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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIK3R3-MYO18A (FusionGDB2 ID:64994)

Fusion Gene Summary for PIK3R3-MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: PIK3R3-MYO18A
Fusion gene ID: 64994
HgeneTgene
Gene symbol

PIK3R3

MYO18A

Gene ID

8503

399687

Gene namephosphoinositide-3-kinase regulatory subunit 3myosin XVIIIA
Synonymsp55|p55-GAMMA|p55PIKMAJN|MYSPDZ|SP-R210|SPR210
Cytomap

1p34.1

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory sunconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2020032720200313
UniProtAcc.

Q92614

Ensembl transtripts involved in fusion geneENST00000262741, ENST00000372006, 
ENST00000340332, ENST00000420542, 
ENST00000354242, ENST00000540385, 
ENST00000423209, ENST00000488808, 
ENST00000354329, ENST00000529578, 
ENST00000533112, ENST00000531253, 
ENST00000527372, 
Fusion gene scores* DoF score9 X 9 X 7=56720 X 17 X 12=4080
# samples 1134
** MAII scorelog2(11/567*10)=-2.36584521141757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/4080*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIK3R3 [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIK3R3(46543187)-MYO18A(27423933), # samples:2
Anticipated loss of major functional domain due to fusion event.PIK3R3-MYO18A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIK3R3-MYO18A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PIK3R3-MYO18A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PIK3R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYO18A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9M4-01APIK3R3chr1

46543187

-MYO18Achr17

27423933

-
ChimerDB4PRADTCGA-ZG-A9M4-01APIK3R3chr1

46543187

-MYO18Achr17

27423933

-


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Fusion Gene ORF analysis for PIK3R3-MYO18A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262741ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000262741ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000262741ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000262741ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000262741ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
Frame-shiftENST00000372006ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000372006ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000372006ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000372006ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000372006ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
In-frameENST00000340332ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000340332ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000340332ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000340332ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000340332ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
In-frameENST00000420542ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000420542ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000420542ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000420542ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000420542ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
In-frameENST00000354242ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000354242ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000354242ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000354242ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000354242ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
Frame-shiftENST00000540385ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000540385ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000540385ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000540385ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000540385ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
Frame-shiftENST00000423209ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000423209ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000423209ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000423209ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
5CDS-intronENST00000423209ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
intron-3CDSENST00000488808ENST00000354329PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
intron-intronENST00000488808ENST00000529578PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
intron-intronENST00000488808ENST00000533112PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
intron-intronENST00000488808ENST00000531253PIK3R3chr1

46543187

-MYO18Achr17

27423933

-
intron-intronENST00000488808ENST00000527372PIK3R3chr1

46543187

-MYO18Achr17

27423933

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340332PIK3R3chr146543187-ENST00000354329MYO18Achr1727423933-36584634722397641
ENST00000420542PIK3R3chr146543187-ENST00000354329MYO18Achr1727423933-37665715802505641
ENST00000354242PIK3R3chr146543187-ENST00000354329MYO18Achr1727423933-37665715802505641

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340332ENST00000354329PIK3R3chr146543187-MYO18Achr1727423933-0.0045604670.9954396
ENST00000420542ENST00000354329PIK3R3chr146543187-MYO18Achr1727423933-0.004524330.9954757
ENST00000354242ENST00000354329PIK3R3chr146543187-MYO18Achr1727423933-0.004524330.9954757

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Fusion Genomic Features for PIK3R3-MYO18A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIK3R3-MYO18A


check button Go to

FGviewer for the breakpoints of chr1:46543187-chr17:27423933

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO18A

Q92614

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3R3chr1:46543187chr17:27423933ENST00000262741-31034_44104.66666666666667462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr17:27423933ENST00000354242-41034_44104.66666666666667403.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr17:27423933ENST00000372006-41134_44104.66666666666667462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr17:27423933ENST00000420542-41134_44104.66666666666667462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr17:27423933ENST00000423209-3934_44104.66666666666667403.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3R3chr1:46543187chr17:27423933ENST00000262741-310358_452104.66666666666667462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr17:27423933ENST00000262741-31065_160104.66666666666667462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr17:27423933ENST00000354242-410358_452104.66666666666667403.0DomainSH2 2
HgenePIK3R3chr1:46543187chr17:27423933ENST00000354242-41065_160104.66666666666667403.0DomainSH2 1
HgenePIK3R3chr1:46543187chr17:27423933ENST00000372006-411358_452104.66666666666667462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr17:27423933ENST00000372006-41165_160104.66666666666667462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr17:27423933ENST00000420542-411358_452104.66666666666667462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr17:27423933ENST00000420542-41165_160104.66666666666667462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr17:27423933ENST00000423209-39358_452104.66666666666667403.0DomainSH2 2
HgenePIK3R3chr1:46543187chr17:27423933ENST00000423209-3965_160104.66666666666667403.0DomainSH2 1
TgeneMYO18Achr1:46543187chr17:27423933ENST0000052737226421246_19711410.02055.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053125326411246_19711410.02040.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053311226401246_19711410.02003.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr1:46543187chr17:27423933ENST0000052737226426_251410.02055.0Compositional biasNote=Lys-rich
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053125326416_251410.02040.0Compositional biasNote=Lys-rich
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053311226406_251410.02003.0Compositional biasNote=Lys-rich
TgeneMYO18Achr1:46543187chr17:27423933ENST0000052737226421188_12171410.02055.0DomainIQ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005273722642220_3111410.02055.0DomainPDZ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005273722642349_4011410.02055.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr1:46543187chr17:27423933ENST000005273722642405_11851410.02055.0DomainMyosin motor
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053125326411188_12171410.02040.0DomainIQ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005312532641220_3111410.02040.0DomainPDZ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005312532641349_4011410.02040.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr1:46543187chr17:27423933ENST000005312532641405_11851410.02040.0DomainMyosin motor
TgeneMYO18Achr1:46543187chr17:27423933ENST0000053311226401188_12171410.02003.0DomainIQ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005331122640220_3111410.02003.0DomainPDZ
TgeneMYO18Achr1:46543187chr17:27423933ENST000005331122640349_4011410.02003.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr1:46543187chr17:27423933ENST000005331122640405_11851410.02003.0DomainMyosin motor
TgeneMYO18Achr1:46543187chr17:27423933ENST000005273722642498_5051410.02055.0Nucleotide bindingATP
TgeneMYO18Achr1:46543187chr17:27423933ENST000005312532641498_5051410.02040.0Nucleotide bindingATP
TgeneMYO18Achr1:46543187chr17:27423933ENST000005331122640498_5051410.02003.0Nucleotide bindingATP


