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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHTF2-RUNDC3B (FusionGDB2 ID:64620)

Fusion Gene Summary for PHTF2-RUNDC3B

check button Fusion gene summary
Fusion gene informationFusion gene name: PHTF2-RUNDC3B
Fusion gene ID: 64620
HgeneTgene
Gene symbol

PHTF2

RUNDC3B

Gene ID

57157

154661

Gene nameputative homeodomain transcription factor 2RUN domain containing 3B
Synonyms-RPIB9|RPIP9
Cytomap

7q11.23-q21.11

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionputative homeodomain transcription factor 2RUN domain-containing protein 3BRPIP-9Rap2 binding protein 9Rap2-interacting protein 9rap2-binding protein 9
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000422959, ENST00000307305, 
ENST00000424760, ENST00000415251, 
ENST00000275575, ENST00000450574, 
ENST00000416283, ENST00000248550, 
ENST00000454592, 		ENST00000338056, 
ENST00000493037, ENST00000394654, 
ENST00000496000, 
Fusion gene scores* DoF score8 X 7 X 6=3366 X 6 X 4=144
# samples 96
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHTF2 [Title/Abstract] AND RUNDC3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHTF2(77583211)-RUNDC3B(87459200), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHTF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RUNDC3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0SV-01APHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+


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Fusion Gene ORF analysis for PHTF2-RUNDC3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000422959ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
In-frameENST00000422959ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000422959ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
5CDS-intronENST00000422959ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000307305ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
In-frameENST00000307305ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000307305ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
5CDS-intronENST00000307305ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000424760ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000424760ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000424760ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-intronENST00000424760ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000415251ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000415251ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000415251ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-intronENST00000415251ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000275575ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
In-frameENST00000275575ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000275575ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
5CDS-intronENST00000275575ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000450574ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000450574ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000450574ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-intronENST00000450574ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000416283ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
In-frameENST00000416283ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000416283ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
5CDS-intronENST00000416283ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000248550ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
In-frameENST00000248550ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
Frame-shiftENST00000248550ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
5CDS-intronENST00000248550ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000454592ENST00000338056PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000454592ENST00000493037PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-3CDSENST00000454592ENST00000394654PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+
intron-intronENST00000454592ENST00000496000PHTF2chr7

77583211

-RUNDC3Bchr7

87459200

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000422959PHTF2chr777583211-ENST00000493037RUNDC3Bchr787459200+300924372022481759
ENST00000307305PHTF2chr777583211-ENST00000493037RUNDC3Bchr787459200+299724252022469755
ENST00000275575PHTF2chr777583211-ENST00000493037RUNDC3Bchr787459200+274521731062217703
ENST00000416283PHTF2chr777583211-ENST00000493037RUNDC3Bchr787459200+293323611262405759
ENST00000248550PHTF2chr777583211-ENST00000493037RUNDC3Bchr787459200+29852413762457793

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000422959ENST00000493037PHTF2chr777583211-RUNDC3Bchr787459200+0.0005475480.9994524
ENST00000307305ENST00000493037PHTF2chr777583211-RUNDC3Bchr787459200+0.0004181970.99958175
ENST00000275575ENST00000493037PHTF2chr777583211-RUNDC3Bchr787459200+0.0004561410.99954385
ENST00000416283ENST00000493037PHTF2chr777583211-RUNDC3Bchr787459200+0.000529860.9994702
ENST00000248550ENST00000493037PHTF2chr777583211-RUNDC3Bchr787459200+0.0003633120.99963665

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Fusion Genomic Features for PHTF2-RUNDC3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHTF2-RUNDC3B


check button Go to

FGviewer for the breakpoints of chr7:77583211-chr7:87459200

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-181946_191779.0786.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-161746_191689.0696.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-171846_191741.0748.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-171846_191745.0752.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-181946_191745.0752.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819136_156779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819164_184779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819497_517779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819553_573779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819634_654779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819668_688779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000248550-1819760_780779.0786.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617136_156689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617164_184689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617497_517689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617553_573689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617634_654689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617668_688689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718136_156741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718164_184741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718497_517741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718553_573741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718634_654741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718668_688741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718136_156745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718164_184745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718497_517745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718553_573745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718634_654745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718668_688745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819136_156745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819164_184745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819497_517745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819553_573745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819634_654745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819668_688745.0752.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-1946_1910353.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-1946_1910357.0DomainPHTF
HgenePHTF2chr7:77583211chr7:87459200ENST00000275575-1617760_780689.0696.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000307305-1718760_780741.0748.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19136_1560353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19164_1840353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19497_5170353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19553_5730353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19634_6540353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19668_6880353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000415251-19760_7800353.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000416283-1718760_780745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000422959-1819760_780745.0752.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19136_1560357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19164_1840357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19497_5170357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19553_5730357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19634_6540357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19668_6880357.0TransmembraneHelical
HgenePHTF2chr7:77583211chr7:87459200ENST00000450574-19760_7800357.0TransmembraneHelical
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST000003380561012317_342425.3333333333333474.0Coiled coilOntology_term=ECO:0000255
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST00000394654911317_342408.3333333333333457.0Coiled coilOntology_term=ECO:0000255
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST00000493037810317_342359.3333333333333408.0Coiled coilOntology_term=ECO:0000255
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST00000338056101214_20425.3333333333333474.0Compositional biasNote=Poly-Gly
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST0000039465491114_20408.3333333333333457.0Compositional biasNote=Poly-Gly
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST0000049303781014_20359.3333333333333408.0Compositional biasNote=Poly-Gly
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST00000338056101257_206425.3333333333333474.0DomainRUN
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST0000039465491157_206408.3333333333333457.0DomainRUN
TgeneRUNDC3Bchr7:77583211chr7:87459200ENST0000049303781057_206359.3333333333333408.0DomainRUN


