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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF21A-GDPD5 (FusionGDB2 ID:64448)

Fusion Gene Summary for PHF21A-GDPD5

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21A-GDPD5
Fusion gene ID: 64448
HgeneTgene
Gene symbol

PHF21A

GDPD5

Gene ID

51317

81544

Gene namePHD finger protein 21Aglycerophosphodiester phosphodiesterase domain containing 5
SynonymsBHC80|BM-006|IDDBCS|NEDMSGDE2|PP1665
Cytomap

11p11.2

11q13.4-q13.5

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)glycerophosphodiester phosphodiesterase domain-containing protein 5glycerophosphodiester phosphodiesterase 2
Modification date2020032720200313
UniProtAcc.

Q8WTR4

Ensembl transtripts involved in fusion geneENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
ENST00000336898, ENST00000376282, 
ENST00000529095, ENST00000526177, 
ENST00000533784, ENST00000529721, 
ENST00000533805, ENST00000443276, 
Fusion gene scores* DoF score19 X 13 X 12=29649 X 7 X 7=441
# samples 2214
** MAII scorelog2(22/2964*10)=-3.75197001878117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/441*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF21A [Title/Abstract] AND GDPD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF21A(45991366)-GDPD5(75173934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHF21A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GDPD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N6-A4VFPHF21Achr11

45991366

-GDPD5chr11

75173934

-


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Fusion Gene ORF analysis for PHF21A-GDPD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257821ENST00000336898PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000376282PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000529095PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000526177PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000533784PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000529721PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000533805PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000257821ENST00000443276PHF21Achr11

45991366

-GDPD5chr11

75173934

-
In-frameENST00000323180ENST00000336898PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000376282PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000529095PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000526177PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000533784PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000529721PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000533805PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000323180ENST00000443276PHF21Achr11

45991366

-GDPD5chr11

75173934

-
In-frameENST00000418153ENST00000336898PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000376282PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000529095PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000526177PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000533784PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000529721PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000533805PHF21Achr11

45991366

-GDPD5chr11

75173934

-
5CDS-intronENST00000418153ENST00000443276PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-3CDSENST00000527753ENST00000336898PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000376282PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000529095PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000526177PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000533784PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000529721PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000533805PHF21Achr11

45991366

-GDPD5chr11

75173934

-
intron-intronENST00000527753ENST00000443276PHF21Achr11

45991366

-GDPD5chr11

75173934

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257821PHF21Achr1145991366-ENST00000336898GDPD5chr1175173934-389413266243026800
ENST00000323180PHF21Achr1145991366-ENST00000336898GDPD5chr1175173934-363810703682770800
ENST00000418153PHF21Achr1145991366-ENST00000336898GDPD5chr1175173934-34678992002599799

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257821ENST00000336898PHF21Achr1145991366-GDPD5chr1175173934-0.0163771170.98362285
ENST00000323180ENST00000336898PHF21Achr1145991366-GDPD5chr1175173934-0.0214899090.97851
ENST00000418153ENST00000336898PHF21Achr1145991366-GDPD5chr1175173934-0.017849840.98215014

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Fusion Genomic Features for PHF21A-GDPD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF21A-GDPD5


