Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARID4B-SOX5 (FusionGDB2 ID:6584)

Fusion Gene Summary for ARID4B-SOX5

Fusion gene summary

Fusion gene information	Fusion gene name: ARID4B-SOX5
	Fusion gene ID: 6584
		Hgene	Tgene
	Gene symbol	ARID4B	SOX5
	Gene ID	51742	6660
	Gene name	AT-rich interaction domain 4B	SRY-box transcription factor 5
	Synonyms	BCAA\|BRCAA1\|RBBP1L1\|RBP1L1\|SAP180	L-SOX5\|L-SOX5B\|L-SOX5F\|LAMSHF
	Cytomap	1q42.3	12p12.1
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1bre	transcription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5
	Modification date	20200320	20200313
	UniProtAcc	Q4LE39	.
	Ensembl transtripts involved in fusion gene	ENST00000366603, ENST00000264183, ENST00000349213, ENST00000494543,	ENST00000546136, ENST00000381381, ENST00000309359, ENST00000451604, ENST00000537393, ENST00000541536, ENST00000396007, ENST00000545921, ENST00000541847, ENST00000441133, ENST00000536850,
Fusion gene scores	* DoF score	23 X 20 X 9=4140	16 X 19 X 9=2736
	# samples	29	18
	** MAII score	log2(29/4140*10)=-3.83550596237175 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2736*10)=-3.92599941855622 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARID4B [Title/Abstract] AND SOX5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARID4B(235377084)-SOX5(24048958), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SOX5	GO:0032332	positive regulation of chondrocyte differentiation	21401405
Tgene	SOX5	GO:0061036	positive regulation of cartilage development	21401405
Tgene	SOX5	GO:0071560	cellular response to transforming growth factor beta stimulus	21401405
Tgene	SOX5	GO:2000741	positive regulation of mesenchymal stem cell differentiation	21401405

Fusion gene breakpoints across ARID4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SOX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-A5GH-01A	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
ChimerDB4	LUSC	TCGA-77-A5GH-01A	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-

Top

Fusion Gene ORF analysis for ARID4B-SOX5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000366603	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000366603	ENST00000381381	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000366603	ENST00000309359	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000366603	ENST00000451604	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000366603	ENST00000537393	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000366603	ENST00000541536	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000366603	ENST00000396007	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000366603	ENST00000545921	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000366603	ENST00000541847	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000366603	ENST00000441133	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000366603	ENST00000536850	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
In-frame	ENST00000264183	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000264183	ENST00000381381	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000264183	ENST00000309359	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000264183	ENST00000451604	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000264183	ENST00000537393	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-5UTR	ENST00000264183	ENST00000541536	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000264183	ENST00000396007	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000264183	ENST00000545921	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000264183	ENST00000541847	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000264183	ENST00000441133	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
5CDS-intron	ENST00000264183	ENST00000536850	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-3CDS	ENST00000349213	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000349213	ENST00000381381	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000349213	ENST00000309359	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000349213	ENST00000451604	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000349213	ENST00000537393	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000349213	ENST00000541536	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000349213	ENST00000396007	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000349213	ENST00000545921	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000349213	ENST00000541847	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000349213	ENST00000441133	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000349213	ENST00000536850	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-3CDS	ENST00000494543	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000494543	ENST00000381381	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000494543	ENST00000309359	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000494543	ENST00000451604	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000494543	ENST00000537393	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-5UTR	ENST00000494543	ENST00000541536	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000494543	ENST00000396007	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000494543	ENST00000545921	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000494543	ENST00000541847	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000494543	ENST00000441133	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-
intron-intron	ENST00000494543	ENST00000536850	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366603	ARID4B	chr1	235377084	-	ENST00000546136	SOX5	chr12	24048958	-	9187	2218	2200	4473	757
ENST00000264183	ARID4B	chr1	235377084	-	ENST00000546136	SOX5	chr12	24048958	-	9308	2339	2321	4594	757

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366603	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-	0.000356448	0.99964356
ENST00000264183	ENST00000546136	ARID4B	chr1	235377084	-	SOX5	chr12	24048958	-	0.000442414	0.99955755

Top

Fusion Genomic Features for ARID4B-SOX5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARID4B-SOX5

Go to
FGviewer for the breakpoints of chr1:235377084-chr12:24048958
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID4B Q4LE39	.
FUNCTION: Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250\|UniProtKB:A2CG63, ECO:0000269\|PubMed:12724404}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

