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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PLAUR-XRCC1 (FusionGDB2 ID:65521) |
Fusion Gene Summary for PLAUR-XRCC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLAUR-XRCC1 | Fusion gene ID: 65521 | Hgene | Tgene | Gene symbol | PLAUR | XRCC1 | Gene ID | 5329 | 7515 |
| Gene name | plasminogen activator, urokinase receptor | X-ray repair cross complementing 1 | |
| Synonyms | CD87|U-PAR|UPAR|URKR | RCC|SCAR26 | |
| Cytomap | 19q13.31 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | urokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor | DNA repair protein XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1X-ray repair cross-complementing protein 1 | |
| Modification date | 20200329 | 20200329 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000339082, ENST00000601723, ENST00000340093, ENST00000221264, | ENST00000262887, ENST00000543982, | |
| Fusion gene scores | * DoF score | 9 X 6 X 8=432 | 4 X 4 X 4=64 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLAUR [Title/Abstract] AND XRCC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PLAUR(44156377)-XRCC1(44050258), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLAUR | GO:0043388 | positive regulation of DNA binding | 22984561 |
| Tgene | XRCC1 | GO:0033194 | response to hydroperoxide | 28002403 |
| Fusion gene breakpoints across PLAUR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across XRCC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-55-8094-01A | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| ChimerDB4 | LUAD | TCGA-55-8094-01A | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
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Fusion Gene ORF analysis for PLAUR-XRCC1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000339082 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| In-frame | ENST00000339082 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| intron-3CDS | ENST00000601723 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| intron-3CDS | ENST00000601723 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| In-frame | ENST00000340093 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| In-frame | ENST00000340093 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| In-frame | ENST00000221264 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| In-frame | ENST00000221264 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000339082 | PLAUR | chr19 | 44156377 | - | ENST00000262887 | XRCC1 | chr19 | 44050258 | - | 1628 | 800 | 46 | 1275 | 409 |
| ENST00000339082 | PLAUR | chr19 | 44156377 | - | ENST00000543982 | XRCC1 | chr19 | 44050258 | - | 1356 | 800 | 46 | 1275 | 409 |
| ENST00000340093 | PLAUR | chr19 | 44156377 | - | ENST00000262887 | XRCC1 | chr19 | 44050258 | - | 1812 | 984 | 170 | 1459 | 429 |
| ENST00000340093 | PLAUR | chr19 | 44156377 | - | ENST00000543982 | XRCC1 | chr19 | 44050258 | - | 1540 | 984 | 170 | 1459 | 429 |
| ENST00000221264 | PLAUR | chr19 | 44156377 | - | ENST00000262887 | XRCC1 | chr19 | 44050258 | - | 1874 | 1046 | 367 | 1521 | 384 |
| ENST00000221264 | PLAUR | chr19 | 44156377 | - | ENST00000543982 | XRCC1 | chr19 | 44050258 | - | 1602 | 1046 | 367 | 1521 | 384 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000339082 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.003497445 | 0.9965025 |
| ENST00000339082 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.003237134 | 0.9967629 |
| ENST00000340093 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.002822439 | 0.9971776 |
| ENST00000340093 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.002536311 | 0.9974637 |
| ENST00000221264 | ENST00000262887 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.00236695 | 0.997633 |
| ENST00000221264 | ENST00000543982 | PLAUR | chr19 | 44156377 | - | XRCC1 | chr19 | 44050258 | - | 0.002000538 | 0.9979995 |
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Fusion Genomic Features for PLAUR-XRCC1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PLAUR-XRCC1 |
| Go to FGviewer for the breakpoints of chr19:44156377-chr19:44050258 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000221264 | - | 5 | 6 | 23_114 | 206.33333333333334 | 291.0 | Domain | Note=UPAR/Ly6 1 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000339082 | - | 6 | 7 | 115_213 | 251.33333333333334 | 282.0 | Domain | Note=UPAR/Ly6 2 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000339082 | - | 6 | 7 | 23_114 | 251.33333333333334 | 282.0 | Domain | Note=UPAR/Ly6 1 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000340093 | - | 6 | 7 | 115_213 | 251.33333333333334 | 336.0 | Domain | Note=UPAR/Ly6 2 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000340093 | - | 6 | 7 | 23_114 | 251.33333333333334 | 336.0 | Domain | Note=UPAR/Ly6 1 |
| Tgene | XRCC1 | chr19:44156377 | chr19:44050258 | ENST00000262887 | 11 | 17 | 538_629 | 475.3333333333333 | 634.0 | Domain | BRCT 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000221264 | - | 5 | 6 | 115_213 | 206.33333333333334 | 291.0 | Domain | Note=UPAR/Ly6 2 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000221264 | - | 5 | 6 | 214_305 | 206.33333333333334 | 291.0 | Domain | Note=UPAR/Ly6 3 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000339082 | - | 6 | 7 | 214_305 | 251.33333333333334 | 282.0 | Domain | Note=UPAR/Ly6 3 |
| Hgene | PLAUR | chr19:44156377 | chr19:44050258 | ENST00000340093 | - | 6 | 7 | 214_305 | 251.33333333333334 | 336.0 | Domain | Note=UPAR/Ly6 3 |
| Tgene | XRCC1 | chr19:44156377 | chr19:44050258 | ENST00000262887 | 11 | 17 | 315_403 | 475.3333333333333 | 634.0 | Domain | BRCT 1 |
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Fusion Gene Sequence for PLAUR-XRCC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000339082_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1628nt_BP=800nt AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC CTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGGACCT CTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAG GACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTGGCCG GGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCT GCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACCGCCA CCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACAC CACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCA TGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGA CAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGA GAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCT CCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTT CAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGAT GGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGT GGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTG GTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGA AGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCA ACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTG >In-frame_ENST00000339082_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=409AA_start in transcript=46_stop in transcript=1275 MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE VVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRR VAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV -------------------------------------------------------------- >In-frame_ENST00000339082_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1356nt_BP=800nt AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC CTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGGACCT CTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAG GACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTGGCCG GGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCT GCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACCGCCA CCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACAC CACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCA TGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGA CAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGA GAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCT CCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTT CAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGAT GGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGT GGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTG >In-frame_ENST00000339082_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=409AA_start in transcript=46_stop in transcript=1275 MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE VVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRR VAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV -------------------------------------------------------------- >In-frame_ENST00000340093_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1812nt_BP=984nt CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC ACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGG ACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCA ACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTG GCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGA GCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACC GCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCA ACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCA CCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGAC AGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGG AGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTG AGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAG CCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCC TGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATG GGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGA GTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTA GAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCC CTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCT >In-frame_ENST00000340093_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=429AA_start in transcript=170_stop in transcript=1459 MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRP KDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT HEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIR -------------------------------------------------------------- >In-frame_ENST00000340093_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1540nt_BP=984nt CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC ACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGG ACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCA ACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTG GCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGA GCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACC GCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCA ACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCA CCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGAC AGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGG AGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTG AGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAG CCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCC TGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATG GGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGA >In-frame_ENST00000340093_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=429AA_start in transcript=170_stop in transcript=1459 MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRP KDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT HEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIR -------------------------------------------------------------- >In-frame_ENST00000221264_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1874nt_BP=1046nt CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGA GTGCGCCCTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTAC CCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTG CAACCAGGGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGA GAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGT CCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTT CCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGA CACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCA CTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATAT GAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGT TCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTG CTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAA ACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTT GGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCAC >In-frame_ENST00000221264_ENST00000262887_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=384AA_start in transcript=367_stop in transcript=1521 MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEVLE LENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGST DENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRP -------------------------------------------------------------- >In-frame_ENST00000221264_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(transcript)=1602nt_BP=1046nt CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGA GTGCGCCCTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTAC CCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTG CAACCAGGGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGA GAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGT CCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTT CCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGA CACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCA CTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATAT GAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGT TCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTG >In-frame_ENST00000221264_ENST00000543982_TCGA-55-8094-01A_PLAUR_chr19_44156377_-_XRCC1_chr19_44050258_length(amino acids)=384AA_start in transcript=367_stop in transcript=1521 MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEVLE LENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGST DENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PLAUR-XRCC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PLAUR-XRCC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PLAUR-XRCC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLAUR | C0004352 | Autistic Disorder | 2 | CTD_human |
| Hgene | PLAUR | C0006826 | Malignant Neoplasms | 1 | CTD_human |
| Hgene | PLAUR | C0007097 | Carcinoma | 1 | CTD_human |
| Hgene | PLAUR | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | PLAUR | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | PLAUR | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | PLAUR | C0027651 | Neoplasms | 1 | CTD_human |
| Hgene | PLAUR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PLAUR | C0086692 | Benign Neoplasm | 1 | CTD_human |
| Hgene | PLAUR | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| Hgene | PLAUR | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| Hgene | PLAUR | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| Hgene | PLAUR | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| Hgene | PLAUR | C0205699 | Carcinomatosis | 1 | CTD_human |
| Hgene | PLAUR | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | PLAUR | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | PLAUR | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| Hgene | PLAUR | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
| Hgene | PLAUR | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
| Tgene | XRCC1 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Tgene | XRCC1 | C0376358 | Malignant neoplasm of prostate | 3 | CTD_human |
| Tgene | XRCC1 | C0025500 | Mesothelioma | 2 | CTD_human |
| Tgene | XRCC1 | C1449861 | Micronuclei, Chromosome-Defective | 2 | CTD_human |
| Tgene | XRCC1 | C1449862 | Micronuclei, Genotoxicant-Induced | 2 | CTD_human |
| Tgene | XRCC1 | C0005612 | Birth Weight | 1 | CTD_human |
| Tgene | XRCC1 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | XRCC1 | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Tgene | XRCC1 | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Tgene | XRCC1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Tgene | XRCC1 | C0028797 | Occupational Diseases | 1 | CTD_human |
| Tgene | XRCC1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | XRCC1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | XRCC1 | C0038362 | Stomatitis | 1 | CTD_human |
| Tgene | XRCC1 | C0041834 | Erythema | 1 | CTD_human |
| Tgene | XRCC1 | C0259783 | mixed gliomas | 1 | CTD_human |
| Tgene | XRCC1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | XRCC1 | C0555198 | Malignant Glioma | 1 | CTD_human |
| Tgene | XRCC1 | C1568868 | Oral Mucositis | 1 | CTD_human |
| Tgene | XRCC1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Tgene | XRCC1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Tgene | XRCC1 | C4539948 | SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 26 | 1 | GENOMICS_ENGLAND;UNIPROT |
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