FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARID1A-THBS3 (FusionGDB2 ID:6489)

Fusion Gene Summary for ARID1A-THBS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID1A-THBS3
Fusion gene ID: 6489
HgeneTgene
Gene symbol

ARID1A

THBS3

Gene ID

8289

7059

Gene nameAT-rich interaction domain 1Athrombospondin 3
SynonymsB120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1TSP3
Cytomap

1p36.11

1q22

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, thrombospondin-3
Modification date2020032920200313
UniProtAcc

O14497

.
Ensembl transtripts involved in fusion geneENST00000324856, ENST00000457599, 
ENST00000374152, ENST00000540690, 
ENST00000368378, ENST00000541576, 
ENST00000457183, ENST00000541990, 
ENST00000486260, 
Fusion gene scores* DoF score29 X 19 X 15=82654 X 4 X 2=32
# samples 454
** MAII scorelog2(45/8265*10)=-4.19901791296264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID1A [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID1A(27059283)-THBS3(155172928), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID1A

GO:0006337

nucleosome disassembly

8895581

HgeneARID1A

GO:0006338

chromatin remodeling

11726552

HgeneARID1A

GO:0030520

intracellular estrogen receptor signaling pathway

12200431

HgeneARID1A

GO:0030521

androgen receptor signaling pathway

12200431

HgeneARID1A

GO:0042921

glucocorticoid receptor signaling pathway

12200431

HgeneARID1A

GO:0045893

positive regulation of transcription, DNA-templated

12200431


check buttonFusion gene breakpoints across ARID1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across THBS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12V-01AARID1Achr1

27059283

+THBS3chr1

155172928

-
ChimerDB4BRCATCGA-C8-A12VARID1Achr1

27059283

+THBS3chr1

155172928

-
ChimerDB4BRCATCGA-C8-A12V-01AARID1Achr1

27059283

+THBS3chr1

155172928

-
ChimerDB4BRCATCGA-C8-A12V-01AARID1Achr1

27059283

-THBS3chr1

155172928

-


Top

Fusion Gene ORF analysis for ARID1A-THBS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324856ENST00000368378ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000324856ENST00000541576ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000324856ENST00000457183ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000324856ENST00000541990ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000324856ENST00000486260ARID1Achr1

27059283

+THBS3chr1

155172928

-
In-frameENST00000457599ENST00000368378ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000457599ENST00000541576ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000457599ENST00000457183ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000457599ENST00000541990ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000457599ENST00000486260ARID1Achr1

27059283

+THBS3chr1

155172928

-
In-frameENST00000374152ENST00000368378ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000374152ENST00000541576ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-intronENST00000374152ENST00000457183ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000374152ENST00000541990ARID1Achr1

27059283

+THBS3chr1

155172928

-
5CDS-5UTRENST00000374152ENST00000486260ARID1Achr1

27059283

+THBS3chr1

155172928

-
intron-3CDSENST00000540690ENST00000368378ARID1Achr1

27059283

+THBS3chr1

155172928

-
intron-intronENST00000540690ENST00000541576ARID1Achr1

27059283

+THBS3chr1

155172928

-
intron-intronENST00000540690ENST00000457183ARID1Achr1

27059283

+THBS3chr1

155172928

-
intron-5UTRENST00000540690ENST00000541990ARID1Achr1

27059283

+THBS3chr1

155172928

-
intron-5UTRENST00000540690ENST00000486260ARID1Achr1

27059283

+THBS3chr1

155172928

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324856ARID1Achr127059283+ENST00000368378THBS3chr1155172928-4659229137144051344
ENST00000457599ARID1Achr127059283+ENST00000368378THBS3chr1155172928-42881920040341344
ENST00000374152ARID1Achr127059283+ENST00000368378THBS3chr1155172928-342210542833168961

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324856ENST00000368378ARID1Achr127059283+THBS3chr1155172928-0.0050804950.9949195
ENST00000457599ENST00000368378ARID1Achr127059283+THBS3chr1155172928-0.003899110.9961009
ENST00000374152ENST00000368378ARID1Achr127059283+THBS3chr1155172928-0.0024054230.99759454