check button Go to

FGviewer for the breakpoints of chr11:45991366-chr11:75173934

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GDPD5

Q8WTR4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000250|UniProtKB:Q640M6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF21Achr11:45991366chr11:75173934ENST00000257821-8184_108234.0682.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:45991366chr11:75173934ENST00000323180-8184_108234.0635.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:45991366chr11:75173934ENST00000418153-8184_108233.0681.0Compositional biasNote=Gln-rich
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217228_48539.0606.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013228_4850487.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013228_4850468.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318228_48539.0606.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012228_4850487.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012228_4850361.0DomainNote=GP-PDE
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217111_12539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217147_16039.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217182_19239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217214_49639.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217518_60539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000033689821764_8939.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013111_1250487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013147_1600487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013182_1920487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST000003762820131_420487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013214_4960487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013518_6050487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000037628201364_890487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013111_1250468.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013147_1600468.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013182_1920468.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST000005261770131_420468.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013214_4960468.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013518_6050468.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052617701364_890468.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318111_12539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318147_16039.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318182_19239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318214_49639.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318518_60539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052972131864_8939.0606.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012111_1250487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012147_1600487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012182_1920487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST000005337840121_420487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012214_4960487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012518_6050487.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053378401264_890487.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012111_1250361.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012147_1600361.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012182_1920361.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST000005338050121_420361.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012214_4960361.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012518_6050361.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053380501264_890361.0Topological domainExtracellular
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217126_14639.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217161_18139.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217193_21339.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000033689821743_6339.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000336898217497_51739.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000033689821790_11039.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013126_1460487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013161_1810487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013193_2130487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000037628201343_630487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000376282013497_5170487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000037628201390_1100487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013126_1460468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013161_1810468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013193_2130468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052617701343_630468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000526177013497_5170468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052617701390_1100468.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318126_14639.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318161_18139.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318193_21339.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052972131843_6339.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000529721318497_51739.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000052972131890_11039.0606.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012126_1460487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012161_1810487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012193_2130487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053378401243_630487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533784012497_5170487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053378401290_1100487.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012126_1460361.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012161_1810361.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012193_2130361.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053380501243_630361.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST00000533805012497_5170361.0TransmembraneHelical
TgeneGDPD5chr11:45991366chr11:75173934ENST0000053380501290_1100361.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF21Achr11:45991366chr11:75173934ENST00000257821-818558_603234.0682.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:45991366chr11:75173934ENST00000323180-818558_603234.0635.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:45991366chr11:75173934ENST00000418153-818558_603233.0681.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:45991366chr11:75173934ENST00000257821-818425_437234.0682.0DNA bindingNote=A.T hook
HgenePHF21Achr11:45991366chr11:75173934ENST00000323180-818425_437234.0635.0DNA bindingNote=A.T hook
HgenePHF21Achr11:45991366chr11:75173934ENST00000418153-818425_437233.0681.0DNA bindingNote=A.T hook
HgenePHF21Achr11:45991366chr11:75173934ENST00000257821-818486_680234.0682.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:45991366chr11:75173934ENST00000323180-818486_680234.0635.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:45991366chr11:75173934ENST00000418153-818486_680233.0681.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:45991366chr11:75173934ENST00000257821-818488_535234.0682.0Zinc fingerPHD-type
HgenePHF21Achr11:45991366chr11:75173934ENST00000323180-818488_535234.0635.0Zinc fingerPHD-type
HgenePHF21Achr11:45991366chr11:75173934ENST00000418153-818488_535233.0681.0Zinc fingerPHD-type
TgeneGDPD5chr11:45991366chr11:75173934ENST000003368982171_4239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:45991366chr11:75173934ENST000005297213181_4239.0606.0Topological domainCytoplasmic


