATCCTTGTTTTGTGACATTTTTTTTTTTTTT
TTTTTTACTCAAAGTTAACCTACCTGTAACTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAAT
GCTCACGCTCCCAACACAAGGTGGGCAGGGAGGCACCATTCAGGAACCTGGACCAAAGCTGACGAGGCTGGGCCAAGCCAGGGATGGGGC
CACAGCCAGAACCCCGAGCCCTACTTCCAGGTTCTGGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGTGAGTGGG
GAGACACCTCAGAGCCCCGCAAAACCCACTGACCGGAGGCAAAAGGCAGTGGGGCTGGGGGTAGTTTTCCATGGTCACAGAGAACTAGTG
GTGGCTCTGAGAAGGGGAGGACCTCTGGGCTTTGATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTATTTCCC
AAGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGCAATCCTCCTGAGTGATCCCATTTCTTAATC
AGTGTAGCCCCAAGAAGGCTGGGGCTATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCCTCCCC
TTCACACCATAACTAGGTAACAGTTTGATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCGCCACATCCCCGCTGGCTGGGGGCCTCA
CTCCAGGAAGGGGCTGGACTGGCTGTCCTTTCCAGTGGCCTGGCTCCGCTGTGTGGATGGGGAGATCGGGGCCAGAGGCAGAACCCTGGT
GAGGAAGCTCCAGTCCTGCTCTCTACCCAGCCCATCTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACAGGGGCTGGTG
GGCACCAAGAGCCAATGGAGTAGACCCCTGGCTGGTAAGGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTAGTCTGT
GTGCTGTGGTTCCTGGGGTGCCCTCCACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCGGGTTGTCACTCAACAAAAGTGCTTTGGA
TTTAAGTTACTATCCTGGCTTTGCCCAACCTCAGCAACCTGTAAGACTGATAATGAAATAAATCATGTTAATCCTAGCTGTGTGCAGTCT
CTCTTACCCTTCTGTGCCCAGCTCAGTCTTCCCTAGGGCTGGGTGTATTAGGACTGGCTTTGTCCCACAGCTTGGGGCCATCGGTCCTGT
CTCCCCTCTGCTGGCCGGGCACAGCTGTGGTGAGGTTGGGCAGCTGAACAGTGTTGGCTTTCATGAGGAGGCAGAAAGCAGAGGCTGGCC
TCAGACTCATACAGAAGGTGGGGGTTGGCTGGGTACGAGGGATGTGGAGCACAAAAGCCTCTCATCCCCCATTAACCAGGGCACCAAGCC
CACAGGTGTCCCCAGCCCACTGGATCAGAAAGAGTTCAGTAAGACCGGAAGCTCCTGGTATGGGTTTCTCCCAGTTCTCTAGGGAAGGCC
ACCTGCAGGTCACTGAAACTTCAAGCACCAGGGAAGATCTAACATTTGAGTCCCTTCCAGGCCATCAGAGGCCTAGTCAGCCACATGGGA
AACTTCCAAGACCTGACTCAGGCATCATTCCACCATGGCTAAGGCACCAGCCGGGGAAGACTTGAAAGAAAGGGGCAGGAGCTCAGATGA
AGAGAAATCCTAAGTTACCTTTCTAGGTCAAGGCCTGTCCCTGGCCATCTCTGAACTTCAGCTAGAGCTTCAAGTCTGTGCCTGGAGCTC
CTGGGAAGGCTACTCACCTTGAACACCACGCTTGACAGGACAGCATGGTGCATGCCGCTGCATCCGTGAGCAGTGTGTCTCCTGCATGCA
GAAAGGGAGCAGAGAAGGCCAGGGGCTTTTGCTAAAAATAGTGGCCAGACCAGAGCTCTGGAGCCACCTGTCCCACCTCAAATGGGTCTG
GGGGTCAGGAGGCAGGGTTTTATCTCTGTCTACCATCTCCCTCGAACCCACACTGCAACAGGAACTGTGAGAGTCTTTGTAAGTAAACTG
CCCTGTCTAGGTCAGTACCCACCTGAGCTTTGGACGCACACAGCTTTTAGTACCCACCTGAGCTTTGGACACACACAGCTTCTAGTGATT
TCTGGGGCCCCACCGTAAAGTGAGCATGCTTTCTGAACTCGCTTCTCTGTGACTGATGTTAGGCTGGGCCCAGAGGCACAGCCGGGGCCT
GCCTAGCACTCACATGCTGGACAGGTCTGGGAGAGGCAGAGTGCCCCACCTGCCACTAGGCTGGGTGCCCACAGCCCGCATGCAGCAGCT