Top

Fusion Genomic Features for ARID1A-THBS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARID1A-THBS3


check button Go to

FGviewer for the breakpoints of chr1:27059283-chr1:155172928

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1A

O14497

.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+420479_482640.02286.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+420561_567640.02286.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+420479_482640.02069.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+420561_567640.02069.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+420295_299640.02286.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+420295_299640.02069.0MotifNote=LXXLL
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523316_354252.0957.0DomainEGF-like 1%3B calcium-binding
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523370_410252.0957.0DomainEGF-like 2%3B calcium-binding
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523414_456252.0957.0DomainEGF-like 3
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523727_941252.0957.0DomainTSP C-terminal
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321316_354132.0837.0DomainEGF-like 1%3B calcium-binding
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321370_410132.0837.0DomainEGF-like 2%3B calcium-binding
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321414_456132.0837.0DomainEGF-like 3
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321727_941132.0837.0DomainTSP C-terminal
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523457_491252.0957.0RepeatNote=TSP type-3 1
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523492_527252.0957.0RepeatNote=TSP type-3 2
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523528_550252.0957.0RepeatNote=TSP type-3 3
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523551_586252.0957.0RepeatNote=TSP type-3 4
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523587_609252.0957.0RepeatNote=TSP type-3 5
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523610_647252.0957.0RepeatNote=TSP type-3 6
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523648_687252.0957.0RepeatNote=TSP type-3 7
TgeneTHBS3chr1:27059283chr1:155172928ENST00000368378523688_723252.0957.0RepeatNote=TSP type-3 8
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321457_491132.0837.0RepeatNote=TSP type-3 1
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321492_527132.0837.0RepeatNote=TSP type-3 2
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321528_550132.0837.0RepeatNote=TSP type-3 3
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321551_586132.0837.0RepeatNote=TSP type-3 4
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321587_609132.0837.0RepeatNote=TSP type-3 5
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321610_647132.0837.0RepeatNote=TSP type-3 6
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321648_687132.0837.0RepeatNote=TSP type-3 7
TgeneTHBS3chr1:27059283chr1:155172928ENST00000457183321688_723132.0837.0RepeatNote=TSP type-3 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4201327_1404640.02286.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+420998_1001640.02286.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3191327_1404257.01903.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+319479_482257.01903.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+319561_567257.01903.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+319998_1001257.01903.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4201327_1404640.02069.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+420998_1001640.02069.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4201017_1108640.02286.0DomainARID
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3191017_1108257.01903.0DomainARID
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4201017_1108640.02069.0DomainARID
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4201368_1387640.02286.0MotifNuclear localization signal
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4201709_1713640.02286.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4201967_1971640.02286.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000324856+4202085_2089640.02286.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3191368_1387257.01903.0MotifNuclear localization signal
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3191709_1713257.01903.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3191967_1971257.01903.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+3192085_2089257.01903.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000374152+319295_299257.01903.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4201368_1387640.02069.0MotifNuclear localization signal
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4201709_1713640.02069.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4201967_1971640.02069.0MotifNote=LXXLL
HgeneARID1Achr1:27059283chr1:155172928ENST00000457599+4202085_2089640.02069.0MotifNote=LXXLL
TgeneTHBS3chr1:27059283chr1:155172928ENST0000036837852323_193252.0957.0DomainNote=Laminin G-like
TgeneTHBS3chr1:27059283chr1:155172928ENST0000045718332123_193132.0837.0DomainNote=Laminin G-like