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Fusion Gene Sequence for PHF21A-GDPD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000257821_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(transcript)=3894nt_BP=1326nt
GGTGAATGGGCTGGTGGTGCTCGCTGCTGCTGCTGAGAGGAGGAGGAGGATGAAGAGTTGGGCTTGTTTGTCTCCTACAGTTTCTCTCCT
GCTGCTCTGATTCCCCCCTCCCGATTCCGGCCCGGGGCCTGTGTGTGTCCCTCCTGGAGGAGGAGGAGGATCCAGTTCCTCCCCCCAACC
CCCTCCTCCCCACCCCCCCTTGCCTGGGGAAGAGGAGGAAAGAAACAGCCCAGAGAGAGAGAGAGAGAGAGAGTGAGTGAGAGAGAGAGG
AGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAGAGGCCCAGAGCAGC
AGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCTGCTTCTCCTGCTCA
GAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCAGTTTCCCCAAAATT
GCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAAGGTAGAGGATGGAG
TTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAATGCTGAC
TTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAGAACCTG
ATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTA
CAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACT
GTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAG
AGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACG
TCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAG
CCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGTGGGAGCGCCTCTGGTTCCTGCTC
CTCACCTTCACCTTTGGCCTCACGCTCACCTGGCTTTACTTCTGGTGGGAAGTCCACAATGACTATGATGAATTCAACTGGTACCTCTAC
AACCGCATGGGCTACTGGAGCGACTGGCCCGTACCCATCCTTGTGACCACAGCTGCTGCCTTCGCATACATCGCTGGCCTCCTGGTCCTG
GCACTATGTCACATTGCCGTGGGGCAGCAGATGAACCTGCACTGGCTGCACAAGATCGGGCTGGTGGTCATCCTGGCTTCCACGGTGGTG
GCCATGTCGGCCGTGGCCCAGCTGTGGGAGGACGAGTGGGAGGTGCTGCTGATCTCCCTGCAGGGCACAGCGCCATTCCTGCATGTGGGG
GCTGTGGCAGCAGTCACCATGCTCTCCTGGATCGTGGCAGGACAGTTCGCCCGCGCAGAGCGGACCTCCTCCCAGGTGACCATTCTCTGT
ACCTTCTTCACCGTGGTGTTTGCCCTCTACCTGGCCCCTCTCACCATCTCCTCTCCCTGCATCATGGAGAAGAAAGACCTCGGCCCCAAG
CCTGCTCTCATTGGCCACCGCGGGGCCCCCATGCTGGCTCCAGAGCACACGCTCATGTCCTTCCGGAAGGCCCTCGAGCAGAAGCTGTAC
