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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHLDB1-NR4A1 (FusionGDB2 ID:64554)

Fusion Gene Summary for PHLDB1-NR4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHLDB1-NR4A1
Fusion gene ID: 64554
HgeneTgene
Gene symbol

PHLDB1

NR4A1

Gene ID

23187

3164

Gene namepleckstrin homology like domain family B member 1nuclear receptor subfamily 4 group A member 1
SynonymsLL5AGFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3
Cytomap

11q23.3

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology-like domain family B member 1LL5alphapleckstrin homology-like domain family B member 1 variant 3pleckstrin homology-like domain family B member 1 variant 4protein LL5-alphanuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucle
Modification date2020032020200329
UniProtAcc.

P22736

Ensembl transtripts involved in fusion geneENST00000361417, ENST00000356063, 
ENST00000534672, ENST00000527898, 
ENST00000524713, 		ENST00000360284, 
ENST00000545748, ENST00000550082, 
ENST00000547206, ENST00000243050, 
ENST00000394825, ENST00000394824, 
ENST00000548232, 
Fusion gene scores* DoF score12 X 11 X 8=105615 X 14 X 4=840
# samples 1216
** MAII scorelog2(12/1056*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHLDB1 [Title/Abstract] AND NR4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHLDB1(118486926)-NR4A1(52448111), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR4A1

GO:0002042

cell migration involved in sprouting angiogenesis

18059339

TgeneNR4A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22427340


check buttonFusion gene breakpoints across PHLDB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NR4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01APHLDB1chr11

118486926

+NR4A1chr12

52448111

+


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Fusion Gene ORF analysis for PHLDB1-NR4A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361417ENST00000360284PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
In-frameENST00000361417ENST00000545748PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
In-frameENST00000361417ENST00000550082PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-3UTRENST00000361417ENST00000547206PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000361417ENST00000243050PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000361417ENST00000394825PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000361417ENST00000394824PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000361417ENST00000548232PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
In-frameENST00000356063ENST00000360284PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
In-frameENST00000356063ENST00000545748PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
In-frameENST00000356063ENST00000550082PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-3UTRENST00000356063ENST00000547206PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000356063ENST00000243050PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000356063ENST00000394825PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000356063ENST00000394824PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
5CDS-5UTRENST00000356063ENST00000548232PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000534672ENST00000360284PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000534672ENST00000545748PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000534672ENST00000550082PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3UTRENST00000534672ENST00000547206PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000534672ENST00000243050PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000534672ENST00000394825PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000534672ENST00000394824PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000534672ENST00000548232PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000527898ENST00000360284PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000527898ENST00000545748PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000527898ENST00000550082PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3UTRENST00000527898ENST00000547206PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000527898ENST00000243050PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000527898ENST00000394825PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000527898ENST00000394824PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000527898ENST00000548232PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000524713ENST00000360284PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000524713ENST00000545748PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3CDSENST00000524713ENST00000550082PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-3UTRENST00000524713ENST00000547206PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000524713ENST00000243050PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000524713ENST00000394825PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000524713ENST00000394824PHLDB1chr11

118486926

+NR4A1chr12

52448111

+
intron-5UTRENST00000524713ENST00000548232PHLDB1chr11

118486926

+NR4A1chr12

52448111

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361417PHLDB1chr11118486926+ENST00000360284NR4A1chr1252448111+26707662522564770
ENST00000361417PHLDB1chr11118486926+ENST00000545748NR4A1chr1252448111+31227662522564770
ENST00000361417PHLDB1chr11118486926+ENST00000550082NR4A1chr1252448111+26707662522564770
ENST00000356063PHLDB1chr11118486926+ENST00000360284NR4A1chr1252448111+2337433782231717
ENST00000356063PHLDB1chr11118486926+ENST00000545748NR4A1chr1252448111+2789433782231717
ENST00000356063PHLDB1chr11118486926+ENST00000550082NR4A1chr1252448111+2337433782231717

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361417ENST00000360284PHLDB1chr11118486926+NR4A1chr1252448111+0.029682210.9703178
ENST00000361417ENST00000545748PHLDB1chr11118486926+NR4A1chr1252448111+0.0159781170.98402184
ENST00000361417ENST00000550082PHLDB1chr11118486926+NR4A1chr1252448111+0.029682210.9703178
ENST00000356063ENST00000360284PHLDB1chr11118486926+NR4A1chr1252448111+0.0366539550.963346
ENST00000356063ENST00000545748PHLDB1chr11118486926+NR4A1chr1252448111+0.0186015010.9813985
ENST00000356063ENST00000550082PHLDB1chr11118486926+NR4A1chr1252448111+0.0366539550.963346

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Fusion Genomic Features for PHLDB1-NR4A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHLDB1chr11118486926+NR4A1chr1252448110+2.81E-091
PHLDB1chr11118486926+NR4A1chr1252448110+2.81E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHLDB1-NR4A1


check button Go to

FGviewer for the breakpoints of chr11:118486926-chr12:52448111

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NR4A1

P22736

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12813, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000002430501882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418583_58612.333333333333334612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000003602841882_9212.333333333333334612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000003948241882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000003948250782_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202583_5860326.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000005482320282_920326.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207583_58612.333333333333334612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr11:118486926chr12:52448111ENST000005500820782_9212.333333333333334612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418264_33912.333333333333334612.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202264_3390326.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207264_33912.333333333333334612.0DNA bindingNuclear receptor
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018360_5950599.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418360_59512.333333333333334612.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418360_5950599.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507360_5950599.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202360_5950326.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207360_59512.333333333333334612.0DomainNR LBD
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418171_46612.333333333333334612.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202171_4660326.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207171_46612.333333333333334612.0RegionRequired for nuclear import
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000024305018303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418267_28712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000036028418303_32712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482418303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000039482507303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202267_2870326.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000054823202303_3270326.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207267_28712.333333333333334612.0Zinc fingerNR C4-type
TgeneNR4A1chr11:118486926chr12:52448111ENST0000055008207303_32712.333333333333334612.0Zinc fingerNR C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHLDB1chr11:118486926chr12:52448111ENST00000356063+4211144_1208118.333333333333331320.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118486926chr12:52448111ENST00000356063+421683_809118.333333333333331320.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118486926chr12:52448111ENST00000361417+5241144_1208118.333333333333331378.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118486926chr12:52448111ENST00000361417+524683_809118.333333333333331378.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118486926chr12:52448111ENST00000356063+4211256_1370118.333333333333331320.0DomainPH
HgenePHLDB1chr11:118486926chr12:52448111ENST00000356063+42164_125118.333333333333331320.0DomainNote=FHA
HgenePHLDB1chr11:118486926chr12:52448111ENST00000361417+5241256_1370118.333333333333331378.0DomainPH
HgenePHLDB1chr11:118486926chr12:52448111ENST00000361417+52464_125118.333333333333331378.0DomainNote=FHA


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Fusion Gene Sequence for PHLDB1-NR4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361417_ENST00000360284_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=2670nt_BP=766nt
ACTAAACTCATTGAATTAGAACAGCACTTGTCCATCTCAAAGAGGATAAATTATTTTTTGCTATCCACCCCAGCTGGAATTTAGACCAGA
CTTACAGGCTTTCTGCTCCTTCCTTCAGTGAAGAAGAGTCTCCAGGGTCCCTCTAGTGCAGGTCAAAGAAGTCCAGTCCAGCTGAGTTCA
GCTCCCTAGGGCCTCCCCAGCCAGTCTCCTGGACCAAGAGCTGGCTTTGCAAGAAAACATCCTACTAAAGCCCTGGGAAAAGAGACAAAT
GGTGAAGAGGAGAATGAAAGGTTGCAGGAGGGAGCTCCTGTTTTAGCCCTGCCACCTACCTGGGGGCCCTCTGGCTACCAGTGTCCTTGG
AGGGGCTTCCTTGCTGCTTCTCCCACTAAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTCAATAGGAACCAAATAGGCCCTGGATGC
CAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAAGTGCAAACGGACAAACCCCACCTGGTG
AGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACGGTGATTGGCTCTGCAGCCAGAGACATC
TCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTCACCCTCTACCCCTGTGGCAATGCCTGC
ACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAAGCCCAATATGGGACACCAGCACCGAGT
CCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTGGCCAGCCCCGAGGCAGCCCCC
GCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTCCTCTACCAGCTGCCAGGAACA
GTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCCTCTGCCTCCTTCAAGTTCGAG
GACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGTGGCTCTGACTACTATGGCAGC
CCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCCTTCGGCCACTTCTCGCCCAGC
CAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCAGCCTTCTTTTCCTTCAGTCCT
CCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAGCTGGGGGAGGGAGAGAGCTAT
TCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGATACACCCGTGACCTCAACCAAG
GCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAGCATTATGGTGTCCGCACATGT
GAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAGGACTGCCCTGTGGACAAGAGG
CGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTCCGAACAGACAGCCTGAAGGGG
CGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCCCTGGTCCGTGCACACCTGGAC
TCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAGGAAGATGCTGGGGATGTACAG
CAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTTGCTGAGCTGTCACCGGCTGAC
CAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCAGGCGAGGGCAAGCTCATCTTC
TGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTGGCCTTCTCAAGGTCCCTGCAC
AGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGGCTGCAGGAGCCGCGGCGGGTG
GAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAGCCAGCCAGCTGCCTGTCACGT
CTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAGCTGGAGGACTTGGTGCCCCCT
CCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCACATGCGCACTCTCATATGCCA

>In-frame_ENST00000361417_ENST00000360284_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=770AA_start in transcript=252_stop in transcript=2564
MGKETNGEEENERLQEGAPVLALPPTWGPSGYQCPWRGFLAASPTKELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQT
DKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQY
GTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPAS
ASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPA
FFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH
YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSL
VRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPG
EGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQP

--------------------------------------------------------------
>In-frame_ENST00000361417_ENST00000545748_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=3122nt_BP=766nt
ACTAAACTCATTGAATTAGAACAGCACTTGTCCATCTCAAAGAGGATAAATTATTTTTTGCTATCCACCCCAGCTGGAATTTAGACCAGA
CTTACAGGCTTTCTGCTCCTTCCTTCAGTGAAGAAGAGTCTCCAGGGTCCCTCTAGTGCAGGTCAAAGAAGTCCAGTCCAGCTGAGTTCA
GCTCCCTAGGGCCTCCCCAGCCAGTCTCCTGGACCAAGAGCTGGCTTTGCAAGAAAACATCCTACTAAAGCCCTGGGAAAAGAGACAAAT
GGTGAAGAGGAGAATGAAAGGTTGCAGGAGGGAGCTCCTGTTTTAGCCCTGCCACCTACCTGGGGGCCCTCTGGCTACCAGTGTCCTTGG
AGGGGCTTCCTTGCTGCTTCTCCCACTAAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTCAATAGGAACCAAATAGGCCCTGGATGC
CAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAAGTGCAAACGGACAAACCCCACCTGGTG
AGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACGGTGATTGGCTCTGCAGCCAGAGACATC
TCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTCACCCTCTACCCCTGTGGCAATGCCTGC
ACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAAGCCCAATATGGGACACCAGCACCGAGT
CCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTGGCCAGCCCCGAGGCAGCCCCC
GCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTCCTCTACCAGCTGCCAGGAACA
GTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCCTCTGCCTCCTTCAAGTTCGAG
GACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGTGGCTCTGACTACTATGGCAGC
CCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCCTTCGGCCACTTCTCGCCCAGC
CAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCAGCCTTCTTTTCCTTCAGTCCT
CCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAGCTGGGGGAGGGAGAGAGCTAT
TCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGATACACCCGTGACCTCAACCAAG
GCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAGCATTATGGTGTCCGCACATGT
GAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAGGACTGCCCTGTGGACAAGAGG
CGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTCCGAACAGACAGCCTGAAGGGG
CGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCCCTGGTCCGTGCACACCTGGAC
TCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAGGAAGATGCTGGGGATGTACAG
CAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTTGCTGAGCTGTCACCGGCTGAC
CAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCAGGCGAGGGCAAGCTCATCTTC
TGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTGGCCTTCTCAAGGTCCCTGCAC
AGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGGCTGCAGGAGCCGCGGCGGGTG
GAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAGCCAGCCAGCTGCCTGTCACGT
CTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAGCTGGAGGACTTGGTGCCCCCT
CCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCACATGCGCACTCTCATATGCCA
CCCCATGTGCCTTTAGTCCACGGACCCCCAGAGCACCCCCAAGCCTGGGCTTGAGCTGCAGAATGACTCCACCTTCTCACCTGCTCCAGG
AGGTTTGCAGGGAGCTCAAGCCCTTGGGGAGGGGGATGCCTTCATGGGGGTGACCCCACGATTTGTCTTATCCCCCCCAGCCTGGCCCCG
GCCTTTATGTTTTTTGTAAGATAAACCGTTTTTAACACATAGCGCCGTGCTGTAAATAAGCCCAGTGCTGCTGTAAATACAGGAAGAAAG
AGCTTGAGGTGGGAGCGGGGCTGGGAGGAAGGGATGGGCCCCGCCTTCCTGGGCAGCCTTTCCAGCCTCCTGCTGGCTCTCTCTTCCTAC
CCTCCTTCCACATGTACATAAACTGTCACTCTAGGAAGAAGACAAATGACAGATTCTGACATTTATATTTGTGTATTTTCCTGGATTTAT

>In-frame_ENST00000361417_ENST00000545748_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=770AA_start in transcript=252_stop in transcript=2564
MGKETNGEEENERLQEGAPVLALPPTWGPSGYQCPWRGFLAASPTKELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQT
DKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQY
GTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPAS
ASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPA
FFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH
YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSL
VRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPG
EGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQP

--------------------------------------------------------------
>In-frame_ENST00000361417_ENST00000550082_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=2670nt_BP=766nt
ACTAAACTCATTGAATTAGAACAGCACTTGTCCATCTCAAAGAGGATAAATTATTTTTTGCTATCCACCCCAGCTGGAATTTAGACCAGA
CTTACAGGCTTTCTGCTCCTTCCTTCAGTGAAGAAGAGTCTCCAGGGTCCCTCTAGTGCAGGTCAAAGAAGTCCAGTCCAGCTGAGTTCA
GCTCCCTAGGGCCTCCCCAGCCAGTCTCCTGGACCAAGAGCTGGCTTTGCAAGAAAACATCCTACTAAAGCCCTGGGAAAAGAGACAAAT
GGTGAAGAGGAGAATGAAAGGTTGCAGGAGGGAGCTCCTGTTTTAGCCCTGCCACCTACCTGGGGGCCCTCTGGCTACCAGTGTCCTTGG
AGGGGCTTCCTTGCTGCTTCTCCCACTAAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTCAATAGGAACCAAATAGGCCCTGGATGC
CAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAAGTGCAAACGGACAAACCCCACCTGGTG
AGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACGGTGATTGGCTCTGCAGCCAGAGACATC
TCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTCACCCTCTACCCCTGTGGCAATGCCTGC
ACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAAGCCCAATATGGGACACCAGCACCGAGT
CCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTGGCCAGCCCCGAGGCAGCCCCC
GCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTCCTCTACCAGCTGCCAGGAACA
GTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCCTCTGCCTCCTTCAAGTTCGAG
GACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGTGGCTCTGACTACTATGGCAGC
CCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCCTTCGGCCACTTCTCGCCCAGC
CAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCAGCCTTCTTTTCCTTCAGTCCT
CCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAGCTGGGGGAGGGAGAGAGCTAT
TCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGATACACCCGTGACCTCAACCAAG
GCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAGCATTATGGTGTCCGCACATGT
GAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAGGACTGCCCTGTGGACAAGAGG
CGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTCCGAACAGACAGCCTGAAGGGG
CGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCCCTGGTCCGTGCACACCTGGAC
TCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAGGAAGATGCTGGGGATGTACAG
CAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTTGCTGAGCTGTCACCGGCTGAC
CAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCAGGCGAGGGCAAGCTCATCTTC
TGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTGGCCTTCTCAAGGTCCCTGCAC
AGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGGCTGCAGGAGCCGCGGCGGGTG
GAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAGCCAGCCAGCTGCCTGTCACGT
CTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAGCTGGAGGACTTGGTGCCCCCT
CCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCACATGCGCACTCTCATATGCCA

>In-frame_ENST00000361417_ENST00000550082_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=770AA_start in transcript=252_stop in transcript=2564
MGKETNGEEENERLQEGAPVLALPPTWGPSGYQCPWRGFLAASPTKELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQT
DKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQY
GTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPAS
ASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPA
FFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH
YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSL
VRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPG
EGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQP

--------------------------------------------------------------
>In-frame_ENST00000356063_ENST00000360284_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=2337nt_BP=433nt
GACCGAGCCGAGCCAGGCTAAGGGACCAGTGTCTCCCTGCCCCCCCCCCACCTCTAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTC
AATAGGAACCAAATAGGCCCTGGATGCCAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAA
GTGCAAACGGACAAACCCCACCTGGTGAGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACG
GTGATTGGCTCTGCAGCCAGAGACATCTCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTC
ACCCTCTACCCCTGTGGCAATGCCTGCACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAA
GCCCAATATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATG
GACCTGGCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGAC
ACCTTCCTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCC
CCTGCCTCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCC
TCCAGTGGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGAT
GGCTCCTTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAG
CCTCCAGCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACC
CACCAGCTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATA
CTGGATACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCA
TGCCAGCATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCT
AACAAGGACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAA
GTTGTCCGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTC
ACTTCCCTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTT
GGGAAGGAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCT
GGCTTTGCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCT
AAGCCAGGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGT
ATCCTGGCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGG
CATGGGCTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAG
CCCCAGCCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTAC
CTCAAGCTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACG

>In-frame_ENST00000356063_ENST00000360284_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=717AA_start in transcript=78_stop in transcript=2231
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
RGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYT
GEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQL
SPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLE
GSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVG
MVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA
EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL

--------------------------------------------------------------
>In-frame_ENST00000356063_ENST00000545748_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=2789nt_BP=433nt
GACCGAGCCGAGCCAGGCTAAGGGACCAGTGTCTCCCTGCCCCCCCCCCACCTCTAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTC
AATAGGAACCAAATAGGCCCTGGATGCCAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAA
GTGCAAACGGACAAACCCCACCTGGTGAGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACG
GTGATTGGCTCTGCAGCCAGAGACATCTCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTC
ACCCTCTACCCCTGTGGCAATGCCTGCACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAA
GCCCAATATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATG
GACCTGGCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGAC
ACCTTCCTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCC
CCTGCCTCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCC
TCCAGTGGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGAT
GGCTCCTTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAG
CCTCCAGCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACC
CACCAGCTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATA
CTGGATACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCA
TGCCAGCATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCT
AACAAGGACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAA
GTTGTCCGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTC
ACTTCCCTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTT
GGGAAGGAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCT
GGCTTTGCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCT
AAGCCAGGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGT
ATCCTGGCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGG
CATGGGCTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAG
CCCCAGCCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTAC
CTCAAGCTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACG
TGTGCACATGCGCACTCTCATATGCCACCCCATGTGCCTTTAGTCCACGGACCCCCAGAGCACCCCCAAGCCTGGGCTTGAGCTGCAGAA
TGACTCCACCTTCTCACCTGCTCCAGGAGGTTTGCAGGGAGCTCAAGCCCTTGGGGAGGGGGATGCCTTCATGGGGGTGACCCCACGATT
TGTCTTATCCCCCCCAGCCTGGCCCCGGCCTTTATGTTTTTTGTAAGATAAACCGTTTTTAACACATAGCGCCGTGCTGTAAATAAGCCC
AGTGCTGCTGTAAATACAGGAAGAAAGAGCTTGAGGTGGGAGCGGGGCTGGGAGGAAGGGATGGGCCCCGCCTTCCTGGGCAGCCTTTCC
AGCCTCCTGCTGGCTCTCTCTTCCTACCCTCCTTCCACATGTACATAAACTGTCACTCTAGGAAGAAGACAAATGACAGATTCTGACATT

>In-frame_ENST00000356063_ENST00000545748_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=717AA_start in transcript=78_stop in transcript=2231
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
RGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYT
GEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQL
SPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLE
GSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVG
MVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA
EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL

--------------------------------------------------------------
>In-frame_ENST00000356063_ENST00000550082_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(transcript)=2337nt_BP=433nt
GACCGAGCCGAGCCAGGCTAAGGGACCAGTGTCTCCCTGCCCCCCCCCCACCTCTAGGAGCTCTGGAGCCTTAGGACCATGGACGCTCTC
AATAGGAACCAAATAGGCCCTGGATGCCAGACCCAGACCATGGTGCAGAAAGGACCCTTGGACCTGATCGAGACAGGCAAAGGGCTGAAA
GTGCAAACGGACAAACCCCACCTGGTGAGCCTGGGCAGTGGGCGACTCAGCACAGCCATCACCCTCCTGCCGCTGGAGGAAGGGAGGACG
GTGATTGGCTCTGCAGCCAGAGACATCTCACTACAGGGCCCAGGCCTGGCTCCAGAGCACTGCTACATCGAGAACCTGCGGGGCACCCTC
ACCCTCTACCCCTGTGGCAATGCCTGCACTATTGATGGGCTCCCTGTCCGGCAGCCTACCCGGCTCACTCAGGAGATGCCCTGTATCCAA
GCCCAATATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATG
GACCTGGCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGAC
ACCTTCCTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCC
CCTGCCTCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCC
TCCAGTGGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGAT
GGCTCCTTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAG
CCTCCAGCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACC
CACCAGCTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATA
CTGGATACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCA
TGCCAGCATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCT
AACAAGGACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAA
GTTGTCCGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTC
ACTTCCCTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTT
GGGAAGGAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCT
GGCTTTGCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCT
AAGCCAGGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGT
ATCCTGGCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGG
CATGGGCTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAG
CCCCAGCCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTAC
CTCAAGCTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACG

>In-frame_ENST00000356063_ENST00000550082_TCGA-D7-A4Z0-01A_PHLDB1_chr11_118486926_+_NR4A1_chr12_52448111_length(amino acids)=717AA_start in transcript=78_stop in transcript=2231
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
RGTLTLYPCGNACTIDGLPVRQPTRLTQEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYT
GEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQL
SPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLE
GSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVG
MVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA
EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL

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Fusion Gene PPI Analysis for PHLDB1-NR4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHLDB1-NR4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHLDB1-NR4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHLDB1C0017638Glioma1CTD_human
HgenePHLDB1C0259783mixed gliomas1CTD_human
HgenePHLDB1C0555198Malignant Glioma1CTD_human
TgeneNR4A1C0011574Involutional Depression1CTD_human
TgeneNR4A1C0014175Endometriosis1CTD_human
TgeneNR4A1C0021655Insulin Resistance1CTD_human
TgeneNR4A1C0022658Kidney Diseases1CTD_human
TgeneNR4A1C0030297Pancreatic Neoplasm1CTD_human
TgeneNR4A1C0033687Proteinuria1CTD_human
TgeneNR4A1C0151744Myocardial Ischemia1CTD_human
TgeneNR4A1C0269102Endometrioma1CTD_human
TgeneNR4A1C0346647Malignant neoplasm of pancreas1CTD_human
TgeneNR4A1C0920563Insulin Sensitivity1CTD_human
TgeneNR4A1C1269683Major Depressive Disorder1CTD_human
TgeneNR4A1C1571983Involutional paraphrenia1CTD_human
TgeneNR4A1C1571984Psychosis, Involutional1CTD_human