Top

Fusion Gene Sequence for ARID1A-THBS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000324856_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(transcript)=4659nt_BP=2291nt
GAAAGCGGAGAGTCACAGCGGGGCCAGGCCCTGGGGAGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAATGAG
CCGGGAGAGCCGGGTCCCGAGCCTACAGAGCCGGGAGCAGCTGAGCCGCCGGCGCCTCGGCCGCCGCCGCCGCCTCCTCCTCCTCCGCCG
CCGCCAGCCCGGAGCCTGAGCCGGCGGGGCGGGGGGGAGAGGAGCGAGCGCAGCGCAGCAGCGGAGCCCCGCGAGGCCCGCCCGGGCGGG
TGGGGAGGGCAGCCCGGGGGACTGGGCCCCGGGGCGGGGTGGGAGGGGGGGAGAAGACGAAGACAGGGCCGGGTCTCTCCGCGGACGAGA
CAGCGGGGATCATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAG
CCGAGCAGCAGCAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGG
AAAGCGAGGGCCCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCG
GAGCCGGCAGCGGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACC
TCACGGAGCCGCCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAG
CCTACGGCTTCGGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAAC
AAAGCCCTGGCCTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCT
TCCCCAACCACCAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTG
GCACTCCGGGCTCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCG
CTCAGCAGCGCTTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACC
AACTGCTCACGTCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCA
AGGGCCCGGCGGACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGA
GCCACCACGCGCCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGCCATCCAGTCCAATGGATCAGA
TGGGCAAGATGAGACCTCAGCCATATGGCGGGACTAACCCATACTCGCAGCAACAGGGACCTCCGTCAGGACCGCAGCAAGGACATGGGT
ACCCAGGGCAGCCATACGGGTCCCAGACCCCGCAGCGGTACCCGATGACCATGCAGGGCCGGGCGCAGAGTGCCATGGGCGGCCTCTCTT
ATACACAGCAGATTCCTCCTTATGGACAACAAGGCCCCAGCGGGTATGGTCAACAGGGCCAGACTCCATATTACAACCAGCAAAGTCCTC
ACCCTCAGCAGCAGCAGCCACCCTACTCCCAGCAACCACCGTCCCAGACCCCTCATGCCCAACCTTCGTATCAGCAGCAGCCACAGTCTC
AACCACCACAGCTCCAGTCCTCTCAGCCTCCATACTCCCAGCAGCCATCCCAGCCTCCACATCAGCAGTCCCCGGCTCCATACCCCTCCC
AGCAGTCGACGACACAGCAGCACCCCCAGAGCCAGCCCCCCTACTCACAGCCACAGGCTCAGTCTCCTTACCAGCAGCAGCAACCTCAGC
AGCCAGCACCCTCGACGCTCTCCCAGCAGGCTGCGTATCCTCAGCCCCAGTCTCAGCAGTCCCAGCAAACTGCCTATTCCCAGCAGCGCT
TCCCTCCACCGCAGGAGCTATCTCAAGATTCATTTGGGTCTCAGGCATCCTCAGCCCCCTCAATGACCTCCAGTAAGGGAGGGCAAGAAG
ATATGAACCTGAGCCTTCAGTCAAGACCCTCCAGCTTGCCTGTGAAGGAAATGTCCCTGATCCGAAACACCATTATGGAGTGTCAGGTGT
GCGGCTTCCATGAGCAGCGTTCCCACTGCAGCCCCAATCCCTGCTTCCGAGGTGTGGACTGCATGGAAGTGTACGAGTACCCAGGCTACC
GCTGTGGGCCCTGCCCCCCTGGCCTGCAGGGCAACGGCACCCACTGCAGTGACATCAATGAGTGTGCTCACGCTGACCCCTGTTTCCCGG
GCTCCAGCTGCATCAACACCATGCCCGGCTTCCACTGTGAGGCCTGTCCTCGAGGGTACAAGGGCACACAGGTGTCTGGTGTGGGCATTG
ACTATGCCCGGGCCAGCAAACAGGTCTGCAATGACATCGATGAATGCAACGATGGCAACAATGGTGGCTGTGACCCAAACTCCATCTGCA
CCAACACTGTGGGCTCTTTCAAGTGTGGTCCCTGCCGCCTGGGTTTCCTGGGCAACCAGAGCCAGGGCTGCCTCCCAGCCCGGACCTGCC
ACAGCCCAGCCCACAGCCCCTGCCACATCCATGCTCACTGTCTCTTTGAACGCAATGGTGCAGTGTCCTGCCAGTGTAACGTGGGCTGGG
CTGGGAATGGGAACGTGTGTGGGACTGACACAGACATCGATGGCTACCCAGACCAAGCACTGCCCTGCATGGACAACAACAAACACTGCA
AACAGGACAACTGCCTTTTGACACCCAACTCTGGGCAGGAAGATGCTGATAATGATGGTGTGGGGGACCAGTGTGATGATGATGCTGATG
GGGATGGGATCAAGAATGTTGAGGACAACTGCCGGCTGTTCCCCAACAAAGACCAGCAGAACTCAGATACAGATTCATTTGGTGATGCCT
GTGACAATTGCCCCAACGTTCCCAACAATGACCAGAAGGACACAGATGGCAATGGGGAAGGAGATGCCTGTGACAACGACGTGGATGGGG
ATGGCATCCCCAATGGATTGGACAATTGCCCTAAAGTCCCCAACCCACTACAGACAGACAGGGATGAGGACGGGGTGGGAGATGCTTGCG
ACAGCTGCCCTGAAATGAGCAATCCTACCCAGACAGATGCAGACAGCGACCTGGTGGGGGATGTCTGTGATACTAATGAAGACAGCGATG
GGGATGGGCATCAGGACACCAAGGACAACTGCCCACAGCTGCCAAATAGCTCCCAGCTGGACTCTGATAACGATGGACTTGGAGATGAGT
GTGATGGGGATGATGACAATGATGGCATCCCAGATTATGTGCCTCCTGGTCCCGATAACTGCCGCCTGGTACCCAATCCCAATCAGAAGG
ACTCAGATGGCAATGGCGTTGGTGATGTGTGTGAGGATGACTTTGACAATGATGCTGTGGTCGACCCCCTGGATGTGTGTCCTGAAAGTG
CAGAGGTAACGCTTACGGATTTTCGGGCCTATCAGACCGTCGTCCTGGATCCTGAGGGTGATGCTCAGATTGACCCAAACTGGGTTGTGC
TCAACCAGGGCATGGAAATCGTTCAGACCATGAACAGTGACCCTGGCTTGGCAGTTGGATACACGGCCTTCAATGGTGTGGACTTTGAAG
GCACCTTCCATGTGAACACAGTGACTGATGATGACTACGCAGGCTTTCTCTTCAGTTATCAAGACAGTGGCCGCTTCTACGTAGTCATGT
GGAAGCAGACCGAGCAGACCTACTGGCAGGCTACACCCTTCCGGGCGGTTGCCCAGCCCGGGCTGCAGCTCAAGGCAGTGACATCAGTGT
CTGGCCCAGGTGAGCACCTCCGAAATGCCCTGTGGCATACTGGCCACACCCCTGATCAGGTACGACTGCTGTGGACAGACCCACGAAATG
TGGGCTGGCGGGACAAGACCTCCTATCGCTGGCAGCTTCTGCACCGGCCTCAAGTTGGCTACATTCGGGTGAAGCTCTATGAGGGACCCC
AGCTTGTGGCGGATTCTGGGGTGATCATTGACACATCCATGCGAGGGGGGCGTCTTGGTGTATTCTGCTTCTCCCAAGAAAACATAATTT
GGTCCAATCTCCAGTATCGATGCAATGACACAGTGCCTGAGGACTTTGAGCCATTCCGGAGGCAGCTGCTCCAGGGAAGGGTGTGAGGAG
GAGGCCACCAGATTCAGAATTCAGAATTTTAGACCCTTTGGCCTTGGGGTCCATCCTGGAGACCCTGAGGTCTAAGCTACAGCCCCTCAG
CCAACCACAGACCCTTCTCTGGCTCCCAAAAGGAGTTCAGTCCCAGAGGGGTGGTCACCCCACCCTTCAGGGGATGAGAAGTTTTCAAGG

>In-frame_ENST00000324856_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(amino acids)=1344AA_start in transcript=371_stop in transcript=4405
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ
IPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQST
TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNL
SLQSRPSSLPVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSC
INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPA
HSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGI
KNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCP
EMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDG
NGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFH
VNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWR

--------------------------------------------------------------
>In-frame_ENST00000457599_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(transcript)=4288nt_BP=1920nt
ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG
CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC
CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC
GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG
CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC
GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC
CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC
CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC
TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC
TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG
TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG
GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG
CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGCCATCCAGTCCAATGGATCAGATGGGCAAGATG
AGACCTCAGCCATATGGCGGGACTAACCCATACTCGCAGCAACAGGGACCTCCGTCAGGACCGCAGCAAGGACATGGGTACCCAGGGCAG
CCATACGGGTCCCAGACCCCGCAGCGGTACCCGATGACCATGCAGGGCCGGGCGCAGAGTGCCATGGGCGGCCTCTCTTATACACAGCAG
ATTCCTCCTTATGGACAACAAGGCCCCAGCGGGTATGGTCAACAGGGCCAGACTCCATATTACAACCAGCAAAGTCCTCACCCTCAGCAG
CAGCAGCCACCCTACTCCCAGCAACCACCGTCCCAGACCCCTCATGCCCAACCTTCGTATCAGCAGCAGCCACAGTCTCAACCACCACAG
CTCCAGTCCTCTCAGCCTCCATACTCCCAGCAGCCATCCCAGCCTCCACATCAGCAGTCCCCGGCTCCATACCCCTCCCAGCAGTCGACG
ACACAGCAGCACCCCCAGAGCCAGCCCCCCTACTCACAGCCACAGGCTCAGTCTCCTTACCAGCAGCAGCAACCTCAGCAGCCAGCACCC
TCGACGCTCTCCCAGCAGGCTGCGTATCCTCAGCCCCAGTCTCAGCAGTCCCAGCAAACTGCCTATTCCCAGCAGCGCTTCCCTCCACCG
CAGGAGCTATCTCAAGATTCATTTGGGTCTCAGGCATCCTCAGCCCCCTCAATGACCTCCAGTAAGGGAGGGCAAGAAGATATGAACCTG
AGCCTTCAGTCAAGACCCTCCAGCTTGCCTGTGAAGGAAATGTCCCTGATCCGAAACACCATTATGGAGTGTCAGGTGTGCGGCTTCCAT
GAGCAGCGTTCCCACTGCAGCCCCAATCCCTGCTTCCGAGGTGTGGACTGCATGGAAGTGTACGAGTACCCAGGCTACCGCTGTGGGCCC
TGCCCCCCTGGCCTGCAGGGCAACGGCACCCACTGCAGTGACATCAATGAGTGTGCTCACGCTGACCCCTGTTTCCCGGGCTCCAGCTGC
ATCAACACCATGCCCGGCTTCCACTGTGAGGCCTGTCCTCGAGGGTACAAGGGCACACAGGTGTCTGGTGTGGGCATTGACTATGCCCGG
GCCAGCAAACAGGTCTGCAATGACATCGATGAATGCAACGATGGCAACAATGGTGGCTGTGACCCAAACTCCATCTGCACCAACACTGTG
GGCTCTTTCAAGTGTGGTCCCTGCCGCCTGGGTTTCCTGGGCAACCAGAGCCAGGGCTGCCTCCCAGCCCGGACCTGCCACAGCCCAGCC
CACAGCCCCTGCCACATCCATGCTCACTGTCTCTTTGAACGCAATGGTGCAGTGTCCTGCCAGTGTAACGTGGGCTGGGCTGGGAATGGG
AACGTGTGTGGGACTGACACAGACATCGATGGCTACCCAGACCAAGCACTGCCCTGCATGGACAACAACAAACACTGCAAACAGGACAAC
TGCCTTTTGACACCCAACTCTGGGCAGGAAGATGCTGATAATGATGGTGTGGGGGACCAGTGTGATGATGATGCTGATGGGGATGGGATC
AAGAATGTTGAGGACAACTGCCGGCTGTTCCCCAACAAAGACCAGCAGAACTCAGATACAGATTCATTTGGTGATGCCTGTGACAATTGC
CCCAACGTTCCCAACAATGACCAGAAGGACACAGATGGCAATGGGGAAGGAGATGCCTGTGACAACGACGTGGATGGGGATGGCATCCCC
AATGGATTGGACAATTGCCCTAAAGTCCCCAACCCACTACAGACAGACAGGGATGAGGACGGGGTGGGAGATGCTTGCGACAGCTGCCCT
GAAATGAGCAATCCTACCCAGACAGATGCAGACAGCGACCTGGTGGGGGATGTCTGTGATACTAATGAAGACAGCGATGGGGATGGGCAT
CAGGACACCAAGGACAACTGCCCACAGCTGCCAAATAGCTCCCAGCTGGACTCTGATAACGATGGACTTGGAGATGAGTGTGATGGGGAT
GATGACAATGATGGCATCCCAGATTATGTGCCTCCTGGTCCCGATAACTGCCGCCTGGTACCCAATCCCAATCAGAAGGACTCAGATGGC
AATGGCGTTGGTGATGTGTGTGAGGATGACTTTGACAATGATGCTGTGGTCGACCCCCTGGATGTGTGTCCTGAAAGTGCAGAGGTAACG
CTTACGGATTTTCGGGCCTATCAGACCGTCGTCCTGGATCCTGAGGGTGATGCTCAGATTGACCCAAACTGGGTTGTGCTCAACCAGGGC
ATGGAAATCGTTCAGACCATGAACAGTGACCCTGGCTTGGCAGTTGGATACACGGCCTTCAATGGTGTGGACTTTGAAGGCACCTTCCAT
GTGAACACAGTGACTGATGATGACTACGCAGGCTTTCTCTTCAGTTATCAAGACAGTGGCCGCTTCTACGTAGTCATGTGGAAGCAGACC
GAGCAGACCTACTGGCAGGCTACACCCTTCCGGGCGGTTGCCCAGCCCGGGCTGCAGCTCAAGGCAGTGACATCAGTGTCTGGCCCAGGT
GAGCACCTCCGAAATGCCCTGTGGCATACTGGCCACACCCCTGATCAGGTACGACTGCTGTGGACAGACCCACGAAATGTGGGCTGGCGG
GACAAGACCTCCTATCGCTGGCAGCTTCTGCACCGGCCTCAAGTTGGCTACATTCGGGTGAAGCTCTATGAGGGACCCCAGCTTGTGGCG
GATTCTGGGGTGATCATTGACACATCCATGCGAGGGGGGCGTCTTGGTGTATTCTGCTTCTCCCAAGAAAACATAATTTGGTCCAATCTC
CAGTATCGATGCAATGACACAGTGCCTGAGGACTTTGAGCCATTCCGGAGGCAGCTGCTCCAGGGAAGGGTGTGAGGAGGAGGCCACCAG
ATTCAGAATTCAGAATTTTAGACCCTTTGGCCTTGGGGTCCATCCTGGAGACCCTGAGGTCTAAGCTACAGCCCCTCAGCCAACCACAGA
CCCTTCTCTGGCTCCCAAAAGGAGTTCAGTCCCAGAGGGGTGGTCACCCCACCCTTCAGGGGATGAGAAGTTTTCAAGGGGTATTACTCA

>In-frame_ENST00000457599_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(amino acids)=1344AA_start in transcript=0_stop in transcript=4034
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ
IPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQST
TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNL
SLQSRPSSLPVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSC
INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPA
HSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGI
KNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCP
EMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDG
NGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFH
VNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWR

--------------------------------------------------------------
>In-frame_ENST00000374152_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(transcript)=3422nt_BP=1054nt
TGGATCTCAAGCAGTACCACAGTTACAAAGTAGTTTTTAGCTTACAAGGTGTTTTCACAAATAGGTGGTATTTTCATTTTTCAAATGACA
AAATTAGGGTTCTGAGGCGGGTCAGTTGACTTAAAGGTTACTAGGTTGGTCTCATTGCTCTTTCAAAGTAACTGTATTTCTTTATAGCAT
ACAGACTAAAAAAACCTGTGTACTTGGGTTATATATTCAGTGGCCAGAGGCCATCAAAGCTCAGGTTAATGAAATGCTCTTTATTTTGTA
GCCATCCAGTCCAATGGATCAGATGGGCAAGATGAGACCTCAGCCATATGGCGGGACTAACCCATACTCGCAGCAACAGGGACCTCCGTC
AGGACCGCAGCAAGGACATGGGTACCCAGGGCAGCCATACGGGTCCCAGACCCCGCAGCGGTACCCGATGACCATGCAGGGCCGGGCGCA
GAGTGCCATGGGCGGCCTCTCTTATACACAGCAGATTCCTCCTTATGGACAACAAGGCCCCAGCGGGTATGGTCAACAGGGCCAGACTCC
ATATTACAACCAGCAAAGTCCTCACCCTCAGCAGCAGCAGCCACCCTACTCCCAGCAACCACCGTCCCAGACCCCTCATGCCCAACCTTC
GTATCAGCAGCAGCCACAGTCTCAACCACCACAGCTCCAGTCCTCTCAGCCTCCATACTCCCAGCAGCCATCCCAGCCTCCACATCAGCA
GTCCCCGGCTCCATACCCCTCCCAGCAGTCGACGACACAGCAGCACCCCCAGAGCCAGCCCCCCTACTCACAGCCACAGGCTCAGTCTCC
TTACCAGCAGCAGCAACCTCAGCAGCCAGCACCCTCGACGCTCTCCCAGCAGGCTGCGTATCCTCAGCCCCAGTCTCAGCAGTCCCAGCA
AACTGCCTATTCCCAGCAGCGCTTCCCTCCACCGCAGGAGCTATCTCAAGATTCATTTGGGTCTCAGGCATCCTCAGCCCCCTCAATGAC
CTCCAGTAAGGGAGGGCAAGAAGATATGAACCTGAGCCTTCAGTCAAGACCCTCCAGCTTGCCTGTGAAGGAAATGTCCCTGATCCGAAA
CACCATTATGGAGTGTCAGGTGTGCGGCTTCCATGAGCAGCGTTCCCACTGCAGCCCCAATCCCTGCTTCCGAGGTGTGGACTGCATGGA
AGTGTACGAGTACCCAGGCTACCGCTGTGGGCCCTGCCCCCCTGGCCTGCAGGGCAACGGCACCCACTGCAGTGACATCAATGAGTGTGC
TCACGCTGACCCCTGTTTCCCGGGCTCCAGCTGCATCAACACCATGCCCGGCTTCCACTGTGAGGCCTGTCCTCGAGGGTACAAGGGCAC
ACAGGTGTCTGGTGTGGGCATTGACTATGCCCGGGCCAGCAAACAGGTCTGCAATGACATCGATGAATGCAACGATGGCAACAATGGTGG
CTGTGACCCAAACTCCATCTGCACCAACACTGTGGGCTCTTTCAAGTGTGGTCCCTGCCGCCTGGGTTTCCTGGGCAACCAGAGCCAGGG
CTGCCTCCCAGCCCGGACCTGCCACAGCCCAGCCCACAGCCCCTGCCACATCCATGCTCACTGTCTCTTTGAACGCAATGGTGCAGTGTC
CTGCCAGTGTAACGTGGGCTGGGCTGGGAATGGGAACGTGTGTGGGACTGACACAGACATCGATGGCTACCCAGACCAAGCACTGCCCTG
CATGGACAACAACAAACACTGCAAACAGGACAACTGCCTTTTGACACCCAACTCTGGGCAGGAAGATGCTGATAATGATGGTGTGGGGGA
CCAGTGTGATGATGATGCTGATGGGGATGGGATCAAGAATGTTGAGGACAACTGCCGGCTGTTCCCCAACAAAGACCAGCAGAACTCAGA
TACAGATTCATTTGGTGATGCCTGTGACAATTGCCCCAACGTTCCCAACAATGACCAGAAGGACACAGATGGCAATGGGGAAGGAGATGC
CTGTGACAACGACGTGGATGGGGATGGCATCCCCAATGGATTGGACAATTGCCCTAAAGTCCCCAACCCACTACAGACAGACAGGGATGA
GGACGGGGTGGGAGATGCTTGCGACAGCTGCCCTGAAATGAGCAATCCTACCCAGACAGATGCAGACAGCGACCTGGTGGGGGATGTCTG
TGATACTAATGAAGACAGCGATGGGGATGGGCATCAGGACACCAAGGACAACTGCCCACAGCTGCCAAATAGCTCCCAGCTGGACTCTGA
TAACGATGGACTTGGAGATGAGTGTGATGGGGATGATGACAATGATGGCATCCCAGATTATGTGCCTCCTGGTCCCGATAACTGCCGCCT
GGTACCCAATCCCAATCAGAAGGACTCAGATGGCAATGGCGTTGGTGATGTGTGTGAGGATGACTTTGACAATGATGCTGTGGTCGACCC
CCTGGATGTGTGTCCTGAAAGTGCAGAGGTAACGCTTACGGATTTTCGGGCCTATCAGACCGTCGTCCTGGATCCTGAGGGTGATGCTCA
GATTGACCCAAACTGGGTTGTGCTCAACCAGGGCATGGAAATCGTTCAGACCATGAACAGTGACCCTGGCTTGGCAGTTGGATACACGGC
CTTCAATGGTGTGGACTTTGAAGGCACCTTCCATGTGAACACAGTGACTGATGATGACTACGCAGGCTTTCTCTTCAGTTATCAAGACAG
TGGCCGCTTCTACGTAGTCATGTGGAAGCAGACCGAGCAGACCTACTGGCAGGCTACACCCTTCCGGGCGGTTGCCCAGCCCGGGCTGCA
GCTCAAGGCAGTGACATCAGTGTCTGGCCCAGGTGAGCACCTCCGAAATGCCCTGTGGCATACTGGCCACACCCCTGATCAGGTACGACT
GCTGTGGACAGACCCACGAAATGTGGGCTGGCGGGACAAGACCTCCTATCGCTGGCAGCTTCTGCACCGGCCTCAAGTTGGCTACATTCG
GGTGAAGCTCTATGAGGGACCCCAGCTTGTGGCGGATTCTGGGGTGATCATTGACACATCCATGCGAGGGGGGCGTCTTGGTGTATTCTG
CTTCTCCCAAGAAAACATAATTTGGTCCAATCTCCAGTATCGATGCAATGACACAGTGCCTGAGGACTTTGAGCCATTCCGGAGGCAGCT
GCTCCAGGGAAGGGTGTGAGGAGGAGGCCACCAGATTCAGAATTCAGAATTTTAGACCCTTTGGCCTTGGGGTCCATCCTGGAGACCCTG
AGGTCTAAGCTACAGCCCCTCAGCCAACCACAGACCCTTCTCTGGCTCCCAAAAGGAGTTCAGTCCCAGAGGGGTGGTCACCCCACCCTT
CAGGGGATGAGAAGTTTTCAAGGGGTATTACTCAGGCACTAACCCCAGGAAAGATGACAGCACATTGCCATAAAGTTTTGGTTGTTTTCT

>In-frame_ENST00000374152_ENST00000368378_TCGA-C8-A12V-01A_ARID1A_chr1_27059283_+_THBS3_chr1_155172928_length(amino acids)=961AA_start in transcript=283_stop in transcript=3168
MDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQ
QSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQ
QPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPVKEMSLIRNTIME
CQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG
VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN
VGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSF
GDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNE
DSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVC
PESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFY
VVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARID1A-THBS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARID1A-THBS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARID1A-THBS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID1AC0024623Malignant neoplasm of stomach3CTD_human
HgeneARID1AC0038356Stomach Neoplasms3CTD_human
HgeneARID1AC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneARID1AC2239176Liver carcinoma3CTD_human
HgeneARID1AC0033578Prostatic Neoplasms2CTD_human
HgeneARID1AC0376358Malignant neoplasm of prostate2CTD_human
HgeneARID1AC0001418Adenocarcinoma1CTD_human
HgeneARID1AC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneARID1AC0005695Bladder Neoplasm1CTD_human
HgeneARID1AC0006413Burkitt Lymphoma1CTD_human
HgeneARID1AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneARID1AC0009402Colorectal Carcinoma1CTD_human
HgeneARID1AC0009404Colorectal Neoplasms1CTD_human
HgeneARID1AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneARID1AC0014170Endometrial Neoplasms1CTD_human
HgeneARID1AC0027708Nephroblastoma1CTD_human
HgeneARID1AC0027819Neuroblastoma1CTD_human
HgeneARID1AC0036920Sezary Syndrome1CTD_human
HgeneARID1AC0079772T-Cell Lymphoma1CTD_human
HgeneARID1AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneARID1AC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneARID1AC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneARID1AC0205643Carcinoma, Cribriform1CTD_human
HgeneARID1AC0205644Carcinoma, Granular Cell1CTD_human
HgeneARID1AC0205645Adenocarcinoma, Tubular1CTD_human
HgeneARID1AC0206656Embryonal Rhabdomyosarcoma1CTD_human
HgeneARID1AC0206698Cholangiocarcinoma1CTD_human
HgeneARID1AC0265338Coffin-Siris syndrome1CTD_human;GENOMICS_ENGLAND
HgeneARID1AC0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneARID1AC0343640African Burkitt's lymphoma1CTD_human
HgeneARID1AC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneARID1AC0376407Granulomatous Slack Skin1CTD_human
HgeneARID1AC0476089Endometrial Carcinoma1CTD_human
HgeneARID1AC0920269Microsatellite Instability1CTD_human
HgeneARID1AC1721098Replication Error Phenotype1CTD_human
HgeneARID1AC2930471Bilateral Wilms Tumor1CTD_human
HgeneARID1AC2931822Nasopharyngeal carcinoma1CTD_human
HgeneARID1AC3805278Extrahepatic Cholangiocarcinoma1CTD_human
HgeneARID1AC4721444Burkitt Leukemia1CTD_human