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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLA2G2A-ITGA6 (FusionGDB2 ID:65449)

Fusion Gene Summary for PLA2G2A-ITGA6

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G2A-ITGA6
Fusion gene ID: 65449
HgeneTgene
Gene symbol

PLA2G2A

ITGA6

Gene ID

5320

3655

Gene namephospholipase A2 group IIAintegrin subunit alpha 6
SynonymsMOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2CD49f|ITGA6B|VLA-6
Cytomap

1p36.13

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionphospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid)integrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6
Modification date2020032220200329
UniProtAcc.

P23229

Ensembl transtripts involved in fusion geneENST00000400520, ENST00000496748, 
ENST00000375111, 		ENST00000409532, 
ENST00000264107, ENST00000343713, 
ENST00000264106, ENST00000375221, 
ENST00000409080, 
Fusion gene scores* DoF score7 X 3 X 2=423 X 3 X 2=18
# samples 73
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLA2G2A [Title/Abstract] AND ITGA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLA2G2A(20301931)-ITGA6(173351992), # samples:1
Anticipated loss of major functional domain due to fusion event.PLA2G2A-ITGA6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PLA2G2A-ITGA6 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLA2G2A-ITGA6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PLA2G2A-ITGA6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G2A

GO:0006644

phospholipid metabolic process

17069818

HgenePLA2G2A

GO:0046473

phosphatidic acid metabolic process

9032461

HgenePLA2G2A

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22837859


check buttonFusion gene breakpoints across PLA2G2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ITGA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6348-01APLA2G2Achr1

20301931

-ITGA6chr2

173351992

+


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Fusion Gene ORF analysis for PLA2G2A-ITGA6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000400520ENST00000409532PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
intron-3CDSENST00000400520ENST00000264107PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
intron-3CDSENST00000400520ENST00000343713PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
intron-3CDSENST00000400520ENST00000264106PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
intron-3CDSENST00000400520ENST00000375221PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
intron-3CDSENST00000400520ENST00000409080PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000409532PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000264107PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000343713PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000264106PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000375221PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
Frame-shiftENST00000496748ENST00000409080PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000409532PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000264107PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000343713PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000264106PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000375221PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+
In-frameENST00000375111ENST00000409080PLA2G2Achr1

20301931

-ITGA6chr2

173351992

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375111PLA2G2Achr120301931-ENST00000409532ITGA6chr2173351992+268897010972221374
ENST00000375111PLA2G2Achr120301931-ENST00000264107ITGA6chr2173351992+438497010972221374
ENST00000375111PLA2G2Achr120301931-ENST00000343713ITGA6chr2173351992+460797010972221374
ENST00000375111PLA2G2Achr120301931-ENST00000264106ITGA6chr2173351992+447797010972275392
ENST00000375111PLA2G2Achr120301931-ENST00000375221ITGA6chr2173351992+460797010972221374
ENST00000375111PLA2G2Achr120301931-ENST00000409080ITGA6chr2173351992+429897010972275392

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375111ENST00000409532PLA2G2Achr120301931-ITGA6chr2173351992+0.0048002420.9951997
ENST00000375111ENST00000264107PLA2G2Achr120301931-ITGA6chr2173351992+0.0010095360.9989905
ENST00000375111ENST00000343713PLA2G2Achr120301931-ITGA6chr2173351992+0.0010179810.998982
ENST00000375111ENST00000264106PLA2G2Achr120301931-ITGA6chr2173351992+0.0003713930.99962854
ENST00000375111ENST00000375221PLA2G2Achr120301931-ITGA6chr2173351992+0.0010179810.998982
ENST00000375111ENST00000409080PLA2G2Achr120301931-ITGA6chr2173351992+0.0004159310.999584

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Fusion Genomic Features for PLA2G2A-ITGA6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLA2G2Achr120301930-ITGA6chr2173351991+0.0269660880.9730339
PLA2G2Achr120301930-ITGA6chr2173351991+0.0269660880.9730339

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLA2G2A-ITGA6


check button Go to

FGviewer for the breakpoints of chr1:20301931-chr2:173351992

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA6

P23229

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410614261079_1083695.66666666666661131.0MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410713261079_1083656.66666666666661648.6666666666667MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000034371313261079_1083651.66666666666661728.3333333333333MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000037522114271079_1083695.66666666666661772.3333333333333MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000040908013251079_1083656.66666666666661092.0MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000040953213261079_1083537.66666666666661085.3333333333333MotifNote=GFFKR motif
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410614261077_1130695.66666666666661131.0Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410713261077_1130656.66666666666661648.6666666666667Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000034371313261077_1130651.66666666666661728.3333333333333Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000037522114271077_1130695.66666666666661772.3333333333333Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000040908013251077_1130656.66666666666661092.0Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000040953213261077_1130537.66666666666661085.3333333333333Topological domainCytoplasmic
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410614261051_1076695.66666666666661131.0TransmembraneHelical
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410713261051_1076656.66666666666661648.6666666666667TransmembraneHelical
TgeneITGA6chr1:20301931chr2:173351992ENST0000034371313261051_1076651.66666666666661728.3333333333333TransmembraneHelical
TgeneITGA6chr1:20301931chr2:173351992ENST0000037522114271051_1076695.66666666666661772.3333333333333TransmembraneHelical
TgeneITGA6chr1:20301931chr2:173351992ENST0000040908013251051_1076656.66666666666661092.0TransmembraneHelical
TgeneITGA6chr1:20301931chr2:173351992ENST0000040953213261051_1076537.66666666666661085.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426363_371695.66666666666661131.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426425_433695.66666666666661131.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426480_488695.66666666666661131.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326363_371656.66666666666661648.6666666666667Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326425_433656.66666666666661648.6666666666667Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326480_488656.66666666666661648.6666666666667Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326363_371651.66666666666661728.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326425_433651.66666666666661728.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326480_488651.66666666666661728.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427363_371695.66666666666661772.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427425_433695.66666666666661772.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427480_488695.66666666666661772.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325363_371656.66666666666661092.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325425_433656.66666666666661092.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325480_488656.66666666666661092.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326363_371537.66666666666661085.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326425_433537.66666666666661085.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326480_488537.66666666666661085.3333333333333Calcium bindingOntology_term=ECO:0000255
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426101_166695.66666666666661131.0RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426176_229695.66666666666661131.0RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426283_339695.66666666666661131.0RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000264106142630_95695.66666666666661131.0RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426340_402695.66666666666661131.0RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426403_458695.66666666666661131.0RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000002641061426459_518695.66666666666661131.0RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326101_166656.66666666666661648.6666666666667RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326176_229656.66666666666661648.6666666666667RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326283_339656.66666666666661648.6666666666667RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000264107132630_95656.66666666666661648.6666666666667RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326340_402656.66666666666661648.6666666666667RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326403_458656.66666666666661648.6666666666667RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000002641071326459_518656.66666666666661648.6666666666667RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326101_166651.66666666666661728.3333333333333RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326176_229651.66666666666661728.3333333333333RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326283_339651.66666666666661728.3333333333333RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000343713132630_95651.66666666666661728.3333333333333RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326340_402651.66666666666661728.3333333333333RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326403_458651.66666666666661728.3333333333333RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000003437131326459_518651.66666666666661728.3333333333333RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427101_166695.66666666666661772.3333333333333RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427176_229695.66666666666661772.3333333333333RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427283_339695.66666666666661772.3333333333333RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000375221142730_95695.66666666666661772.3333333333333RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427340_402695.66666666666661772.3333333333333RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427403_458695.66666666666661772.3333333333333RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000003752211427459_518695.66666666666661772.3333333333333RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325101_166656.66666666666661092.0RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325176_229656.66666666666661092.0RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325283_339656.66666666666661092.0RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000409080132530_95656.66666666666661092.0RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325340_402656.66666666666661092.0RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325403_458656.66666666666661092.0RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000004090801325459_518656.66666666666661092.0RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326101_166537.66666666666661085.3333333333333RepeatFG-GAP 2
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326176_229537.66666666666661085.3333333333333RepeatFG-GAP 3
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326283_339537.66666666666661085.3333333333333RepeatFG-GAP 4
TgeneITGA6chr1:20301931chr2:173351992ENST00000409532132630_95537.66666666666661085.3333333333333RepeatFG-GAP 1
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326340_402537.66666666666661085.3333333333333RepeatFG-GAP 5
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326403_458537.66666666666661085.3333333333333RepeatFG-GAP 6
TgeneITGA6chr1:20301931chr2:173351992ENST000004095321326459_518537.66666666666661085.3333333333333RepeatFG-GAP 7
TgeneITGA6chr1:20301931chr2:173351992ENST00000264106142624_1050695.66666666666661131.0Topological domainExtracellular
TgeneITGA6chr1:20301931chr2:173351992ENST00000264107132624_1050656.66666666666661648.6666666666667Topological domainExtracellular
TgeneITGA6chr1:20301931chr2:173351992ENST00000343713132624_1050651.66666666666661728.3333333333333Topological domainExtracellular
TgeneITGA6chr1:20301931chr2:173351992ENST00000375221142724_1050695.66666666666661772.3333333333333Topological domainExtracellular
TgeneITGA6chr1:20301931chr2:173351992ENST00000409080132524_1050656.66666666666661092.0Topological domainExtracellular
TgeneITGA6chr1:20301931chr2:173351992ENST00000409532132624_1050537.66666666666661085.3333333333333Topological domainExtracellular


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Fusion Gene Sequence for PLA2G2A-ITGA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375111_ENST00000409532_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=2688nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGTTTCTTCAAGAGAAATAAGAAAGATCATTATGATGCCACAT
ATCACAAGGCTGAGATCCATGCTCAGCCATCTGATAAAGAGAGGCTTACTTCTGATGCATAGTATTGATCTACTTCTGTAATTGTGTGGA
TTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGATACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAG
TATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGTGGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTT
CACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAATTTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTA
CACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTTACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAA

>In-frame_ENST00000375111_ENST00000409532_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=374AA_start in transcript=1097_stop in transcript=2221
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEI

--------------------------------------------------------------
>In-frame_ENST00000375111_ENST00000264107_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=4384nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGTTTCTTCAAGAGAAATAAGAAAGATCATTATGATGCCACAT
ATCACAAGGCTGAGATCCATGCTCAGCCATCTGATAAAGAGAGGCTTACTTCTGATGCATAGTATTGATCTACTTCTGTAATTGTGTGGA
TTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGATACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAG
TATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGTGGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTT
CACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAATTTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTA
CACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTTACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAA
TGGATTTTTCTTTAACTGCCGTAATTTAACTTTCTGGGTTGCCTTTATTTTTGGCGTGGCTGACTTACATCATGTGTTGGGGAAGGGCCT
GCCCAGTTGCACTCAGGTGACATCCTCCAGATAGTGTAGCTGAGGAGGCACCTACACTCACCTGCACTAACAGAGTGGCCGTCCTAACCT
CGGGCCTGCTGCGCAGACGTCCATCACGTTAGCTGTCCCACATCACAAGACTATGCCATTGGGGTAGTTGTGTTTCAACGGAAAGTGCTG
TCTTAAACTAAATGTGCAATAGAAGGTGATGTTGCCATCCTACCGTCTTTTCCTGTTTCCTAGCTGTGTGAATACCTGCTCACGTCAAAT
GCATACAAGTTTCATTCTCCCTTTCACTAAAACACACAGGTGCAACAGACTTGAATGCTAGTTATACTTATTTGTATATGGTATTTATTT
TTTCTTTTCTTTACAAACCATTTTGTTATTGACTAACAGGCCAAAGAGTCTCCAGTTTACCCTTCAGGTTGGTTTAATCAATCAGAATTA
GAGCATGGGAGGTCATCACTTTGACCTAAATTATTTACTGCAAAAAGAAAATCTTTATAAATGTACCAGAGAGAGTTGTTTTAATAACTT
ATCTATAAACTATAACCTCTCCTTCATGACAGCCTCCACCCCACAACCCAAAAGGTTTAAGAAATAGAATTATAACTGTAAAGATGTTTA
TTTCAGGCATTGGATATTTTTTACTTTAGAAGCCTGCATAATGTTTCTGGATTTCATACTGTAACATTCAGGAATTCTTGGAGAAAATGG
GTTTATTCACTGAACTCTAGTGCGGTTTACTCACTGCTGCAAATACTGTATATTCAGGACTTGAAAGAAATGGTGAATGCCTATGGTGGA
TCCAAACTGATCCAGTATAAGACTACTGAATCTGCTACCAAAACAGTTAATCAGTGAGTCGATGTTCTATTTTTTGTTTTGTTTCCTCCC
CTATCTGTATTCCCAAAAATTACTTTGGGGCTAATTTAACAAGAACTTTAAATTGTGTTTTAATTGTAAAAATGGCAGGGGGTGGAATTA
TTACTCTATACATTCAACAGAGACTGAATAGATATGAAAGCTGATTTTTTTTAATTACCATGCTTCACAATGTTAAGTTATATGGGGAGC
AACAGCAAACAGGTGCTAATTTGTTTTGGATATAGTATAAGCAGTGTCTGTGTTTTGAAAGAATAGAACACAGTTTGTAGTGCCACTGTT
GTTTTGGGGGGGCTTTTTTCTTTTCGGAAATCTTAAACCTTAAGATACTAAGGACGTTGTTTTGGTTGTACTTTGGAATTCTTAGTCACA
AAATATATTTTGTTTACAAAAATTTCTGTAAAACAGGTTATAACAGTGTTTAAAGTCTCAGTTTCTTGCTTGGGGAACTTGTGTCCCTAA
TGTGTTTAGATTGCTAGATTGCTAAGGAGCTGATACTTTGACAGTGTTTTTAGACCTGTGTTACTAAAAAAAAGATGAATGTCCTGAAAA
GGGTGTTGGGAGGGTGGTTCAACAAAGAAACAAAGATGTTATGGTGTTTAGATTTATGGTTGTTAAAAATGTCATCTCAAGTCAAGTCAC
TGGTCTGTTTGCATTTGATACATTTTTGTACTAACTAGCATTGTAAAATTATTTCATGATTAGAAATTACCTGTGGATATTTGTATAAAA

>In-frame_ENST00000375111_ENST00000264107_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=374AA_start in transcript=1097_stop in transcript=2221
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEI

--------------------------------------------------------------
>In-frame_ENST00000375111_ENST00000343713_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=4607nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGTTTCTTCAAGAGAAATAAGAAAGATCATTATGATGCCACAT
ATCACAAGGCTGAGATCCATGCTCAGCCATCTGATAAAGAGAGGCTTACTTCTGATGCATAGTATTGATCTACTTCTGTAATTGTGTGGA
TTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGATACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAG
TATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGTGGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTT
CACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAATTTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTA
CACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTTACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAA
TGGATTTTTCTTTAACTGCCGTAATTTAACTTTCTGGGTTGCCTTTATTTTTGGCGTGGCTGACTTACATCATGTGTTGGGGAAGGGCCT
GCCCAGTTGCACTCAGGTGACATCCTCCAGATAGTGTAGCTGAGGAGGCACCTACACTCACCTGCACTAACAGAGTGGCCGTCCTAACCT
CGGGCCTGCTGCGCAGACGTCCATCACGTTAGCTGTCCCACATCACAAGACTATGCCATTGGGGTAGTTGTGTTTCAACGGAAAGTGCTG
TCTTAAACTAAATGTGCAATAGAAGGTGATGTTGCCATCCTACCGTCTTTTCCTGTTTCCTAGCTGTGTGAATACCTGCTCACGTCAAAT
GCATACAAGTTTCATTCTCCCTTTCACTAAAACACACAGGTGCAACAGACTTGAATGCTAGTTATACTTATTTGTATATGGTATTTATTT
TTTCTTTTCTTTACAAACCATTTTGTTATTGACTAACAGGCCAAAGAGTCTCCAGTTTACCCTTCAGGTTGGTTTAATCAATCAGAATTA
GAGCATGGGAGGTCATCACTTTGACCTAAATTATTTACTGCAAAAAGAAAATCTTTATAAATGTACCAGAGAGAGTTGTTTTAATAACTT
ATCTATAAACTATAACCTCTCCTTCATGACAGCCTCCACCCCACAACCCAAAAGGTTTAAGAAATAGAATTATAACTGTAAAGATGTTTA
TTTCAGGCATTGGATATTTTTTACTTTAGAAGCCTGCATAATGTTTCTGGATTTCATACTGTAACATTCAGGAATTCTTGGAGAAAATGG
GTTTATTCACTGAACTCTAGTGCGGTTTACTCACTGCTGCAAATACTGTATATTCAGGACTTGAAAGAAATGGTGAATGCCTATGGTGGA
TCCAAACTGATCCAGTATAAGACTACTGAATCTGCTACCAAAACAGTTAATCAGTGAGTCGATGTTCTATTTTTTGTTTTGTTTCCTCCC
CTATCTGTATTCCCAAAAATTACTTTGGGGCTAATTTAACAAGAACTTTAAATTGTGTTTTAATTGTAAAAATGGCAGGGGGTGGAATTA
TTACTCTATACATTCAACAGAGACTGAATAGATATGAAAGCTGATTTTTTTTAATTACCATGCTTCACAATGTTAAGTTATATGGGGAGC
AACAGCAAACAGGTGCTAATTTGTTTTGGATATAGTATAAGCAGTGTCTGTGTTTTGAAAGAATAGAACACAGTTTGTAGTGCCACTGTT
GTTTTGGGGGGGCTTTTTTCTTTTCGGAAATCTTAAACCTTAAGATACTAAGGACGTTGTTTTGGTTGTACTTTGGAATTCTTAGTCACA
AAATATATTTTGTTTACAAAAATTTCTGTAAAACAGGTTATAACAGTGTTTAAAGTCTCAGTTTCTTGCTTGGGGAACTTGTGTCCCTAA
TGTGTTTAGATTGCTAGATTGCTAAGGAGCTGATACTTTGACAGTGTTTTTAGACCTGTGTTACTAAAAAAAAGATGAATGTCCTGAAAA
GGGTGTTGGGAGGGTGGTTCAACAAAGAAACAAAGATGTTATGGTGTTTAGATTTATGGTTGTTAAAAATGTCATCTCAAGTCAAGTCAC
TGGTCTGTTTGCATTTGATACATTTTTGTACTAACTAGCATTGTAAAATTATTTCATGATTAGAAATTACCTGTGGATATTTGTATAAAA
GTGTGAAATAAATTTTTTATAAAAGTGTTCATTGTTTCGTAACACAGCATTGTATATGTGAAGCAAACTCTAAAATTATAAATGACAACC
TGAATTATCTATTTCATCAAACCAAAGTTCAGTGTTTTTATTTTTGGTGTCTCATGTAATCTCAGATCAGCCAAAGATACTAGTGCCAAA
GCAATGGGATTCGGGGTTTTTTTCTGTTTTCGCTCTATGTAGGTGATCCTCAAGTCTTTCATTTTCCTTCTTTATGATTAAAAGAAACCT

>In-frame_ENST00000375111_ENST00000343713_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=374AA_start in transcript=1097_stop in transcript=2221
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEI

--------------------------------------------------------------
>In-frame_ENST00000375111_ENST00000264106_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=4477nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGATTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGAT
ACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAGTATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGT
GGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTTCACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAAT
TTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTACACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTT
ACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAATGGATTTTTCTTTAACTGCCGTAATTTAACTTTCTGGGTT
GCCTTTATTTTTGGCGTGGCTGACTTACATCATGTGTTGGGGAAGGGCCTGCCCAGTTGCACTCAGGTGACATCCTCCAGATAGTGTAGC
TGAGGAGGCACCTACACTCACCTGCACTAACAGAGTGGCCGTCCTAACCTCGGGCCTGCTGCGCAGACGTCCATCACGTTAGCTGTCCCA
CATCACAAGACTATGCCATTGGGGTAGTTGTGTTTCAACGGAAAGTGCTGTCTTAAACTAAATGTGCAATAGAAGGTGATGTTGCCATCC
TACCGTCTTTTCCTGTTTCCTAGCTGTGTGAATACCTGCTCACGTCAAATGCATACAAGTTTCATTCTCCCTTTCACTAAAACACACAGG
TGCAACAGACTTGAATGCTAGTTATACTTATTTGTATATGGTATTTATTTTTTCTTTTCTTTACAAACCATTTTGTTATTGACTAACAGG
CCAAAGAGTCTCCAGTTTACCCTTCAGGTTGGTTTAATCAATCAGAATTAGAGCATGGGAGGTCATCACTTTGACCTAAATTATTTACTG
CAAAAAGAAAATCTTTATAAATGTACCAGAGAGAGTTGTTTTAATAACTTATCTATAAACTATAACCTCTCCTTCATGACAGCCTCCACC
CCACAACCCAAAAGGTTTAAGAAATAGAATTATAACTGTAAAGATGTTTATTTCAGGCATTGGATATTTTTTACTTTAGAAGCCTGCATA
ATGTTTCTGGATTTCATACTGTAACATTCAGGAATTCTTGGAGAAAATGGGTTTATTCACTGAACTCTAGTGCGGTTTACTCACTGCTGC
AAATACTGTATATTCAGGACTTGAAAGAAATGGTGAATGCCTATGGTGGATCCAAACTGATCCAGTATAAGACTACTGAATCTGCTACCA
AAACAGTTAATCAGTGAGTCGATGTTCTATTTTTTGTTTTGTTTCCTCCCCTATCTGTATTCCCAAAAATTACTTTGGGGCTAATTTAAC
AAGAACTTTAAATTGTGTTTTAATTGTAAAAATGGCAGGGGGTGGAATTATTACTCTATACATTCAACAGAGACTGAATAGATATGAAAG
CTGATTTTTTTTAATTACCATGCTTCACAATGTTAAGTTATATGGGGAGCAACAGCAAACAGGTGCTAATTTGTTTTGGATATAGTATAA
GCAGTGTCTGTGTTTTGAAAGAATAGAACACAGTTTGTAGTGCCACTGTTGTTTTGGGGGGGCTTTTTTCTTTTCGGAAATCTTAAACCT
TAAGATACTAAGGACGTTGTTTTGGTTGTACTTTGGAATTCTTAGTCACAAAATATATTTTGTTTACAAAAATTTCTGTAAAACAGGTTA
TAACAGTGTTTAAAGTCTCAGTTTCTTGCTTGGGGAACTTGTGTCCCTAATGTGTTTAGATTGCTAGATTGCTAAGGAGCTGATACTTTG
ACAGTGTTTTTAGACCTGTGTTACTAAAAAAAAGATGAATGTCCTGAAAAGGGTGTTGGGAGGGTGGTTCAACAAAGAAACAAAGATGTT
ATGGTGTTTAGATTTATGGTTGTTAAAAATGTCATCTCAAGTCAAGTCACTGGTCTGTTTGCATTTGATACATTTTTGTACTAACTAGCA
TTGTAAAATTATTTCATGATTAGAAATTACCTGTGGATATTTGTATAAAAGTGTGAAATAAATTTTTTATAAAAGTGTTCATTGTTTCGT
AACACAGCATTGTATATGTGAAGCAAACTCTAAAATTATAAATGACAACCTGAATTATCTATTTCATCAAACCAAAGTTCAGTGTTTTTA
TTTTTGGTGTCTCATGTAATCTCAGATCAGCCAAAGATACTAGTGCCAAAGCAATGGGATTCGGGGTTTTTTTCTGTTTTCGCTCTATGT

>In-frame_ENST00000375111_ENST00000264106_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=392AA_start in transcript=1097_stop in transcript=2275
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRI

--------------------------------------------------------------
>In-frame_ENST00000375111_ENST00000375221_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=4607nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGTTTCTTCAAGAGAAATAAGAAAGATCATTATGATGCCACAT
ATCACAAGGCTGAGATCCATGCTCAGCCATCTGATAAAGAGAGGCTTACTTCTGATGCATAGTATTGATCTACTTCTGTAATTGTGTGGA
TTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGATACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAG
TATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGTGGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTT
CACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAATTTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTA
CACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTTACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAA
TGGATTTTTCTTTAACTGCCGTAATTTAACTTTCTGGGTTGCCTTTATTTTTGGCGTGGCTGACTTACATCATGTGTTGGGGAAGGGCCT
GCCCAGTTGCACTCAGGTGACATCCTCCAGATAGTGTAGCTGAGGAGGCACCTACACTCACCTGCACTAACAGAGTGGCCGTCCTAACCT
CGGGCCTGCTGCGCAGACGTCCATCACGTTAGCTGTCCCACATCACAAGACTATGCCATTGGGGTAGTTGTGTTTCAACGGAAAGTGCTG
TCTTAAACTAAATGTGCAATAGAAGGTGATGTTGCCATCCTACCGTCTTTTCCTGTTTCCTAGCTGTGTGAATACCTGCTCACGTCAAAT
GCATACAAGTTTCATTCTCCCTTTCACTAAAACACACAGGTGCAACAGACTTGAATGCTAGTTATACTTATTTGTATATGGTATTTATTT
TTTCTTTTCTTTACAAACCATTTTGTTATTGACTAACAGGCCAAAGAGTCTCCAGTTTACCCTTCAGGTTGGTTTAATCAATCAGAATTA
GAGCATGGGAGGTCATCACTTTGACCTAAATTATTTACTGCAAAAAGAAAATCTTTATAAATGTACCAGAGAGAGTTGTTTTAATAACTT
ATCTATAAACTATAACCTCTCCTTCATGACAGCCTCCACCCCACAACCCAAAAGGTTTAAGAAATAGAATTATAACTGTAAAGATGTTTA
TTTCAGGCATTGGATATTTTTTACTTTAGAAGCCTGCATAATGTTTCTGGATTTCATACTGTAACATTCAGGAATTCTTGGAGAAAATGG
GTTTATTCACTGAACTCTAGTGCGGTTTACTCACTGCTGCAAATACTGTATATTCAGGACTTGAAAGAAATGGTGAATGCCTATGGTGGA
TCCAAACTGATCCAGTATAAGACTACTGAATCTGCTACCAAAACAGTTAATCAGTGAGTCGATGTTCTATTTTTTGTTTTGTTTCCTCCC
CTATCTGTATTCCCAAAAATTACTTTGGGGCTAATTTAACAAGAACTTTAAATTGTGTTTTAATTGTAAAAATGGCAGGGGGTGGAATTA
TTACTCTATACATTCAACAGAGACTGAATAGATATGAAAGCTGATTTTTTTTAATTACCATGCTTCACAATGTTAAGTTATATGGGGAGC
AACAGCAAACAGGTGCTAATTTGTTTTGGATATAGTATAAGCAGTGTCTGTGTTTTGAAAGAATAGAACACAGTTTGTAGTGCCACTGTT
GTTTTGGGGGGGCTTTTTTCTTTTCGGAAATCTTAAACCTTAAGATACTAAGGACGTTGTTTTGGTTGTACTTTGGAATTCTTAGTCACA
AAATATATTTTGTTTACAAAAATTTCTGTAAAACAGGTTATAACAGTGTTTAAAGTCTCAGTTTCTTGCTTGGGGAACTTGTGTCCCTAA
TGTGTTTAGATTGCTAGATTGCTAAGGAGCTGATACTTTGACAGTGTTTTTAGACCTGTGTTACTAAAAAAAAGATGAATGTCCTGAAAA
GGGTGTTGGGAGGGTGGTTCAACAAAGAAACAAAGATGTTATGGTGTTTAGATTTATGGTTGTTAAAAATGTCATCTCAAGTCAAGTCAC
TGGTCTGTTTGCATTTGATACATTTTTGTACTAACTAGCATTGTAAAATTATTTCATGATTAGAAATTACCTGTGGATATTTGTATAAAA
GTGTGAAATAAATTTTTTATAAAAGTGTTCATTGTTTCGTAACACAGCATTGTATATGTGAAGCAAACTCTAAAATTATAAATGACAACC
TGAATTATCTATTTCATCAAACCAAAGTTCAGTGTTTTTATTTTTGGTGTCTCATGTAATCTCAGATCAGCCAAAGATACTAGTGCCAAA
GCAATGGGATTCGGGGTTTTTTTCTGTTTTCGCTCTATGTAGGTGATCCTCAAGTCTTTCATTTTCCTTCTTTATGATTAAAAGAAACCT

>In-frame_ENST00000375111_ENST00000375221_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=374AA_start in transcript=1097_stop in transcript=2221
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEI

--------------------------------------------------------------
>In-frame_ENST00000375111_ENST00000409080_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(transcript)=4298nt_BP=970nt
GAAGGAAAAAGAGCAACAGATCCAGGGAGCATTCACCTGCCCTGTCTCCAAACAGCCTTGTGCCTCACCTACCCCCAACCTCCCAGAGGG
AGCAGCTATTTAAGGGGAGCAGGAGTGCAGAACAAACAAGACGGCCTGGGGATACAACTCTGGAGTCCTCTGAGAGAGCCACCAAGGAGG
AGCAGGGGAGCGACGGCCGGGGCAGAAGTTGAGACCACCCAGCAGAGGAGCTAGGCCAGTCCATCTGCATTTGTCACCCAAGAACTCTTA
CCATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGGAATTTGGTGAATTTCCACAGAATGATCA
AGTTGACGACAGGAAAGGAAGCCGCACTCAGTTATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAA
CGGATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGCACCAAATTTCTGAGCTACAAGTTTAGCA
ACTCGGGGAGCAGAATCACCTGTGCAAAACAGGACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTA
GAAACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGAGTCCCCTCTTCCC
TGGAAACCTTCCACCCAGTGCTGAATTTCCCTCTCTCATACCCTCCCTCCCTACCCTAACCAAGTTCCTTGGCCATGCAGAAAGCATCCC
TCACCCATCCTAGAGGCCAGGCAGGAGCCCTTCTATACCCACCCAGAATGAGACATCCAGCAGATTTCCAGCCTTCTACTGCTCTCCTCC
ACCTCAACTCCGTGCTTAACCAAAGAAGCTGTACTCCGGGGGGTCTCTTCTGAATAAAGCAATTAGCAAATCAAAAAGGTGTACCAGAAC
TAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTGACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATG
ACGCCCATGAGGCTAAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCTTTCCCTGAGAAACAGT
TGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAGCTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGG
TTTTAAGTACAACTGAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAATCAAGATAATTTGGCTC
CAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCGGTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAG
TTGTTGGCGAGCAAGCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAACTTAGGTAAACCTCTTA
CAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAAATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCA
AAGGATTGGAAAAGGTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCAAGAAAGAAACGGGAAA
TTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTTGCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACT
GTGTGAACATCAGATGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAACAGCACATTTCTAGAGG
AATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTCATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAG
GCACTCAGGTTCGAGTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATCCTAGTGGCTATTCTCG
CTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAGTGTGGATTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGAT
ACCATGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAGTATATTGATAACCTTGAAAAAAAACAGTGGATCACAAAGT
GGAACGAAAATGAAAGCTACTCATAGCGGGGGCCTAAAAAAAAAAAGCTTCACAGTACCCAAACTGCTTTTTCCAACTCAGAAATTCAAT
TTGGATTTAAAAGCCTGCTCAATCCCTGAGGACTGATTTCAGAGTGACTACACACAGTACGAACCTACAGTTTTAACTGTGGATATTGTT
ACGTAGCCTAAGGCTCCTGTTTTGCACAGCCAAATTTAAAACTGTTGGAATGGATTTTTCTTTAACTGCCGTAATTTAACTTTCTGGGTT
GCCTTTATTTTTGGCGTGGCTGACTTACATCATGTGTTGGGGAAGGGCCTGCCCAGTTGCACTCAGGTGACATCCTCCAGATAGTGTAGC
TGAGGAGGCACCTACACTCACCTGCACTAACAGAGTGGCCGTCCTAACCTCGGGCCTGCTGCGCAGACGTCCATCACGTTAGCTGTCCCA
CATCACAAGACTATGCCATTGGGGTAGTTGTGTTTCAACGGAAAGTGCTGTCTTAAACTAAATGTGCAATAGAAGGTGATGTTGCCATCC
TACCGTCTTTTCCTGTTTCCTAGCTGTGTGAATACCTGCTCACGTCAAATGCATACAAGTTTCATTCTCCCTTTCACTAAAACACACAGG
TGCAACAGACTTGAATGCTAGTTATACTTATTTGTATATGGTATTTATTTTTTCTTTTCTTTACAAACCATTTTGTTATTGACTAACAGG
CCAAAGAGTCTCCAGTTTACCCTTCAGGTTGGTTTAATCAATCAGAATTAGAGCATGGGAGGTCATCACTTTGACCTAAATTATTTACTG
CAAAAAGAAAATCTTTATAAATGTACCAGAGAGAGTTGTTTTAATAACTTATCTATAAACTATAACCTCTCCTTCATGACAGCCTCCACC
CCACAACCCAAAAGGTTTAAGAAATAGAATTATAACTGTAAAGATGTTTATTTCAGGCATTGGATATTTTTTACTTTAGAAGCCTGCATA
ATGTTTCTGGATTTCATACTGTAACATTCAGGAATTCTTGGAGAAAATGGGTTTATTCACTGAACTCTAGTGCGGTTTACTCACTGCTGC
AAATACTGTATATTCAGGACTTGAAAGAAATGGTGAATGCCTATGGTGGATCCAAACTGATCCAGTATAAGACTACTGAATCTGCTACCA
AAACAGTTAATCAGTGAGTCGATGTTCTATTTTTTGTTTTGTTTCCTCCCCTATCTGTATTCCCAAAAATTACTTTGGGGCTAATTTAAC
AAGAACTTTAAATTGTGTTTTAATTGTAAAAATGGCAGGGGGTGGAATTATTACTCTATACATTCAACAGAGACTGAATAGATATGAAAG
CTGATTTTTTTTAATTACCATGCTTCACAATGTTAAGTTATATGGGGAGCAACAGCAAACAGGTGCTAATTTGTTTTGGATATAGTATAA
GCAGTGTCTGTGTTTTGAAAGAATAGAACACAGTTTGTAGTGCCACTGTTGTTTTGGGGGGGCTTTTTTCTTTTCGGAAATCTTAAACCT
TAAGATACTAAGGACGTTGTTTTGGTTGTACTTTGGAATTCTTAGTCACAAAATATATTTTGTTTACAAAAATTTCTGTAAAACAGGTTA
TAACAGTGTTTAAAGTCTCAGTTTCTTGCTTGGGGAACTTGTGTCCCTAATGTGTTTAGATTGCTAGATTGCTAAGGAGCTGATACTTTG
ACAGTGTTTTTAGACCTGTGTTACTAAAAAAAAGATGAATGTCCTGAAAAGGGTGTTGGGAGGGTGGTTCAACAAAGAAACAAAGATGTT
ATGGTGTTTAGATTTATGGTTGTTAAAAATGTCATCTCAAGTCAAGTCACTGGTCTGTTTGCATTTGATACATTTTTGTACTAACTAGCA
TTGTAAAATTATTTCATGATTAGAAATTACCTGTGGATATTTGTATAAAAGTGTGAAATAAATTTTTTATAAAAGTGTTCATTGTTTCGT

>In-frame_ENST00000375111_ENST00000409080_TCGA-G9-6348-01A_PLA2G2A_chr1_20301931_-_ITGA6_chr2_173351992_length(amino acids)=392AA_start in transcript=1097_stop in transcript=2275
MIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKA
KVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKV
TCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLN
YLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLA2G2A-ITGA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410614261077_1083695.66666666666661131.0HPS5
TgeneITGA6chr1:20301931chr2:173351992ENST0000026410713261077_1083656.66666666666661648.6666666666667HPS5
TgeneITGA6chr1:20301931chr2:173351992ENST0000034371313261077_1083651.66666666666661728.3333333333333HPS5
TgeneITGA6chr1:20301931chr2:173351992ENST0000037522114271077_1083695.66666666666661772.3333333333333HPS5
TgeneITGA6chr1:20301931chr2:173351992ENST0000040908013251077_1083656.66666666666661092.0HPS5
TgeneITGA6chr1:20301931chr2:173351992ENST0000040953213261077_1083537.66666666666661085.3333333333333HPS5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLA2G2A-ITGA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLA2G2A-ITGA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLA2G2AC0005586Bipolar Disorder2PSYGENET
HgenePLA2G2AC0004153Atherosclerosis1CTD_human
HgenePLA2G2AC0011581Depressive disorder1PSYGENET
HgenePLA2G2AC0014175Endometriosis1CTD_human
HgenePLA2G2AC0035126Reperfusion Injury1CTD_human
HgenePLA2G2AC0151744Myocardial Ischemia1CTD_human
HgenePLA2G2AC0269102Endometrioma1CTD_human
HgenePLA2G2AC0349218Recurrent depressive disorder1PSYGENET
HgenePLA2G2AC1563937Atherogenesis1CTD_human
TgeneITGA6C1856934Epidermolysis bullosa with pyloric atresia2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneITGA6C0003873Rheumatoid Arthritis1CTD_human