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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIGQ-ERCC1 (FusionGDB2 ID:64860)

Fusion Gene Summary for PIGQ-ERCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGQ-ERCC1
Fusion gene ID: 64860
HgeneTgene
Gene symbol

PIGQ

ERCC1

Gene ID

9091

2067

Gene namephosphatidylinositol glycan anchor biosynthesis class QERCC excision repair 1, endonuclease non-catalytic subunit
SynonymsEIEE77|GPI1|c407A10.1COFS4|RAD10|UV20
Cytomap

16p13.3

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol N-acetylglucosaminyltransferase subunit QN-acetylglucosaminyl transferase component Gpi1N-acetylglucosamyl transferase component GPI1PIG-Qc407A10.1 (GPI1 (N-acetylglucosaminyl transferase component))phosphatidylinositol glycan, cDNA excision repair protein ERCC-1excision repair cross-complementation group 1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Modification date2020031320200329
UniProtAcc.

P07992

Ensembl transtripts involved in fusion geneENST00000409527, ENST00000321878, 
ENST00000026218, ENST00000470411, 
ENST00000544860, 		ENST00000300853, 
ENST00000423698, ENST00000588738, 
ENST00000340192, ENST00000591636, 
ENST00000589165, ENST00000013807, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 8 X 5=400
# samples 311
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGQ [Title/Abstract] AND ERCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIGQ(626254)-ERCC1(45920155), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC1

GO:0006289

nucleotide-excision repair

3290851


check buttonFusion gene breakpoints across PIGQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ERCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-76-4926-01BPIGQchr16

626254

+ERCC1chr19

45920155

-


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Fusion Gene ORF analysis for PIGQ-ERCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409527ENST00000300853PIGQchr16

626254

+ERCC1chr19

45920155

-
In-frameENST00000409527ENST00000423698PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000409527ENST00000588738PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000409527ENST00000340192PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000409527ENST00000591636PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000409527ENST00000589165PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000409527ENST00000013807PIGQchr16

626254

+ERCC1chr19

45920155

-
In-frameENST00000321878ENST00000300853PIGQchr16

626254

+ERCC1chr19

45920155

-
In-frameENST00000321878ENST00000423698PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000321878ENST00000588738PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000321878ENST00000340192PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000321878ENST00000591636PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000321878ENST00000589165PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000321878ENST00000013807PIGQchr16

626254

+ERCC1chr19

45920155

-
In-frameENST00000026218ENST00000300853PIGQchr16

626254

+ERCC1chr19

45920155

-
In-frameENST00000026218ENST00000423698PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000026218ENST00000588738PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000026218ENST00000340192PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000026218ENST00000591636PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000026218ENST00000589165PIGQchr16

626254

+ERCC1chr19

45920155

-
5CDS-intronENST00000026218ENST00000013807PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-3CDSENST00000470411ENST00000300853PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-3CDSENST00000470411ENST00000423698PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-intronENST00000470411ENST00000588738PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-intronENST00000470411ENST00000340192PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-intronENST00000470411ENST00000591636PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-intronENST00000470411ENST00000589165PIGQchr16

626254

+ERCC1chr19

45920155

-
3UTR-intronENST00000470411ENST00000013807PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-3CDSENST00000544860ENST00000300853PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-3CDSENST00000544860ENST00000423698PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-intronENST00000544860ENST00000588738PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-intronENST00000544860ENST00000340192PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-intronENST00000544860ENST00000591636PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-intronENST00000544860ENST00000589165PIGQchr16

626254

+ERCC1chr19

45920155

-
intron-intronENST00000544860ENST00000013807PIGQchr16

626254

+ERCC1chr19

45920155

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409527PIGQchr16626254+ENST00000300853ERCC1chr1945920155-382211111421479445
ENST00000409527PIGQchr16626254+ENST00000423698ERCC1chr1945920155-382111111421479445
ENST00000321878PIGQchr16626254+ENST00000300853ERCC1chr1945920155-3812110129591643438
ENST00000321878PIGQchr16626254+ENST00000423698ERCC1chr1945920155-3811110129591643438
ENST00000026218PIGQchr16626254+ENST00000300853ERCC1chr1945920155-3741103028881572438
ENST00000026218PIGQchr16626254+ENST00000423698ERCC1chr1945920155-3740103028881572438

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409527ENST00000300853PIGQchr16626254+ERCC1chr1945920155-0.089067720.9109323
ENST00000409527ENST00000423698PIGQchr16626254+ERCC1chr1945920155-0.088291520.9117085
ENST00000321878ENST00000300853PIGQchr16626254+ERCC1chr1945920155-0.082618620.9173814
ENST00000321878ENST00000423698PIGQchr16626254+ERCC1chr1945920155-0.0820174140.9179825
ENST00000026218ENST00000300853PIGQchr16626254+ERCC1chr1945920155-0.0872151850.91278476
ENST00000026218ENST00000423698PIGQchr16626254+ERCC1chr1945920155-0.0866277440.9133722

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Fusion Genomic Features for PIGQ-ERCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIGQ-ERCC1


check button Go to

FGviewer for the breakpoints of chr16:626254-chr19:45920155

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERCC1

P07992

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. {ECO:0000269|PubMed:17273966, ECO:0000269|PubMed:23623389, ECO:0000269|PubMed:24036546}.; FUNCTION: [Isoform 2]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.; FUNCTION: [Isoform 3]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.; FUNCTION: [Isoform 4]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410278_298314.0761.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411278_298314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512278_298314.0582.0TransmembraneHelical
TgeneERCC1chr16:626254chr19:45920155ENST0000042369839134_156103.0226.0DNA bindingOntology_term=ECO:0000255
TgeneERCC1chr16:626254chr19:45920155ENST0000001380738220_297175.0324.0RegionHhH2%2C dimerization with ERCC4/XPF
TgeneERCC1chr16:626254chr19:45920155ENST00000300853410220_297175.0298.0RegionHhH2%2C dimerization with ERCC4/XPF
TgeneERCC1chr16:626254chr19:45920155ENST0000034019249220_297175.0274.0RegionHhH2%2C dimerization with ERCC4/XPF
TgeneERCC1chr16:626254chr19:45920155ENST0000042369839220_297103.0226.0RegionHhH2%2C dimerization with ERCC4/XPF
TgeneERCC1chr16:626254chr19:45920155ENST00000589165410220_297175.0298.0RegionHhH2%2C dimerization with ERCC4/XPF

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410214_536314.0761.0Compositional biasNote=Leu-rich
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411214_536314.0582.0Compositional biasNote=Leu-rich
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512214_536314.0582.0Compositional biasNote=Leu-rich
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13214_5360300.0Compositional biasNote=Leu-rich
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410349_371314.0761.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410378_400314.0761.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410446_468314.0761.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000026218+410475_497314.0761.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411349_371314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411378_400314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411446_468314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000321878+411475_497314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512349_371314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512378_400314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512446_468314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000409527+512475_497314.0582.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13278_2980300.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13349_3710300.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13378_4000300.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13446_4680300.0TransmembraneHelical
HgenePIGQchr16:626254chr19:45920155ENST00000470411+13475_4970300.0TransmembraneHelical
TgeneERCC1chr16:626254chr19:45920155ENST0000001380738134_156175.0324.0DNA bindingOntology_term=ECO:0000255
TgeneERCC1chr16:626254chr19:45920155ENST00000300853410134_156175.0298.0DNA bindingOntology_term=ECO:0000255
TgeneERCC1chr16:626254chr19:45920155ENST0000034019249134_156175.0274.0DNA bindingOntology_term=ECO:0000255
TgeneERCC1chr16:626254chr19:45920155ENST00000589165410134_156175.0298.0DNA bindingOntology_term=ECO:0000255
TgeneERCC1chr16:626254chr19:45920155ENST000000138073817_23175.0324.0MotifNuclear localization signal
TgeneERCC1chr16:626254chr19:45920155ENST0000030085341017_23175.0298.0MotifNuclear localization signal
TgeneERCC1chr16:626254chr19:45920155ENST000003401924917_23175.0274.0MotifNuclear localization signal
TgeneERCC1chr16:626254chr19:45920155ENST000004236983917_23103.0226.0MotifNuclear localization signal
TgeneERCC1chr16:626254chr19:45920155ENST0000058916541017_23175.0298.0MotifNuclear localization signal


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Fusion Gene Sequence for PIGQ-ERCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000409527_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3822nt_BP=1111nt
CTAGTTTCCAACAACAGAGGCTGCAGCCACCCAGCCCCGAAGCAGGGCCCAGCGAGACAGGGCCCAGTGGGGCCTTATTCTCTCTCTTGC
AGCCCCAAGCGTGACCCAGCTGCAGAGAAGCTGAGACGGTGATTCGGACTGACTGGACTCTGGCCTCCAGCCTCCCGGCATGGTGCTCAA
GGCCTTCTTCCCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGTGGTCCTGGC
GGTCCTGCACTTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGCCGTGCTGGG
CACCTGGTGCCACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGAGCCCTGGCT
GCGGCTGTGCCGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCCTGGTGAGGA
CCAGGTCATGCTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCAGGCTGGAGC
CACCACTGCCAGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTTTGATGAGGG
CCCCGTGCGGCTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACCCATTTGCCT
GCTGTTGGCCAGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGGGAGCAAACT
CTCCACGTGCGAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCAGCTGATGAG
GAAGGCCAACACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCGCATCGGGCA
TCTGGCCGACGCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGCAC
ATTGATCCTCGCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATGGA
GAAGCTAGAGCAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTGAC
CACATTTGGATCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGGCT
GTTTGATGTCCTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTCCC
AGGCCAGGCTCCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTCAG
CTTTCTTTAGTTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCCTC
CTCCCCAGACTCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTCCT
CTTCTTGGTGGATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACTGT
GTGACCTCTCTCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACCAC
CTCTGTCTCTGGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGCTT
CGCTCCTTCTGGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTCCC
TGGCTCCATCATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTCAC
CTGTGGCTGAGACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGGAC
TGTGTCTTCTAGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTCCT
CTTCTTGGTGGTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGTTC
TTTCAGCTGCTGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGCCC
ATTCACTGCCTCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCTGA
CCTAGGCCCTGTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGGAT
GGGCTGCAGAGGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCACC
TCCTGCCTCCGTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCCAA
TTTGCCCTTGACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTGGA
ACAGGAGAGGGAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGATC
TCGGCTCACTGCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACCAC
GCCCAGCCAATTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTCGC
CTCGGCCTCCCAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTCCA
TCTTAAAGTGAGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTACAG
AATATTTATGGCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAACA
TAAATGAGCAAGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAGTT
TAACTATAGTTCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACTCT

>In-frame_ENST00000409527_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=445AA_start in transcript=142_stop in transcript=1479
MDSGLQPPGMVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGVAVLGTWCHCRQEPEESLGRFL
ESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGAPGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVAR
SEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIF
STRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRSRIGHLADALVPVADKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETY

--------------------------------------------------------------
>In-frame_ENST00000409527_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3821nt_BP=1111nt
CTAGTTTCCAACAACAGAGGCTGCAGCCACCCAGCCCCGAAGCAGGGCCCAGCGAGACAGGGCCCAGTGGGGCCTTATTCTCTCTCTTGC
AGCCCCAAGCGTGACCCAGCTGCAGAGAAGCTGAGACGGTGATTCGGACTGACTGGACTCTGGCCTCCAGCCTCCCGGCATGGTGCTCAA
GGCCTTCTTCCCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGTGGTCCTGGC
GGTCCTGCACTTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGCCGTGCTGGG
CACCTGGTGCCACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGAGCCCTGGCT
GCGGCTGTGCCGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCCTGGTGAGGA
CCAGGTCATGCTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCAGGCTGGAGC
CACCACTGCCAGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTTTGATGAGGG
CCCCGTGCGGCTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACCCATTTGCCT
GCTGTTGGCCAGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGGGAGCAAACT
CTCCACGTGCGAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCAGCTGATGAG
GAAGGCCAACACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCGCATCGGGCA
TCTGGCCGACGCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGCAC
ATTGATCCTCGCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATGGA
GAAGCTAGAGCAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTGAC
CACATTTGGATCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGGCT
GTTTGATGTCCTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTCCC
AGGCCAGGCTCCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTCAG
CTTTCTTTAGTTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCCTC
CTCCCCAGACTCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTCCT
CTTCTTGGTGGATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACTGT
GTGACCTCTCTCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACCAC
CTCTGTCTCTGGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGCTT
CGCTCCTTCTGGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTCCC
TGGCTCCATCATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTCAC
CTGTGGCTGAGACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGGAC
TGTGTCTTCTAGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTCCT
CTTCTTGGTGGTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGTTC
TTTCAGCTGCTGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGCCC
ATTCACTGCCTCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCTGA
CCTAGGCCCTGTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGGAT
GGGCTGCAGAGGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCACC
TCCTGCCTCCGTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCCAA
TTTGCCCTTGACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTGGA
ACAGGAGAGGGAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGATC
TCGGCTCACTGCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACCAC
GCCCAGCCAATTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTCGC
CTCGGCCTCCCAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTCCA
TCTTAAAGTGAGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTACAG
AATATTTATGGCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAACA
TAAATGAGCAAGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAGTT
TAACTATAGTTCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACTCT

>In-frame_ENST00000409527_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=445AA_start in transcript=142_stop in transcript=1479
MDSGLQPPGMVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGVAVLGTWCHCRQEPEESLGRFL
ESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGAPGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVAR
SEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIF
STRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRSRIGHLADALVPVADKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETY

--------------------------------------------------------------
>In-frame_ENST00000321878_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3812nt_BP=1101nt
GCGGCAACGCGCGGAGCCGGCGGAAGTGGGGCTCGGGTCCCGCGGCGGGGCTGGAGGCAGCGAGCGCCGTCGTCTGCCCGGGCCCGCCCA
TCGGGGTCCCCAACCCCATCCGGACCCCGCCGCCCGAGCGCGCGGCCCCGGAAGCACCCGCCTCCCGGCATGGTGCTCAAGGCCTTCTTC
CCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGTGGTCCTGGCGGTCCTGCAC
TTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGCCGTGCTGGGCACCTGGTGC
CACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGAGCCCTGGCTGCGGCTGTGC
CGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCCTGGTGAGGACCAGGTCATG
CTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCAGGCTGGAGCCACCACTGCC
AGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTTTGATGAGGGCCCCGTGCGG
CTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACCCATTTGCCTGCTGTTGGCC
AGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGGGAGCAAACTCTCCACGTGC
GAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCAGCTGATGAGGAAGGCCAAC
ACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCGCATCGGGCATCTGGCCGAC
GCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGCACATTGATCCTC
GCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATGGAGAAGCTAGAG
CAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTGACCACATTTGGA
TCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGGCTGTTTGATGTC
CTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTCCCAGGCCAGGCT
CCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTCAGCTTTCTTTAG
TTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCCTCCTCCCCAGAC
TCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTCCTCTTCTTGGTG
GATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACTGTGTGACCTCTC
TCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACCACCTCTGTCTCT
GGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGCTTCGCTCCTTCT
GGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTCCCTGGCTCCATC
ATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTCACCTGTGGCTGA
GACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGGACTGTGTCTTCT
AGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTCCTCTTCTTGGTG
GTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGTTCTTTCAGCTGC
TGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGCCCATTCACTGCC
TCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCTGACCTAGGCCCT
GTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGGATGGGCTGCAGA
GGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCACCTCCTGCCTCC
GTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCCAATTTGCCCTTG
ACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTGGAACAGGAGAGG
GAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACT
GCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCCCAGCCAA
TTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTCGCCTCGGCCTCC
CAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTCCATCTTAAAGTG
AGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTACAGAATATTTATG
GCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAACATAAATGAGCA
AGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAGTTTAACTATAGT
TCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACTCTGTAAAGGAGT

>In-frame_ENST00000321878_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=438AA_start in transcript=2959_stop in transcript=1643
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------
>In-frame_ENST00000321878_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3811nt_BP=1101nt
GCGGCAACGCGCGGAGCCGGCGGAAGTGGGGCTCGGGTCCCGCGGCGGGGCTGGAGGCAGCGAGCGCCGTCGTCTGCCCGGGCCCGCCCA
TCGGGGTCCCCAACCCCATCCGGACCCCGCCGCCCGAGCGCGCGGCCCCGGAAGCACCCGCCTCCCGGCATGGTGCTCAAGGCCTTCTTC
CCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGTGGTCCTGGCGGTCCTGCAC
TTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGCCGTGCTGGGCACCTGGTGC
CACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGAGCCCTGGCTGCGGCTGTGC
CGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCCTGGTGAGGACCAGGTCATG
CTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCAGGCTGGAGCCACCACTGCC
AGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTTTGATGAGGGCCCCGTGCGG
CTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACCCATTTGCCTGCTGTTGGCC
AGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGGGAGCAAACTCTCCACGTGC
GAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCAGCTGATGAGGAAGGCCAAC
ACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCGCATCGGGCATCTGGCCGAC
GCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGCACATTGATCCTC
GCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATGGAGAAGCTAGAG
CAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTGACCACATTTGGA
TCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGGCTGTTTGATGTC
CTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTCCCAGGCCAGGCT
CCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTCAGCTTTCTTTAG
TTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCCTCCTCCCCAGAC
TCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTCCTCTTCTTGGTG
GATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACTGTGTGACCTCTC
TCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACCACCTCTGTCTCT
GGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGCTTCGCTCCTTCT
GGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTCCCTGGCTCCATC
ATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTCACCTGTGGCTGA
GACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGGACTGTGTCTTCT
AGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTCCTCTTCTTGGTG
GTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGTTCTTTCAGCTGC
TGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGCCCATTCACTGCC
TCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCTGACCTAGGCCCT
GTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGGATGGGCTGCAGA
GGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCACCTCCTGCCTCC
GTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCCAATTTGCCCTTG
ACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTGGAACAGGAGAGG
GAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACT
GCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCCCAGCCAA
TTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTCGCCTCGGCCTCC
CAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTCCATCTTAAAGTG
AGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTACAGAATATTTATG
GCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAACATAAATGAGCA
AGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAGTTTAACTATAGT
TCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACTCTGTAAAGGAGT

>In-frame_ENST00000321878_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=438AA_start in transcript=2959_stop in transcript=1643
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------
>In-frame_ENST00000026218_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3741nt_BP=1030nt
GTCTGCCCGGGCCCGCCCATCGGGGTCCCCAACCCCATCCGGACCCCGCCGCCCGAGCGCGCGGCCCCGGAAGCACCCGCCTCCCGGCAT
GGTGCTCAAGGCCTTCTTCCCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGT
GGTCCTGGCGGTCCTGCACTTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGC
CGTGCTGGGCACCTGGTGCCACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGA
GCCCTGGCTGCGGCTGTGCCGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCC
TGGTGAGGACCAGGTCATGCTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCA
GGCTGGAGCCACCACTGCCAGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTT
TGATGAGGGCCCCGTGCGGCTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACC
CATTTGCCTGCTGTTGGCCAGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGG
GAGCAAACTCTCCACGTGCGAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCA
GCTGATGAGGAAGGCCAACACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCG
CATCGGGCATCTGGCCGACGCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGC
CGACTGCACATTGATCCTCGCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCT
CCTGATGGAGAAGCTAGAGCAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGAC
CCTCCTGACCACATTTGGATCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGC
CCGGAGGCTGTTTGATGTCCTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAAT
CGTCCTCCCAGGCCAGGCTCCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGG
CACCTTCAGCTTTCTTTAGTTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGT
GGGAGCCTCCTCCCCAGACTCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTG
CTTCTTCCTCTTCTTGGTGGATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTC
AGTCACTGTGTGACCTCTCTCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGG
CCCCACCACCTCTGTCTCTGGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGC
CTGAGGCTTCGCTCCTTCTGGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGC
CTCCGTCCCTGGCTCCATCATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTC
CACCTTCACCTGTGGCTGAGACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGG
GGACAGGACTGTGTCTTCTAGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGG
CTTCTTCCTCTTCTTGGTGGTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGC
CTCTGGTTCTTTCAGCTGCTGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGC
CCCGTGCCCATTCACTGCCTCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGC
CAAGGCTGACCTAGGCCCTGTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACT
TGCTGGGATGGGCTGCAGAGGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGT
GAGTCCACCTCCTGCCTCCGTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTT
GCCTGCCAATTTGCCCTTGACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGC
TTAAGTGGAACAGGAGAGGGAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGT
GGCATGATCTCGGCTCACTGCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACC
TGCCACCACGCCCAGCCAATTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGA
TCTGCTCGCCTCGGCCTCCCAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGA
GTGACTCCATCTTAAAGTGAGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTA
TAATTACAGAATATTTATGGCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTA
AATATAACATAAATGAGCAAGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACA
CTCCAAGTTTAACTATAGTTCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACA

>In-frame_ENST00000026218_ENST00000300853_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=438AA_start in transcript=2888_stop in transcript=1572
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------
>In-frame_ENST00000026218_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(transcript)=3740nt_BP=1030nt
GTCTGCCCGGGCCCGCCCATCGGGGTCCCCAACCCCATCCGGACCCCGCCGCCCGAGCGCGCGGCCCCGGAAGCACCCGCCTCCCGGCAT
GGTGCTCAAGGCCTTCTTCCCCACGTGCTGCGTCTCGACGGACAGCGGGCTGCTGGTGGGACGGTGGGTGCCGGAGCAGAGCAGCGCCGT
GGTCCTGGCGGTCCTGCACTTTCCCTTCATCCCCATCCAGGTCAAGCAGCTCCTGGCCCAGGTGCGGCAGGCCAGCCAGGTGGGCGTGGC
CGTGCTGGGCACCTGGTGCCACTGCCGGCAGGAGCCCGAGGAGAGCCTGGGCCGCTTCCTGGAGAGCCTGGGTGCTGTCTTCCCCCATGA
GCCCTGGCTGCGGCTGTGCCGGGAGAGAGGCGGCACGTTCTGGAGCTGCGAGGCCACCCACCGGCAAGCGCCCACTGCCCCCGGTGCCCC
TGGTGAGGACCAGGTCATGCTCATCTTCTATGACCAGCGCCAGGTGTTGCTGTCACAGCTACACCTGCCCACCGTCCTGCCCGACCGCCA
GGCTGGAGCCACCACTGCCAGCACGGGGGGCCTGGCTGCCGTCTTCGACACGGTAGCACGCAGTGAGGTGCTCTTCCGCAGTGACCGCTT
TGATGAGGGCCCCGTGCGGCTGAGCCACTGGCAGTCGGAGGGCGTGGAGGCCAGCATCCTCGCGGAGCTGGCCAGGCGAGCCTCGGGACC
CATTTGCCTGCTGTTGGCCAGCCTGCTGTCGCTGGTCTCAGCTGTCAGTGCCTGCCGAGTGTTCAAGCTCTGGCCCCTGTCCTTCCTCGG
GAGCAAACTCTCCACGTGCGAACAGCTCCGGCACCGGCTGGAGCACCTCACGCTAATCTTCAGTACACGGAAGGCGGAGAACCCTGCCCA
GCTGATGAGGAAGGCCAACACGGTGGCCTCTGTGCTGCTGGACGTGGCCCTGGGCCTCATGCTGCTGTCCTGGCTCCACGGGAGAAGCCG
CATCGGGCATCTGGCCGACGCCCTCGTTCCTGTGGCTGACAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGC
CGACTGCACATTGATCCTCGCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCT
CCTGATGGAGAAGCTAGAGCAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGAC
CCTCCTGACCACATTTGGATCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGC
CCGGAGGCTGTTTGATGTCCTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAAT
CGTCCTCCCAGGCCAGGCTCCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGG
CACCTTCAGCTTTCTTTAGTTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGT
GGGAGCCTCCTCCCCAGACTCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTG
CTTCTTCCTCTTCTTGGTGGATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTC
AGTCACTGTGTGACCTCTCTCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGG
CCCCACCACCTCTGTCTCTGGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGC
CTGAGGCTTCGCTCCTTCTGGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGC
CTCCGTCCCTGGCTCCATCATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTC
CACCTTCACCTGTGGCTGAGACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGG
GGACAGGACTGTGTCTTCTAGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGG
CTTCTTCCTCTTCTTGGTGGTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGC
CTCTGGTTCTTTCAGCTGCTGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGC
CCCGTGCCCATTCACTGCCTCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGC
CAAGGCTGACCTAGGCCCTGTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACT
TGCTGGGATGGGCTGCAGAGGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGT
GAGTCCACCTCCTGCCTCCGTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTT
GCCTGCCAATTTGCCCTTGACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGC
TTAAGTGGAACAGGAGAGGGAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGT
GGCATGATCTCGGCTCACTGCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACC
TGCCACCACGCCCAGCCAATTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGA
TCTGCTCGCCTCGGCCTCCCAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGA
GTGACTCCATCTTAAAGTGAGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTA
TAATTACAGAATATTTATGGCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTA
AATATAACATAAATGAGCAAGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACA
CTCCAAGTTTAACTATAGTTCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACA

>In-frame_ENST00000026218_ENST00000423698_TCGA-76-4926-01B_PIGQ_chr16_626254_+_ERCC1_chr19_45920155_length(amino acids)=438AA_start in transcript=2888_stop in transcript=1572
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIGQ-ERCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIGQ-ERCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIGQ-ERCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIGQC0014544Epilepsy1GENOMICS_ENGLAND
HgenePIGQC0029124Optic Atrophy1GENOMICS_ENGLAND
HgenePIGQC0393706Early infantile epileptic encephalopathy with suppression bursts1ORPHANET
HgenePIGQC0424605Developmental delay (disorder)1GENOMICS_ENGLAND
HgenePIGQC0557874Global developmental delay1GENOMICS_ENGLAND
HgenePIGQC2674422Seizures, intractable1GENOMICS_ENGLAND
HgenePIGQC4552072X-linked infantile spasms1GENOMICS_ENGLAND
TgeneERCC1C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneERCC1C0043346Xeroderma Pigmentosum2GENOMICS_ENGLAND
TgeneERCC1C1853100CEREBROOCULOFACIOSKELETAL SYNDROME 42CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneERCC1C0001956Alcohol Use Disorder1PSYGENET
TgeneERCC1C0004403Autosome Abnormalities1CTD_human
TgeneERCC1C0006826Malignant Neoplasms1CTD_human
TgeneERCC1C0007873Uterine Cervical Neoplasm1CTD_human
TgeneERCC1C0008625Chromosome Aberrations1CTD_human
TgeneERCC1C0015625Fanconi Anemia1GENOMICS_ENGLAND
TgeneERCC1C0024121Lung Neoplasms1CGI;CTD_human
TgeneERCC1C0024623Malignant neoplasm of stomach1CTD_human
TgeneERCC1C0025202melanoma1CTD_human
TgeneERCC1C0027627Neoplasm Metastasis1CTD_human
TgeneERCC1C0027651Neoplasms1CTD_human
TgeneERCC1C0027654Embryonal Neoplasm1CTD_human
TgeneERCC1C0027658Neoplasms, Germ Cell and Embryonal1CTD_human
TgeneERCC1C0038356Stomach Neoplasms1CTD_human
TgeneERCC1C0039590Testicular Neoplasms1CTD_human
TgeneERCC1C0086692Benign Neoplasm1CTD_human
TgeneERCC1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneERCC1C0153594Malignant neoplasm of testis1CTD_human
TgeneERCC1C0205851Germ cell tumor1CTD_human
TgeneERCC1C0205852Neoplasms, Embryonal and Mixed1CTD_human
TgeneERCC1C0220722Cerebrooculofacioskeletal Syndrome 11ORPHANET
TgeneERCC1C0242379Malignant neoplasm of lung1CGI;CTD_human
TgeneERCC1C0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneERCC1C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneERCC1C0311375Arsenic Poisoning1CTD_human
TgeneERCC1C0740345Germ Cell Cancer1CTD_human
TgeneERCC1C0751038Cockayne Syndrome, Type II1ORPHANET
TgeneERCC1C0751364Cancer, Embryonal1CTD_human
TgeneERCC1C0751365Cancer, Embryonal and Mixed1CTD_human
TgeneERCC1C0751851Arsenic Encephalopathy1CTD_human
TgeneERCC1C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneERCC1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneERCC1C1720811Tumor of Rete Testis1CTD_human
TgeneERCC1C1859312CAMFAK syndrome1ORPHANET
TgeneERCC1C2931277Pena Shokeir syndrome Type 21ORPHANET
TgeneERCC1C2931822Nasopharyngeal carcinoma1CTD_human
TgeneERCC1C4048328cervical cancer1CTD_human
TgeneERCC1C4721453Peripheral Nervous System Diseases1CTD_human