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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHA7-MMP9 (FusionGDB2 ID:65814)

Fusion Gene Summary for PLEKHA7-MMP9

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHA7-MMP9
Fusion gene ID: 65814
HgeneTgene
Gene symbol

PLEKHA7

MMP9

Gene ID

144100

4318

Gene namepleckstrin homology domain containing A7matrix metallopeptidase 9
Synonyms-CLG4B|GELB|MANDP2|MMP-9
Cytomap

11p15.2-p15.1

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family A member 7PH domain-containing family A member 7pleckstrin homology domain containing, family A member 2pleckstrin homology domain containing, family A member 7pleckstrin homology domain-containing family Amatrix metalloproteinase-9macrophage gelatinasematrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)type V collagenase
Modification date2020031320200329
UniProtAcc.

P14780

Ensembl transtripts involved in fusion geneENST00000531066, ENST00000355661, 
ENST00000448080, ENST00000532079, 
ENST00000332954, 		ENST00000372330, 
Fusion gene scores* DoF score18 X 12 X 7=15125 X 4 X 4=80
# samples 225
** MAII scorelog2(22/1512*10)=-2.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHA7 [Title/Abstract] AND MMP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHA7(16872738)-MMP9(44638505), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMMP9

GO:0006508

proteolysis

2551898|15863497|19022250|24164424

TgeneMMP9

GO:0034614

cellular response to reactive oxygen species

26514923

TgeneMMP9

GO:0043388

positive regulation of DNA binding

22984561

TgeneMMP9

GO:0071276

cellular response to cadmium ion

26514923

TgeneMMP9

GO:1900122

positive regulation of receptor binding

24164424

TgeneMMP9

GO:2001258

negative regulation of cation channel activity

24164424


check buttonFusion gene breakpoints across PLEKHA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MMP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7785-01APLEKHA7chr11

16872738

-MMP9chr20

44638505

+
ChimerDB4PRADTCGA-EJ-7785-01APLEKHA7chr11

16872738

-MMP9chr20

44638505

+


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Fusion Gene ORF analysis for PLEKHA7-MMP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000531066ENST00000372330PLEKHA7chr11

16872738

-MMP9chr20

44638505

+
In-frameENST00000355661ENST00000372330PLEKHA7chr11

16872738

-MMP9chr20

44638505

+
In-frameENST00000448080ENST00000372330PLEKHA7chr11

16872738

-MMP9chr20

44638505

+
intron-3CDSENST00000532079ENST00000372330PLEKHA7chr11

16872738

-MMP9chr20

44638505

+
intron-3CDSENST00000332954ENST00000372330PLEKHA7chr11

16872738

-MMP9chr20

44638505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531066PLEKHA7chr1116872738-ENST00000372330MMP9chr2044638505+2917738422723893
ENST00000355661PLEKHA7chr1116872738-ENST00000372330MMP9chr2044638505+2886707112692893
ENST00000448080PLEKHA7chr1116872738-ENST00000372330MMP9chr2044638505+2890711152696893

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531066ENST00000372330PLEKHA7chr1116872738-MMP9chr2044638505+0.0023381960.9976618
ENST00000355661ENST00000372330PLEKHA7chr1116872738-MMP9chr2044638505+0.0023767350.99762326
ENST00000448080ENST00000372330PLEKHA7chr1116872738-MMP9chr2044638505+0.0023540790.9976459

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Fusion Genomic Features for PLEKHA7-MMP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHA7chr1116872737-MMP9chr2044638504+0.014601920.98539805
PLEKHA7chr1116872737-MMP9chr2044638504+0.014601920.98539805

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHA7-MMP9


check button Go to

FGviewer for the breakpoints of chr11:16872738-chr20:44638505

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MMP9

P14780

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000269|PubMed:1480034}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-82354_87232.01122.0DomainWW 2
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-8239_42232.01122.0DomainWW 1
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-82354_87232.01123.0DomainWW 2
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-8239_42232.01123.0DomainWW 1
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013225_27346.0708.0DomainFibronectin type-II 1
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013283_33146.0708.0DomainFibronectin type-II 2
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013342_39046.0708.0DomainFibronectin type-II 3
TgeneMMP9chr11:16872738chr20:44638505ENST0000037233001397_10446.0708.0MotifCysteine switch
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013518_56346.0708.0RepeatNote=Hemopexin 1
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013564_60846.0708.0RepeatNote=Hemopexin 2
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013610_65746.0708.0RepeatNote=Hemopexin 3
TgeneMMP9chr11:16872738chr20:44638505ENST00000372330013658_70446.0708.0RepeatNote=Hemopexin 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-8231067_1094232.01122.0Coiled coilOntology_term=ECO:0000255
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-823700_801232.01122.0Coiled coilOntology_term=ECO:0000255
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-8231067_1094232.01123.0Coiled coilOntology_term=ECO:0000255
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-823700_801232.01123.0Coiled coilOntology_term=ECO:0000255
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-823567_599232.01122.0Compositional biasNote=Pro-rich
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-823845_942232.01122.0Compositional biasNote=Pro-rich
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-823567_599232.01123.0Compositional biasNote=Pro-rich
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-823845_942232.01123.0Compositional biasNote=Pro-rich
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-823164_282232.01122.0DomainPH
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-823164_282232.01123.0DomainPH


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Fusion Gene Sequence for PLEKHA7-MMP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000531066_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(transcript)=2917nt_BP=738nt
CCCCCTCCCCCCCACCCCGCGGCGGCTCCGCGCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCC
TACGGGGTGTGCCGGGATGGCCGCGTCTTCTTCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTC
AACTCGGGCCACATGATCCGCTCAGACCTGCCCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAAC
CAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACAT
ATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCT
GGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTG
GTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTAC
TATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGC
CGCAAATATTCCTTTAAGGAATACCTGTACCGCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCG
CTGCTGCTTCTCCAGAAGCAACTGTCCCTGCCCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGG
GTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAA
GACTTGCCGCGGGCGGTGATTGACGACGCCTTTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTAC
AGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACAC
GCCTTTCCTCCTGGCCCCGGCATTCAGGGAGACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACT
CGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCC
GACGGCTTGCCCTGGTGCAGTACCACGGCCAACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGAC
GGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGC
TACCGCTGGTGCGCCACCACCGCCAACTACGACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGC
AACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGC
CTCTGGTGCGCTACCACCTCGAACTTTGACAGCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCG
CATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCC
TTGCATAAGGACGACGTGAATGGCATCCGGCACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAG
CCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCA
GCTGGCCCCACAGGTCCCCCCACTGCTGGCCCTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATC
TTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCG
CAGGGCCCCTTCCTTATCGCCGACAAGTGGCCCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTC
TTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTG
GCCCAGGTGACCGGGGCCCTCCGGAGTGGCAGGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAG
ATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAA
GCCTATTTCTGCCAGGACCGCTTCTACTGGCGCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGAC
ATCCTGCAGTGCCCTGAGGACTAGGGCTCCCGTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCA
GTTTGCCGGATACAAACTGGTATTCTGTTCTGGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTT

>In-frame_ENST00000531066_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(amino acids)=893AA_start in transcript=42_stop in transcript=2723
MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF
SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR
LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG
ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE
HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT
DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL
GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG
PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF
KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM

--------------------------------------------------------------
>In-frame_ENST00000355661_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(transcript)=2886nt_BP=707nt
GCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTCTTCT
TCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGACCTGC
CCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGA
CGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGT
CCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAG
TCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTT
CTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCG
GGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTGTACC
GCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTGC
CCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACCTTTG
AGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCCT
TTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAGTTTG
GTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGAG
ACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCCTGCC
ACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCCA
ACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAGTTTC
CATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTACG
ACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTCCCCT
TCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGACA
GCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTAGATC
ATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGGC
ACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCCACCG
GACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGCC
CTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAACCAGC
TGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGGC
CCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTGTACA
CAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGCA
GGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAGGTGG
ACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGGC
GCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGACATCCTGCAGTGCCCTGAGGACTAGGGCTCCC
GTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCAGTTTGCCGGATACAAACTGGTATTCTGTTCT
GGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTTGGAGTGTTTCTAATAAACTTGGATTCTCTAA

>In-frame_ENST00000355661_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(amino acids)=893AA_start in transcript=11_stop in transcript=2692
MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF
SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR
LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG
ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE
HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT
DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL
GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG
PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF
KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM

--------------------------------------------------------------
>In-frame_ENST00000448080_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(transcript)=2890nt_BP=711nt
CCGCGCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTC
TTCTTCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGAC
CTGCCCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCT
GTGACGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGA
CCGTCCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGT
AAAGTCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGAC
AGTTCTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTC
CTCGGGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTG
TACCGCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCC
CTGCCCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACC
TTTGAGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGAC
GCCTTTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAG
TTTGGTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAG
GGAGACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCC
TGCCACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACG
GCCAACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAG
TTTCCATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAAC
TACGACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTC
CCCTTCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTT
GACAGCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTA
GATCATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATC
CGGCACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCC
ACCGGACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCT
GGCCCTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAAC
CAGCTGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAG
TGGCCCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTG
TACACAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGT
GGCAGGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAG
GTGGACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTAC
TGGCGCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGACATCCTGCAGTGCCCTGAGGACTAGGGC
TCCCGTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCAGTTTGCCGGATACAAACTGGTATTCTG
TTCTGGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTTGGAGTGTTTCTAATAAACTTGGATTCT

>In-frame_ENST00000448080_ENST00000372330_TCGA-EJ-7785-01A_PLEKHA7_chr11_16872738_-_MMP9_chr20_44638505_length(amino acids)=893AA_start in transcript=15_stop in transcript=2696
MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF
SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR
LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG
ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE
HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT
DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL
GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG
PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF
KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLEKHA7-MMP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000355661-823538_696232.01122.0CTNND1
HgenePLEKHA7chr11:16872738chr20:44638505ENST00000448080-823538_696232.01123.0CTNND1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PLEKHA7-MMP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMMP9P14780DB01197CaptoprilInhibitorSmall moleculeApproved
TgeneMMP9P14780DB01197CaptoprilInhibitorSmall moleculeApproved
TgeneMMP9P14780DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
TgeneMMP9P14780DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
TgeneMMP9P14780DB01017MinocyclineInhibitorSmall moleculeApproved|Investigational
TgeneMMP9P14780DB01017MinocyclineInhibitorSmall moleculeApproved|Investigational
TgeneMMP9P14780DB01296GlucosamineAntagonistSmall moleculeApproved|Investigational
TgeneMMP9P14780DB01296GlucosamineAntagonistSmall moleculeApproved|Investigational
TgeneMMP9P14780DB01593ZincSmall moleculeApproved|Investigational
TgeneMMP9P14780DB01593ZincSmall moleculeApproved|Investigational
TgeneMMP9P14780DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneMMP9P14780DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneMMP9P14780DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational
TgeneMMP9P14780DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational
TgeneMMP9P14780DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
TgeneMMP9P14780DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical

Top

Related Diseases for PLEKHA7-MMP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLEKHA7C0017605Angle Closure Glaucoma2CTD_human
HgenePLEKHA7C0008924Cleft upper lip1GENOMICS_ENGLAND
TgeneMMP9C0027626Neoplasm Invasiveness7CTD_human
TgeneMMP9C0027627Neoplasm Metastasis5CTD_human
TgeneMMP9C2937358Cerebral Hemorrhage5CTD_human
TgeneMMP9C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneMMP9C0007621Neoplastic Cell Transformation3CTD_human
TgeneMMP9C0002152Alloxan Diabetes2CTD_human
TgeneMMP9C0004096Asthma2CTD_human
TgeneMMP9C0005586Bipolar Disorder2PSYGENET
TgeneMMP9C0006663Calcinosis2CTD_human
TgeneMMP9C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneMMP9C0021368Inflammation2CTD_human
TgeneMMP9C0027051Myocardial Infarction2CTD_human
TgeneMMP9C0031051Pericementitis2CTD_human
TgeneMMP9C0031099Periodontitis2CTD_human
TgeneMMP9C0036341Schizophrenia2PSYGENET
TgeneMMP9C0038433Streptozotocin Diabetes2CTD_human
TgeneMMP9C0263628Tumoral calcinosis2CTD_human
TgeneMMP9C0521174Microcalcification2CTD_human
TgeneMMP9C0003486Aortic Aneurysm1CTD_human
TgeneMMP9C0003493Aortic Diseases1CTD_human
TgeneMMP9C0003496Aortic Rupture1CTD_human
TgeneMMP9C0004114Astrocytoma1CTD_human
TgeneMMP9C0005398Cholestasis, Extrahepatic1CTD_human
TgeneMMP9C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneMMP9C0005695Bladder Neoplasm1CTD_human
TgeneMMP9C0005967Bone neoplasms1CTD_human
TgeneMMP9C0006114Cerebral Edema1CTD_human
TgeneMMP9C0006142Malignant neoplasm of breast1CTD_human
TgeneMMP9C0007102Malignant tumor of colon1CTD_human
TgeneMMP9C0007114Malignant neoplasm of skin1CTD_human
TgeneMMP9C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneMMP9C0007137Squamous cell carcinoma1CTD_human
TgeneMMP9C0007786Brain Ischemia1CTD_human
TgeneMMP9C0009324Ulcerative Colitis1CTD_human
TgeneMMP9C0009375Colonic Neoplasms1CTD_human
TgeneMMP9C0011882Diabetic Neuropathies1CTD_human
TgeneMMP9C0017636Glioblastoma1CTD_human
TgeneMMP9C0019193Hepatitis, Toxic1CTD_human
TgeneMMP9C0020507Hyperplasia1CTD_human
TgeneMMP9C0020538Hypertensive disease1CTD_human
TgeneMMP9C0023176Lead Poisoning1CTD_human
TgeneMMP9C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMMP9C0023895Liver diseases1CTD_human
TgeneMMP9C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneMMP9C0024143Lupus Nephritis1CTD_human
TgeneMMP9C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneMMP9C0024796Marfan Syndrome1CTD_human
TgeneMMP9C0026552Morphine Dependence1CTD_human
TgeneMMP9C0026766Multiple Organ Failure1CTD_human
TgeneMMP9C0028754Obesity1CTD_human
TgeneMMP9C0029172Oral Submucous Fibrosis1CTD_human
TgeneMMP9C0030297Pancreatic Neoplasm1CTD_human
TgeneMMP9C0033578Prostatic Neoplasms1CTD_human
TgeneMMP9C0034067Pulmonary Emphysema1CTD_human
TgeneMMP9C0034069Pulmonary Fibrosis1CTD_human
TgeneMMP9C0034189Pyemia1CTD_human
TgeneMMP9C0035126Reperfusion Injury1CTD_human
TgeneMMP9C0035309Retinal Diseases1CTD_human
TgeneMMP9C0036690Septicemia1CTD_human
TgeneMMP9C0037286Skin Neoplasms1CTD_human
TgeneMMP9C0038358Gastric ulcer1CTD_human
TgeneMMP9C0038587Substance Withdrawal Syndrome1CTD_human
TgeneMMP9C0086189Drug Withdrawal Symptoms1CTD_human
TgeneMMP9C0086565Liver Dysfunction1CTD_human
TgeneMMP9C0087169Withdrawal Symptoms1CTD_human
TgeneMMP9C0151526Premature Birth1CTD_human
TgeneMMP9C0162871Aortic Aneurysm, Abdominal1CTD_human
TgeneMMP9C0162872Aortic Aneurysm, Thoracic1CTD_human
TgeneMMP9C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneMMP9C0221227Centriacinar Emphysema1CTD_human