TGCTGCACCCCAAGTCCAGGTCGGGCTCAGCTCTGGCTCACAGACTGGAGACAATGCAGATGCCAGAGCAAAGGGCCAGGAAGGGTCAAA
ACATTTTATTCTCTTTTTTTTTTCTTTTTTAATAAAGTTAAACAGTAAAACAAAAATTCACAAGCTGCCTCCCTGTCCACCCCCGCCTCC
CTCCCCTGCCCTCGGTCTTCGGCATTGGTTCCCTTTGCTCCACCCCACTCACAGAGACACAGGGCATCCAACTGAGAAAACGAAACTGCT
CTAAGCACACGGAGACGTGATGAAGGGAGGAGGTGAACTGTTTCCACATTCAAGATTAAACTGAGTGAATCTGCATTTTCTGGGTTCTGG
GTGGTTGCCCTTCATTAGCCAAATTGAAAAAAGAAATTCCCTGGACCAGATGCTGAAAGAGAAAAGAGGGGTTGGTAGTTGGCTATGGAT
TTTCTAAGGAAGATCACTTTGCTCTGATTATGGAAAAGTCTTCAAGGGCTGCTTCAAACTCAAACACAGAGAGAAACTCTATGGGTATCA
AACAGCTCAGGCTGTTTTTGGGTGCAAGAGGGAGCACGTGACTGTATTATACATGGGTAGCTTCTGACCTCAGCATTATCTATATAGTAC
CTTTGCTCTTGCAGAGAAGCCTTGGTACTAGGCAGTTAGAGATGCCTCCCTGACCCTGCAGAGATGCGGTGGCTAAAGGTCCCAAGGCAA
GGGGTGCCTGGGAACCTTCCTGTCTTCATCCTTAGCAACAGCCGAGTGGATAGATGCCCTGCTAGATGAGAATTCAGCTGCCCCCGCTCA
TGGGCCCCTCTGACTCCCAAAGAGCTGCCTAAGAGGCAATGAGTGTGTTGGCTTGTGATCTGGGAACTCCCAAGAACAGCAGGCCCACCT
ACCTTCAAAGCTGAAGCCGCCAGGACCGCCAAAGAATGCCTTGAAGATATTGTTTGGATCAAAATCTGTAGAGCAGGGCAAGTAACATGG
AAGGGAAGAAAAGGTGAAAAATTAGAAATGTTCGAAGAGAACTGATGACACTGAGAACAGATCTCCAAAGCTTTCCTGGAGAGTCTCACT
CCCCTCCTTTCCCAACACTTCAGACTGCAAGTGAGCAAACCTGCCCCATCCCGTGCAAAACATGCTACCTGATCCCACTCCTAGGACATG
TTCCCTTCTCCTTCCAACTGCTGCCCCAAAGGAAGCTTTCTCTGCTTCAGCTTGCTTCATTGGGCTGTTTTCTCAACAAATGGAATGCCA
TTTGCACTTACACAAGACTTTCCCCATACTCTGTCTCCCTATAATGCTGGAGCGGCTACTAAAAAGGATAAAATGTATCACTTAAATGTT

>In-frame_ENST00000418153_ENST00000393892_TCGA-QR-A70G-01B_PHF21A_chr11_46098305_-_CNP_chr17_40120086_length(amino acids)=471AA_start in transcript=200_stop in transcript=1615
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDE
DTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERER
LEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFK
KELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLW
PSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PHF21A-CNP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF21A-CNP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF21A-CNP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHF21AC1832588Chromosome 11p11.2 Deletion Syndrome2GENOMICS_ENGLAND;ORPHANET
HgenePHF21AC0036421Systemic Scleroderma1GENOMICS_ENGLAND
HgenePHF21AC1849193PEELING SKIN SYNDROME1GENOMICS_ENGLAND
HgenePHF21AC3714756Intellectual Disability1GENOMICS_ENGLAND
HgenePHF21AC4721610Carcinoma, Ovarian Epithelial1CTD_human
TgeneCNPC0036341Schizophrenia5PSYGENET
TgeneCNPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCNPC0041696Unipolar Depression1PSYGENET
TgeneCNPC1269683Major Depressive Disorder1PSYGENET