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Fusion Gene Sequence for PHTF2-RUNDC3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000422959_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(transcript)=3009nt_BP=2437nt
TCCGGCGCAAAATCCTGCGGGAGAGGGGGTGGGGCAACCCTCTGGAGGCAGCGCGCCCGCGGGCAGCCTCGTTGTGGCTCCTTGGGCTCT
GTTGGCGGCGGCGCTAGCTTCGGAGTCTCCCGCGCGCACCTCAGCCGCCTCCTAGCGGCGCGGCGCTCGCTCCTACGCCTAAAATGACCA
ATGTGTGATTTCAGTGGAATAAATGGCGTCCAAAGTCACAGATGCTATAGTCTGGTATCAAAAGAAGATTGGAGCATATGATCAACAAAT
ATGGGAAAAATCTGTTGAACAGAGAGAAATCAAGTTTATTAAACTGGGGCTAAGGAATAAACCAAAGAAAACAGCACATGTGAAACCAGA
CCTCATAGATGTTGATCTTGTAAGAGGGTCTGCATTTGCAAAGGCAAAGCCTGAAAGTCCTTGGACTTCTCTGACCAGAAAGGGAATTGT
TCGAGTTGTATTTTTCCCCTTTTTCTTCCGGTGGTGGTTACAAGTAACATCAAAGGTCATCTTTTTCTGGCTTCTTGTCCTTTATCTTCT
TCAAGTTGCTGCAATAGTATTATTCTGCTCCACTTCTAGCCCACACAGCATACCTCTGACAGAGGTGATTGGGCCGATATGGCTGATGCT
GCTCCTGGGAACTGTGCATTGCCAGATTGTTTCCACAAGAACACCCAAACCTCCTCTAAGTACAGGGGGTAAAAGAAGAAGGAAATTAAG
AAAAGCAGCCCATTTGGAAGTACATAGGGAAGGAGATGGTTCTAGTACCACAGATAACACACAAGAGGGAGCAGTTCAGAACCACGGTAC
AAGCACCTCTCACAGCGTTGGCACTGTCTTCAGAGATCTCTGGCATGCTGCTTTCTTTTTATCAGGATCAAAGAAAGCAAAGAATTCAAT
TGATAAATCAACTGAAACTGACAATGGCTATGTATCCCTTGATGGGAAGAAGACTGTTAAAAGCGGTGAAGATGGAATACAAAACCATGA
ACCTCAGTGTGAAACTATTCGACCAGAAGAGACAGCCTGGAACACAGGAACACTGAGGAATGGTCCTAGCAAAGATACCCAAAGGACAAT
AACAAATGTCTCTGATGAAGTCTCCAGTGAGGAAGGTCCTGAAACAGGATACTCATTACGTCGTCATGTGGACAGGACTTCTGAAGGTGT
TCTTCGGAATAGAAAGTCACACCATTATAAGAAACATTACCCTAATGAGGACGCCCCTAAATCGGGTACTAGTTGCAGCTCTCGCTGTTC
AAGTTCCAGACAGGATTCTGAGAGTGCAAGGCCAGAATCTGAAACAGAAGATGTGTTATGGGAAGACTTGTTACATTGTGCAGAATGCCA
TTCATCTTGTACCAGTGAGACAGATGTGGAAAATCATCAGATTAATCCATGTGTGAAAAAAGAATATAGAGATGACCCTTTTCATCAGAG
TCATTTGCCCTGGCTCCATAGTTCCCACCCAGGATTAGAAAAAATAAGTGCTATAGTATGGGAAGGTAATGATTGTAAGAAAGCAGACAT
GTCTGTACTTGAAATCAGTGGAATGATAATGAACAGAGTGAACAGCCATATACCAGGAATAGGATACCAGATTTTTGGAAATGCAGTCTC
TCTCATACTGGGTTTAACTCCATTTGTTTTCCGACTTTCTCAAGCTACAGACTTGGAACAACTCACAGCACATTCTGCTTCAGAACTTTA
TGTGATTGCATTTGGTTCTAATGAAGATGTCATAGTTCTTTCTATGGTTATAATAAGTTTTGTGGTTCGCGTGTCTCTTGTGTGGATTTT
CTTTTTTTTGCTCTGTGTAGCAGAAAGAACTTATAAACAGCGATTACTTTTTGCAAAACTCTTTGGACATTTAACATCTGCAAGGAGGGC
TCGAAAATCTGAGGTTCCTCATTTCCGGTTGAAGAAAGTACAGAATATAAAAATGTGGCTATCTCTCCGTTCCTATCTTAAGCGTCGAGG
TCCTCAGCGATCAGTTGATGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGCTACTTCATGT
ACACGAGATCTTCCTTGATTGTCACTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTAAGATTTGTTACCCT
TGGATCAGAAACAAGTAAAAAATATAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATGGAGAAAAAACCTAA
CAAAAAGGAGGAACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATTATATGG
GCTTACAATGAATCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGGATTTAA
TTTAAAGGTAAGGAAGATACTCCCTCATTACTTGGCCTCTGTGGATCTCTAACGTCAGTGGCAAGTTACAAGTCTCTAACAAGCTTAAAA
TCTAATGACTACCTTGCAAGTCCTACAACAGAGATGACAAGTCCAGGCCTAACTCCATCCTGAAAATTTTTGTGTAAAAGCCAAAACTTT
TTATGTTGTAAATGTTTAATTTACATGTTTGACTGCTGGGAAGACCTTTGAAATTTTATATTGTTCTGGTACATGTCTGAAATTCTATTG
CTTGGAGAGAATCCCCTCCAGATAAGAGATTTTGAGTGAAAAACATAATGATCCTGCCATTTTTCATTTTTAAAATTCTTACATTTGTCA
TTGAGAAAGTTCAAAATGGAATAGGCTTTAAAAAAAAAAAAACTTTCAAAGATCCGCCAAATCATTCATAGCAAATTGTACATATTGTTC
AGCTGATTTTTATATATTTAAATACACCTTAGTGGCCAGAGACTGACTTCAAGGTTTTATTCCAGAGACTCCAGAGACTTAAGCTAAGTA

