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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PKN1-LDLR (FusionGDB2 ID:65365)

Fusion Gene Summary for PKN1-LDLR

check button Fusion gene summary
Fusion gene informationFusion gene name: PKN1-LDLR
Fusion gene ID: 65365
HgeneTgene
Gene symbol

PKN1

LDLR

Gene ID

5585

3949

Gene nameprotein kinase N1low density lipoprotein receptor
SynonymsDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1FH|FHC|FHCL1|LDLCQ2
Cytomap

19p13.12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase Nlow-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3
Modification date2020032920200322
UniProtAcc.

Q5SW96

Ensembl transtripts involved in fusion geneENST00000242783, ENST00000587429, 
ENST00000342216, 		ENST00000558518, 
ENST00000557933, ENST00000455727, 
ENST00000535915, ENST00000545707, 
ENST00000558013, ENST00000560628, 
Fusion gene scores* DoF score10 X 7 X 8=5604 X 6 X 4=96
# samples 125
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKN1 [Title/Abstract] AND LDLR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPKN1(14557373)-LDLR(11227535), # samples:2
Anticipated loss of major functional domain due to fusion event.PKN1-LDLR seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PKN1-LDLR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PKN1-LDLR seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PKN1-LDLR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PKN1-LDLR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKN1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

HgenePKN1

GO:0006468

protein phosphorylation

17332740

HgenePKN1

GO:0035407

histone H3-T11 phosphorylation

18066052


check buttonFusion gene breakpoints across PKN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LDLR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A26W-01APKN1chr19

14557373

+LDLRchr19

11227535

+
ChimerDB4BRCATCGA-C8-A26W-01APKN1chr19

14557373

+LDLRchr19

11227535

+
ChimerDB4BRCATCGA-C8-A26W-01APKN1chr19

14557373

-LDLRchr19

11226770

+


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Fusion Gene ORF analysis for PKN1-LDLR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000242783ENST00000558518PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000242783ENST00000557933PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000242783ENST00000455727PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000242783ENST00000535915PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000242783ENST00000545707PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000242783ENST00000558013PKN1chr19

14557373

+LDLRchr19

11227535

+
5CDS-intronENST00000242783ENST00000560628PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000558518PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000557933PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000455727PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000535915PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000545707PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-3CDSENST00000587429ENST00000558013PKN1chr19

14557373

+LDLRchr19

11227535

+
intron-intronENST00000587429ENST00000560628PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000558518PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000557933PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000455727PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000535915PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000545707PKN1chr19

14557373

+LDLRchr19

11227535

+
In-frameENST00000342216ENST00000558013PKN1chr19

14557373

+LDLRchr19

11227535

+
5CDS-intronENST00000342216ENST00000560628PKN1chr19

14557373

+LDLRchr19

11227535

+
Frame-shiftENST00000242783ENST00000558518PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000242783ENST00000557933PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000242783ENST00000455727PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000242783ENST00000535915PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000242783ENST00000545707PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000242783ENST00000558013PKN1chr19

14557373

-LDLRchr19

11226770

+
5CDS-intronENST00000242783ENST00000560628PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000558518PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000557933PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000455727PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000535915PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000545707PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-3CDSENST00000587429ENST00000558013PKN1chr19

14557373

-LDLRchr19

11226770

+
intron-intronENST00000587429ENST00000560628PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000558518PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000557933PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000455727PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000535915PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000545707PKN1chr19

14557373

-LDLRchr19

11226770

+
Frame-shiftENST00000342216ENST00000558013PKN1chr19

14557373

-LDLRchr19

11226770

+
5CDS-intronENST00000342216ENST00000560628PKN1chr19

14557373

-LDLRchr19

11226770

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242783PKN1chr1914557373+ENST00000558518LDLRchr1911227535+25007751651652495
ENST00000242783PKN1chr1914557373+ENST00000557933LDLRchr1911227535+19247751651916583
ENST00000242783PKN1chr1914557373+ENST00000455727LDLRchr1911227535+18217751651652495
ENST00000242783PKN1chr1914557373+ENST00000535915LDLRchr1911227535+18757751651652495
ENST00000242783PKN1chr1914557373+ENST00000545707LDLRchr1911227535+17947751651499444
ENST00000242783PKN1chr1914557373+ENST00000558013LDLRchr1911227535+21437751651646493
ENST00000342216PKN1chr1914557373+ENST00000558518LDLRchr1911227535+2384659311536501
ENST00000342216PKN1chr1914557373+ENST00000557933LDLRchr1911227535+1808659311800589
ENST00000342216PKN1chr1914557373+ENST00000455727LDLRchr1911227535+1705659311536501
ENST00000342216PKN1chr1914557373+ENST00000535915LDLRchr1911227535+1759659311536501
ENST00000342216PKN1chr1914557373+ENST00000545707LDLRchr1911227535+1678659311383450
ENST00000342216PKN1chr1914557373+ENST00000558013LDLRchr1911227535+2027659311530499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242783ENST00000558518PKN1chr1914557373+LDLRchr1911227535+0.0223056340.9776944
ENST00000242783ENST00000557933PKN1chr1914557373+LDLRchr1911227535+0.104310410.8956896
ENST00000242783ENST00000455727PKN1chr1914557373+LDLRchr1911227535+0.0251608550.97483915
ENST00000242783ENST00000535915PKN1chr1914557373+LDLRchr1911227535+0.0263980830.97360194
ENST00000242783ENST00000545707PKN1chr1914557373+LDLRchr1911227535+0.0124698660.9875301
ENST00000242783ENST00000558013PKN1chr1914557373+LDLRchr1911227535+0.0229390150.977061
ENST00000342216ENST00000558518PKN1chr1914557373+LDLRchr1911227535+0.040118120.95988184
ENST00000342216ENST00000557933PKN1chr1914557373+LDLRchr1911227535+0.115699830.88430023
ENST00000342216ENST00000455727PKN1chr1914557373+LDLRchr1911227535+0.0383747440.9616252
ENST00000342216ENST00000535915PKN1chr1914557373+LDLRchr1911227535+0.041301130.9586988
ENST00000342216ENST00000545707PKN1chr1914557373+LDLRchr1911227535+0.0212414040.9787586
ENST00000342216ENST00000558013PKN1chr1914557373+LDLRchr1911227535+0.0337029620.96629703

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Fusion Genomic Features for PKN1-LDLR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PKN1chr1914557373+LDLRchr1911227534+1.98E-131
PKN1chr1914557373+LDLRchr1911227534+1.98E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PKN1-LDLR


