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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLCB1-RBL1 (FusionGDB2 ID:65558)

Fusion Gene Summary for PLCB1-RBL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCB1-RBL1
Fusion gene ID: 65558
HgeneTgene
Gene symbol

PLCB1

RBL1

Gene ID

23236

5933

Gene namephospholipase C beta 1RB transcriptional corepressor like 1
SynonymsEIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1BCP107|PRB1|p107
Cytomap

20p12.3

20q11.23

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C, retinoblastoma-like protein 1107 kDa retinoblastoma-associated proteinretinoblastoma-like 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000378641, ENST00000338037, 
ENST00000378637, ENST00000494924, 
ENST00000373664, ENST00000344359, 
ENST00000598590, 
Fusion gene scores* DoF score24 X 20 X 10=48008 X 9 X 5=360
# samples 229
** MAII scorelog2(22/4800*10)=-4.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLCB1 [Title/Abstract] AND RBL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLCB1(8131018)-RBL1(35651229), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLCB1

GO:0035722

interleukin-12-mediated signaling pathway

11743656

HgenePLCB1

GO:0035723

interleukin-15-mediated signaling pathway

11743656

HgenePLCB1

GO:0046330

positive regulation of JNK cascade

9500449

HgenePLCB1

GO:0070498

interleukin-1-mediated signaling pathway

8872139

TgeneRBL1

GO:0043550

regulation of lipid kinase activity

16286473


check buttonFusion gene breakpoints across PLCB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RBL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-A5C4-01APLCB1chr20

8131018

+RBL1chr20

35651229

-
ChimerDB4LUSCTCGA-22-A5C4PLCB1chr20

8131018

+RBL1chr20

35651229

-
ChimerDB4LUSCTCGA-22-A5C4-01APLCB1chr20

8131018

-RBL1chr20

35651229

-


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Fusion Gene ORF analysis for PLCB1-RBL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000378641ENST00000373664PLCB1chr20

8131018

+RBL1chr20

35651229

-
In-frameENST00000378641ENST00000344359PLCB1chr20

8131018

+RBL1chr20

35651229

-
5CDS-intronENST00000378641ENST00000598590PLCB1chr20

8131018

+RBL1chr20

35651229

-
In-frameENST00000338037ENST00000373664PLCB1chr20

8131018

+RBL1chr20

35651229

-
In-frameENST00000338037ENST00000344359PLCB1chr20

8131018

+RBL1chr20

35651229

-
5CDS-intronENST00000338037ENST00000598590PLCB1chr20

8131018

+RBL1chr20

35651229

-
In-frameENST00000378637ENST00000373664PLCB1chr20

8131018

+RBL1chr20

35651229

-
In-frameENST00000378637ENST00000344359PLCB1chr20

8131018

+RBL1chr20

35651229

-
5CDS-intronENST00000378637ENST00000598590PLCB1chr20

8131018

+RBL1chr20

35651229

-
intron-3CDSENST00000494924ENST00000373664PLCB1chr20

8131018

+RBL1chr20

35651229

-
intron-3CDSENST00000494924ENST00000344359PLCB1chr20

8131018

+RBL1chr20

35651229

-
intron-intronENST00000494924ENST00000598590PLCB1chr20

8131018

+RBL1chr20

35651229

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378641PLCB1chr208131018+ENST00000373664RBL1chr2035651229-38876524751476333
ENST00000378641PLCB1chr208131018+ENST00000344359RBL1chr2035651229-14346524751314279
ENST00000338037PLCB1chr208131018+ENST00000373664RBL1chr2035651229-3439204271028333
ENST00000338037PLCB1chr208131018+ENST00000344359RBL1chr2035651229-98620427866279
ENST00000378637PLCB1chr208131018+ENST00000373664RBL1chr2035651229-341518031004333
ENST00000378637PLCB1chr208131018+ENST00000344359RBL1chr2035651229-9621803842279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378641ENST00000373664PLCB1chr208131018+RBL1chr2035651229-0.0002581240.99974185
ENST00000378641ENST00000344359PLCB1chr208131018+RBL1chr2035651229-0.001559570.99844044
ENST00000338037ENST00000373664PLCB1chr208131018+RBL1chr2035651229-0.0001856690.99981433
ENST00000338037ENST00000344359PLCB1chr208131018+RBL1chr2035651229-0.0005125990.9994874
ENST00000378637ENST00000373664PLCB1chr208131018+RBL1chr2035651229-0.0001849780.99981505
ENST00000378637ENST00000344359PLCB1chr208131018+RBL1chr2035651229-0.0004813960.99951863

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Fusion Genomic Features for PLCB1-RBL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLCB1-RBL1


check button Go to

FGviewer for the breakpoints of chr20:8131018-chr20:35651229

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCB1chr20:8131018chr20:35651229ENST00000338037+232316_46759.01217.0DomainPI-PLC X-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000338037+232540_65659.01217.0DomainPI-PLC Y-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000338037+232656_78659.01217.0DomainC2
HgenePLCB1chr20:8131018chr20:35651229ENST00000378637+232316_46759.01174.0DomainPI-PLC X-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000378637+232540_65659.01174.0DomainPI-PLC Y-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000378637+232656_78659.01174.0DomainC2
HgenePLCB1chr20:8131018chr20:35651229ENST00000378641+233316_46759.02075.6666666666665DomainPI-PLC X-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000378641+233540_65659.02075.6666666666665DomainPI-PLC Y-box
HgenePLCB1chr20:8131018chr20:35651229ENST00000378641+233656_78659.02075.6666666666665DomainC2
TgeneRBL1chr20:8131018chr20:35651229ENST000003443591521385_584794.01015.0RegionDomain A
TgeneRBL1chr20:8131018chr20:35651229ENST000003443591521385_949794.01015.0RegionPocket%3B binds T and E1A
TgeneRBL1chr20:8131018chr20:35651229ENST000003443591521585_780794.01015.0RegionSpacer
TgeneRBL1chr20:8131018chr20:35651229ENST000003443591521781_949794.01015.0RegionDomain B
TgeneRBL1chr20:8131018chr20:35651229ENST000003736641522385_584794.01069.0RegionDomain A
TgeneRBL1chr20:8131018chr20:35651229ENST000003736641522385_949794.01069.0RegionPocket%3B binds T and E1A
TgeneRBL1chr20:8131018chr20:35651229ENST000003736641522585_780794.01069.0RegionSpacer
TgeneRBL1chr20:8131018chr20:35651229ENST000003736641522781_949794.01069.0RegionDomain B


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Fusion Gene Sequence for PLCB1-RBL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000378641_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=3887nt_BP=652nt
CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA
CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA
GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC
CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG
AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG
CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT
CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT
TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG
AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC
CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA
CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG
TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT
ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC
ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC
ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAG
AACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACG
ACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTT
GGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTA
AAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGT
CCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAG
CCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGA
GGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAA
AACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAA
ACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATG
CTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTC
TGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTAT
AAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATG
GGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTC
AAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTA
TGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATC
ACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGT
ATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATT
AGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTG
TTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTT
AACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTA
TGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTT
GGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAAT
TACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGC
TATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGT
GGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGC
CCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATC
ACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGA
AAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAATTG

>In-frame_ENST00000378641_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=333AA_start in transcript=475_stop in transcript=1476
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------
>In-frame_ENST00000378641_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=1434nt_BP=652nt
CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA
CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA
GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC
CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG
AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG
CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT
CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT
TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG
AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC
CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA
CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG
TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT
ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC
ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC
ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAG

>In-frame_ENST00000378641_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=279AA_start in transcript=475_stop in transcript=1314
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------
>In-frame_ENST00000338037_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=3439nt_BP=204nt
GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC
CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC
TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA
CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT
GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT
CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT
TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA
ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT
CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT
ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAG
AGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAA
CGACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAG
TTGGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTT
TAAAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATA
GTCCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACC
AGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGG
GAGGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGT
AAAACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAG
AAACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCA
TGCTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTC
TCTGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTT
ATAAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAA
TGGGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTC
TCAAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGAT
TATGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAA
TCACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCA
GTATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTA
TTAGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAG
TGTTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCT
TTAACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTT
TATGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGAT
TTGGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAA
ATTACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTT
GCTATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCT
GTGGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATA
GCCCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGA
TCACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCA
GAAAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAAT

>In-frame_ENST00000338037_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=333AA_start in transcript=27_stop in transcript=1028
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------
>In-frame_ENST00000338037_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=986nt_BP=204nt
GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC
CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC
TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA
CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT
GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT
CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT
TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA
ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT
CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT
ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTC

>In-frame_ENST00000338037_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=279AA_start in transcript=27_stop in transcript=866
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------
>In-frame_ENST00000378637_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=3415nt_BP=180nt
CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC
AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG
GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT
GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA
ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG
AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA
ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA
TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC
TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC
AAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCC
ATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAA
AGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTTGGAGCTCTGTCCTTCAAACCTT
TTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTAAAATATTTATCCAAAATGTAGT
TGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGTCCGGCCAGGCGCTGTGGCTCAC
GCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCC
CATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAA
CCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAAAACTCCATCTCAAAAAATATAT
ATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAAACCCCATAACTTTTTAGCTCTC
TTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATGCTTTGAGATATTTGTATTCTTA
ATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTCTGGCCCACTGTGGTAATTCCAC
ATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTATAAACAGATTTGTACCTGAGCCC
CAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATGGGGCACTTTCTTCTTTTGTAAA
CTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTCAAAATAGGCAGCTGCTTCTGAA
GCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTATGTGTGATATACTGTTTTTGAG
ATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATCACATAAATATCATCTCATGCCT
CATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGTATTGTTAGTGCATCATGAGTTT
CCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATTAGGGATGCTTTTTTCAGTACTA
GGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTGTTAGGGATGCTTTTCAGTACTA
GGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTTAACGTTTACTTTTTCTAGTGTG
TGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTATGTTTCTAACTGCAAACCTTAA
TTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTTGGCCGTCACTAATTAGTATTCT
CAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAATTACATCCTCATTCTTTGTGTAG
TATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGCTATAATTGTTATTTTTATCTTC
ATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGTGGCTCATGCCTATAATCCCAAC
ACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGCCCTCATCTCTACAAAAAATAAA
AAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATCACTTGAGACTGGGAGATTCTGA
GGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGAAAAGGAAAAAAAGAAATTCTGG

>In-frame_ENST00000378637_ENST00000373664_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=333AA_start in transcript=3_stop in transcript=1004
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------
>In-frame_ENST00000378637_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(transcript)=962nt_BP=180nt
CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC
AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG
GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT
GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA
ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG
AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA
ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA
TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC
TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC
AAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAACTGTTAATCCTGCCTCTTT

>In-frame_ENST00000378637_ENST00000344359_TCGA-22-A5C4-01A_PLCB1_chr20_8131018_+_RBL1_chr20_35651229_length(amino acids)=279AA_start in transcript=3_stop in transcript=842
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE
FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT
PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLCB1-RBL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLCB1-RBL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLCB1-RBL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLCB1C0037769West Syndrome2ORPHANET
HgenePLCB1C0005586Bipolar Disorder1PSYGENET
HgenePLCB1C0007102Malignant tumor of colon1CTD_human
HgenePLCB1C0009375Colonic Neoplasms1CTD_human
HgenePLCB1C0030193Pain1CTD_human
HgenePLCB1C0036341Schizophrenia1CTD_human
HgenePLCB1C0041696Unipolar Depression1PSYGENET
HgenePLCB1C0234230Pain, Burning1CTD_human
HgenePLCB1C0234238Ache1CTD_human
HgenePLCB1C0234254Radiating pain1CTD_human
HgenePLCB1C0458257Pain, Splitting1CTD_human
HgenePLCB1C0458259Pain, Crushing1CTD_human
HgenePLCB1C0751407Pain, Migratory1CTD_human
HgenePLCB1C0751408Suffering, Physical1CTD_human
HgenePLCB1C1269683Major Depressive Disorder1PSYGENET
HgenePLCB1C2713368Hematopoetic Myelodysplasia1CTD_human
HgenePLCB1C3150988EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 121CTD_human;GENOMICS_ENGLAND
HgenePLCB1C3463824MYELODYSPLASTIC SYNDROME1CTD_human