>In-frame_ENST00000422959_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(amino acids)=759AA_start in transcript=202_stop in transcript=2481
MASKVTDAIVWYQKKIGAYDQQIWEKSVEQREIKFIKLGLRNKPKKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPF
FFRWWLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEV
HREGDGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIR
PEETAWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSE
SARPESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISG
MIMNRVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVA
ERTYKQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVHEIFLDC
HYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLL

--------------------------------------------------------------
>In-frame_ENST00000307305_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(transcript)=2997nt_BP=2425nt
TCCGGCGCAAAATCCTGCGGGAGAGGGGGTGGGGCAACCCTCTGGAGGCAGCGCGCCCGCGGGCAGCCTCGTTGTGGCTCCTTGGGCTCT
GTTGGCGGCGGCGCTAGCTTCGGAGTCTCCCGCGCGCACCTCAGCCGCCTCCTAGCGGCGCGGCGCTCGCTCCTACGCCTAAAATGACCA
ATGTGTGATTTCAGTGGAATAAATGGCGTCCAAAGTCACAGATGCTATAGTCTGGTATCAAAAGAAGATTGGAGCATATGATCAACAAAT
ATGGGAAAAATCTGTTGAACAGAGAGAAATCAAGGGGCTAAGGAATAAACCAAAGAAAACAGCACATGTGAAACCAGACCTCATAGATGT
TGATCTTGTAAGAGGGTCTGCATTTGCAAAGGCAAAGCCTGAAAGTCCTTGGACTTCTCTGACCAGAAAGGGAATTGTTCGAGTTGTATT
TTTCCCCTTTTTCTTCCGGTGGTGGTTACAAGTAACATCAAAGGTCATCTTTTTCTGGCTTCTTGTCCTTTATCTTCTTCAAGTTGCTGC
AATAGTATTATTCTGCTCCACTTCTAGCCCACACAGCATACCTCTGACAGAGGTGATTGGGCCGATATGGCTGATGCTGCTCCTGGGAAC
TGTGCATTGCCAGATTGTTTCCACAAGAACACCCAAACCTCCTCTAAGTACAGGGGGTAAAAGAAGAAGGAAATTAAGAAAAGCAGCCCA
TTTGGAAGTACATAGGGAAGGAGATGGTTCTAGTACCACAGATAACACACAAGAGGGAGCAGTTCAGAACCACGGTACAAGCACCTCTCA
CAGCGTTGGCACTGTCTTCAGAGATCTCTGGCATGCTGCTTTCTTTTTATCAGGATCAAAGAAAGCAAAGAATTCAATTGATAAATCAAC
TGAAACTGACAATGGCTATGTATCCCTTGATGGGAAGAAGACTGTTAAAAGCGGTGAAGATGGAATACAAAACCATGAACCTCAGTGTGA
AACTATTCGACCAGAAGAGACAGCCTGGAACACAGGAACACTGAGGAATGGTCCTAGCAAAGATACCCAAAGGACAATAACAAATGTCTC
TGATGAAGTCTCCAGTGAGGAAGGTCCTGAAACAGGATACTCATTACGTCGTCATGTGGACAGGACTTCTGAAGGTGTTCTTCGGAATAG
AAAGTCACACCATTATAAGAAACATTACCCTAATGAGGACGCCCCTAAATCGGGTACTAGTTGCAGCTCTCGCTGTTCAAGTTCCAGACA
GGATTCTGAGAGTGCAAGGCCAGAATCTGAAACAGAAGATGTGTTATGGGAAGACTTGTTACATTGTGCAGAATGCCATTCATCTTGTAC
