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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PID1-MRPS6 (FusionGDB2 ID:64776)

Fusion Gene Summary for PID1-MRPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: PID1-MRPS6
Fusion gene ID: 64776
HgeneTgene
Gene symbol

PID1

MRPS6

Gene ID

55022

64968

Gene namephosphotyrosine interaction domain containing 1mitochondrial ribosomal protein S6
SynonymsHMFN2073|NYGGF4|P-CLI1|PCLI1C21orf101|MRP-S6|RPMS6|S6mt
Cytomap

2q36.3

21q22.11

Type of geneprotein-codingprotein-coding
DescriptionPTB-containing, cubilin and LRP1-interacting proteinphosphotyrosine interaction domain-containing protein 128S ribosomal protein S6, mitochondrialmitochondrial small ribosomal subunit protein bS6m
Modification date2020031320200313
UniProtAcc.

P82932

Ensembl transtripts involved in fusion geneENST00000482518, ENST00000392054, 
ENST00000409462, ENST00000392055, 
ENST00000354069, 		ENST00000399312, 
ENST00000482679, 
Fusion gene scores* DoF score9 X 9 X 4=32413 X 6 X 7=546
# samples 1015
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/546*10)=-1.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PID1 [Title/Abstract] AND MRPS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPID1(230020534)-MRPS6(35497641), # samples:4
Anticipated loss of major functional domain due to fusion event.PID1-MRPS6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePID1

GO:0001933

negative regulation of protein phosphorylation

19079291

HgenePID1

GO:0045444

fat cell differentiation

16815647

HgenePID1

GO:0046325

negative regulation of glucose import

19079291

HgenePID1

GO:0046627

negative regulation of insulin receptor signaling pathway

19079291

HgenePID1

GO:0070346

positive regulation of fat cell proliferation

16815647

HgenePID1

GO:1903077

negative regulation of protein localization to plasma membrane

19079291


check buttonFusion gene breakpoints across PID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRPS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U7-01APID1chr2

230020534

-MRPS6chr21

35497641

+
ChimerDB4SARCTCGA-DX-A3U7PID1chr2

230020533

-MRPS6chr21

35497640

+
ChimerDB4SARCTCGA-DX-A3U7PID1chr2

230020533

-MRPS6chr21

35514707

+
ChimerDB4SARCTCGA-DX-A3U7PID1chr2

230135729

-MRPS6chr21

35497640

+
ChimerDB4SARCTCGA-DX-A3U7-01APID1chr2

230020534

-MRPS6chr21

35497641

+
ChimerDB4SARCTCGA-3B-A9HT-01APID1chr2

230020534

-MRPS6chr21

35497641

+
ChimerDB4SARCTCGA-DX-A3U7-01APID1chr2

230020534

-MRPS6chr21

35497641

+


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Fusion Gene ORF analysis for PID1-MRPS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000482518ENST00000399312PID1chr2

230020534

-MRPS6chr21

35497641

+
5UTR-3UTRENST00000482518ENST00000482679PID1chr2

230020534

-MRPS6chr21

35497641

+
Frame-shiftENST00000392054ENST00000399312PID1chr2

230020534

-MRPS6chr21

35497641

+
5CDS-3UTRENST00000392054ENST00000482679PID1chr2

230020534

-MRPS6chr21

35497641

+
intron-3CDSENST00000409462ENST00000399312PID1chr2

230020534

-MRPS6chr21

35497641

+
intron-3UTRENST00000409462ENST00000482679PID1chr2

230020534

-MRPS6chr21

35497641

+
In-frameENST00000392055ENST00000399312PID1chr2

230020534

-MRPS6chr21

35497641

+
5CDS-3UTRENST00000392055ENST00000482679PID1chr2

230020534

-MRPS6chr21

35497641

+
In-frameENST00000354069ENST00000399312PID1chr2

230020534

-MRPS6chr21

35497641

+
5CDS-3UTRENST00000354069ENST00000482679PID1chr2

230020534

-MRPS6chr21

35497641

+
5UTR-3CDSENST00000482518ENST00000399312PID1chr2

230020533

-MRPS6chr21

35497640

+
5UTR-3UTRENST00000482518ENST00000482679PID1chr2

230020533

-MRPS6chr21

35497640

+
Frame-shiftENST00000392054ENST00000399312PID1chr2

230020533

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000392054ENST00000482679PID1chr2

230020533

-MRPS6chr21

35497640

+
intron-3CDSENST00000409462ENST00000399312PID1chr2

230020533

-MRPS6chr21

35497640

+
intron-3UTRENST00000409462ENST00000482679PID1chr2

230020533

-MRPS6chr21

35497640

+
In-frameENST00000392055ENST00000399312PID1chr2

230020533

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000392055ENST00000482679PID1chr2

230020533

-MRPS6chr21

35497640

+
In-frameENST00000354069ENST00000399312PID1chr2

230020533

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000354069ENST00000482679PID1chr2

230020533

-MRPS6chr21

35497640

+
5UTR-3CDSENST00000482518ENST00000399312PID1chr2

230020533

-MRPS6chr21

35514707

+
5UTR-3UTRENST00000482518ENST00000482679PID1chr2

230020533

-MRPS6chr21

35514707

+
In-frameENST00000392054ENST00000399312PID1chr2

230020533

-MRPS6chr21

35514707

+
5CDS-3UTRENST00000392054ENST00000482679PID1chr2

230020533

-MRPS6chr21

35514707

+
intron-3CDSENST00000409462ENST00000399312PID1chr2

230020533

-MRPS6chr21

35514707

+
intron-3UTRENST00000409462ENST00000482679PID1chr2

230020533

-MRPS6chr21

35514707

+
Frame-shiftENST00000392055ENST00000399312PID1chr2

230020533

-MRPS6chr21

35514707

+
5CDS-3UTRENST00000392055ENST00000482679PID1chr2

230020533

-MRPS6chr21

35514707

+
Frame-shiftENST00000354069ENST00000399312PID1chr2

230020533

-MRPS6chr21

35514707

+
5CDS-3UTRENST00000354069ENST00000482679PID1chr2

230020533

-MRPS6chr21

35514707

+
intron-3CDSENST00000482518ENST00000399312PID1chr2

230135729

-MRPS6chr21

35497640

+
intron-3UTRENST00000482518ENST00000482679PID1chr2

230135729

-MRPS6chr21

35497640

+
5UTR-3CDSENST00000392054ENST00000399312PID1chr2

230135729

-MRPS6chr21

35497640

+
5UTR-3UTRENST00000392054ENST00000482679PID1chr2

230135729

-MRPS6chr21

35497640

+
In-frameENST00000409462ENST00000399312PID1chr2

230135729

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000409462ENST00000482679PID1chr2

230135729

-MRPS6chr21

35497640

+
In-frameENST00000392055ENST00000399312PID1chr2

230135729

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000392055ENST00000482679PID1chr2

230135729

-MRPS6chr21

35497640

+
intron-3CDSENST00000354069ENST00000399312PID1chr2

230135729

-MRPS6chr21

35497640

+
intron-3UTRENST00000354069ENST00000482679PID1chr2

230135729

-MRPS6chr21

35497640

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392055PID1chr2230020534-ENST00000399312MRPS6chr2135497641+118641980751223
ENST00000354069PID1chr2230020534-ENST00000399312MRPS6chr2135497641+107430710639209
ENST00000392055PID1chr2230020533-ENST00000399312MRPS6chr2135497640+118641980751223
ENST00000354069PID1chr2230020533-ENST00000399312MRPS6chr2135497640+107430710639209
ENST00000392054PID1chr2230020533-ENST00000399312MRPS6chr2135514707+1237610199651150
ENST00000409462PID1chr2230135729-ENST00000399312MRPS6chr2135497640+103426775599174
ENST00000392055PID1chr2230135729-ENST00000399312MRPS6chr2135497640+103927280604174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392055ENST00000399312PID1chr2230020534-MRPS6chr2135497641+0.0069551580.9930448
ENST00000354069ENST00000399312PID1chr2230020534-MRPS6chr2135497641+0.0040750230.99592495
ENST00000392055ENST00000399312PID1chr2230020533-MRPS6chr2135497640+0.0069551580.9930448
ENST00000354069ENST00000399312PID1chr2230020533-MRPS6chr2135497640+0.0040750230.99592495
ENST00000392054ENST00000399312PID1chr2230020533-MRPS6chr2135514707+0.487234830.5127652
ENST00000409462ENST00000399312PID1chr2230135729-MRPS6chr2135497640+0.0305269380.96947306
ENST00000392055ENST00000399312PID1chr2230135729-MRPS6chr2135497640+0.020130420.9798696

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Fusion Genomic Features for PID1-MRPS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PID1chr2230020533-MRPS6chr2135514707+4.79E-050.9999521
PID1chr2230135729-MRPS6chr2135497640+1.81E-060.9999982
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976
PID1chr2230020533-MRPS6chr2135514707+4.79E-050.9999521
PID1chr2230135729-MRPS6chr2135497640+1.81E-060.9999982
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976
PID1chr2230020533-MRPS6chr2135497640+2.88E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PID1-MRPS6


check button Go to

FGviewer for the breakpoints of chr2:230020534-chr21:35497641

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPS6

P82932

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePID1chr2:230020533chr21:35497640ENST00000354069-2393_25092.0251.0DomainPID
HgenePID1chr2:230020533chr21:35497640ENST00000392054-3493_25090.0249.0DomainPID
HgenePID1chr2:230020533chr21:35497640ENST00000392055-2393_25059.0218.0DomainPID
HgenePID1chr2:230020533chr21:35497640ENST00000409462-1293_2500169.0DomainPID
HgenePID1chr2:230020533chr21:35514707ENST00000354069-2393_25092.0251.0DomainPID
HgenePID1chr2:230020533chr21:35514707ENST00000392054-3493_25090.0249.0DomainPID
HgenePID1chr2:230020533chr21:35514707ENST00000392055-2393_25059.0218.0DomainPID
HgenePID1chr2:230020533chr21:35514707ENST00000409462-1293_2500169.0DomainPID
HgenePID1chr2:230020534chr21:35497641ENST00000354069-2393_25092.0251.0DomainPID
HgenePID1chr2:230020534chr21:35497641ENST00000392054-3493_25090.0249.0DomainPID
HgenePID1chr2:230020534chr21:35497641ENST00000392055-2393_25059.0218.0DomainPID
HgenePID1chr2:230020534chr21:35497641ENST00000409462-1293_2500169.0DomainPID
HgenePID1chr2:230135729chr21:35497640ENST00000354069-1393_2500251.0DomainPID
HgenePID1chr2:230135729chr21:35497640ENST00000392054-1493_2500249.0DomainPID
HgenePID1chr2:230135729chr21:35497640ENST00000392055-1393_25010.0218.0DomainPID
HgenePID1chr2:230135729chr21:35497640ENST00000409462-1293_25010.0169.0DomainPID


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Fusion Gene Sequence for PID1-MRPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7-01A_PID1_chr2_230020534_-_MRPS6_chr21_35497641_length(transcript)=1186nt_BP=419nt
AGTCCTCTCGCAGCTGCGCCAGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAG
CCCCCTACGCCCACCCGGCGGCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCT
CGCCCCCCGGCGCGATCGACAGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGC
AGCACTTTCAGACCATGCTGAAGTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGG
CCATTGAGCTGTGCACGACCACACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCCAGAGACTGCTGCTACTTTGAAACGTACGA
TAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTC
AGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATA
TAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAA
AATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGAC
GAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCC
CCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTA
GTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGT
GAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAATGTATTATATGGACAACTTTTGCTTTGAGTAATAAACT

>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7-01A_PID1_chr2_230020534_-_MRPS6_chr21_35497641_length(amino acids)=223AA_start in transcript=80_stop in transcript=751
MLAAPYAHPAAVASARTHIPRTPTPDVKRDPSPSPPGAIDSLASVSSAKTQGWKMWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFH
EPEAIELCTTTPLMKTRTHSGCKPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHL

--------------------------------------------------------------
>In-frame_ENST00000354069_ENST00000399312_TCGA-DX-A3U7-01A_PID1_chr2_230020534_-_MRPS6_chr21_35497641_length(transcript)=1074nt_BP=307nt
ATGAAAAGCCTTGTACAAGAGGCTTCGTGCCATGTTCAGCCTGCCCCTTAGCCTTCCACTGTGTGAGGACACAGCATTCCTTCCTTCCAA
GTGCTGCAGCTCTCACAAGACAATCAAACAAGCCCGCACCTTGATCATGATCTTCCTAGCCTCCGGAACGCACTTTCAGACCATGCTGAA
GTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGGCCATTGAGCTGTGCACGACCAC
ACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCCAGAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGG
AGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTA
TTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATAT
TGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAG
GAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTT
TGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGG
AACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAG
GACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGT

>In-frame_ENST00000354069_ENST00000399312_TCGA-DX-A3U7-01A_PID1_chr2_230020534_-_MRPS6_chr21_35497641_length(amino acids)=209AA_start in transcript=10_stop in transcript=639
MYKRLRAMFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGTHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLM
KTRTHSGCKPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKH

--------------------------------------------------------------
>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35497640_length(transcript)=1186nt_BP=419nt
AGTCCTCTCGCAGCTGCGCCAGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAG
CCCCCTACGCCCACCCGGCGGCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCT
CGCCCCCCGGCGCGATCGACAGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGC
AGCACTTTCAGACCATGCTGAAGTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGG
CCATTGAGCTGTGCACGACCACACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCCAGAGACTGCTGCTACTTTGAAACGTACGA
TAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTC
AGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATA
TAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAA
AATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGAC
GAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCC
CCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTA
GTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGT
GAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAATGTATTATATGGACAACTTTTGCTTTGAGTAATAAACT

>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35497640_length(amino acids)=223AA_start in transcript=80_stop in transcript=751
MLAAPYAHPAAVASARTHIPRTPTPDVKRDPSPSPPGAIDSLASVSSAKTQGWKMWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFH
EPEAIELCTTTPLMKTRTHSGCKPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHL

--------------------------------------------------------------
>In-frame_ENST00000354069_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35497640_length(transcript)=1074nt_BP=307nt
ATGAAAAGCCTTGTACAAGAGGCTTCGTGCCATGTTCAGCCTGCCCCTTAGCCTTCCACTGTGTGAGGACACAGCATTCCTTCCTTCCAA
GTGCTGCAGCTCTCACAAGACAATCAAACAAGCCCGCACCTTGATCATGATCTTCCTAGCCTCCGGAACGCACTTTCAGACCATGCTGAA
GTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGGCCATTGAGCTGTGCACGACCAC
ACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCCAGAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGG
AGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTA
TTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATAT
TGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAG
GAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTT
TGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGG
AACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAG
GACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGT

>In-frame_ENST00000354069_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35497640_length(amino acids)=209AA_start in transcript=10_stop in transcript=639
MYKRLRAMFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGTHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLM
KTRTHSGCKPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKH

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>In-frame_ENST00000392054_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35514707_length(transcript)=1237nt_BP=610nt
AGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAGCCCCCTACGCCCACCCGGCG
GCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCTCGCCCCCCGGCGCGATCGAC
AGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGCAGGAGAGATTTGCAGACACA
GAAGCGGCACAGAGAAGGCCATTGTGAAGATCAAGGCAGAAACCGGAGTTATGGCATCATAAGCCAAGGAATGCCAAGGATTGCTGGCAA
CCACCTGATGTTAGAAGAGTCGAGGACATGTTCTTCTCCAGAGCTTTTGGATGGTGTGTGGCCCTGCCAACCTTTACATTTTGGACTTCC
AGCCTCCGAAATGCACTTTCAGACCATGCTGAAGTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCA
TGAGCCGGAGGCCATTGAGCTGTGCACGACCACACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGGTATTTCTTGGTGGATTTTT
ATGCACCCACCGCAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGA
CCCAGGAACTAAAAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATT
CGCCAGATTTTAGCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCA
TGTGTTGCAGGTGCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGC
TTCTCTGTAACCTGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAA
CAGTAACACCATTTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAA

>In-frame_ENST00000392054_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230020533_-_MRPS6_chr21_35514707_length(amino acids)=150AA_start in transcript=199_stop in transcript=651
MPKPRAGRCGSRPRSACRRDLQTQKRHREGHCEDQGRNRSYGIISQGMPRIAGNHLMLEESRTCSSPELLDGVWPCQPLHFGLPASEMHF

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>In-frame_ENST00000409462_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230135729_-_MRPS6_chr21_35497640_length(transcript)=1034nt_BP=267nt
TCTCGCAGCTGCGCCAGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAGCCCCC
TACGCCCACCCGGCGGCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCTCGCCC
CCCGGCGCGATCGACAGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGCAGCCA
GAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCG
CTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAA
AGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAA
GGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGT
AATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATT
TTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAG
TGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAG
CAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAATGTATTATAT

>In-frame_ENST00000409462_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230135729_-_MRPS6_chr21_35497640_length(amino acids)=174AA_start in transcript=75_stop in transcript=599
MLAAPYAHPAAVASARTHIPRTPTPDVKRDPSPSPPGAIDSLASVSSAKTQGWKMWQPATERLQPETAATLKRTIEALMDRGAIVRDLEN

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>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230135729_-_MRPS6_chr21_35497640_length(transcript)=1039nt_BP=272nt
AGTCCTCTCGCAGCTGCGCCAGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAG
CCCCCTACGCCCACCCGGCGGCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCT
CGCCCCCCGGCGCGATCGACAGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGC
AGCCAGAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGTGAAC
GAGCGCTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCAGCTG
TTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAAGAAT
GTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTA
TATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTT
TGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTGCAGT
ACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTTTTTG
AAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAATGTAT

>In-frame_ENST00000392055_ENST00000399312_TCGA-DX-A3U7_PID1_chr2_230135729_-_MRPS6_chr21_35497640_length(amino acids)=174AA_start in transcript=80_stop in transcript=604
MLAAPYAHPAAVASARTHIPRTPTPDVKRDPSPSPPGAIDSLASVSSAKTQGWKMWQPATERLQPETAATLKRTIEALMDRGAIVRDLEN

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Fusion Gene PPI Analysis for PID1-MRPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PID1-MRPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PID1-MRPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMRPS6C0010054Coronary Arteriosclerosis1CTD_human
TgeneMRPS6C1956346Coronary Artery Disease1CTD_human