GGGCTCCAGGCTGACATTACCATCAGCCTGGACGGCGTGCCCTTCCTCATGCATGACACCACCCTGCGGCGCACCACCAACGTGGAGGAG
GAGTTCCCGGAGCTGGCCCGCAGGCCTGCCTCCATGCTTAACTGGACCACCCTGCAGAGACTCAACGCTGGCCAGTGGTTCCTGAAGACT
GACCCCTTCTGGACAGCCAGCTCCCTGTCACCCTCCGACCACAGAGAGGCCCAGAACCAGTCCATCTGCAGCCTGGCAGAGCTCCTGGAG
CTGGCCAAGGGCAATGCCACACTGCTGCTCAACCTGCGTGACCCGCCCCGGGAGCACCCCTACCGCAGCAGTTTTATCAACGTGACTCTG
GAGGCCGTGCTGCACTCCGGCTTCCCCCAGCACCAGGTCATGTGGCTGCCTAGCAGGCAGAGGCCCCTGGTGCGGAAGGTGGCTCCCGGC
TTCCAACAGACATCAGGCTCCAAGGAGGCAGTCGCCAGCCTGCGGAGAGGCCACATCCAGCGGCTGAACCTGCGCTACACTCAGGTGTCC
CGCCAGGAGCTCAGGGACTACGCGTCCTGGAACCTGAGTGTGAACCTCTACACAGTCAACGCACCGTGGCTCTTCTCCCTGCTGTGGTGT
GCGGGGGTCCCATCCGTCACCTCTGACAACTCCCACGCCCTGTCCCAGGTGCCTTCCCCCCTCTGGATCATGCCCCCGGACGAGTACTGT
CTCATGTGGGTCACTGCCGACCTGGTCTCCTTCACCCTCATCGTGGGCATCTTCGTGCTCCAGAAGTGGCGCCTGGGTGGCATACGGAGC
TACAACCCTGAGCAGATCATGCTGAGTGCTGCGGTGCGCCGGACCAGCCGGGACGTCAGCATCATGAAGGAGAAGCTTATTTTCTCAGAG
ATCAGCGATGGTGTAGAGGTCTCCGATGTGCTCTCCGTATGTTCAGACAACAGTTATGACACATATGCCAACAGCACCGCCACCCCTGTG
GGCCCCCGAGGGGGTGGCAGCCACACCAAGACCCTCATAGAGCGGAGTGGGCGTTAGCTGAAGACATGTCTGTCCCACCTGTACCTGACA
CAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAAGTGTGTCTGAACTCGGAGTGCTCTGGGAGCGGGCTCCACAGCCTCCTTGTGGGCTCC
AGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGGGACTCCCTGTCTCCTGAGGCCCAGCTGGGCCAGGACTCCATCCTTTCAGATGCCCCT
GCAGGCCTGGGGCTCCTTCTGGGAAGTATGGGGCCTAGGGCTTGGTCCCCCTCTTCTGAGGCCCTCTCCTGTATCCCGACCTGGAAGCTT
TGATGGGTCATGGGCCATGCCATACCCCCTGTGGCAATGGAGTGTGTGGATGCTCACCTGTGCCATCTGTCCTCCTGTCTGTGCCAGGAG
GCACCTGAGTTCTCTGCTGTTATCCTGCCCCAAGGGCCTGGGCCGAGCCTCTACCTGAAGCAACTCTGCTCTTCCTGTCAGTCTCAAAGC
ACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTGCAATGTGGAGACACGTCCTCCTCCCCAACCCACCTCATGCCACCGCCAACCCCCTGC
CCCAGGAGCGGGCCTGAGCCACGTCCTCTAGGAGCAGCTGGAGATGGCCAAAAGAGTGAGCTCAGGACTACTGGATCCCATGCCCAGGTG
TCCAGCAGACCTCAAGGCAGAAGGGTCACCTAACCCAGGAGTCCACAGACTGATGTGACCTCAGGTTCCCACATCAGTGGCCACAGGGCA
GGGCCCACCTGGTAGAAGTGTTCTGGATATGGCCAGGGTGGGTGTGTGGCTAAGTGGGCCTGAACAGAGGGAACCTAGGGCCCTTGGCCA

>In-frame_ENST00000257821_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(amino acids)=800AA_start in transcript=624_stop in transcript=3026
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ
PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL
QTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWY
LYNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLH
VGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQK
LYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAEL
LELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQ
VSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGI

--------------------------------------------------------------
>In-frame_ENST00000323180_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(transcript)=3638nt_BP=1070nt
GTGAGAGAGAGAGGAGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAG
AGGCCCAGAGCAGCAGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCT
GCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCA
GTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAA
GGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATC
CACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGC
TACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCAC
AGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTG
CTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCT
CTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAG
TCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGG
CAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGTGGGAGCGCC
TCTGGTTCCTGCTCCTCACCTTCACCTTTGGCCTCACGCTCACCTGGCTTTACTTCTGGTGGGAAGTCCACAATGACTATGATGAATTCA
ACTGGTACCTCTACAACCGCATGGGCTACTGGAGCGACTGGCCCGTACCCATCCTTGTGACCACAGCTGCTGCCTTCGCATACATCGCTG
GCCTCCTGGTCCTGGCACTATGTCACATTGCCGTGGGGCAGCAGATGAACCTGCACTGGCTGCACAAGATCGGGCTGGTGGTCATCCTGG
CTTCCACGGTGGTGGCCATGTCGGCCGTGGCCCAGCTGTGGGAGGACGAGTGGGAGGTGCTGCTGATCTCCCTGCAGGGCACAGCGCCAT
TCCTGCATGTGGGGGCTGTGGCAGCAGTCACCATGCTCTCCTGGATCGTGGCAGGACAGTTCGCCCGCGCAGAGCGGACCTCCTCCCAGG
TGACCATTCTCTGTACCTTCTTCACCGTGGTGTTTGCCCTCTACCTGGCCCCTCTCACCATCTCCTCTCCCTGCATCATGGAGAAGAAAG
ACCTCGGCCCCAAGCCTGCTCTCATTGGCCACCGCGGGGCCCCCATGCTGGCTCCAGAGCACACGCTCATGTCCTTCCGGAAGGCCCTCG
AGCAGAAGCTGTACGGGCTCCAGGCTGACATTACCATCAGCCTGGACGGCGTGCCCTTCCTCATGCATGACACCACCCTGCGGCGCACCA
CCAACGTGGAGGAGGAGTTCCCGGAGCTGGCCCGCAGGCCTGCCTCCATGCTTAACTGGACCACCCTGCAGAGACTCAACGCTGGCCAGT
GGTTCCTGAAGACTGACCCCTTCTGGACAGCCAGCTCCCTGTCACCCTCCGACCACAGAGAGGCCCAGAACCAGTCCATCTGCAGCCTGG
CAGAGCTCCTGGAGCTGGCCAAGGGCAATGCCACACTGCTGCTCAACCTGCGTGACCCGCCCCGGGAGCACCCCTACCGCAGCAGTTTTA
TCAACGTGACTCTGGAGGCCGTGCTGCACTCCGGCTTCCCCCAGCACCAGGTCATGTGGCTGCCTAGCAGGCAGAGGCCCCTGGTGCGGA
AGGTGGCTCCCGGCTTCCAACAGACATCAGGCTCCAAGGAGGCAGTCGCCAGCCTGCGGAGAGGCCACATCCAGCGGCTGAACCTGCGCT
ACACTCAGGTGTCCCGCCAGGAGCTCAGGGACTACGCGTCCTGGAACCTGAGTGTGAACCTCTACACAGTCAACGCACCGTGGCTCTTCT
CCCTGCTGTGGTGTGCGGGGGTCCCATCCGTCACCTCTGACAACTCCCACGCCCTGTCCCAGGTGCCTTCCCCCCTCTGGATCATGCCCC
CGGACGAGTACTGTCTCATGTGGGTCACTGCCGACCTGGTCTCCTTCACCCTCATCGTGGGCATCTTCGTGCTCCAGAAGTGGCGCCTGG
GTGGCATACGGAGCTACAACCCTGAGCAGATCATGCTGAGTGCTGCGGTGCGCCGGACCAGCCGGGACGTCAGCATCATGAAGGAGAAGC
TTATTTTCTCAGAGATCAGCGATGGTGTAGAGGTCTCCGATGTGCTCTCCGTATGTTCAGACAACAGTTATGACACATATGCCAACAGCA
CCGCCACCCCTGTGGGCCCCCGAGGGGGTGGCAGCCACACCAAGACCCTCATAGAGCGGAGTGGGCGTTAGCTGAAGACATGTCTGTCCC
ACCTGTACCTGACACAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAAGTGTGTCTGAACTCGGAGTGCTCTGGGAGCGGGCTCCACAGCC
TCCTTGTGGGCTCCAGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGGGACTCCCTGTCTCCTGAGGCCCAGCTGGGCCAGGACTCCATCC
TTTCAGATGCCCCTGCAGGCCTGGGGCTCCTTCTGGGAAGTATGGGGCCTAGGGCTTGGTCCCCCTCTTCTGAGGCCCTCTCCTGTATCC
CGACCTGGAAGCTTTGATGGGTCATGGGCCATGCCATACCCCCTGTGGCAATGGAGTGTGTGGATGCTCACCTGTGCCATCTGTCCTCCT
GTCTGTGCCAGGAGGCACCTGAGTTCTCTGCTGTTATCCTGCCCCAAGGGCCTGGGCCGAGCCTCTACCTGAAGCAACTCTGCTCTTCCT
GTCAGTCTCAAAGCACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTGCAATGTGGAGACACGTCCTCCTCCCCAACCCACCTCATGCCAC
CGCCAACCCCCTGCCCCAGGAGCGGGCCTGAGCCACGTCCTCTAGGAGCAGCTGGAGATGGCCAAAAGAGTGAGCTCAGGACTACTGGAT
CCCATGCCCAGGTGTCCAGCAGACCTCAAGGCAGAAGGGTCACCTAACCCAGGAGTCCACAGACTGATGTGACCTCAGGTTCCCACATCA
GTGGCCACAGGGCAGGGCCCACCTGGTAGAAGTGTTCTGGATATGGCCAGGGTGGGTGTGTGGCTAAGTGGGCCTGAACAGAGGGAACCT

>In-frame_ENST00000323180_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(amino acids)=800AA_start in transcript=368_stop in transcript=2770
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ
PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL
QTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWY
LYNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLH
VGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQK
LYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAEL
LELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQ
VSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGI

--------------------------------------------------------------
>In-frame_ENST00000418153_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(transcript)=3467nt_BP=899nt
CCTCCTCCTCCTGCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCT
GAAGGAGAGCCAGTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGA
GAAAGTGGAGAAGGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAA
TGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAG
TAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAAC
TACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTC
CCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGA
CCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGC
AGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTC
TGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGT
GGGAGCGCCTCTGGTTCCTGCTCCTCACCTTCACCTTTGGCCTCACGCTCACCTGGCTTTACTTCTGGTGGGAAGTCCACAATGACTATG
ATGAATTCAACTGGTACCTCTACAACCGCATGGGCTACTGGAGCGACTGGCCCGTACCCATCCTTGTGACCACAGCTGCTGCCTTCGCAT
ACATCGCTGGCCTCCTGGTCCTGGCACTATGTCACATTGCCGTGGGGCAGCAGATGAACCTGCACTGGCTGCACAAGATCGGGCTGGTGG
TCATCCTGGCTTCCACGGTGGTGGCCATGTCGGCCGTGGCCCAGCTGTGGGAGGACGAGTGGGAGGTGCTGCTGATCTCCCTGCAGGGCA
CAGCGCCATTCCTGCATGTGGGGGCTGTGGCAGCAGTCACCATGCTCTCCTGGATCGTGGCAGGACAGTTCGCCCGCGCAGAGCGGACCT
CCTCCCAGGTGACCATTCTCTGTACCTTCTTCACCGTGGTGTTTGCCCTCTACCTGGCCCCTCTCACCATCTCCTCTCCCTGCATCATGG
AGAAGAAAGACCTCGGCCCCAAGCCTGCTCTCATTGGCCACCGCGGGGCCCCCATGCTGGCTCCAGAGCACACGCTCATGTCCTTCCGGA
AGGCCCTCGAGCAGAAGCTGTACGGGCTCCAGGCTGACATTACCATCAGCCTGGACGGCGTGCCCTTCCTCATGCATGACACCACCCTGC
GGCGCACCACCAACGTGGAGGAGGAGTTCCCGGAGCTGGCCCGCAGGCCTGCCTCCATGCTTAACTGGACCACCCTGCAGAGACTCAACG
CTGGCCAGTGGTTCCTGAAGACTGACCCCTTCTGGACAGCCAGCTCCCTGTCACCCTCCGACCACAGAGAGGCCCAGAACCAGTCCATCT
GCAGCCTGGCAGAGCTCCTGGAGCTGGCCAAGGGCAATGCCACACTGCTGCTCAACCTGCGTGACCCGCCCCGGGAGCACCCCTACCGCA
GCAGTTTTATCAACGTGACTCTGGAGGCCGTGCTGCACTCCGGCTTCCCCCAGCACCAGGTCATGTGGCTGCCTAGCAGGCAGAGGCCCC
TGGTGCGGAAGGTGGCTCCCGGCTTCCAACAGACATCAGGCTCCAAGGAGGCAGTCGCCAGCCTGCGGAGAGGCCACATCCAGCGGCTGA
ACCTGCGCTACACTCAGGTGTCCCGCCAGGAGCTCAGGGACTACGCGTCCTGGAACCTGAGTGTGAACCTCTACACAGTCAACGCACCGT
GGCTCTTCTCCCTGCTGTGGTGTGCGGGGGTCCCATCCGTCACCTCTGACAACTCCCACGCCCTGTCCCAGGTGCCTTCCCCCCTCTGGA
TCATGCCCCCGGACGAGTACTGTCTCATGTGGGTCACTGCCGACCTGGTCTCCTTCACCCTCATCGTGGGCATCTTCGTGCTCCAGAAGT
GGCGCCTGGGTGGCATACGGAGCTACAACCCTGAGCAGATCATGCTGAGTGCTGCGGTGCGCCGGACCAGCCGGGACGTCAGCATCATGA
AGGAGAAGCTTATTTTCTCAGAGATCAGCGATGGTGTAGAGGTCTCCGATGTGCTCTCCGTATGTTCAGACAACAGTTATGACACATATG
CCAACAGCACCGCCACCCCTGTGGGCCCCCGAGGGGGTGGCAGCCACACCAAGACCCTCATAGAGCGGAGTGGGCGTTAGCTGAAGACAT
GTCTGTCCCACCTGTACCTGACACAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAAGTGTGTCTGAACTCGGAGTGCTCTGGGAGCGGGC
TCCACAGCCTCCTTGTGGGCTCCAGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGGGACTCCCTGTCTCCTGAGGCCCAGCTGGGCCAGG
ACTCCATCCTTTCAGATGCCCCTGCAGGCCTGGGGCTCCTTCTGGGAAGTATGGGGCCTAGGGCTTGGTCCCCCTCTTCTGAGGCCCTCT
CCTGTATCCCGACCTGGAAGCTTTGATGGGTCATGGGCCATGCCATACCCCCTGTGGCAATGGAGTGTGTGGATGCTCACCTGTGCCATC
TGTCCTCCTGTCTGTGCCAGGAGGCACCTGAGTTCTCTGCTGTTATCCTGCCCCAAGGGCCTGGGCCGAGCCTCTACCTGAAGCAACTCT
GCTCTTCCTGTCAGTCTCAAAGCACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTGCAATGTGGAGACACGTCCTCCTCCCCAACCCACC
TCATGCCACCGCCAACCCCCTGCCCCAGGAGCGGGCCTGAGCCACGTCCTCTAGGAGCAGCTGGAGATGGCCAAAAGAGTGAGCTCAGGA
CTACTGGATCCCATGCCCAGGTGTCCAGCAGACCTCAAGGCAGAAGGGTCACCTAACCCAGGAGTCCACAGACTGATGTGACCTCAGGTT
CCCACATCAGTGGCCACAGGGCAGGGCCCACCTGGTAGAAGTGTTCTGGATATGGCCAGGGTGGGTGTGTGGCTAAGTGGGCCTGAACAG

>In-frame_ENST00000418153_ENST00000336898_TCGA-N6-A4VF_PHF21A_chr11_45991366_-_GDPD5_chr11_75173934_length(amino acids)=799AA_start in transcript=200_stop in transcript=2599
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ
PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL
QTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYL
YNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHV
GAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKL
YGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELL
ELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQV
SRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PHF21A-GDPD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF21A-GDPD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF21A-GDPD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHF21AC1832588Chromosome 11p11.2 Deletion Syndrome2GENOMICS_ENGLAND;ORPHANET
HgenePHF21AC0036421Systemic Scleroderma1GENOMICS_ENGLAND
HgenePHF21AC1849193PEELING SKIN SYNDROME1GENOMICS_ENGLAND
HgenePHF21AC3714756Intellectual Disability1GENOMICS_ENGLAND
HgenePHF21AC4721610Carcinoma, Ovarian Epithelial1CTD_human