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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLAU-ZMAT2 (FusionGDB2 ID:65513)

Fusion Gene Summary for PLAU-ZMAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAU-ZMAT2
Fusion gene ID: 65513
HgeneTgene
Gene symbol

PLAU

ZMAT2

Gene ID

5328

153527

Gene nameplasminogen activator, urokinasezinc finger matrin-type 2
SynonymsATF|BDPLT5|QPD|UPA|URK|u-PAPtg-12|Snu23
Cytomap

10q22.2

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionurokinase-type plasminogen activatorU-plasminogen activatorplasminogen activator, urinaryzinc finger matrin-type protein 2
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000446342, ENST00000494287, 
ENST00000372764, ENST00000372762, 
ENST00000274712, 
Fusion gene scores* DoF score4 X 4 X 4=643 X 3 X 3=27
# samples 53
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLAU [Title/Abstract] AND ZMAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLAU(75677254)-ZMAT2(140080404), # samples:1
Anticipated loss of major functional domain due to fusion event.PLAU-ZMAT2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PLAU-ZMAT2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAU

GO:0010469

regulation of signaling receptor activity

8837777

HgenePLAU

GO:0014910

regulation of smooth muscle cell migration

8837777

HgenePLAU

GO:0030335

positive regulation of cell migration

25168896

HgenePLAU

GO:0031639

plasminogen activation

25978044

HgenePLAU

GO:0033628

regulation of cell adhesion mediated by integrin

8837777

HgenePLAU

GO:2000097

regulation of smooth muscle cell-matrix adhesion

8837777

TgeneZMAT2

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across PLAU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZMAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2M5-06APLAUchr10

75677254

-ZMAT2chr5

140080404

+


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Fusion Gene ORF analysis for PLAU-ZMAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000446342ENST00000274712PLAUchr10

75677254

-ZMAT2chr5

140080404

+
intron-3CDSENST00000494287ENST00000274712PLAUchr10

75677254

-ZMAT2chr5

140080404

+
Frame-shiftENST00000372764ENST00000274712PLAUchr10

75677254

-ZMAT2chr5

140080404

+
Frame-shiftENST00000372762ENST00000274712PLAUchr10

75677254

-ZMAT2chr5

140080404

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PLAU-ZMAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLAU-ZMAT2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PLAU-ZMAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PLAU-ZMAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLAU-ZMAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLAU-ZMAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLAUC0027051Myocardial Infarction6CTD_human
HgenePLAUC0034065Pulmonary Embolism6CTD_human
HgenePLAUC0040053Thrombosis6CTD_human
HgenePLAUC0087086Thrombus6CTD_human
HgenePLAUC0524702Pulmonary Thromboembolisms6CTD_human
HgenePLAUC2937358Cerebral Hemorrhage5CTD_human
HgenePLAUC0003838Arterial Occlusive Diseases4CTD_human
HgenePLAUC0007786Brain Ischemia4CTD_human
HgenePLAUC0018128Graft Occlusion, Vascular4CTD_human
HgenePLAUC0019080Hemorrhage4CTD_human
HgenePLAUC0042487Venous Thrombosis4CTD_human
HgenePLAUC0149871Deep Vein Thrombosis4CTD_human
HgenePLAUC0151699Intracranial Hemorrhage4CTD_human
HgenePLAUC0553692Brain hemorrhage4CTD_human
HgenePLAUC0751893Posterior Fossa Hemorrhage4CTD_human
HgenePLAUC0917798Cerebral Ischemia4CTD_human
HgenePLAUC0007785Cerebral Infarction3CTD_human
HgenePLAUC0033578Prostatic Neoplasms3CTD_human
HgenePLAUC0238281Middle Cerebral Artery Syndrome3CTD_human
HgenePLAUC0376358Malignant neoplasm of prostate3CTD_human
HgenePLAUC0740376Middle Cerebral Artery Thrombosis3CTD_human
HgenePLAUC0740391Middle Cerebral Artery Occlusion3CTD_human
HgenePLAUC0740392Infarction, Middle Cerebral Artery3CTD_human
HgenePLAUC0751010Cerebral Infarction, Left Hemisphere3CTD_human
HgenePLAUC0751011Cerebral Infarction, Right Hemisphere3CTD_human
HgenePLAUC0751012Anterior Choroidal Artery Infarction3CTD_human
HgenePLAUC0751014Subcortical Infarction3CTD_human
HgenePLAUC0751845Middle Cerebral Artery Embolus3CTD_human
HgenePLAUC0751846Left Middle Cerebral Artery Infarction3CTD_human
HgenePLAUC0751847Embolic Infarction, Middle Cerebral Artery3CTD_human
HgenePLAUC0751848Thrombotic Infarction, Middle Cerebral Artery3CTD_human
HgenePLAUC0751849Right Middle Cerebral Artery Infarction3CTD_human
HgenePLAUC0887799Posterior Choroidal Artery Infarction3CTD_human
HgenePLAUC0007820Cerebrovascular Disorders2CTD_human
HgenePLAUC0010068Coronary heart disease2CTD_human
HgenePLAUC0022116Ischemia2CTD_human
HgenePLAUC0023890Liver Cirrhosis2CTD_human
HgenePLAUC0027626Neoplasm Invasiveness2CTD_human
HgenePLAUC0034152Henoch-Schoenlein Purpura2CTD_human
HgenePLAUC0042386Vasculitis, Hemorrhagic2CTD_human
HgenePLAUC0086922Rheumatoid Purpura2CTD_human
HgenePLAUC0239946Fibrosis, Liver2CTD_human
HgenePLAUC0241832Cerebrovascular Insufficiency2CTD_human
HgenePLAUC0242461Purpura, Nonthrombocytopenic2CTD_human
HgenePLAUC0376362Purpura Hemorrhagica2CTD_human
HgenePLAUC0596298Cerebrovascular Occlusion2CTD_human
HgenePLAUC0001418Adenocarcinoma1CTD_human
HgenePLAUC0002962Angina Pectoris1CTD_human
HgenePLAUC0002965Angina, Unstable1CTD_human
HgenePLAUC0003460Anuria1CTD_human
HgenePLAUC0004096Asthma1CTD_human
HgenePLAUC0005967Bone neoplasms1CTD_human
HgenePLAUC0006114Cerebral Edema1CTD_human
HgenePLAUC0007138Carcinoma, Transitional Cell1CTD_human
HgenePLAUC0007273Carotid Artery Diseases1CTD_human
HgenePLAUC0007781Intracranial Embolism and Thrombosis1CTD_human
HgenePLAUC0017661IGA Glomerulonephritis1CTD_human
HgenePLAUC0018814Heart Rupture, Post-Infarction1CTD_human
HgenePLAUC0018965Hematuria1CTD_human
HgenePLAUC0020649Hypotension1CTD_human
HgenePLAUC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePLAUC0024623Malignant neoplasm of stomach1CTD_human
HgenePLAUC0027627Neoplasm Metastasis1CTD_human
HgenePLAUC0027643Neoplasm Recurrence, Local1CTD_human
HgenePLAUC0027697Nephritis1CTD_human
HgenePLAUC0030297Pancreatic Neoplasm1CTD_human
HgenePLAUC0035126Reperfusion Injury1CTD_human
HgenePLAUC0038356Stomach Neoplasms1CTD_human
HgenePLAUC0038454Cerebrovascular accident1CTD_human
HgenePLAUC0040038Thromboembolism1CTD_human
HgenePLAUC0042510Ventricular Fibrillation1CTD_human
HgenePLAUC0086666Myocardial Preinfarction Syndrome1CTD_human
HgenePLAUC0149649Cholesterol Embolism1CTD_human
HgenePLAUC0205641Adenocarcinoma, Basal Cell1CTD_human
HgenePLAUC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgenePLAUC0205643Carcinoma, Cribriform1CTD_human
HgenePLAUC0205644Carcinoma, Granular Cell1CTD_human
HgenePLAUC0205645Adenocarcinoma, Tubular1CTD_human
HgenePLAUC0279530Malignant Bone Neoplasm1CTD_human
HgenePLAUC0338575Sagittal Sinus Thrombosis1CTD_human
HgenePLAUC0346647Malignant neoplasm of pancreas1CTD_human
HgenePLAUC0403823Asthenozoospermia1CTD_human
HgenePLAUC0472387Vasogenic Cerebral Edema1CTD_human
HgenePLAUC0472388Cytotoxic Cerebral Edema1CTD_human
HgenePLAUC0577631Carotid Atherosclerosis1CTD_human
HgenePLAUC0600178External Carotid Artery Diseases1CTD_human
HgenePLAUC0750969Vasogenic Brain Edema1CTD_human
HgenePLAUC0750970Cytotoxic Brain Edema1CTD_human
HgenePLAUC0750986Internal Carotid Artery Diseases1CTD_human
HgenePLAUC0750987Arterial Diseases, Common Carotid1CTD_human
HgenePLAUC0751823Septic Phlebitis, Sagittal Sinus1CTD_human
HgenePLAUC0751824Sagittal Sinus Thrombophlebitis1CTD_human
HgenePLAUC0751956Acute Cerebrovascular Accidents1CTD_human
HgenePLAUC0877855Cerebral Embolism and Thrombosis1CTD_human
HgenePLAUC0936247Brain Embolism and Thrombosis1CTD_human
HgenePLAUC1527311Brain Edema1CTD_human
HgenePLAUC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgenePLAUC1800706Idiopathic Pulmonary Fibrosis1CTD_human
HgenePLAUC1866423Quebec platelet disorder1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePLAUC4721508Hamman-Rich Disease1CTD_human
HgenePLAUC4721509Usual Interstitial Pneumonia1CTD_human
HgenePLAUC4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human