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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLCB1-NLGN2 (FusionGDB2 ID:65554)

Fusion Gene Summary for PLCB1-NLGN2

Fusion gene summary

Fusion gene information	Fusion gene name: PLCB1-NLGN2
	Fusion gene ID: 65554
		Hgene	Tgene
	Gene symbol	PLCB1	NLGN2
	Gene ID	23236	57555
	Gene name	phospholipase C beta 1	neuroligin 2
	Synonyms	EIEE12\|PI-PLC\|PLC-154\|PLC-I\|PLC-beta-1\|PLC154\|PLCB1A\|PLCB1B	-
	Cytomap	20p12.3	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C,	neuroligin-2
	Modification date	20200313	20200313
	UniProtAcc	.	Q8NFZ4
	Ensembl transtripts involved in fusion gene	ENST00000378641, ENST00000338037, ENST00000378637, ENST00000494924,	ENST00000575301, ENST00000572893, ENST00000302926,
Fusion gene scores	* DoF score	24 X 20 X 10=4800	4 X 4 X 2=32
	# samples	22	4
	** MAII score	log2(22/4800*10)=-4.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PLCB1 [Title/Abstract] AND NLGN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLCB1(8630065)-NLGN2(7320966), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLCB1	GO:0035722	interleukin-12-mediated signaling pathway	11743656
Hgene	PLCB1	GO:0035723	interleukin-15-mediated signaling pathway	11743656
Hgene	PLCB1	GO:0046330	positive regulation of JNK cascade	9500449
Hgene	PLCB1	GO:0070498	interleukin-1-mediated signaling pathway	8872139
Tgene	NLGN2	GO:1902474	positive regulation of protein localization to synapse	24613359

Fusion gene breakpoints across PLCB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NLGN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA984410	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+

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Fusion Gene ORF analysis for PLCB1-NLGN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000378641	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000378641	ENST00000572893	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000378641	ENST00000302926	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
In-frame	ENST00000338037	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000338037	ENST00000572893	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000338037	ENST00000302926	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
In-frame	ENST00000378637	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000378637	ENST00000572893	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
5CDS-intron	ENST00000378637	ENST00000302926	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
intron-3CDS	ENST00000494924	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
intron-intron	ENST00000494924	ENST00000572893	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+
intron-intron	ENST00000494924	ENST00000302926	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378641	PLCB1	chr20	8630065	-	ENST00000575301	NLGN2	chr17	7320966	+	2061	1024	475	1032	185
ENST00000338037	PLCB1	chr20	8630065	-	ENST00000575301	NLGN2	chr17	7320966	+	1613	576	27	584	185
ENST00000378637	PLCB1	chr20	8630065	-	ENST00000575301	NLGN2	chr17	7320966	+	1589	552	3	560	185

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378641	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+	0.009842265	0.99015766
ENST00000338037	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+	0.005117335	0.9948827
ENST00000378637	ENST00000575301	PLCB1	chr20	8630065	-	NLGN2	chr17	7320966	+	0.0073267	0.99267334

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Fusion Genomic Features for PLCB1-NLGN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLCB1-NLGN2

Go to
FGviewer for the breakpoints of chr20:8630065-chr17:7320966
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NLGN2 Q8NFZ4
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q69ZK9}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NLGN2

chr20:8630065

chr17:7320966

ENST00000302926

15_677

836.0

Topological domain

Extracellular

Tgene

NLGN2

chr20:8630065

chr17:7320966

ENST00000302926

699_835

836.0

Topological domain

Cytoplasmic

Tgene

NLGN2

chr20:8630065

chr17:7320966

ENST00000575301

15_677

836.0

Topological domain

Extracellular

Tgene

NLGN2

chr20:8630065

chr17:7320966

ENST00000575301

699_835

836.0

Topological domain

Cytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000338037

316_467

1217.0

Domain

PI-PLC X-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000338037

540_656

1217.0

Domain

PI-PLC Y-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000338037

656_786

1217.0

Domain

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378637

316_467

1174.0

Domain

PI-PLC X-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378637

540_656

1174.0

Domain

PI-PLC Y-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378637

656_786

1174.0

Domain

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378641

316_467

2075.6666666666665

Domain

PI-PLC X-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378641

540_656

2075.6666666666665

Domain

PI-PLC Y-box

Hgene

PLCB1

chr20:8630065

chr17:7320966

ENST00000378641

656_786

2075.6666666666665

Domain

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Fusion Gene Sequence for PLCB1-NLGN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000378641_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(transcript)=2061nt_BP=1024nt
CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA
CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA
GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC
CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG
AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG
CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT
CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT
TTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAA
GGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGT
GAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCT
GGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAA
AAATTTAGAGGCTTGTAGTCTTCCATCTTCAAGGGGGCCCTGACCCTGCTGCCCAGTGGCCTGGGGCCACCGCCACCCCCACCGCCCCCC
TCCCTTCATCCCTTCGGGCCCTTCCCCCCGCCCCCTCCCACCGCCACCAGCCACAACAACACGCTACCCCACCCCCACTCCACCACTCGG
GTATAGGGGGTGGGTGGGGAGGCCCTCCTCCCCGGCCCTCCCTGGCCCGGCCACTCCGAAGGCAGGGAGGAGGACTTGGCAACTGGCTTT
TCTCCTGTGGAGTCGTCACACGCCATCCAGCAGCGCTAAGGTGGACATGGGATTCCTCCCTGCGATGCGTGTCTTTCCCACGCAGAGAAG
CCCAGTCTCTTCTCTGGATCTGGGCCTTTGAACAACTGGGGGGCGTTTTCTCCCCCCCATTGGGACACCAGTCTTCGGTGTGTGGAATGT
GGTATTTTCCCGCGTGGAGGTGTGCTTTCTCACAACGGGGTGTGTTTTCCCATGTGCAGGGTGAGGTTTTTTTTTGCCACCCTGGACACA
TGTTGGCCCCCTCAAAGAATTTCTGTGGGGATTTGTACCCCAGAATCCTGTTCCCCCATCCCTTCTCCCACCTCCTCCCCTCTCCCTCCC
CCTGGAGACCCTGGAAGTGGTGTGTTCACATACAGTGACCCTTGGCCACCAGACCACAGAGGATGGAGCCTGGGAAGCAGCGAGGAAATC
ACAGCCCCCTCGCCCCTGCCTCCCTTGCCCCTACCCCGGCGAAGCATGTTCCCCCCGACGCCCCCCTTGGCACAAGTCAGATGAAGCACG
TTCTGCCGGGGAGGCCCTCACCTTCCAGAGAGGACAGACACAGATTTCCTGCTGGGGGAGGGAGGAGTCCACGCATCCTGATGCTGCCTG
GAAGCTTATTTTCCCGTGGCCAGGACGCATTTCTCTGAGTGGAAACAGGTTCTTGCATGTGGATGTGTGTTTCCCCAGGCAGACGGCCCC

>In-frame_ENST00000378641_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(amino acids)=185AA_start in transcript=475_stop in transcript=1032
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL
DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNLEACSLP

--------------------------------------------------------------
>In-frame_ENST00000338037_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(transcript)=1613nt_BP=576nt
GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC
CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC
TTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCC
AAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTC
GTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTG
CTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTC
AAAAATTTAGAGGCTTGTAGTCTTCCATCTTCAAGGGGGCCCTGACCCTGCTGCCCAGTGGCCTGGGGCCACCGCCACCCCCACCGCCCC
CCTCCCTTCATCCCTTCGGGCCCTTCCCCCCGCCCCCTCCCACCGCCACCAGCCACAACAACACGCTACCCCACCCCCACTCCACCACTC
GGGTATAGGGGGTGGGTGGGGAGGCCCTCCTCCCCGGCCCTCCCTGGCCCGGCCACTCCGAAGGCAGGGAGGAGGACTTGGCAACTGGCT
TTTCTCCTGTGGAGTCGTCACACGCCATCCAGCAGCGCTAAGGTGGACATGGGATTCCTCCCTGCGATGCGTGTCTTTCCCACGCAGAGA
AGCCCAGTCTCTTCTCTGGATCTGGGCCTTTGAACAACTGGGGGGCGTTTTCTCCCCCCCATTGGGACACCAGTCTTCGGTGTGTGGAAT
GTGGTATTTTCCCGCGTGGAGGTGTGCTTTCTCACAACGGGGTGTGTTTTCCCATGTGCAGGGTGAGGTTTTTTTTTGCCACCCTGGACA
CATGTTGGCCCCCTCAAAGAATTTCTGTGGGGATTTGTACCCCAGAATCCTGTTCCCCCATCCCTTCTCCCACCTCCTCCCCTCTCCCTC
CCCCTGGAGACCCTGGAAGTGGTGTGTTCACATACAGTGACCCTTGGCCACCAGACCACAGAGGATGGAGCCTGGGAAGCAGCGAGGAAA
TCACAGCCCCCTCGCCCCTGCCTCCCTTGCCCCTACCCCGGCGAAGCATGTTCCCCCCGACGCCCCCCTTGGCACAAGTCAGATGAAGCA
CGTTCTGCCGGGGAGGCCCTCACCTTCCAGAGAGGACAGACACAGATTTCCTGCTGGGGGAGGGAGGAGTCCACGCATCCTGATGCTGCC
TGGAAGCTTATTTTCCCGTGGCCAGGACGCATTTCTCTGAGTGGAAACAGGTTCTTGCATGTGGATGTGTGTTTCCCCAGGCAGACGGCC

>In-frame_ENST00000338037_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(amino acids)=185AA_start in transcript=27_stop in transcript=584
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL
DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNLEACSLP

--------------------------------------------------------------
>In-frame_ENST00000378637_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(transcript)=1589nt_BP=552nt
CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC
AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG
GAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTT
TTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTC
GTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGAT
GCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAATTTAGAGGCTTGTAGTCTT
CCATCTTCAAGGGGGCCCTGACCCTGCTGCCCAGTGGCCTGGGGCCACCGCCACCCCCACCGCCCCCCTCCCTTCATCCCTTCGGGCCCT
TCCCCCCGCCCCCTCCCACCGCCACCAGCCACAACAACACGCTACCCCACCCCCACTCCACCACTCGGGTATAGGGGGTGGGTGGGGAGG
CCCTCCTCCCCGGCCCTCCCTGGCCCGGCCACTCCGAAGGCAGGGAGGAGGACTTGGCAACTGGCTTTTCTCCTGTGGAGTCGTCACACG
CCATCCAGCAGCGCTAAGGTGGACATGGGATTCCTCCCTGCGATGCGTGTCTTTCCCACGCAGAGAAGCCCAGTCTCTTCTCTGGATCTG
GGCCTTTGAACAACTGGGGGGCGTTTTCTCCCCCCCATTGGGACACCAGTCTTCGGTGTGTGGAATGTGGTATTTTCCCGCGTGGAGGTG
TGCTTTCTCACAACGGGGTGTGTTTTCCCATGTGCAGGGTGAGGTTTTTTTTTGCCACCCTGGACACATGTTGGCCCCCTCAAAGAATTT
CTGTGGGGATTTGTACCCCAGAATCCTGTTCCCCCATCCCTTCTCCCACCTCCTCCCCTCTCCCTCCCCCTGGAGACCCTGGAAGTGGTG
TGTTCACATACAGTGACCCTTGGCCACCAGACCACAGAGGATGGAGCCTGGGAAGCAGCGAGGAAATCACAGCCCCCTCGCCCCTGCCTC
CCTTGCCCCTACCCCGGCGAAGCATGTTCCCCCCGACGCCCCCCTTGGCACAAGTCAGATGAAGCACGTTCTGCCGGGGAGGCCCTCACC
TTCCAGAGAGGACAGACACAGATTTCCTGCTGGGGGAGGGAGGAGTCCACGCATCCTGATGCTGCCTGGAAGCTTATTTTCCCGTGGCCA
GGACGCATTTCTCTGAGTGGAAACAGGTTCTTGCATGTGGATGTGTGTTTCCCCAGGCAGACGGCCCCTCTCTTCCCAGCACTTCCCTGC

>In-frame_ENST00000378637_ENST00000575301_AA984410_PLCB1_chr20_8630065_-_NLGN2_chr17_7320966_length(amino acids)=185AA_start in transcript=3_stop in transcript=560
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL
DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNLEACSLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLCB1-NLGN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PLCB1-NLGN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PLCB1-NLGN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PLCB1	C0037769	West Syndrome	2	ORPHANET
Hgene	PLCB1	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	PLCB1	C0007102	Malignant tumor of colon	1	CTD_human
Hgene	PLCB1	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	PLCB1	C0030193	Pain	1	CTD_human
Hgene	PLCB1	C0036341	Schizophrenia	1	CTD_human
Hgene	PLCB1	C0041696	Unipolar Depression	1	PSYGENET
Hgene	PLCB1	C0234230	Pain, Burning	1	CTD_human
Hgene	PLCB1	C0234238	Ache	1	CTD_human
Hgene	PLCB1	C0234254	Radiating pain	1	CTD_human
Hgene	PLCB1	C0458257	Pain, Splitting	1	CTD_human
Hgene	PLCB1	C0458259	Pain, Crushing	1	CTD_human
Hgene	PLCB1	C0751407	Pain, Migratory	1	CTD_human
Hgene	PLCB1	C0751408	Suffering, Physical	1	CTD_human
Hgene	PLCB1	C1269683	Major Depressive Disorder	1	PSYGENET
Hgene	PLCB1	C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Hgene	PLCB1	C3150988	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12	1	CTD_human;GENOMICS_ENGLAND
Hgene	PLCB1	C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human
Tgene	NLGN2	C0036341	Schizophrenia	1	PSYGENET