TgeneMMP9C0238281Middle Cerebral Artery Syndrome1CTD_human
TgeneMMP9C0243026Sepsis1CTD_human
TgeneMMP9C0264393Panacinar Emphysema1CTD_human
TgeneMMP9C0271673Symmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneMMP9C0271674Asymmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneMMP9C0271678Diabetic Mononeuropathy1CTD_human
TgeneMMP9C0271680Diabetic Polyneuropathies1CTD_human
TgeneMMP9C0271685Diabetic Amyotrophy1CTD_human
TgeneMMP9C0271686Diabetic Autonomic Neuropathy1CTD_human
TgeneMMP9C0279530Malignant Bone Neoplasm1CTD_human
TgeneMMP9C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneMMP9C0280785Diffuse Astrocytoma1CTD_human
TgeneMMP9C0334579Anaplastic astrocytoma1CTD_human
TgeneMMP9C0334580Protoplasmic astrocytoma1CTD_human
TgeneMMP9C0334581Gemistocytic astrocytoma1CTD_human
TgeneMMP9C0334582Fibrillary Astrocytoma1CTD_human
TgeneMMP9C0334583Pilocytic Astrocytoma1CTD_human
TgeneMMP9C0334588Giant Cell Glioblastoma1CTD_human
TgeneMMP9C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneMMP9C0340288Stable angina1CTD_human
TgeneMMP9C0340630Aortic Aneurysm, Thoracoabdominal1CTD_human
TgeneMMP9C0346647Malignant neoplasm of pancreas1CTD_human
TgeneMMP9C0376358Malignant neoplasm of prostate1CTD_human
TgeneMMP9C0393835Diabetic Asymmetric Polyneuropathy1CTD_human
TgeneMMP9C0432226Metaphyseal anadysplasia1ORPHANET
TgeneMMP9C0432291Mandibuloacral dysostosis1CTD_human
TgeneMMP9C0472387Vasogenic Cerebral Edema1CTD_human
TgeneMMP9C0472388Cytotoxic Cerebral Edema1CTD_human
TgeneMMP9C0547065Mixed oligoastrocytoma1CTD_human
TgeneMMP9C0600272Morphine Abuse1CTD_human
TgeneMMP9C0678222Breast Carcinoma1CTD_human
TgeneMMP9C0740376Middle Cerebral Artery Thrombosis1CTD_human
TgeneMMP9C0740391Middle Cerebral Artery Occlusion1CTD_human
TgeneMMP9C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneMMP9C0741160Aortic Aneurysm, Ruptured1CTD_human
TgeneMMP9C0750935Cerebral Astrocytoma1CTD_human
TgeneMMP9C0750936Intracranial Astrocytoma1CTD_human
TgeneMMP9C0750969Vasogenic Brain Edema1CTD_human
TgeneMMP9C0750970Cytotoxic Brain Edema1CTD_human
TgeneMMP9C0751074Diabetic Neuralgia1CTD_human
TgeneMMP9C0751845Middle Cerebral Artery Embolus1CTD_human
TgeneMMP9C0751846Left Middle Cerebral Artery Infarction1CTD_human
TgeneMMP9C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
TgeneMMP9C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
TgeneMMP9C0751849Right Middle Cerebral Artery Infarction1CTD_human
TgeneMMP9C0860207Drug-Induced Liver Disease1CTD_human
TgeneMMP9C0917798Cerebral Ischemia1CTD_human
TgeneMMP9C0948089Acute Coronary Syndrome1CTD_human
TgeneMMP9C1257931Mammary Neoplasms, Human1CTD_human
TgeneMMP9C1262760Hepatitis, Drug-Induced1CTD_human
TgeneMMP9C1458155Mammary Neoplasms1CTD_human
TgeneMMP9C1527303Chronic Airflow Obstruction1CTD_human
TgeneMMP9C1527311Brain Edema1CTD_human
TgeneMMP9C1621958Glioblastoma Multiforme1CTD_human
TgeneMMP9C1704230Grade I Astrocytoma1CTD_human
TgeneMMP9C1719672Severe Sepsis1CTD_human
TgeneMMP9C2239176Liver carcinoma1CTD_human
TgeneMMP9C2350878Focal Emphysema1CTD_human
TgeneMMP9C2751322Metaphyseal Anadysplasia 21CTD_human;GENOMICS_ENGLAND
TgeneMMP9C2936380Neointima1CTD_human
TgeneMMP9C2936381Neointima Formation1CTD_human
TgeneMMP9C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneMMP9C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneMMP9C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneMMP9C4704874Mammary Carcinoma, Human1CTD_human
TgeneMMP9C4721507Alveolitis, Fibrosing1CTD_human
TgeneMMP9C4721845Marfan Syndrome, Type I1CTD_human