CAGTGAGACAGATGTGGAAAATCATCAGATTAATCCATGTGTGAAAAAAGAATATAGAGATGACCCTTTTCATCAGAGTCATTTGCCCTG
GCTCCATAGTTCCCACCCAGGATTAGAAAAAATAAGTGCTATAGTATGGGAAGGTAATGATTGTAAGAAAGCAGACATGTCTGTACTTGA
AATCAGTGGAATGATAATGAACAGAGTGAACAGCCATATACCAGGAATAGGATACCAGATTTTTGGAAATGCAGTCTCTCTCATACTGGG
TTTAACTCCATTTGTTTTCCGACTTTCTCAAGCTACAGACTTGGAACAACTCACAGCACATTCTGCTTCAGAACTTTATGTGATTGCATT
TGGTTCTAATGAAGATGTCATAGTTCTTTCTATGGTTATAATAAGTTTTGTGGTTCGCGTGTCTCTTGTGTGGATTTTCTTTTTTTTGCT
CTGTGTAGCAGAAAGAACTTATAAACAGCGATTACTTTTTGCAAAACTCTTTGGACATTTAACATCTGCAAGGAGGGCTCGAAAATCTGA
GGTTCCTCATTTCCGGTTGAAGAAAGTACAGAATATAAAAATGTGGCTATCTCTCCGTTCCTATCTTAAGCGTCGAGGTCCTCAGCGATC
AGTTGATGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGCTACTTCATGTACACGAGATCTT
CCTTGATTGTCACTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTAAGATTTGTTACCCTTGGATCAGAAAC
AAGTAAAAAATATAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATGGAGAAAAAACCTAACAAAAAGGAGGA
ACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATTATATGGGCTTACAATGAA
TCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGGATTTAATTTAAAGGTAAG
GAAGATACTCCCTCATTACTTGGCCTCTGTGGATCTCTAACGTCAGTGGCAAGTTACAAGTCTCTAACAAGCTTAAAATCTAATGACTAC
CTTGCAAGTCCTACAACAGAGATGACAAGTCCAGGCCTAACTCCATCCTGAAAATTTTTGTGTAAAAGCCAAAACTTTTTATGTTGTAAA
TGTTTAATTTACATGTTTGACTGCTGGGAAGACCTTTGAAATTTTATATTGTTCTGGTACATGTCTGAAATTCTATTGCTTGGAGAGAAT
CCCCTCCAGATAAGAGATTTTGAGTGAAAAACATAATGATCCTGCCATTTTTCATTTTTAAAATTCTTACATTTGTCATTGAGAAAGTTC
AAAATGGAATAGGCTTTAAAAAAAAAAAAACTTTCAAAGATCCGCCAAATCATTCATAGCAAATTGTACATATTGTTCAGCTGATTTTTA
TATATTTAAATACACCTTAGTGGCCAGAGACTGACTTCAAGGTTTTATTCCAGAGACTCCAGAGACTTAAGCTAAGTATTTTTTCATTCT

>In-frame_ENST00000307305_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(amino acids)=755AA_start in transcript=202_stop in transcript=2469
MASKVTDAIVWYQKKIGAYDQQIWEKSVEQREIKGLRNKPKKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFFRW
WLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEVHREG
DGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIRPEET
AWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSESARP
ESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISGMIMN
RVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVAERTY
KQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVHEIFLDCHYNW
ELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLLYNIT

--------------------------------------------------------------
>In-frame_ENST00000275575_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(transcript)=2745nt_BP=2173nt
GGCGGCGCTAGCTTCGGAGTCTCCCGCGCGCACCTCAGCCGCCTCCTAGCGGCGCGGCGCTCGCTCCTACGCCTAAAATGACCAATGTGT
GATTTCAGTGGAATAAATGGCGTCCAAAGTCACAGATGCTATAGTCTGGTATCAAAAGAAGATTGGAGCATATGATCAACAAATATGGGA
AAAATCTGTTGAACAGAGAGAAATCAAGGGGCTAAGGAATAAACCAAAGAAAACAGCACATGTGAAACCAGACCTCATAGATGTTGATCT
TGTAAGAGGGTCTGCATTTGCAAAGGCAAAGCCTGAAAGTCCTTGGACTTCTCTGACCAGAAAGGGAATTGTTCGAGTTGTATTTTTCCC
CTTTTTCTTCCGGTGGTGGTTACAAGTAACATCAAAGGTCATCTTTTTCTGGCTTCTTGTCCTTTATCTTCTTCAAGTTGCTGCAATAGT
ATTATTCTGCTCCACTTCTAGCCCACACAGCATACCTCTGACAGAGGTGATTGGGCCGATATGGCTGATGCTGCTCCTGGGAACTGTGCA
TTGCCAGATTGTTTCCACAAGAACACCCAAACCTCCTCTAAGTACAGGGGGTAAAAGAAGAAGGAAATTAAGAAAAGCAGCCCATTTGGA
AGTACATAGGGAAGGAGATGGTTCTAGTACCACAGATAACACACAAGAGGGAGCAGTTCAGAACCACGGTACAAGCACCTCTCACAGCGT
TGGCACTGTCTTCAGAGATCTCTGGCATGCTGCTTTCTTTTTATCAGGATCAAAGAAAGCAAAGAATTCAATTGATAAATCAACTGAAAC
TGACAATGGCTATGTATCCCTTGATGGGAAGAAGACTGTTAAAAGCGGTGAAGATGGAATACAAAACCATGAACCTCAGTGTGAAACTAT
TCGACCAGAAGAGACAGCCTGGAACACAGGAACACTGAGGAATGGTCCTAGCAAAGATACCCAAAGGACAATAACAAATGTCTCTGATGA
AGTCTCCAGTGAGGAAGGTCCTGAAACAGGATACTCATTACGTCGTCATGTGGACAGGACTTCTGAAGGTGTTCTTCGGAATAGAAAGTC
ACACCATTATAAGAAACATTACCCTAATGAGGACGCCCCTAAATCGGGTACTAGTTGCAGCTCTCGCTGTTCAAGTTCCAGACAGGATTC
TGAGAGTGCAAGGCCAGAATCTGAAACAGAAGATGTGTTATGGGAAGACTTGTTACATTGTGCAGAATGCCATTCATCTTGTACCAGTGA
GACAGATGTGGAAAATCATCAGATTAATCCATGTGTGAAAAAAGAATATAGAGATGACCCTTTTCATCAGAGTCATTTGCCCTGGCTCCA
TAGTTCCCACCCAGGATTAGAAAAAATAAGTGCTATAGTATGGGAAGGTAATGATTGTAAGAAAGCAGACATGTCTGTACTTGAAATCAG
TGGAATGATAATGAACAGAGTGAACAGCCATATACCAGGAATAGGATACCAGATTTTTGGAAATGCAGTCTCTCTCATACTGGGTTTAAC
TCCATTTGTTTTCCGACTTTCTCAAGCTACAGACTTGGAACAACTCACAGCACATTCTGCTTCAGAACTTTATGTGATTGCATTTGGTTC
TAATGAAGATGTCATAGTTCTTTCTATGGTTATAATAAGTTTTGTGGTTCGCGTGTCTCTTGTGTGGATTTTCTTTTTTTTGCTCTGTGT
AGCAGAAAGAACTTATAAACAGCGATTACTTTTTGCAAAACTCTTTGGACATTTAACATCTGCAAGGAGGGCTCGAAAATCTGAGGTTCC
TCATTTCCGGTTGAAGAAAGTACAGAATATAAAAATGTGGCTATCTCTCCGTTCCTATCTTAAGCGTCGAGGTCCTCAGCGATCAGTTGA
TGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGATAAACCTCTACTTGAAAATGGAGAAAAA
ACCTAACAAAAAGGAGGAACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATT
ATATGGGCTTACAATGAATCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGG
ATTTAATTTAAAGGTAAGGAAGATACTCCCTCATTACTTGGCCTCTGTGGATCTCTAACGTCAGTGGCAAGTTACAAGTCTCTAACAAGC
TTAAAATCTAATGACTACCTTGCAAGTCCTACAACAGAGATGACAAGTCCAGGCCTAACTCCATCCTGAAAATTTTTGTGTAAAAGCCAA
AACTTTTTATGTTGTAAATGTTTAATTTACATGTTTGACTGCTGGGAAGACCTTTGAAATTTTATATTGTTCTGGTACATGTCTGAAATT
CTATTGCTTGGAGAGAATCCCCTCCAGATAAGAGATTTTGAGTGAAAAACATAATGATCCTGCCATTTTTCATTTTTAAAATTCTTACAT
TTGTCATTGAGAAAGTTCAAAATGGAATAGGCTTTAAAAAAAAAAAAACTTTCAAAGATCCGCCAAATCATTCATAGCAAATTGTACATA
TTGTTCAGCTGATTTTTATATATTTAAATACACCTTAGTGGCCAGAGACTGACTTCAAGGTTTTATTCCAGAGACTCCAGAGACTTAAGC

>In-frame_ENST00000275575_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(amino acids)=703AA_start in transcript=106_stop in transcript=2217
MASKVTDAIVWYQKKIGAYDQQIWEKSVEQREIKGLRNKPKKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFFRW
WLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEVHREG
DGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIRPEET
AWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSESARP
ESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISGMIMN
RVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVAERTY
KQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQINLYLKMEKKPNKKE

--------------------------------------------------------------
>In-frame_ENST00000416283_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(transcript)=2933nt_BP=2361nt
AAGTAACCAGAGTGCTATGTCTGCATGCTGTTCAGTCTCCTTTTGGAAGGTGGGAAATAAAGTCATTTGTATGTTTTTCTCTCTTGCACA
GCCTAAAATGACCAATGTGTGATTTCAGTGGAATAAATGGCGTCCAAAGTCACAGATGCTATAGTCTGGTATCAAAAGAAGATTGGAGCA
TATGATCAACAAATATGGGAAAAATCTGTTGAACAGAGAGAAATCAAGTTTATTAAACTGGGGCTAAGGAATAAACCAAAGAAAACAGCA
CATGTGAAACCAGACCTCATAGATGTTGATCTTGTAAGAGGGTCTGCATTTGCAAAGGCAAAGCCTGAAAGTCCTTGGACTTCTCTGACC
AGAAAGGGAATTGTTCGAGTTGTATTTTTCCCCTTTTTCTTCCGGTGGTGGTTACAAGTAACATCAAAGGTCATCTTTTTCTGGCTTCTT
GTCCTTTATCTTCTTCAAGTTGCTGCAATAGTATTATTCTGCTCCACTTCTAGCCCACACAGCATACCTCTGACAGAGGTGATTGGGCCG
ATATGGCTGATGCTGCTCCTGGGAACTGTGCATTGCCAGATTGTTTCCACAAGAACACCCAAACCTCCTCTAAGTACAGGGGGTAAAAGA
AGAAGGAAATTAAGAAAAGCAGCCCATTTGGAAGTACATAGGGAAGGAGATGGTTCTAGTACCACAGATAACACACAAGAGGGAGCAGTT
CAGAACCACGGTACAAGCACCTCTCACAGCGTTGGCACTGTCTTCAGAGATCTCTGGCATGCTGCTTTCTTTTTATCAGGATCAAAGAAA
GCAAAGAATTCAATTGATAAATCAACTGAAACTGACAATGGCTATGTATCCCTTGATGGGAAGAAGACTGTTAAAAGCGGTGAAGATGGA
ATACAAAACCATGAACCTCAGTGTGAAACTATTCGACCAGAAGAGACAGCCTGGAACACAGGAACACTGAGGAATGGTCCTAGCAAAGAT
ACCCAAAGGACAATAACAAATGTCTCTGATGAAGTCTCCAGTGAGGAAGGTCCTGAAACAGGATACTCATTACGTCGTCATGTGGACAGG
ACTTCTGAAGGTGTTCTTCGGAATAGAAAGTCACACCATTATAAGAAACATTACCCTAATGAGGACGCCCCTAAATCGGGTACTAGTTGC
AGCTCTCGCTGTTCAAGTTCCAGACAGGATTCTGAGAGTGCAAGGCCAGAATCTGAAACAGAAGATGTGTTATGGGAAGACTTGTTACAT
TGTGCAGAATGCCATTCATCTTGTACCAGTGAGACAGATGTGGAAAATCATCAGATTAATCCATGTGTGAAAAAAGAATATAGAGATGAC
CCTTTTCATCAGAGTCATTTGCCCTGGCTCCATAGTTCCCACCCAGGATTAGAAAAAATAAGTGCTATAGTATGGGAAGGTAATGATTGT
AAGAAAGCAGACATGTCTGTACTTGAAATCAGTGGAATGATAATGAACAGAGTGAACAGCCATATACCAGGAATAGGATACCAGATTTTT
GGAAATGCAGTCTCTCTCATACTGGGTTTAACTCCATTTGTTTTCCGACTTTCTCAAGCTACAGACTTGGAACAACTCACAGCACATTCT
GCTTCAGAACTTTATGTGATTGCATTTGGTTCTAATGAAGATGTCATAGTTCTTTCTATGGTTATAATAAGTTTTGTGGTTCGCGTGTCT
CTTGTGTGGATTTTCTTTTTTTTGCTCTGTGTAGCAGAAAGAACTTATAAACAGCGATTACTTTTTGCAAAACTCTTTGGACATTTAACA
TCTGCAAGGAGGGCTCGAAAATCTGAGGTTCCTCATTTCCGGTTGAAGAAAGTACAGAATATAAAAATGTGGCTATCTCTCCGTTCCTAT
CTTAAGCGTCGAGGTCCTCAGCGATCAGTTGATGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCC
CAGCTACTTCATGTACACGAGATCTTCCTTGATTGTCACTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTA
AGATTTGTTACCCTTGGATCAGAAACAAGTAAAAAATATAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATG
GAGAAAAAACCTAACAAAAAGGAGGAACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCT
TTTAGATTATATGGGCTTACAATGAATCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGAC
TTGCTTGGATTTAATTTAAAGGTAAGGAAGATACTCCCTCATTACTTGGCCTCTGTGGATCTCTAACGTCAGTGGCAAGTTACAAGTCTC
TAACAAGCTTAAAATCTAATGACTACCTTGCAAGTCCTACAACAGAGATGACAAGTCCAGGCCTAACTCCATCCTGAAAATTTTTGTGTA
AAAGCCAAAACTTTTTATGTTGTAAATGTTTAATTTACATGTTTGACTGCTGGGAAGACCTTTGAAATTTTATATTGTTCTGGTACATGT
CTGAAATTCTATTGCTTGGAGAGAATCCCCTCCAGATAAGAGATTTTGAGTGAAAAACATAATGATCCTGCCATTTTTCATTTTTAAAAT
TCTTACATTTGTCATTGAGAAAGTTCAAAATGGAATAGGCTTTAAAAAAAAAAAAACTTTCAAAGATCCGCCAAATCATTCATAGCAAAT
TGTACATATTGTTCAGCTGATTTTTATATATTTAAATACACCTTAGTGGCCAGAGACTGACTTCAAGGTTTTATTCCAGAGACTCCAGAG

>In-frame_ENST00000416283_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(amino acids)=759AA_start in transcript=126_stop in transcript=2405
MASKVTDAIVWYQKKIGAYDQQIWEKSVEQREIKFIKLGLRNKPKKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPF
FFRWWLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEV
HREGDGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIR
PEETAWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSE
SARPESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISG
MIMNRVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVA
ERTYKQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVHEIFLDC
HYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLL

--------------------------------------------------------------
>In-frame_ENST00000248550_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(transcript)=2985nt_BP=2413nt
TGGGAAATAAAGTCATTTGTATGTTTTTCTCTCTTGCACAGCCTAAAATGACCAATGTGTGATTTCAGTGGAATAAATGGCGTCCAAAGT
CACAGATGCTATAGTCTGGTATCAAAAGAAGGAGTTTCTCTCTGTGGCCACCACCGCCCCAGGCCCACAGCAAGTACTGCCTGGCTACTG
CCAGTGTTCACTCAAGGACCAAGGGCTCTTCATTCAGTGTTTGATTGGAGCATATGATCAACAAATATGGGAAAAATCTGTTGAACAGAG
AGAAATCAAGTTTATTAAACTGGGGCTAAGGAATAAACCAAAGAAAACAGCACATGTGAAACCAGACCTCATAGATGTTGATCTTGTAAG
AGGGTCTGCATTTGCAAAGGCAAAGCCTGAAAGTCCTTGGACTTCTCTGACCAGAAAGGGAATTGTTCGAGTTGTATTTTTCCCCTTTTT
CTTCCGGTGGTGGTTACAAGTAACATCAAAGGTCATCTTTTTCTGGCTTCTTGTCCTTTATCTTCTTCAAGTTGCTGCAATAGTATTATT
CTGCTCCACTTCTAGCCCACACAGCATACCTCTGACAGAGGTGATTGGGCCGATATGGCTGATGCTGCTCCTGGGAACTGTGCATTGCCA
GATTGTTTCCACAAGAACACCCAAACCTCCTCTAAGTACAGGGGGTAAAAGAAGAAGGAAATTAAGAAAAGCAGCCCATTTGGAAGTACA
TAGGGAAGGAGATGGTTCTAGTACCACAGATAACACACAAGAGGGAGCAGTTCAGAACCACGGTACAAGCACCTCTCACAGCGTTGGCAC
TGTCTTCAGAGATCTCTGGCATGCTGCTTTCTTTTTATCAGGATCAAAGAAAGCAAAGAATTCAATTGATAAATCAACTGAAACTGACAA
TGGCTATGTATCCCTTGATGGGAAGAAGACTGTTAAAAGCGGTGAAGATGGAATACAAAACCATGAACCTCAGTGTGAAACTATTCGACC
AGAAGAGACAGCCTGGAACACAGGAACACTGAGGAATGGTCCTAGCAAAGATACCCAAAGGACAATAACAAATGTCTCTGATGAAGTCTC
CAGTGAGGAAGGTCCTGAAACAGGATACTCATTACGTCGTCATGTGGACAGGACTTCTGAAGGTGTTCTTCGGAATAGAAAGTCACACCA
TTATAAGAAACATTACCCTAATGAGGACGCCCCTAAATCGGGTACTAGTTGCAGCTCTCGCTGTTCAAGTTCCAGACAGGATTCTGAGAG
TGCAAGGCCAGAATCTGAAACAGAAGATGTGTTATGGGAAGACTTGTTACATTGTGCAGAATGCCATTCATCTTGTACCAGTGAGACAGA
TGTGGAAAATCATCAGATTAATCCATGTGTGAAAAAAGAATATAGAGATGACCCTTTTCATCAGAGTCATTTGCCCTGGCTCCATAGTTC
CCACCCAGGATTAGAAAAAATAAGTGCTATAGTATGGGAAGGTAATGATTGTAAGAAAGCAGACATGTCTGTACTTGAAATCAGTGGAAT
GATAATGAACAGAGTGAACAGCCATATACCAGGAATAGGATACCAGATTTTTGGAAATGCAGTCTCTCTCATACTGGGTTTAACTCCATT
TGTTTTCCGACTTTCTCAAGCTACAGACTTGGAACAACTCACAGCACATTCTGCTTCAGAACTTTATGTGATTGCATTTGGTTCTAATGA
AGATGTCATAGTTCTTTCTATGGTTATAATAAGTTTTGTGGTTCGCGTGTCTCTTGTGTGGATTTTCTTTTTTTTGCTCTGTGTAGCAGA
AAGAACTTATAAACAGCGATTACTTTTTGCAAAACTCTTTGGACATTTAACATCTGCAAGGAGGGCTCGAAAATCTGAGGTTCCTCATTT
CCGGTTGAAGAAAGTACAGAATATAAAAATGTGGCTATCTCTCCGTTCCTATCTTAAGCGTCGAGGTCCTCAGCGATCAGTTGATGTAAT
AGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGCTACTTCATGTACACGAGATCTTCCTTGATTGTCA
CTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTAAGATTTGTTACCCTTGGATCAGAAACAAGTAAAAAATA
TAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATGGAGAAAAAACCTAACAAAAAGGAGGAACTGACACTAGT
GAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATTATATGGGCTTACAATGAATCCGCTGCTTTA
TAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGGATTTAATTTAAAGGTAAGGAAGATACTCCC
TCATTACTTGGCCTCTGTGGATCTCTAACGTCAGTGGCAAGTTACAAGTCTCTAACAAGCTTAAAATCTAATGACTACCTTGCAAGTCCT
ACAACAGAGATGACAAGTCCAGGCCTAACTCCATCCTGAAAATTTTTGTGTAAAAGCCAAAACTTTTTATGTTGTAAATGTTTAATTTAC
ATGTTTGACTGCTGGGAAGACCTTTGAAATTTTATATTGTTCTGGTACATGTCTGAAATTCTATTGCTTGGAGAGAATCCCCTCCAGATA
AGAGATTTTGAGTGAAAAACATAATGATCCTGCCATTTTTCATTTTTAAAATTCTTACATTTGTCATTGAGAAAGTTCAAAATGGAATAG
GCTTTAAAAAAAAAAAAACTTTCAAAGATCCGCCAAATCATTCATAGCAAATTGTACATATTGTTCAGCTGATTTTTATATATTTAAATA
CACCTTAGTGGCCAGAGACTGACTTCAAGGTTTTATTCCAGAGACTCCAGAGACTTAAGCTAAGTATTTTTTCATTCTTTCAGATTTTCA

>In-frame_ENST00000248550_ENST00000493037_TCGA-A2-A0SV-01A_PHTF2_chr7_77583211_-_RUNDC3B_chr7_87459200_length(amino acids)=793AA_start in transcript=76_stop in transcript=2457
MASKVTDAIVWYQKKEFLSVATTAPGPQQVLPGYCQCSLKDQGLFIQCLIGAYDQQIWEKSVEQREIKFIKLGLRNKPKKTAHVKPDLID
VDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFFRWWLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLG
TVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEVHREGDGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKS
TETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIRPEETAWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRN
RKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSESARPESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLP
WLHSSHPGLEKISAIVWEGNDCKKADMSVLEISGMIMNRVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIA
FGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVAERTYKQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQR
SVDVIVSSAFLLTISVVFICCAQLLHVHEIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKE

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Fusion Gene PPI Analysis for PHTF2-RUNDC3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHTF2-RUNDC3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHTF2-RUNDC3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource