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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIK3CB-BFSP2 (FusionGDB2 ID:64960)

Fusion Gene Summary for PIK3CB-BFSP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PIK3CB-BFSP2
Fusion gene ID: 64960
HgeneTgene
Gene symbol

PIK3CB

BFSP2

Gene ID

5291

8419

Gene namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betabeaded filament structural protein 2
SynonymsP110BETA|PI3K|PI3KBETA|PIK3C1CP47|CP49|CTRCT12|LIFL-L|PHAKOSIN
Cytomap

3q22.3

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase p110 subunit betaPI3-kinase subunit betaPI3K-betaPtdIns-3-kinase p110phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit betaphosphoinositidphakinin49 kDa cytoskeletal proteinbeaded filament protein CP49beaded filament structural protein 2, phakininbfps2, Cytoskeletal protein, 49-kDlens fiber cell beaded filament protein CP 47lens fiber cell beaded filament protein CP 49lens intermedia
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000477593, ENST00000544716, 
ENST00000289153, 		ENST00000302334, 
ENST00000511434, 
Fusion gene scores* DoF score15 X 13 X 11=21453 X 5 X 3=45
# samples 175
** MAII scorelog2(17/2145*10)=-3.65737099624921
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIK3CB [Title/Abstract] AND BFSP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIK3CB(138452203)-BFSP2(133185672), # samples:3
Anticipated loss of major functional domain due to fusion event.PIK3CB-BFSP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PIK3CB-BFSP2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIK3CB-BFSP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIK3CB

GO:0016310

phosphorylation

25327288


check buttonFusion gene breakpoints across PIK3CB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BFSP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2756-01APIK3CBchr3

138452203

-BFSP2chr3

133185672

+
ChimerDB4LUSCTCGA-66-2756PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
ChimerDB4LUSCTCGA-66-2756PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
ChimerDB4LUSCTCGA-66-2756-01APIK3CBchr3

138452203

-BFSP2chr3

133185672

+
ChimerDB4LUSCTCGA-66-2756-01APIK3CBchr3

138452202

-BFSP2chr3

133185671

+


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Fusion Gene ORF analysis for PIK3CB-BFSP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000477593ENST00000302334PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
5CDS-3UTRENST00000477593ENST00000511434PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
intron-3CDSENST00000544716ENST00000302334PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
intron-3UTRENST00000544716ENST00000511434PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
In-frameENST00000289153ENST00000302334PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
5CDS-3UTRENST00000289153ENST00000511434PIK3CBchr3

138452203

-BFSP2chr3

133185672

+
Frame-shiftENST00000477593ENST00000302334PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
5CDS-3UTRENST00000477593ENST00000511434PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
intron-3CDSENST00000544716ENST00000302334PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
intron-3UTRENST00000544716ENST00000511434PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
In-frameENST00000289153ENST00000302334PIK3CBchr3

138452202

-BFSP2chr3

133185671

+
5CDS-3UTRENST00000289153ENST00000511434PIK3CBchr3

138452202

-BFSP2chr3

133185671

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000289153PIK3CBchr3138452203-ENST00000302334BFSP2chr3133185672+1628105001406468
ENST00000289153PIK3CBchr3138452202-ENST00000302334BFSP2chr3133185671+1628105001406468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000289153ENST00000302334PIK3CBchr3138452203-BFSP2chr3133185672+0.0005808330.9994192
ENST00000289153ENST00000302334PIK3CBchr3138452202-BFSP2chr3133185671+0.0005808330.9994192

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Fusion Genomic Features for PIK3CB-BFSP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PIK3CBchr3138452202-BFSP2chr3133185671+5.33E-091
PIK3CBchr3138452202-BFSP2chr3133185671+5.33E-091
PIK3CBchr3138452202-BFSP2chr3133185671+5.33E-091
PIK3CBchr3138452202-BFSP2chr3133185671+5.33E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIK3CB-BFSP2


check button Go to

FGviewer for the breakpoints of chr3:138452203-chr3:133185672

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-622194_285350.01071.0DomainPI3K-RBD
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-62226_115350.01071.0DomainPI3K-ABD
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-723194_285350.01071.0DomainPI3K-RBD
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-72326_115350.01071.0DomainPI3K-ABD
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-622194_285350.01071.0DomainPI3K-RBD
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-62226_115350.01071.0DomainPI3K-ABD
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-723194_285350.01071.0DomainPI3K-RBD
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-72326_115350.01071.0DomainPI3K-ABD
TgeneBFSP2chr3:138452202chr3:133185671ENST0000030233437309_400297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452203chr3:133185672ENST0000030233437309_400297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452202chr3:133185671ENST0000030233437396_415297.0416.0RegionNote=Tail
TgeneBFSP2chr3:138452203chr3:133185672ENST0000030233437396_415297.0416.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-622327_496350.01071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-622524_701350.01071.0DomainPIK helical
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-622800_1067350.01071.0DomainPI3K/PI4K
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-723327_496350.01071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-723524_701350.01071.0DomainPIK helical
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-723800_1067350.01071.0DomainPI3K/PI4K
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-622327_496350.01071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-622524_701350.01071.0DomainPIK helical
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-622800_1067350.01071.0DomainPI3K/PI4K
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-723327_496350.01071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-723524_701350.01071.0DomainPIK helical
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-723800_1067350.01071.0DomainPI3K/PI4K
HgenePIK3CBchr3:138452202chr3:133185671ENST00000289153-622410_418350.01071.0MotifNote=Nuclear localization signal
HgenePIK3CBchr3:138452202chr3:133185671ENST00000477593-723410_418350.01071.0MotifNote=Nuclear localization signal
HgenePIK3CBchr3:138452203chr3:133185672ENST00000289153-622410_418350.01071.0MotifNote=Nuclear localization signal
HgenePIK3CBchr3:138452203chr3:133185672ENST00000477593-723410_418350.01071.0MotifNote=Nuclear localization signal
TgeneBFSP2chr3:138452202chr3:133185671ENST0000030233437115_144297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452202chr3:133185671ENST0000030233437199_253297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452203chr3:133185672ENST0000030233437115_144297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452203chr3:133185672ENST0000030233437199_253297.0416.0Coiled coilOntology_term=ECO:0000255
TgeneBFSP2chr3:138452202chr3:133185671ENST0000030233437104_415297.0416.0DomainIF rod
TgeneBFSP2chr3:138452203chr3:133185672ENST0000030233437104_415297.0416.0DomainIF rod
TgeneBFSP2chr3:138452202chr3:133185671ENST00000302334372_114297.0416.0RegionNote=Head
TgeneBFSP2chr3:138452203chr3:133185672ENST00000302334372_114297.0416.0RegionNote=Head


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Fusion Gene Sequence for PIK3CB-BFSP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000289153_ENST00000302334_TCGA-66-2756-01A_PIK3CB_chr3_138452203_-_BFSP2_chr3_133185672_length(transcript)=1628nt_BP=1050nt
ATGTGCTTCAGTTTCATAATGCCTCCTGCTATGGCAGACATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATA
CCTGTGGATTTCCTTTTGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTCTTATATTAAGCAGATGTTATGG
AAGCAAGTTCACAATTACCCAATGTTCAACCTCCTTATGGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAG
GAGCTTGAAGATGAAACACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGACAAGAAGTTGTGACCCAGGGGAA
AAATTAGACTCAAAAATTGGAGTCCTTATAGGAAAAGGTCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGA
AAAATGCGCAAATTCAGCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAAACAAACATATCCACCAGAGCAT
GAACCATCCATCCCTGAAAACTTAGAAGATAAACTTTATGGGGGAAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTT
AGCTTTCAAGTGTCTCCTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAACGTTTGACTATTCATGGGAAGGAAGATGAA
GTTAGCCCCTATGATTATGTGTTGCAAGTCAGCGGGAGAGTAGAATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGG
AACTGTGTGATGAACAGAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGAAAATGTATGAACAAGAAATGATTGCCATA
GAGGCTGCCATAAATCGAAATTCATCTAATCTTCCTCTTCCATTACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAAC
AACCCTTTCCAAATTGTCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAACAACAGGCGGAGGTGGCCCACATGTCCCAG
ACCCAGGAGGAGAAGCTGGCAGCTGCCCTCAGGGTGGAGTTACACAACACTTCGTGCCAAGTCCAGAGCCTCCAGGCTGAGACAGAATCC
TTACGTGCCCTGAAACGAGGCCTGGAGAACACCTTGCACGATGCCAAGCACTGGCATGACATGGAGCTCCAGAACCTGGGCGCTGTGGTC
GGCCGGCTGGAGGCGGAGCTCAGGGAAATCCGAGCGGAGGCGGAGCAGCAGCAACAGGAGCGCGCGCATCTGCTGGCCCGCAAGTGCCAG
CTGCAGAAGGACGTGGCGTCCTACCACGCCCTGCTGGACAGGGAGGAGAGCGGCTGATGGAGAAACTTCCTCTTTTTCATGAAGAAAACA
CCCTTCCTCAACAGCTGACCCAAGAAGTTGCTTGAGGAGCTTTCTCCTGAGCTCCAGTCCCTGCTGGATTCCCTGGTTAATTCAGCTTGA
GCTGAAAAGCTTCCTGGAAGTGGAGAGGATCCTTCTGCTTTAATCTGAGTAGTCTGTAGCTTGAGCAATCTCCCTTGTCCTCCTTCAAAT

>In-frame_ENST00000289153_ENST00000302334_TCGA-66-2756-01A_PIK3CB_chr3_138452203_-_BFSP2_chr3_133185672_length(amino acids)=468AA_start in transcript=0_stop in transcript=1406
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYE
ELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIR
NCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKQQAEVAHMSQ
TQEEKLAAALRVELHNTSCQVQSLQAETESLRALKRGLENTLHDAKHWHDMELQNLGAVVGRLEAELREIRAEAEQQQQERAHLLARKCQ

--------------------------------------------------------------
>In-frame_ENST00000289153_ENST00000302334_TCGA-66-2756_PIK3CB_chr3_138452202_-_BFSP2_chr3_133185671_length(transcript)=1628nt_BP=1050nt
ATGTGCTTCAGTTTCATAATGCCTCCTGCTATGGCAGACATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATA
CCTGTGGATTTCCTTTTGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTCTTATATTAAGCAGATGTTATGG
AAGCAAGTTCACAATTACCCAATGTTCAACCTCCTTATGGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAG
GAGCTTGAAGATGAAACACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGACAAGAAGTTGTGACCCAGGGGAA
AAATTAGACTCAAAAATTGGAGTCCTTATAGGAAAAGGTCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGA
AAAATGCGCAAATTCAGCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAAACAAACATATCCACCAGAGCAT
GAACCATCCATCCCTGAAAACTTAGAAGATAAACTTTATGGGGGAAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTT
AGCTTTCAAGTGTCTCCTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAACGTTTGACTATTCATGGGAAGGAAGATGAA
GTTAGCCCCTATGATTATGTGTTGCAAGTCAGCGGGAGAGTAGAATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGG
AACTGTGTGATGAACAGAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGAAAATGTATGAACAAGAAATGATTGCCATA
GAGGCTGCCATAAATCGAAATTCATCTAATCTTCCTCTTCCATTACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAAC
AACCCTTTCCAAATTGTCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAACAACAGGCGGAGGTGGCCCACATGTCCCAG
ACCCAGGAGGAGAAGCTGGCAGCTGCCCTCAGGGTGGAGTTACACAACACTTCGTGCCAAGTCCAGAGCCTCCAGGCTGAGACAGAATCC
TTACGTGCCCTGAAACGAGGCCTGGAGAACACCTTGCACGATGCCAAGCACTGGCATGACATGGAGCTCCAGAACCTGGGCGCTGTGGTC
GGCCGGCTGGAGGCGGAGCTCAGGGAAATCCGAGCGGAGGCGGAGCAGCAGCAACAGGAGCGCGCGCATCTGCTGGCCCGCAAGTGCCAG
CTGCAGAAGGACGTGGCGTCCTACCACGCCCTGCTGGACAGGGAGGAGAGCGGCTGATGGAGAAACTTCCTCTTTTTCATGAAGAAAACA
CCCTTCCTCAACAGCTGACCCAAGAAGTTGCTTGAGGAGCTTTCTCCTGAGCTCCAGTCCCTGCTGGATTCCCTGGTTAATTCAGCTTGA
GCTGAAAAGCTTCCTGGAAGTGGAGAGGATCCTTCTGCTTTAATCTGAGTAGTCTGTAGCTTGAGCAATCTCCCTTGTCCTCCTTCAAAT

>In-frame_ENST00000289153_ENST00000302334_TCGA-66-2756_PIK3CB_chr3_138452202_-_BFSP2_chr3_133185671_length(amino acids)=468AA_start in transcript=0_stop in transcript=1406
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYE
ELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIR
NCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKQQAEVAHMSQ
TQEEKLAAALRVELHNTSCQVQSLQAETESLRALKRGLENTLHDAKHWHDMELQNLGAVVGRLEAELREIRAEAEQQQQERAHLLARKCQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIK3CB-BFSP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIK3CB-BFSP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIK3CB-BFSP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIK3CBC0033578Prostatic Neoplasms1CTD_human
HgenePIK3CBC0036341Schizophrenia1CTD_human
HgenePIK3CBC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgenePIK3CBC0376358Malignant neoplasm of prostate1CTD_human
TgeneBFSP2C3808115CATARACT 12, MULTIPLE TYPES3GENOMICS_ENGLAND;UNIPROT
TgeneBFSP2C1833118Cataract, Pulverulent1ORPHANET
TgeneBFSP2C1852438CATARACT, COPPOCK-LIKE1ORPHANET
TgeneBFSP2C1854021Cataract, Central Saccular, With Sutural Opacities1ORPHANET