154_159

613.6666666666666

1313.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

268_567

613.6666666666666

1313.0

Compositional bias

Note=Glu-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

154_159

613.6666666666666

1313.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

268_567

613.6666666666666

1313.0

Compositional bias

Note=Glu-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

306_398

613.6666666666666

1313.0

Domain

ARID

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

306_398

613.6666666666666

1313.0

Domain

ARID

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

465_473

613.6666666666666

1313.0

Region

Note=Antigenic epitope

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

465_473

613.6666666666666

1313.0

Region

Note=Antigenic epitope

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000309359

193_274

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000309359

448_515

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000381381

193_274

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000381381

448_515

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000396007

193_274

378.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000396007

448_515

378.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000451604

193_274

12.666666666666666

764.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000451604

448_515

12.666666666666666

764.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000541536

-1

193_274

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000541536

-1

448_515

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000545921

193_274

2.6666666666666665

754.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000545921

448_515

2.6666666666666665

754.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000546136

-1

193_274

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000546136

-1

448_515

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000309359

556_624

751.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000381381

556_624

643.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000396007

556_624

378.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000451604

556_624

12.666666666666666

764.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000541536

-1

556_624

77.0

643.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000545921

556_624

2.6666666666666665

754.0

DNA binding

HMG box

Tgene

SOX5

chr1:235377084

chr12:24048958

ENST00000546136

-1

556_624

77.0

751.0

DNA binding

HMG box

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

1231_1270

613.6666666666666

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

728_754

613.6666666666666

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

1231_1270

1227.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

728_754

1227.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

1231_1270

613.6666666666666

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

728_754

613.6666666666666

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

1095_1101

613.6666666666666

1313.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

1271_1303

613.6666666666666

1313.0

Compositional bias

Note=Ser-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

1095_1101

1227.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

1271_1303

1227.0

Compositional bias

Note=Ser-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

154_159

1227.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

268_567

1227.0

Compositional bias

Note=Glu-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

1095_1101

613.6666666666666

1313.0

Compositional bias

Note=Poly-Ser

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

1271_1303

613.6666666666666

1313.0

Compositional bias

Note=Ser-rich

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

306_398

1227.0

Domain

ARID

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000264183

1130_1137

613.6666666666666

1313.0

Region

Note=Antigenic epitope

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

1130_1137

1227.0

Region

Note=Antigenic epitope

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000349213

465_473

1227.0

Region

Note=Antigenic epitope

Hgene

ARID4B

chr1:235377084

chr12:24048958

ENST00000366603

1130_1137

613.6666666666666

1313.0

Region

Note=Antigenic epitope

Top

Fusion Gene Sequence for ARID4B-SOX5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000366603_ENST00000546136_TCGA-77-A5GH-01A_ARID4B_chr1_235377084_-_SOX5_chr12_24048958_length(transcript)=9187nt_BP=2218nt
GGCGGGGCCAGATGTTGATCTCGCTCCCACTTGTCGGGTCTGAGCCCGGAACGGGACGTGGGCAGGGGCTCTGTGGCGGGCCGGTCCTGC
CCGCGGCCCACAGGCCCTCCTGGCCCCTCGGTGGCCCCCGGCCGGCCTCTCGCTCGGACGCGGCGCGTGGGGGCGCGGATTCGCTCGGCC
GGGCGCCGAGGCCCTAGGGGAGAGCGGCCGGCCCTGCGCCGGACGCCGGGCTTGTTGTGAGTTTCTTCTCTGACAGAAATGGCGTCATTG
TCGTAGACGGGAAACTCCGTCGGGTCTCGACAATGGGGACGGGAAGCTGCCGAGCTGTGTGCAGCTGAACCTGGTGTTTTAGAGGATACC
TTGGTCCCAGAGTCATCATGAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACTGATGTGAGTGCTAAATACAGAGGAGCCTTTT
GTGAAGCCAAGATCAAGACAGCAAAAAGACTTGTCAAAGTCAAGGTGACATTTAGACATGATTCTTCAACAGTGGAAGTTCAGGATGACC
ACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAGTGAAGAATCTTGATGGTGCATATCAGGAAGCTGTTATCAATAAACTAACAG
ATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACTGAGACGATCTTCACTGTGCCTGAAAGGAGAGAGGCATTTTG
CTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCAGTCATAGGAAAGAAAACAAATAGAGGAAGAA
GATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAACAGATTGATGAGCTACTAGGCA
AAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTGTAGTGATGAGA
TTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACTA
GTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACT
GGAAGACTGAATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATA
GCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAGCAATTGTACAAATTTATGGAAGATAGAGGTA
CACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTTAAGTTATTCAGACTTGTACACAAACTTGGAGGATTTGATA
ATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTAAATTCAGCTGCAGGATACAATGTTAAATGTG
CTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTTCAGATGGCATTGCCAGAGAAAGTTGTTAACA
AGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACAGAGATCAAAGAAATAAAGATGGAGGAGGAGA
GGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCTCTCTGGGAAGTAAAAAGAATT
TATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGATGACAAAGATG
ATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGAGATGAAACGAATAAAGAAG
AAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGATGAAGATGATGATGACAACAATGAGGAAGAGG
AGTTTGAGTGCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGGAAAAATCAAAAAATGTATGAAGCTAGTATTAAAGATT
CTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGAGGATGTCTTCCAAGCGACCAGCCTCTCCGTA
TGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCAGCCTTTCACCTTCC
CTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGTGGCCATAGGACTCC
CACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACCTCAGAAGGC
AGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGCTGATGTTGT
TGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTCAAAGGACTG
GAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAGGCAACTCAT
GGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCAGATTGAGAA
ACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACACAAAATCAA
TTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTATTCCCTCCTGATCAACGGACACTGGCTGCAGC
TGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACCCTTACCCTGTTCAGCTGATCCCAACTACCAT
GGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATGCTGCCCAGCTAGCTGCAATGCAGGTATCTCC
AGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCAGCATTCACACAGACAAGAGCACAAACAGCCC
ACCACCCAAAAGCAAGGATGAAGTGGCACAGCCACTGAACCTATCAGCTAAACCCAAGACCTCTGATGGCAAATCACCCACATCACCCAC
CTCTCCCCATATGCCAGCTCTGAGAATAAACAGTGGGGCAGGCCCCCTCAAAGCCTCTGTCCCAGCAGCGTTAGCTAGTCCTTCAGCCAG
AGTTAGCACAATAGGTTACTTAAATGACCATGATGCTGTCACCAAGGCAATCCAAGAAGCTCGGCAAATGAAGGAGCAACTCCGACGGGA
ACAACAGGTGCTTGATGGGAAGGTGGCTGTTGTGAATAGTCTGGGTCTCAATAACTGCCGAACAGAAAAGGAAAAAACAACACTGGAGAG
TCTGACTCAGCAACTGGCAGTTAAACAGAATGAAGAAGGAAAATTTAGCCATGCAATGATGGATTTCAATCTGAGTGGAGATTCTGATGG
AAGTGCTGGAGTCTCAGAGTCAAGAATTTATAGGGAATCCCGAGGGCGTGGTAGCAATGAACCCCACATAAAGCGTCCAATGAATGCCTT
CATGGTGTGGGCTAAAGATGAACGGAGAAAGATCCTTCAAGCCTTTCCTGACATGCACAACTCCAACATCAGCAAGATATTGGGATCTCG
CTGGAAAGCTATGACAAACCTAGAGAAACAGCCATATTATGAGGAGCAAGCCCGTCTCAGCAAGCAGCACCTGGAGAAGTACCCTGACTA
TAAGTACAAGCCCAGGCCAAAGCGCACCTGCCTGGTGGATGGCAAAAAGCTGCGCATTGGTGAATACAAGGCAATCATGCGCAACAGGCG
GCAGGAAATGCGGCAGTACTTCAATGTTGGGCAACAAGCACAGATCCCCATTGCCACTGCTGGTGTTGTGTACCCTGGAGCCATCGCCAT
GGCTGGGATGCCCTCCCCTCACCTGCCCTCGGAGCACTCAAGCGTGTCTAGCAGCCCAGAGCCTGGGATGCCTGTTATCCAGAGCACTTA
CGGTGTGAAAGGAGAGGAGCCACATATCAAAGAAGAGATACAGGCCGAGGACATCAATGGAGAAATTTATGATGAGTACGACGAGGAAGA
GGATGATCCAGATGTAGATTATGGGAGTGACAGTGAAAACCATATTGCAGGACAAGCCAACTGATAAGGGTCAAAAGATTGTTGTGACCT
TAGGACTTAAAGAAGCCCTAACTGGTTCATCCTTACCAGTGGCCAAGCACATTAACTTTCTCATACACTGACTGTTACTTTAACTGTTAG
TCTTAAATAGTTGGGACATCAGCTGACTAATAGACCTCAGCCTCAAAAGGCTTGGAAAGAAAAAACAAATACAACAAGCAAACAACAATA
TCAACAACAAGAGATTGAAATAAGCTATGGGTAAAATAATGCCAGTAATTCAGCTGCTACATCCAAGCACTGAAGTCTTACCCGTCAACT
TTTTTTTTTTTTTAAATAAACTTTATGGCTGTTTGTTCTACAATGTTCTAGAAATTCTCACTCAGGTACACAGTGCCAACAAGTGGCTTG
TGAATGTGTTTTGTTGTTTTGTGCTACAATTTTTAAAAAGAAAAAAGTTTTGTTTTGTTTTTTGGGGTTTCTGGGTTTTTTCCTTTTCTT
TTTCTTTCCTTTCATTTTTTTTCTTTGTAATGCACCTGACAGAAAAAAAAGAAAAATGAATTTCTCTTTACTTCTCTCCACCTTCTCCAT
CTCTCTACTTTAAAGATGGAAGTCTGTGCATGAGGGGAAAGAGGGAAAAAGAGCCTGTTTTTAACTTCCTTGCTATCCACCACAAAATAA
GCAATTATTTTCTTTAGAGGACTTTATCTATTGCACACCACACTACATCTTTGAGCAAGTGCCAAATTTGTACTGAAGTGTTGACCAAGT
TCATTTTTTCTCTTTACTTTTTCCTTTTCCTTCTTAAGTTAGGACAGTGTTAAATCTTAGACAATCCCTTGAAAAACCTGAAATACCAGC
AGCTGGTGAGATTTGACTTTTTTTTTTAATGGAAACTGTAGGTGCTGTTCTCAGGTGAAAAGAGAGAGAGAGAGAGAGACATAAGAAATT
TAGAGAAAAATATTTTCTGATCTTGGATTTTTGTGTGTATGTATGTATGTGATTATGGTACTAATAATAGGAATAACGTTGGACCATTGT
GAGTTAAACCCACATCTGGGGATGAAATCCCACATCCTCCCAAGTGACTGGTCTAGAAATAATCTTGACCTTGACTTTGCACTTCAAATG
ACAACTTAACCAAGTATAGGGCTCAGAAATTATATTTTTAAATGTCTGATTATTATTGGATGGATCAGGTGGCCCTGTGTAATAGAGGTG
TGCATGTATAACATGGAAGCTACTAGCAAACTGCTCCCAGATGTCCTTTCTCCCTGGTCAGTTGGTTCCATTAACGTTTGCTACTTAGTG
ATTTTTGTTTTTCCTGTTGATATTTTGAGCAAAACAATCATTGTTTTCATTGAATATATTTGGCCATTTTTTCAGACAAATAGAATTAGC
TTATTTCTTCAACATTCCATCCTTTCCCGATCAGGAAATGAAACTGATGATTTTATAAGGTATTTTTCACCCCTCCATGAAGTGAGGTGG
AGGCCTTTAGCATTTCAGAAGTGTGGGCCATATGTAGTTCATGCCATAAAAAGTAGGATTTAATTAAAAGTCATTGCAGCCCAATAAAAT
GGAGCCTGGCTGCACCCAGGGATCCTTGCCACTGCTCTTCCCTTGCTGTCAGATTAATCCACTGAAGTCCAACTTTGGTTCAAGCAGAGT
ATTTGCAAAGAGCAACAACTGAATGTGATGGGACTGCTTATGTAGATTTTGCCAGCCAAATGCCAAGGCAGTTGTAGGGCCTGTACAAAT
AAATGCAAAATCATTTCAAGTCAATTGCCATTATTTGTATTGAAGTATCAGATAGATAGTAAATACTGCAACTAGTAGCTTGATGTGCTA
TAGTTTTCACTCCAGTCATCATTTTCCTATCTCACCCCCCGAAACACCACCCTAAAGTTGGATTTTTACATATAAATAAAAAAAGAATCC
CTTTTATTTTTCTCTCTCTCAGAAGACTTGCTCTGGGGTTTTGCTTGGAGGAGCTGATCATATCCTGCATGTCAGAGATTTCATTTTGTT
TGTTTTTCTGTTTGTTTGTTTTTGATGACTTTATTTACATTTGAACTGCCTCTTTTTGCTAGTGTTGTAATGATGATGATGATAAAATAA
TAATAATAATAGTAATAATAATAATAATGGTCAGCTGTTCCCAGATTAGTAAGTTATGTATAATTTATTTTATTTCTCCCTTTCTATTTT
ATTCTGCTCTGATTTGGAAGTGCAGCCAATAAGCTGTTAGATATTTAAAACAAATTTCCATCTCCAACTCATATATGTATGTATATGTAT
ATATATATATACATATATATACACACATATACACACACACACACACATTTACCCACAATTTTACTTCTCTTTCCGTAAGTTTTCTCTTTT
TTAAGAATTTTGGCCCCAACAATATCAGTTCTGATGTTTAAAACAAAGGAGTGAATTAATAGGAGGGTCGTGTTCAATCTTAATTAACTT
ATGCTCTCATCACTCATTTTAGTTATTTAATTGCCACAGTCATCTAGAGCCAATTTTTTTTTGTTTTTGTTTGTTTTGTTTTTAAGCACT
CTGGATAAGGAAAAAATAGACACTTGTTTTTATATCATTTTTATGTACAATGTGAAAACAGATTTTTAAAAAATTTGTTCTCTGTCTTTG
TTAACAAATTCCTTCCGATTTATGTGGGTTCACCTCTCACGTTTGCTGGATACTTACTTTACACCATGTTATGAAAGATGCTTTGTTTTC
ATTTCATGAGTTTGGGCTACAAGAATACTTTGTTTTAGCTCCAGGTAGATGCCATTGAAGGCATTCATGGCTGAAATCAATTCTAACACA
CTTACCGATGAATTGACAACACTTTGGTGTTTGGTCTTTTTTTTGTTATATTTTGTTTTATTTGAAGGGGAAAACAAAATTGTTAATGGT
GACTTTTAACTGCTGAAATTCAAAATTTGATTTTAGTTAGGTTTATGTCCGAGACTAAACTGTGCATGAACCGAAACAAAAAGCAAGTTC
ATACCGCTGCATTCTGTTCTCTTGTTCTGACGGTTAATTCACTGGACATCAAATTTTCTTTGCCCTAGTTTTCCCCAAAAGAAAACAAAA
GCAAAAATAGTTATATTAATGTTGAAAGTGCTTTGAAGTCACTTGATAAAAGGTGCTATGAATAGCAACTTACTGTGTTACTACATTGCC
TTTTTGGCATTGGTTGATTTATAATTTTGGTAAAGGATCCTAAAACCCTGTATTCTTTTTCTGTGCCCCATAATGACCAAAAAAGATAAA
GAAAATGAGAGTAAGATCAAAAGATCAAACTAAAACATAAACAGTCTCCTTCCTGTCTGCTTTCTTACCTATCTGTTCACACTTTATCTC
TTTCCCTTTCTCTCTCTCTCTCACATGCGCGCGCGCGCGCGCGCACACACACACACACACACACTTGCCCCAACACTGAGAAATAATCTT
GCCAGAATTCTGGTTTTTATAGTTGTTGTAGTCCGTTTCTCTAAAAATAGTCCTGTTTTCATATGAATCTAAGAGAACATTACCGGAGAA
AATAAAGTTACTCATTTATAGTTACTAATAATAAGTTAGTGATTAACTTACCACAATTGGATAAAATATAAAACTATTCTTCAGCACATT
TATACCTAAATTAGTGAAGTCCATTTGTGAAGTTCATTTGGCATCTGCAGTTAAGAGTTAACCATGTATAAAATCCCTCCCAAAGAACAT
AATCATCGTTAGAACCAAATCCTCTTATAAAGAACAAATATAAAAAAGTTTTCTGTGGTGAAGCTATTTTATAGATTTGATTTCCGGAGT
AGAATTTTACCTTAATTCACTTAAAGAAAATTAACCATTTTTTGGTCCAACTTCAGATATTTTCTTAATCCAGAAGCTGTGACTGTTCCC
AGAAGAAACCTCTTATATCACATTTAAAACATAAAAAATAATTACACTTTCACTCATTCTAATGGGTAAATTGTTGAATTGTAATAAACA
ACTGTATATTTACAAACAGGTTTATAAGGTATTTGTCTATCAAATTAATAATAAAATAAAACTTACGGGGTCTGCAAGGAAAACTATGAA
GGCCACTTAAAGTGGTTCAGGTATCCCTTTGTCTTGTAGGGCATAGCTGTTGGTTTAGCCAGGCTTTTACAGTATTTAATTTTAAAGTAT
CCTATAACTATCAACTTCCCAGGTTGAAGACGATGTGTTGAGTTTCCTACTGATTGATTGATTCCTGTCCTCCCCAGTGTTTCCGTCACT
GGTTCACTAAAACAGTATTTATATAGCTCCACTGGCTCTAAAGCTCTTAGTCCTTCTAATATTTTGGATTTTACAAGTAAAAATGGAAAA
AAAATAGAAAAGAGACAATCAAATGCCTGGAGCTTAAAACAAAGTATGTGCAACCTACCATCTCACTTGAAATTTAATAAAATAATAAGT
AATTATGTAAATATAACATAGAGTTATAGATTTATATTTTGTTCATAACACATAGTGTAATATAAGTTGTATATTTTCATGTTTTTGGTT
TTATGTTATCATTCATGCCACAATAAAAATAAAACAGGAGTTTATGTGCTCTTAAAAAAAAGATGTGGGTTGCCACCAACCTGTTTTTCG
TTTTTGTTTTTTGTTTATTTTATTTTATTTTTTTGCATTCTCCTTTTTCAGTATTACTGCCATGCAAGGCACCAATAAAAACAGCAAATG

>In-frame_ENST00000366603_ENST00000546136_TCGA-77-A5GH-01A_ARID4B_chr1_235377084_-_SOX5_chr12_24048958_length(amino acids)=757AA_start in transcript=2200_stop in transcript=4473
MRMECERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNK
VMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFG
EIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLP
PLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLG
AAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAV
TKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRES
RGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVD
GKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEI

--------------------------------------------------------------
>In-frame_ENST00000264183_ENST00000546136_TCGA-77-A5GH-01A_ARID4B_chr1_235377084_-_SOX5_chr12_24048958_length(transcript)=9308nt_BP=2339nt
AAAGGGGGGGAACCTAGAGTCGGTGGGGGGGAAGCGATGTTTGCCCGTCAGTCGAGTCCGGAGTGAGGAGCTCGGTCGCCGAAGCGGAGG
GAGACTCTTGAGCTTCATCTTGCCGCCGCCACGGCCACCGCCTGGACCTTTGCCCGGAGGGAGCTGCAGAGGGTCCATCGCCGCCGTCCT
CTGGAGGGCAGCGCGATTGGGGGCCCGGACCTCCAGTCCGGGGGGGATTTTTCGTCGTCCCCCTCCCCCCAACCAGGGAGCCCGAGCGGC
CGCCAAACAAAGGTACCAGTCGCCGCCGCGGGAGGAGGAGGAGCCGGAGCCTCTGCCTCAGCAGCCGCTGGACCCGCCGCCCTTCTTCCC
CATCTCTCCCCCGGGCCTGCTGGTTTTGGGGGGGAGAAGGAGAGAGGGGACTCTGGACGTGCCAGGGTCAGATCTCGCCTCCGAGGAAGG
TGCAGCTGAACCTGGTGTTTTAGAGGATACCTTGGTCCCAGAGTCATCATGAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACT
GATGTGAGTGCTAAATACAGAGGAGCCTTTTGTGAAGCCAAGATCAAGACAGCAAAAAGACTTGTCAAAGTCAAGGTGACATTTAGACAT
GATTCTTCAACAGTGGAAGTTCAGGATGACCACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAGTGAAGAATCTTGATGGTGCA
TATCAGGAAGCTGTTATCAATAAACTAACAGATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACTGAGACGATCT
TCACTGTGCCTGAAAGGAGAGAGGCATTTTGCTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCA
GTCATAGGAAAGAAAACAAATAGAGGAAGAAGATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGAT
GATAGGAAACAGATTGATGAGCTACTAGGCAAAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCA
TTGGTGGTTTGTCCTGATTGTAGTGATGAGATTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCA
GTTCCAAGAAAAGATGTCCATGAAATTACTAGTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAA
TTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTGAATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAG
GAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAG
CAATTGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTTAAGTTATTC
AGACTTGTACACAAACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTA
AATTCAGCTGCAGGATACAATGTTAAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTT
CAGATGGCATTGCCAGAGAAAGTTGTTAACAAGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACA
GAGATCAAAGAAATAAAGATGGAGGAGGAGAGGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAAT
ATTAAGCCCTCTCTGGGAAGTAAAAAGAATTTATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCA
GAAGACAATGAAAATCTGGATGACAAAGATGATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAA
GCAAAATCTGGAGATGAAACGAATAAAGAAGAAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGAT
GAAGATGATGATGACAACAATGAGGAAGAGGAGTTTGAGTGCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGGAAAAAT
CAAAAAATGTATGAAGCTAGTATTAAAGATTCTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGA
GGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGG
AGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGC
TGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCC
CACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTG
AACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCC
CCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCG
AGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGC
AGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGC
AGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTAT
TCCCTCCTGATCAACGGACACTGGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACC
CTTACCCTGTTCAGCTGATCCCAACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATG
CTGCCCAGCTAGCTGCAATGCAGGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCA
GCATTCACACAGACAAGAGCACAAACAGCCCACCACCCAAAAGCAAGGATGAAGTGGCACAGCCACTGAACCTATCAGCTAAACCCAAGA
CCTCTGATGGCAAATCACCCACATCACCCACCTCTCCCCATATGCCAGCTCTGAGAATAAACAGTGGGGCAGGCCCCCTCAAAGCCTCTG
TCCCAGCAGCGTTAGCTAGTCCTTCAGCCAGAGTTAGCACAATAGGTTACTTAAATGACCATGATGCTGTCACCAAGGCAATCCAAGAAG
CTCGGCAAATGAAGGAGCAACTCCGACGGGAACAACAGGTGCTTGATGGGAAGGTGGCTGTTGTGAATAGTCTGGGTCTCAATAACTGCC
GAACAGAAAAGGAAAAAACAACACTGGAGAGTCTGACTCAGCAACTGGCAGTTAAACAGAATGAAGAAGGAAAATTTAGCCATGCAATGA
TGGATTTCAATCTGAGTGGAGATTCTGATGGAAGTGCTGGAGTCTCAGAGTCAAGAATTTATAGGGAATCCCGAGGGCGTGGTAGCAATG
AACCCCACATAAAGCGTCCAATGAATGCCTTCATGGTGTGGGCTAAAGATGAACGGAGAAAGATCCTTCAAGCCTTTCCTGACATGCACA
ACTCCAACATCAGCAAGATATTGGGATCTCGCTGGAAAGCTATGACAAACCTAGAGAAACAGCCATATTATGAGGAGCAAGCCCGTCTCA
GCAAGCAGCACCTGGAGAAGTACCCTGACTATAAGTACAAGCCCAGGCCAAAGCGCACCTGCCTGGTGGATGGCAAAAAGCTGCGCATTG
GTGAATACAAGGCAATCATGCGCAACAGGCGGCAGGAAATGCGGCAGTACTTCAATGTTGGGCAACAAGCACAGATCCCCATTGCCACTG
CTGGTGTTGTGTACCCTGGAGCCATCGCCATGGCTGGGATGCCCTCCCCTCACCTGCCCTCGGAGCACTCAAGCGTGTCTAGCAGCCCAG
AGCCTGGGATGCCTGTTATCCAGAGCACTTACGGTGTGAAAGGAGAGGAGCCACATATCAAAGAAGAGATACAGGCCGAGGACATCAATG
GAGAAATTTATGATGAGTACGACGAGGAAGAGGATGATCCAGATGTAGATTATGGGAGTGACAGTGAAAACCATATTGCAGGACAAGCCA
ACTGATAAGGGTCAAAAGATTGTTGTGACCTTAGGACTTAAAGAAGCCCTAACTGGTTCATCCTTACCAGTGGCCAAGCACATTAACTTT
CTCATACACTGACTGTTACTTTAACTGTTAGTCTTAAATAGTTGGGACATCAGCTGACTAATAGACCTCAGCCTCAAAAGGCTTGGAAAG
AAAAAACAAATACAACAAGCAAACAACAATATCAACAACAAGAGATTGAAATAAGCTATGGGTAAAATAATGCCAGTAATTCAGCTGCTA
CATCCAAGCACTGAAGTCTTACCCGTCAACTTTTTTTTTTTTTTAAATAAACTTTATGGCTGTTTGTTCTACAATGTTCTAGAAATTCTC
ACTCAGGTACACAGTGCCAACAAGTGGCTTGTGAATGTGTTTTGTTGTTTTGTGCTACAATTTTTAAAAAGAAAAAAGTTTTGTTTTGTT
TTTTGGGGTTTCTGGGTTTTTTCCTTTTCTTTTTCTTTCCTTTCATTTTTTTTCTTTGTAATGCACCTGACAGAAAAAAAAGAAAAATGA
ATTTCTCTTTACTTCTCTCCACCTTCTCCATCTCTCTACTTTAAAGATGGAAGTCTGTGCATGAGGGGAAAGAGGGAAAAAGAGCCTGTT
TTTAACTTCCTTGCTATCCACCACAAAATAAGCAATTATTTTCTTTAGAGGACTTTATCTATTGCACACCACACTACATCTTTGAGCAAG
TGCCAAATTTGTACTGAAGTGTTGACCAAGTTCATTTTTTCTCTTTACTTTTTCCTTTTCCTTCTTAAGTTAGGACAGTGTTAAATCTTA
GACAATCCCTTGAAAAACCTGAAATACCAGCAGCTGGTGAGATTTGACTTTTTTTTTTAATGGAAACTGTAGGTGCTGTTCTCAGGTGAA
AAGAGAGAGAGAGAGAGAGACATAAGAAATTTAGAGAAAAATATTTTCTGATCTTGGATTTTTGTGTGTATGTATGTATGTGATTATGGT
ACTAATAATAGGAATAACGTTGGACCATTGTGAGTTAAACCCACATCTGGGGATGAAATCCCACATCCTCCCAAGTGACTGGTCTAGAAA
TAATCTTGACCTTGACTTTGCACTTCAAATGACAACTTAACCAAGTATAGGGCTCAGAAATTATATTTTTAAATGTCTGATTATTATTGG
ATGGATCAGGTGGCCCTGTGTAATAGAGGTGTGCATGTATAACATGGAAGCTACTAGCAAACTGCTCCCAGATGTCCTTTCTCCCTGGTC
AGTTGGTTCCATTAACGTTTGCTACTTAGTGATTTTTGTTTTTCCTGTTGATATTTTGAGCAAAACAATCATTGTTTTCATTGAATATAT
TTGGCCATTTTTTCAGACAAATAGAATTAGCTTATTTCTTCAACATTCCATCCTTTCCCGATCAGGAAATGAAACTGATGATTTTATAAG
GTATTTTTCACCCCTCCATGAAGTGAGGTGGAGGCCTTTAGCATTTCAGAAGTGTGGGCCATATGTAGTTCATGCCATAAAAAGTAGGAT
TTAATTAAAAGTCATTGCAGCCCAATAAAATGGAGCCTGGCTGCACCCAGGGATCCTTGCCACTGCTCTTCCCTTGCTGTCAGATTAATC
CACTGAAGTCCAACTTTGGTTCAAGCAGAGTATTTGCAAAGAGCAACAACTGAATGTGATGGGACTGCTTATGTAGATTTTGCCAGCCAA
ATGCCAAGGCAGTTGTAGGGCCTGTACAAATAAATGCAAAATCATTTCAAGTCAATTGCCATTATTTGTATTGAAGTATCAGATAGATAG
TAAATACTGCAACTAGTAGCTTGATGTGCTATAGTTTTCACTCCAGTCATCATTTTCCTATCTCACCCCCCGAAACACCACCCTAAAGTT
GGATTTTTACATATAAATAAAAAAAGAATCCCTTTTATTTTTCTCTCTCTCAGAAGACTTGCTCTGGGGTTTTGCTTGGAGGAGCTGATC
ATATCCTGCATGTCAGAGATTTCATTTTGTTTGTTTTTCTGTTTGTTTGTTTTTGATGACTTTATTTACATTTGAACTGCCTCTTTTTGC
TAGTGTTGTAATGATGATGATGATAAAATAATAATAATAATAGTAATAATAATAATAATGGTCAGCTGTTCCCAGATTAGTAAGTTATGT
ATAATTTATTTTATTTCTCCCTTTCTATTTTATTCTGCTCTGATTTGGAAGTGCAGCCAATAAGCTGTTAGATATTTAAAACAAATTTCC
ATCTCCAACTCATATATGTATGTATATGTATATATATATATACATATATATACACACATATACACACACACACACACATTTACCCACAAT
TTTACTTCTCTTTCCGTAAGTTTTCTCTTTTTTAAGAATTTTGGCCCCAACAATATCAGTTCTGATGTTTAAAACAAAGGAGTGAATTAA
TAGGAGGGTCGTGTTCAATCTTAATTAACTTATGCTCTCATCACTCATTTTAGTTATTTAATTGCCACAGTCATCTAGAGCCAATTTTTT
TTTGTTTTTGTTTGTTTTGTTTTTAAGCACTCTGGATAAGGAAAAAATAGACACTTGTTTTTATATCATTTTTATGTACAATGTGAAAAC
AGATTTTTAAAAAATTTGTTCTCTGTCTTTGTTAACAAATTCCTTCCGATTTATGTGGGTTCACCTCTCACGTTTGCTGGATACTTACTT
TACACCATGTTATGAAAGATGCTTTGTTTTCATTTCATGAGTTTGGGCTACAAGAATACTTTGTTTTAGCTCCAGGTAGATGCCATTGAA
GGCATTCATGGCTGAAATCAATTCTAACACACTTACCGATGAATTGACAACACTTTGGTGTTTGGTCTTTTTTTTGTTATATTTTGTTTT
ATTTGAAGGGGAAAACAAAATTGTTAATGGTGACTTTTAACTGCTGAAATTCAAAATTTGATTTTAGTTAGGTTTATGTCCGAGACTAAA
CTGTGCATGAACCGAAACAAAAAGCAAGTTCATACCGCTGCATTCTGTTCTCTTGTTCTGACGGTTAATTCACTGGACATCAAATTTTCT
TTGCCCTAGTTTTCCCCAAAAGAAAACAAAAGCAAAAATAGTTATATTAATGTTGAAAGTGCTTTGAAGTCACTTGATAAAAGGTGCTAT
GAATAGCAACTTACTGTGTTACTACATTGCCTTTTTGGCATTGGTTGATTTATAATTTTGGTAAAGGATCCTAAAACCCTGTATTCTTTT
TCTGTGCCCCATAATGACCAAAAAAGATAAAGAAAATGAGAGTAAGATCAAAAGATCAAACTAAAACATAAACAGTCTCCTTCCTGTCTG
CTTTCTTACCTATCTGTTCACACTTTATCTCTTTCCCTTTCTCTCTCTCTCTCACATGCGCGCGCGCGCGCGCGCACACACACACACACA
CACACTTGCCCCAACACTGAGAAATAATCTTGCCAGAATTCTGGTTTTTATAGTTGTTGTAGTCCGTTTCTCTAAAAATAGTCCTGTTTT
CATATGAATCTAAGAGAACATTACCGGAGAAAATAAAGTTACTCATTTATAGTTACTAATAATAAGTTAGTGATTAACTTACCACAATTG
GATAAAATATAAAACTATTCTTCAGCACATTTATACCTAAATTAGTGAAGTCCATTTGTGAAGTTCATTTGGCATCTGCAGTTAAGAGTT
AACCATGTATAAAATCCCTCCCAAAGAACATAATCATCGTTAGAACCAAATCCTCTTATAAAGAACAAATATAAAAAAGTTTTCTGTGGT
GAAGCTATTTTATAGATTTGATTTCCGGAGTAGAATTTTACCTTAATTCACTTAAAGAAAATTAACCATTTTTTGGTCCAACTTCAGATA
TTTTCTTAATCCAGAAGCTGTGACTGTTCCCAGAAGAAACCTCTTATATCACATTTAAAACATAAAAAATAATTACACTTTCACTCATTC
TAATGGGTAAATTGTTGAATTGTAATAAACAACTGTATATTTACAAACAGGTTTATAAGGTATTTGTCTATCAAATTAATAATAAAATAA
AACTTACGGGGTCTGCAAGGAAAACTATGAAGGCCACTTAAAGTGGTTCAGGTATCCCTTTGTCTTGTAGGGCATAGCTGTTGGTTTAGC
CAGGCTTTTACAGTATTTAATTTTAAAGTATCCTATAACTATCAACTTCCCAGGTTGAAGACGATGTGTTGAGTTTCCTACTGATTGATT
GATTCCTGTCCTCCCCAGTGTTTCCGTCACTGGTTCACTAAAACAGTATTTATATAGCTCCACTGGCTCTAAAGCTCTTAGTCCTTCTAA
TATTTTGGATTTTACAAGTAAAAATGGAAAAAAAATAGAAAAGAGACAATCAAATGCCTGGAGCTTAAAACAAAGTATGTGCAACCTACC
ATCTCACTTGAAATTTAATAAAATAATAAGTAATTATGTAAATATAACATAGAGTTATAGATTTATATTTTGTTCATAACACATAGTGTA
ATATAAGTTGTATATTTTCATGTTTTTGGTTTTATGTTATCATTCATGCCACAATAAAAATAAAACAGGAGTTTATGTGCTCTTAAAAAA
AAGATGTGGGTTGCCACCAACCTGTTTTTCGTTTTTGTTTTTTGTTTATTTTATTTTATTTTTTTGCATTCTCCTTTTTCAGTATTACTG

>In-frame_ENST00000264183_ENST00000546136_TCGA-77-A5GH-01A_ARID4B_chr1_235377084_-_SOX5_chr12_24048958_length(amino acids)=757AA_start in transcript=2321_stop in transcript=4594
MRMECERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNK
VMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFG
EIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLP
PLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLG
AAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAV
TKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRES
RGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVD
GKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARID4B-SOX5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARID4B-SOX5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARID4B-SOX5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARID4B	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Tgene	SOX5	C0004238	Atrial Fibrillation	1	CTD_human
Tgene	SOX5	C0036341	Schizophrenia	1	PSYGENET
Tgene	SOX5	C0235480	Paroxysmal atrial fibrillation	1	CTD_human
Tgene	SOX5	C1510586	Autism Spectrum Disorders	1	CTD_human
Tgene	SOX5	C2585653	Persistent atrial fibrillation	1	CTD_human
Tgene	SOX5	C3468561	familial atrial fibrillation	1	CTD_human
Tgene	SOX5	C4749915	Developmental and speech delay due to SOX5 deficiency	1	ORPHANET
Tgene	SOX5	C4755260	12p12.1 microdeletion syndrome	1	ORPHANET