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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIAS1-MEF2A (FusionGDB2 ID:64696)

Fusion Gene Summary for PIAS1-MEF2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS1-MEF2A
Fusion gene ID: 64696
HgeneTgene
Gene symbol

PIAS1

MEF2A

Gene ID

8554

4205

Gene nameprotein inhibitor of activated STAT 1myocyte enhancer factor 2A
SynonymsDDXBP1|GBP|GU/RH-II|ZMIZ3ADCAD1|RSRFC4|RSRFC9|mef2
Cytomap

15q23

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT prmyocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1
Modification date2020031320200313
UniProtAcc.

Q02078

Ensembl transtripts involved in fusion geneENST00000249636, ENST00000545237, 
ENST00000567417, 		ENST00000453228, 
ENST00000354410, ENST00000558856, 
ENST00000558812, ENST00000338042, 
ENST00000557785, ENST00000449277, 
ENST00000557942, 
Fusion gene scores* DoF score13 X 12 X 7=109211 X 10 X 5=550
# samples 1511
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIAS1 [Title/Abstract] AND MEF2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIAS1(68346688)-MEF2A(100211528), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS1

GO:0016925

protein sumoylation

18579533

HgenePIAS1

GO:0033235

positive regulation of protein sumoylation

17696781|21965678

TgeneMEF2A

GO:0000122

negative regulation of transcription by RNA polymerase II

16484498

TgeneMEF2A

GO:0000165

MAPK cascade

9858528

TgeneMEF2A

GO:0006351

transcription, DNA-templated

16043483

TgeneMEF2A

GO:0010613

positive regulation of cardiac muscle hypertrophy

24161931

TgeneMEF2A

GO:0045944

positive regulation of transcription by RNA polymerase II

7760790|9858528|10748098|15466416|20590529|21468593

TgeneMEF2A

GO:0071277

cellular response to calcium ion

16484498


check buttonFusion gene breakpoints across PIAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MEF2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KY-01APIAS1chr15

68346688

+MEF2Achr15

100211528

+
ChimerDB4SARCTCGA-DX-A1KY-01APIAS1chr15

68346688

+MEF2Achr15

100211528

+
ChimerDB4SARCTCGA-DX-A1KY-01APIAS1chr15

68346688

+MEF2Achr15

100211725

+


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Fusion Gene ORF analysis for PIAS1-MEF2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000249636ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-3CDSENST00000545237ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000545237ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-3CDSENST00000567417ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211528

+
intron-intronENST00000567417ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211528

+
5CDS-intronENST00000249636ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211725

+
5CDS-intronENST00000249636ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000545237ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000453228PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000354410PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000558856PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000558812PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000338042PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000557785PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000449277PIAS1chr15

68346688

+MEF2Achr15

100211725

+
intron-intronENST00000567417ENST00000557942PIAS1chr15

68346688

+MEF2Achr15

100211725

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000249636PIAS1chr1568346688+ENST00000453228MEF2Achr15100211528+50591721481407419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000249636ENST00000453228PIAS1chr1568346688+MEF2Achr15100211528+0.0008683070.99913174

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Fusion Genomic Features for PIAS1-MEF2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PIAS1chr1568346688+MEF2Achr15100211724+0.319330330.68066967
PIAS1chr1568346688+MEF2Achr15100211527+0.0018143950.9981856
PIAS1chr1568346688+MEF2Achr15100211724+0.319330330.68066967
PIAS1chr1568346688+MEF2Achr15100211527+0.0018143950.9981856

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIAS1-MEF2A


check button Go to

FGviewer for the breakpoints of chr15:68346688-chr15:100211528

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEF2A

Q02078

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEF2Achr15:68346688chr15:100211528ENST00000354410011141_1860500.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000354410011420_4460500.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST000003544100114_310500.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST0000044927719141_18618.0430.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST0000044927719420_44618.0430.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000453228210141_18686.0498.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000453228210420_44686.0498.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000557785311141_18686.0498.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000557785311420_44686.0498.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000557942312141_18686.0506.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000557942312420_44686.0506.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000558812110141_18618.0438.0Compositional biasNote=Ser/Thr-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST00000558812110420_44618.0438.0Compositional biasNote=Gln/Pro-rich
TgeneMEF2Achr15:68346688chr15:100211528ENST0000035441001158_860500.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST000004492771958_8618.0430.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST0000055881211058_8618.0438.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST000003544100113_570500.0DomainMADS-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114577_6348.0652.0Compositional biasNote=Ser-rich
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+11411_458.0652.0DomainSAP
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114124_2888.0652.0DomainPINIT
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+11419_238.0652.0MotifNote=LXXLL motif
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114368_3808.0652.0MotifNuclear localization signal
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+11456_648.0652.0MotifNuclear localization signal
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114462_4738.0652.0RegionSUMO1-binding
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114520_6158.0652.0RegionNote=4 X 4 AA repeats of N-T-S-L
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114520_5238.0652.0RepeatNote=1
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114557_5608.0652.0RepeatNote=2
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114598_6018.0652.0RepeatNote=3%3B approximate
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114612_6158.0652.0RepeatNote=4%3B approximate
HgenePIAS1chr15:68346688chr15:100211528ENST00000249636+114320_3978.0652.0Zinc fingerSP-RING-type
TgeneMEF2Achr15:68346688chr15:100211528ENST00000449277194_3118.0430.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST000004532282104_3186.0498.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST000005577853114_3186.0498.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST000005579423124_3186.0506.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST000005588121104_3118.0438.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Achr15:68346688chr15:100211528ENST0000045322821058_8686.0498.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST0000055778531158_8686.0498.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST0000055794231258_8686.0506.0DNA bindingMef2-type
TgeneMEF2Achr15:68346688chr15:100211528ENST00000449277193_5718.0430.0DomainMADS-box
TgeneMEF2Achr15:68346688chr15:100211528ENST000004532282103_5786.0498.0DomainMADS-box
TgeneMEF2Achr15:68346688chr15:100211528ENST000005577853113_5786.0498.0DomainMADS-box
TgeneMEF2Achr15:68346688chr15:100211528ENST000005579423123_5786.0506.0DomainMADS-box
TgeneMEF2Achr15:68346688chr15:100211528ENST000005588121103_5718.0438.0DomainMADS-box


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Fusion Gene Sequence for PIAS1-MEF2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000249636_ENST00000453228_TCGA-DX-A1KY-01A_PIAS1_chr15_68346688_+_MEF2A_chr15_100211528_length(transcript)=5059nt_BP=172nt
GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG
GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGACTTTAAG
AAAGAAAGGCCTTAATGGTTGTGAGAGCCCTGATGCTGACGATTACTTTGAGCACAGTCCACTCTCGGAGGACAGATTCAGCAAACTAAA
TGAAGATAGTGATTTTATTTTCAAACGAGGCCCTCCTGGTCTGCCACCTCAGAACTTTTCAATGTCTGTCACAGTTCCAGTGACCAGCCC
CAATGCTTTGTCCTACACTAACCCAGGGAGTTCACTGGTGTCCCCATCTTTGGCAGCCAGCTCAACGTTAACAGATTCAAGCATGCTCTC
TCCACCTCAAACCACATTACATAGAAATGTGTCTCCTGGAGCTCCTCAGAGACCACCAAGTACTGGCAATGCAGGTGGGATGTTGAGCAC
TACAGACCTCACAGTGCCAAATGGAGCTGGAAGCAGTCCAGTGGGGAATGGATTTGTAAACTCAAGAGCTTCTCCAAATTTGATTGGAGC
TACTGGTGCAAATAGCTTAGGCAAAGTCATGCCTACAAAGTCTCCCCCTCCACCAGGTGGTGGTAATCTTGGAATGAACAGTAGGAAACC
AGATCTTCGAGTTGTCATCCCCCCTTCAAGCAAGGGCATGATGCCTCCACTAAATACCCAGAGGATCAGTAGTTCTCAAGCCACTCAACC
TCTTGCTACCCCAGTCGTGTCTGTGACAACCCCAAGCTTGCCTCCGCAAGGACTTGTGTACTCAGCAATGCCGACTGCCTACAACACTGA
TTATTCACTGACCAGCGCTGACCTGTCAGCCCTTCAAGGCTTCAACTCGCCAGGAATGCTGTCGCTGGGACAGGTGTCGGCCTGGCAGCA
GCACCACCTAGGACAAGCAGCCCTCAGCTCTCTTGTTGCTGGAGGGCAGTTATCTCAGGGTTCCAATTTATCCATTAATACCAACCAAAA
CATCAGCATCAAGTCCGAACCGATTTCACCTCCTCGGGATCGTATGACCCCATCGGGCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCCGCCGCCACCACCGCAGCCCCAGCCACAACCCCCGCAGCCCCAGCCCCGACAGGAAATGGGGCGCTCCCCTGTGGACAGTCTGAG
CAGCTCTAGTAGCTCCTATGATGGCAGTGATCGGGAGGATCCACGGGGCGACTTCCATTCTCCAATTGTGCTTGGCCGACCCCCAAACAC
TGAGGACAGAGAAAGCCCTTCTGTAAAGCGAATGAGGATGGACGCGTGGGTGACCTAAGGCTTCCAAGCTGATGTTTGTACTTTTGTGTT
ACTGCAGTGACCTGCCCTACATATCTAAATCGGTAAATAAGGACATGAGTTAAATATATTTATATGTACATACATATATATATCCCTTTA
CATATATATGTATGTGGGTGTGAGTGTGTATGTGTGGGTGTGTGTTACATACACAGAATCAGGCACTTACCTGCAAACTCCTTGTAGGTC
TGCAGATGTGTGTCCCATGGCAGACAAAGCACCCTGTAGGCACAGACAAGTCTGGCACTTCCTTGGACTACTTGTTTCGTAAAGATAACC
AGTTTTTGCAGAGAAACGTGTACCCATATATAATTCTCCCACACTAGCTTGCAGAAACCTAGAGGGCCCCCTACTTGTTTTATTTAACTG
TGCAGTGACTGTAGTTACTTAAGAGAAAATGCTTTGTAGAACAGAGCAGTAGAAAAGCAGGAACCAAGAAAGCAATACTGTACATAAAAT
GTCATTTATATTTTCCAACCTGGCATGGGTGTCTGTTGCAAAGGGGTGCATGGGAAAGGGCTGTTGATATTAAAAACAAACAAAACAAAA
AAGCCCCACACATAACTGTTTTGCACGTGCAAAAATGTATTGGGTCAAGAAGTGATCTTTAGCTAATAAAGAAAGAGAATAGAAAACACG
CATGAGATATTCAGAAAATACTAGCCTAGAAATATAGAGCATTAACAAAGTAAAATTAATATATTAAGTTATAATTGGAATATGTCAGAA
GTTTCTTTTTACATTCATATCTTAAAAATTAAAGAAACTGATTTTAGCTCATGTATATTTTATATGAAAGAAAACACCCTTATGAATTGA
TGACTATATATAAAATTATATTCACTACTTTTGAACACATTCTGCTATGAATTATTTATATAAGCCAAAGCTATATGTTGTAACTTTTTT
TTAGAGAATAGCTTTATCTTGGTTTAACTCTTTAGTTTTATTTTAAGAGGGGAAAACAAAAATATCTTGCAAGCAGAACCTTGGAAAAAA
AAAGCCATGAACACTTATTCTAAATGTAAATTAAAAGTTGAGCCAAACTCTTTGTGTATATAGCATCTTAAATATATTATCACCTTTGAT
GTAAGTACCTATGTATTGTATGGTCACCAGATTAAAAAGTATATTTTTGTGGATTGCCGCCAATCTGGGGGGAAAAGGCGAGGTCCTTTA
TTAAGTATTCACTGTTTAATATTTACTATTTTGTTAAATATACTGTACTTTGGATTTTAATTATTAGCCCAGTTTTTTCAGAGGATTGTA
TAAAGGGGTTTCTCCCCTCACTGGTGGTGAATGTGTGATGTTACATTGTAATCTTTGTGCTGTATGGGTTGAGCATCATTATATATTTTG
TATGTGTACATAAATAGCAAAGTGGCAAAAAAAATTGGTGTTAAGTTCATCCTGCATAAGTATAAAATGTGTTGTAACAGATTTTGTAAG
GCATTATTTAAAACTTGCCTTTTGTGAGGAAAAAATGTAGTAGAAAAAGCTGACCTAATTTAATTAATATTAGAGAAAATGGCAAAATAG
TAGATGAGCACAAAGGTTTTATAAGTGGTAAATGATTAGGGGAAAATAATCATGGGGAAAGGGATCTTTTTTCCTTGACCCTCTGAAAAC
AGAACGATGCAGCTGGTTACAAAATCCTACCGTTATCAGCTCTTCTGCACATTGCAGTGATGCTTTGGTATGCGGGGAGAAACACTCTTA
GGGTGCTGGTCCTTGGCATGACTCTTGCCATTCTAATTGGAATTAGTGCCACCCTCAGCTTGGATTTTGAACAAGGCCTTATTCTTTCAG
GAAGACAACTAATGGATGATAGCAAGTTCATCCACTTACTGGGCTTGTGCCATGAGCAAAATTCAAAGTCCTGTATATCTTTCATTGTAG
ATTTTTAAATACTCCTTTTCCTAAAAAACTCAAGGGTTTAAAAATTGCTATTTTATATTTTAAATGATATTGAGCAGCTACCTACAATTT
CTATGTACATTTTGTTCCCCCCCCCCCACCCCCCCCCCAAATTACGTTCCTTTTGACATTTTCCTCATCTGCTGTTTGTGACAAGTCATC
AGCCAGATTTCCTGACTGACACATAGGTATGATCAGTGCAGGAGAGACCTGCGCACCACAGGCTGCAAACTGGAGGTTCTGTTCTCATGG
CAGTTTGGGCAGTAACTTTTGAGAGAGGCCAAAAAAAGGAGGATGACATGCTGTCTCCTCTCTTCAGTATAGACATTAGGCTCTTATTCA
GAAAGGATTTTTCTTTAAAAATGTACTTACTTTACTGAACTACTTACAGGCACATTTCTTCATAAGGCCACACCTAATCCAAACAAGACA
GTCTCCCAACACTGAAGTTCCAAAATAATCCTTACCACTTTGTAAACCATTTATAGCTTTGAAAGTGTTAAGTGATTCCTTCGTTATTAT
TTATGCATGTTCATGAACTTCTGCTGTACATTGGAATAGGAGTTAACACATTCACATTTACTGTCTATTTTCTTGTGTGCCTTATGAGAT
GGCTTTTCTGACTGTATCTCAATAGTCTTTCTTTCTATGCAGGTTTATAATCAGTACAACTACTGTTTTCTAAAATACTACTACTCAAGG
CTCGGAGTTTGTATTTAAATTACACTGACCAAGTAACAATGTATTCCATTTCAGGAACTGAATATTTGACTGTTAACCTTTTTCCCATAC
GTCCAGTGTGGCATGGAGCATATGGACTTGACAGACATCTCTCACCCAGACGCCCACGTGTGAACACACCCACATCCACATCTCTGGGTG
GAAACCAGCCTAGAGAGGGGACGACGCTAATGGTGTTGCTTTAGAACCGTCTTTTCTTACCCTTTTAGACTCGTGTTTTGTATGAGACAC
CATTGCAAGAAAATTTTATCCCTCCAGAAGTATTTTATTACTAAAGAACAAAAGCAAAAAAAGCTTAAATTGCACTGGTTAAAGTACAGT
TTCCAACAGCTGTCCTTCCTCAGTACTCTAATGGCCACTCCACCGCGAGTGGAAGTCACTGTTGTGTGTACACAGGTGGTCCCAATCAAA
ACTCCATCTTTTGAGCCCAATTATGTCCATTTTGTTATAGACTAAATCAGGGGTTTGTTCTACAAGAACAATACATGTTTTACCCTTTCC
TTTAACTAGAAGGATAACTAGTAATGCATCAACATAATTTCTGTATTAACCATCATGCGCACAAGAAATACATAGTAAATAAGGAAGCTG
AAAACTCCTGGCATTGGATCTTAAGCTAGATGATTAGAATGTGAAAAAGATTTTACAAATGTAAAACTTCTATTTCTCTGTAGAAACTTT
CTTCACTTTGCTGTGCAAGAAGACACTGCTTTGCTATATTTAAAATGGCTTTTTTAAAAGAGATTTATGTATTTGGTAAATGTTTGTAGT
CAACAGTTCACACAAGAAGCTGTACACGGTTTGATCATGTAAAACCGTTTGGCGGCACAAGCTGGACTTTGTTGCCATCCTTGAGATGAA
CCTTTTAAGAAAAATAAGTTAATCTCAATTTTTCCCTGAATGTGTTGTTTTTCTTCATTATACAATAAATATAATAGTGAACTTTTTATC

>In-frame_ENST00000249636_ENST00000453228_TCGA-DX-A1KY-01A_PIAS1_chr15_68346688_+_MEF2A_chr15_100211528_length(amino acids)=419AA_start in transcript=148_stop in transcript=1407
MADSAELKTLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAA
SSTLTDSSMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPG
GGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGM
LSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQ

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Fusion Gene PPI Analysis for PIAS1-MEF2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIAS1-MEF2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIAS1-MEF2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIAS1C0037274Dermatologic disorders1CTD_human
HgenePIAS1C0274861Arsenic Poisoning, Inorganic1CTD_human
HgenePIAS1C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgenePIAS1C0311375Arsenic Poisoning1CTD_human
HgenePIAS1C0751851Arsenic Encephalopathy1CTD_human
HgenePIAS1C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneMEF2AC0033975Psychotic Disorders1PSYGENET
TgeneMEF2AC0349204Nonorganic psychosis1PSYGENET