check button Go to

FGviewer for the breakpoints of chr19:14557373-chr19:11227535

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LDLR

Q5SW96

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422112_193203.33333333333334943.0DomainREM-1 2
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+42225_100203.33333333333334943.0DomainREM-1 1
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422112_193209.33333333333334949.0DomainREM-1 2
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+42225_100209.33333333333334949.0DomainREM-1 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816663_712400.3333333333333693.0DomainEGF-like 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917663_712527.3333333333334820.0DomainEGF-like 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916663_712441.3333333333333683.0DomainEGF-like 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018663_712568.3333333333334859.0DomainEGF-like 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018663_712568.3333333333334861.0DomainEGF-like 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816823_828400.3333333333333693.0MotifNPXY motif
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917823_828527.3333333333334820.0MotifNPXY motif
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916823_828441.3333333333333683.0MotifNPXY motif
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018823_828568.3333333333334859.0MotifNPXY motif
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018823_828568.3333333333334861.0MotifNPXY motif
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816721_768400.3333333333333693.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816811_860400.3333333333333693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917721_768527.3333333333334820.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917811_860527.3333333333334820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916721_768441.3333333333333683.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916811_860441.3333333333333683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018721_768568.3333333333334859.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018811_860568.3333333333334859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018721_768568.3333333333334861.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018811_860568.3333333333334861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816439_485400.3333333333333693.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816486_528400.3333333333333693.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816529_572400.3333333333333693.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816573_615400.3333333333333693.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816616_658400.3333333333333693.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917529_572527.3333333333334820.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917573_615527.3333333333334820.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917616_658527.3333333333334820.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916439_485441.3333333333333683.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916486_528441.3333333333333683.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916529_572441.3333333333333683.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916573_615441.3333333333333683.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916616_658441.3333333333333683.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018573_615568.3333333333334859.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018616_658568.3333333333334859.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018573_615568.3333333333334861.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018616_658568.3333333333334861.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816789_810400.3333333333333693.0TransmembraneHelical
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917789_810527.3333333333334820.0TransmembraneHelical
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916789_810441.3333333333333683.0TransmembraneHelical
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018789_810568.3333333333334859.0TransmembraneHelical
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018789_810568.3333333333334861.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422201_280203.33333333333334943.0DomainREM-1 3
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422307_470203.33333333333334943.0DomainC2
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422615_874203.33333333333334943.0DomainProtein kinase
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422875_942203.33333333333334943.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422201_280209.33333333333334949.0DomainREM-1 3
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422307_470209.33333333333334949.0DomainC2
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422615_874209.33333333333334949.0DomainProtein kinase
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422875_942209.33333333333334949.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14557373chr19:11227535ENST00000242783+422621_629203.33333333333334943.0Nucleotide bindingATP
HgenePKN1chr19:14557373chr19:11227535ENST00000342216+422621_629209.33333333333334949.0Nucleotide bindingATP
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816107_145400.3333333333333693.0DomainLDL-receptor class A 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816146_186400.3333333333333693.0DomainLDL-receptor class A 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816195_233400.3333333333333693.0DomainLDL-receptor class A 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816234_272400.3333333333333693.0DomainLDL-receptor class A 6
TgeneLDLRchr19:14557373chr19:11227535ENST0000045572781625_65400.3333333333333693.0DomainLDL-receptor class A 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816274_313400.3333333333333693.0DomainLDL-receptor class A 7
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816314_353400.3333333333333693.0DomainEGF-like 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816354_393400.3333333333333693.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:14557373chr19:11227535ENST0000045572781666_106400.3333333333333693.0DomainLDL-receptor class A 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917107_145527.3333333333334820.0DomainLDL-receptor class A 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917146_186527.3333333333334820.0DomainLDL-receptor class A 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917195_233527.3333333333334820.0DomainLDL-receptor class A 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917234_272527.3333333333334820.0DomainLDL-receptor class A 6
TgeneLDLRchr19:14557373chr19:11227535ENST0000053591591725_65527.3333333333334820.0DomainLDL-receptor class A 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917274_313527.3333333333334820.0DomainLDL-receptor class A 7
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917314_353527.3333333333334820.0DomainEGF-like 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917354_393527.3333333333334820.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:14557373chr19:11227535ENST0000053591591766_106527.3333333333334820.0DomainLDL-receptor class A 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916107_145441.3333333333333683.0DomainLDL-receptor class A 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916146_186441.3333333333333683.0DomainLDL-receptor class A 4
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916195_233441.3333333333333683.0DomainLDL-receptor class A 5
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916234_272441.3333333333333683.0DomainLDL-receptor class A 6
TgeneLDLRchr19:14557373chr19:11227535ENST0000054570791625_65441.3333333333333683.0DomainLDL-receptor class A 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916274_313441.3333333333333683.0DomainLDL-receptor class A 7
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916314_353441.3333333333333683.0DomainEGF-like 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916354_393441.3333333333333683.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:14557373chr19:11227535ENST0000054570791666_106441.3333333333333683.0DomainLDL-receptor class A 2
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018107_145568.3333333333334859.0DomainLDL-receptor class A 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018146_186568.3333333333334859.0DomainLDL-receptor class A 4
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018195_233568.3333333333334859.0DomainLDL-receptor class A 5
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018234_272568.3333333333334859.0DomainLDL-receptor class A 6
TgeneLDLRchr19:14557373chr19:11227535ENST00000558013101825_65568.3333333333334859.0DomainLDL-receptor class A 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018274_313568.3333333333334859.0DomainLDL-receptor class A 7
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018314_353568.3333333333334859.0DomainEGF-like 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018354_393568.3333333333334859.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:14557373chr19:11227535ENST00000558013101866_106568.3333333333334859.0DomainLDL-receptor class A 2
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018107_145568.3333333333334861.0DomainLDL-receptor class A 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018146_186568.3333333333334861.0DomainLDL-receptor class A 4
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018195_233568.3333333333334861.0DomainLDL-receptor class A 5
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018234_272568.3333333333334861.0DomainLDL-receptor class A 6
TgeneLDLRchr19:14557373chr19:11227535ENST00000558518101825_65568.3333333333334861.0DomainLDL-receptor class A 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018274_313568.3333333333334861.0DomainLDL-receptor class A 7
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018314_353568.3333333333334861.0DomainEGF-like 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018354_393568.3333333333334861.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:14557373chr19:11227535ENST00000558518101866_106568.3333333333334861.0DomainLDL-receptor class A 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000455727816397_438400.3333333333333693.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917397_438527.3333333333334820.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917439_485527.3333333333334820.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:14557373chr19:11227535ENST00000535915917486_528527.3333333333334820.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:14557373chr19:11227535ENST00000545707916397_438441.3333333333333683.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018397_438568.3333333333334859.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018439_485568.3333333333334859.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018486_528568.3333333333334859.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005580131018529_572568.3333333333334859.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018397_438568.3333333333334861.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018439_485568.3333333333334861.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018486_528568.3333333333334861.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:14557373chr19:11227535ENST000005585181018529_572568.3333333333334861.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:14557373chr19:11227535ENST0000045572781622_788400.3333333333333693.0Topological domainExtracellular
TgeneLDLRchr19:14557373chr19:11227535ENST0000053591591722_788527.3333333333334820.0Topological domainExtracellular
TgeneLDLRchr19:14557373chr19:11227535ENST0000054570791622_788441.3333333333333683.0Topological domainExtracellular
TgeneLDLRchr19:14557373chr19:11227535ENST00000558013101822_788568.3333333333334859.0Topological domainExtracellular
TgeneLDLRchr19:14557373chr19:11227535ENST00000558518101822_788568.3333333333334861.0Topological domainExtracellular


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Fusion Gene Sequence for PKN1-LDLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000242783_ENST00000558518_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=2500nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACC
ACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAG
GTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTG
TCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGC
ATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGA
CAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTT
GTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGG
ACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATG
ACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAG
GCCCAGAGAAGCAAGTGGCTTTCAACACACAACAGCAGATGGCACCAACGGGACCCCCTGGCCCTGCCTCATCCACCAATCTCTAAGCCA
AACCCCTAAACTCAGGAGTCAACGTGTTTACCTCTTCTATGCAAGCCTTGCTAGACAGCCAGGTTAGCCTTTGCCCTGTCACCCCCGAAT
CATGACCCACCCAGTGTCTTTCGAGGTGGGTTTGTACCTTCCTTAAGCCAGGAAAGGGATTCATGGCGTCGGAAATGATCTGGCTGAATC
CGTGGTGGCACCGAGACCAAACTCATTCACCAAATGATGCCACTTCCCAGAGGCAGAGCCTGAGTCACTGGTCACCCTTAATATTTATTA
AGTGCCTGAGACACCCGGTTACCTTGGCCGTGAGGACACGTGGCCTGCACCCAGGTGTGGCTGTCAGGACACCAGCCTGGTGCCCATCCT

>In-frame_ENST00000242783_ENST00000558518_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=495AA_start in transcript=165_stop in transcript=1652
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETS
TVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRL

--------------------------------------------------------------
>In-frame_ENST00000242783_ENST00000557933_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1924nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACC
ACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAG
GTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTG
TCCATTGTCCTCCCCATCGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCG
TCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGA
AGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGTGG
CGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAA
GCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGG

>In-frame_ENST00000242783_ENST00000557933_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=583AA_start in transcript=165_stop in transcript=1916
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETS
TVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIATELGLWSRGQLCDRACLS
LQCSSSSFAWGSSFYGRTGGLRTSTASTLTTPSIRRPQRMRSTFATTRTATATPRDRWSVWRMTWREHLPGVPSLPRTLPETSPALFYSK

--------------------------------------------------------------
>In-frame_ENST00000242783_ENST00000455727_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1821nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACC
ACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAG
GTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTG
TCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGC
ATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGA
CAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTT
GTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGG

>In-frame_ENST00000242783_ENST00000455727_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=495AA_start in transcript=165_stop in transcript=1652
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETS
TVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRL

--------------------------------------------------------------
>In-frame_ENST00000242783_ENST00000535915_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1875nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACC
ACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAG
GTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTG
TCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGC
ATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGA
CAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTT
GTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGG

>In-frame_ENST00000242783_ENST00000535915_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=495AA_start in transcript=165_stop in transcript=1652
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETS
TVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRL

--------------------------------------------------------------
>In-frame_ENST00000242783_ENST00000545707_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1794nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGAGGCTGAGGCTGCAGTGGCCACC
CAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGG
CTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAG
AAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAG
AACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAAC
CAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAG
AACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTAT
TCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAG

>In-frame_ENST00000242783_ENST00000545707_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=444AA_start in transcript=165_stop in transcript=1499
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPREAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVA

--------------------------------------------------------------
>In-frame_ENST00000242783_ENST00000558013_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=2143nt_BP=775nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGAGTGAGCCTCGCAGCTGGTCCCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTG
GAGCTGGAGCGGGAGCGGCTGCGGCGGGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGAC
CTGGGCCGCAGCCTGGGCCCCGTAGAGCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCAC
GCCCACGTGGTGCTTCCCGACCCGGCGGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTG
AGCCGCGTGGCGGGCCTGGAGAAGCAGTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGC
AGCACCAAGGACCGGAAGCTGCTGCTGACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGC
CGGGCGCTGCAGGCCGGCCAGCTGGAGAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCC
TTGGCCGTCTTTGAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACC
ACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAG
GTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTG
TCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGC
ATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGATG
GTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTA
TTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTG
CCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCT
CCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCCCAG
AGAAGCAAGTGGCTTTCAACACACAACAGCAGATGGCACCAACGGGACCCCCTGGCCCTGCCTCATCCACCAATCTCTAAGCCAAACCCC

>In-frame_ENST00000242783_ENST00000558013_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=493AA_start in transcript=165_stop in transcript=1646
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQ
LQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDII
RMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT
GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETS
TVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRL

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000558518_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=2384nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTA
TCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAG
GAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACA
GCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCA
CCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCT
CGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCA
GAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGT
GGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCA
AAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTT
GGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTT
TTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCCCAGAGAAGCAAGTGGCTTTCAAC
ACACAACAGCAGATGGCACCAACGGGACCCCCTGGCCCTGCCTCATCCACCAATCTCTAAGCCAAACCCCTAAACTCAGGAGTCAACGTG
TTTACCTCTTCTATGCAAGCCTTGCTAGACAGCCAGGTTAGCCTTTGCCCTGTCACCCCCGAATCATGACCCACCCAGTGTCTTTCGAGG
TGGGTTTGTACCTTCCTTAAGCCAGGAAAGGGATTCATGGCGTCGGAAATGATCTGGCTGAATCCGTGGTGGCACCGAGACCAAACTCAT
TCACCAAATGATGCCACTTCCCAGAGGCAGAGCCTGAGTCACTGGTCACCCTTAATATTTATTAAGTGCCTGAGACACCCGGTTACCTTG
GCCGTGAGGACACGTGGCCTGCACCCAGGTGTGGCTGTCAGGACACCAGCCTGGTGCCCATCCTCCCGACCCCTACCCACTTCCATTCCC

>In-frame_ENST00000342216_ENST00000558518_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=501AA_start in transcript=31_stop in transcript=1536
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAV
ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLL

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000557933_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1808nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTA
TCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAG
GAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACA
GCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCA
CCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGCCACGGA
GCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTT
CTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATT
TGCCACAACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTC
CCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTA
TATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTG

>In-frame_ENST00000342216_ENST00000557933_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=589AA_start in transcript=31_stop in transcript=1800
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAV
ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIATELGLWSRGQLC
DRACLSLQCSSSSFAWGSSFYGRTGGLRTSTASTLTTPSIRRPQRMRSTFATTRTATATPRDRWSVWRMTWREHLPGVPSLPRTLPETSP

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000455727_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1705nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTA
TCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAG
GAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACA
GCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCA
CCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCT
CGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCA
GAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGT
GGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCA

>In-frame_ENST00000342216_ENST00000455727_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=501AA_start in transcript=31_stop in transcript=1536
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAV
ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLL

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000535915_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1759nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTA
TCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAG
GAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACA
GCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCA
CCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCT
CGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCA
GAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGT
GGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCA
AAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTT

>In-frame_ENST00000342216_ENST00000535915_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=501AA_start in transcript=31_stop in transcript=1536
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAV
ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLL

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000545707_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=1678nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAA
GGTCAGCTCCACAGCCGTAAGGACACAGCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCAC
CACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCT
GTCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAG
CATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGAG
ACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCT
TGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCG
GACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGAT

>In-frame_ENST00000342216_ENST00000545707_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=450AA_start in transcript=31_stop in transcript=1383
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPREAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ
ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA

--------------------------------------------------------------
>In-frame_ENST00000342216_ENST00000558013_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(transcript)=2027nt_BP=659nt
AAGAGGGCGGGGCCCTCAGCCCGGACCCAGGATGGCGGAGGCCAATAACCCCTCGGAGCAGGAGCTGGAGAGTGAGCCTCGCAGCTGGTC
CCTGCTAGAGCAGCTGGGCCTGGCCGGGGCAGACCTGGCGGCCCCCGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAGCGGCTGCGGCG
GGAAATCCGCAAGGAGCTGAAGCTGAAGGAGGGTGCTGAGAACCTGCGGCGGGCCACCACTGACCTGGGCCGCAGCCTGGGCCCCGTAGA
GCTGCTGCTGCGGGGCTCCTCGCGCCGCCTCGACCTGCTGCACCAGCAGCTGCAGGAGCTGCACGCCCACGTGGTGCTTCCCGACCCGGC
GGCCACCCACGATGGCCCCCAGTCCCCTGGTGCGGGTGGCCCCACCTGCTCGGCCACCAACCTGAGCCGCGTGGCGGGCCTGGAGAAGCA
GTTGGCCATTGAGCTGAAGGTGAAGCAGGGGGCGGAGAACATGATCCAGACCTACAGCAATGGCAGCACCAAGGACCGGAAGCTGCTGCT
GACAGCCCAGCAGATGTTGCAGGACAGTAAGACCAAGATTGACATCATCCGCATGCAACTCCGCCGGGCGCTGCAGGCCGGCCAGCTGGA
GAACCAGGCAGCCCCGGATGACACCCAAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGA
TGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT
TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCC
AGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTA
TCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAG
GAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACA
GCACACAACCACCCGACCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACCACGGTGGAGATAGTGACAATGTCTCA
CCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCT
CGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCA
GAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGATGGTCAGTCTGGAGGATGACGTGGCGTG
AACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCAT
TGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATT
TTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGT
TTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCCCAGAGAAGCAAGTGGCTTTCAACACACAA
CAGCAGATGGCACCAACGGGACCCCCTGGCCCTGCCTCATCCACCAATCTCTAAGCCAAACCCCTAAACTCAGGAGTCAACGTGTTTACC

>In-frame_ENST00000342216_ENST00000558013_TCGA-C8-A26W-01A_PKN1_chr19_14557373_+_LDLR_chr19_11227535_length(amino acids)=499AA_start in transcript=31_stop in transcript=1530
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRL
DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
TKIDIIRMQLRRALQAGQLENQAAPDDTQDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF
SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAV
ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLL

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Fusion Gene PPI Analysis for PKN1-LDLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PKN1-LDLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PKN1-LDLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLDLRC0745103Hyperlipoproteinemia Type IIa61CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneLDLRC0020445Hypercholesterolemia, Familial9CTD_human;GENOMICS_ENGLAND
TgeneLDLRC1704417Hyperlipoproteinemia Type IIb7CTD_human
TgeneLDLRC0020443Hypercholesterolemia6CTD_human;GENOMICS_ENGLAND
TgeneLDLRC0004153Atherosclerosis5CTD_human
TgeneLDLRC1563937Atherogenesis5CTD_human
TgeneLDLRC0400966Non-alcoholic Fatty Liver Disease3CTD_human
TgeneLDLRC3241937Nonalcoholic Steatohepatitis3CTD_human
TgeneLDLRC0010054Coronary Arteriosclerosis2CTD_human
TgeneLDLRC0020473Hyperlipidemia2CTD_human
TgeneLDLRC1706412Lipidemias2CTD_human
TgeneLDLRC1956346Coronary Artery Disease2CTD_human
TgeneLDLRC0010068Coronary heart disease1CTD_human
TgeneLDLRC0015695Fatty Liver1CTD_human
TgeneLDLRC0020507Hyperplasia1CTD_human
TgeneLDLRC0028754Obesity1CTD_human
TgeneLDLRC0034362Q Fever1CTD_human
TgeneLDLRC0085762Alcohol abuse1PSYGENET
TgeneLDLRC0242339Dyslipidemias1CTD_human
TgeneLDLRC0519066Acute Q fever1CTD_human
TgeneLDLRC0598784Dyslipoproteinemias1CTD_human
TgeneLDLRC1443892Chronic Q Fever1CTD_human
TgeneLDLRC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneLDLRC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneLDLRC2711227Steatohepatitis1CTD_human
TgeneLDLRC2973787Coxiella burnetii Infection1CTD_human
TgeneLDLRC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human