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Fusion Gene Sequence for PIK3R3-MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000340332_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(transcript)=3658nt_BP=463nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTGCGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATA
CTTTGACTTTGCGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGAAGTGCCAGCGACTGAC
GGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGAGGAGGTTTGACAGTGA
GCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACATGCTCCTCGCTGAGGCTTT
CAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGAGGCAGAGCTCCAGGACAT
TTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAAAGTCAAGGATCAGGAAGA
AGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGCGGATGAGACAGACCCA
TTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGATGGAGGTGCAGCTAGA
GGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCGACCAGGTGAACCGGCG
GGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCATGCTGGACCACCTGAA
GAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGGCAGCCGTGAAAGCACG
GAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGGAGGAGCAGCTGAGCCG
CCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGAAGCACAAGGCTGCCGT
GGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAAGCAGGAGCTGCAGGAGAA
GCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCAGGAAGCTAAGATACGGGA
GCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGAAAACATGGAGAAGCTGAC
TGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCCGGGACACCAAGGAGGA
GATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCCTGGAGGCTGCTAACCA
GAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGGAGAGTGATGAGAATGA
GGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTCTGATGTGGACTCGGAGCT
GGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGATGGCAGCTTAAAGAGTTC
CAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGATACTC
CCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCACCCC
AGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCCT
GACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAGA
ACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCATGGA
GCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCATGGGG
AGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTTAATT
TAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAAT
GTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGAA
TGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTCCAGC
CCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTGATCC
AAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGATCAG
AAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCCT
GCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCACCAG
ACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTGTGCT

>In-frame_ENST00000340332_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(amino acids)=641AA_start in transcript=472_stop in transcript=2397
MQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLE
EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR
DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR
EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL
AQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI
AAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQ
DMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDS

--------------------------------------------------------------
>In-frame_ENST00000420542_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(transcript)=3766nt_BP=571nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT
GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA
AAATGCAGGGAGATTATACTTTGACTTTGCGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAA
GAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCA
GAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACAT
GCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGA
GGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAA
AGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGA
GCGGATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACA
GATGGAGGTGCAGCTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAG
CGACCAGGTGAACCGGCGGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCT
CATGCTGGACCACCTGAAGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGC
GGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCT
GGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAA
GAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAA
GCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCA
GGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGA
AAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCT
CCGGGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAG
CCTGGAGGCTGCTAACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGAT
GGAGAGTGATGAGAATGAGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTC
TGATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGA
TGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACAC
CTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGT
TGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGAT
CTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAA
GAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGT
GGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAG
GTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTG
TCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCC
CAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCG
GGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGG
ACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACA
GCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGG
TTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGT
CATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTAT
CCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTG

>In-frame_ENST00000420542_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(amino acids)=641AA_start in transcript=580_stop in transcript=2505
MQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLE
EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR
DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR
EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL
AQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI
AAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQ
DMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDS

--------------------------------------------------------------
>In-frame_ENST00000354242_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(transcript)=3766nt_BP=571nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT
GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA
AAATGCAGGGAGATTATACTTTGACTTTGCGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAA
GAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCA
GAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACAT
GCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGA
GGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAA
AGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGA
GCGGATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACA
GATGGAGGTGCAGCTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAG
CGACCAGGTGAACCGGCGGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCT
CATGCTGGACCACCTGAAGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGC
GGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCT
GGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAA
GAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAA
GCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCA
GGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGA
AAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCT
CCGGGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAG
CCTGGAGGCTGCTAACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGAT
GGAGAGTGATGAGAATGAGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTC
TGATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGA
TGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACAC
CTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGT
TGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGAT
CTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAA
GAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGT
GGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAG
GTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTG
TCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCC
CAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCG
GGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGG
ACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACA
GCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGG
TTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGT
CATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTAT
CCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTG

>In-frame_ENST00000354242_ENST00000354329_TCGA-ZG-A9M4-01A_PIK3R3_chr1_46543187_-_MYO18A_chr17_27423933_length(amino acids)=641AA_start in transcript=580_stop in transcript=2505
MQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLE
EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR
DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR
EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL
AQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI
AAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQ
DMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIK3R3-MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIK3R3-MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIK3R3-MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource