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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PLEKHG1-MTHFD1L (FusionGDB2 ID:65855) |
Fusion Gene Summary for PLEKHG1-MTHFD1L |
Fusion gene summary |
Fusion gene information | Fusion gene name: PLEKHG1-MTHFD1L | Fusion gene ID: 65855 | Hgene | Tgene | Gene symbol | PLEKHG1 | MTHFD1L | Gene ID | 57480 | 25902 |
Gene name | pleckstrin homology and RhoGEF domain containing G1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | |
Synonyms | ARHGEF41 | FTHFSDC1|MTC1THFS|dJ292B18.2 | |
Cytomap | 6q25.1 | 6q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | pleckstrin homology domain-containing family G member 1pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q6UB35 | |
Ensembl transtripts involved in fusion gene | ENST00000367328, ENST00000358517, | ENST00000367321, ENST00000367307, ENST00000478643, | |
Fusion gene scores | * DoF score | 11 X 11 X 10=1210 | 14 X 17 X 13=3094 |
# samples | 19 | 27 | |
** MAII score | log2(19/1210*10)=-2.67093572383101 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/3094*10)=-3.51844188439821 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLEKHG1 [Title/Abstract] AND MTHFD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PLEKHG1(150971922)-MTHFD1L(151355629), # samples:2 MTHFD1L(151358253)-PLEKHG1(150971864), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | PLEKHG1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PLEKHG1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MTHFD1L | GO:0006760 | folic acid-containing compound metabolic process | 12937168 |
Tgene | MTHFD1L | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | 12937168 |
Tgene | MTHFD1L | GO:0015942 | formate metabolic process | 16171773 |
Fusion gene breakpoints across PLEKHG1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MTHFD1L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8591 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
ChimerDB4 | BLCA | TCGA-BT-A20W-01A | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
ChimerDB4 | LGG | TCGA-E1-A7YN | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
ChimerDB4 | LUAD | TCGA-44-2656-01A | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
ChimerDB4 | LUSC | TCGA-34-A5IX | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
ChimerDB4 | SKCM | TCGA-ER-A42L-06A | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
ChimerDB4 | STAD | TCGA-BR-8591-01A | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
ChimerDB4 | STAD | TCGA-VQ-A91A-01A | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
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Fusion Gene ORF analysis for PLEKHG1-MTHFD1L |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
5CDS-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
5CDS-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
Frame-shift | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
5CDS-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
5CDS-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + |
In-frame | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
5CDS-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
5CDS-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
In-frame | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
5CDS-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
5CDS-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + |
In-frame | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
In-frame | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
5CDS-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
In-frame | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
In-frame | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
5CDS-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + |
In-frame | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
5CDS-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
5CDS-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
In-frame | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
5CDS-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
5CDS-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + |
5UTR-3CDS | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
5UTR-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
5UTR-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
intron-3CDS | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
intron-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
intron-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355629 | + |
5UTR-3CDS | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
5UTR-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
5UTR-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
intron-3CDS | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
intron-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
intron-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277131 | + |
Frame-shift | ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
5CDS-intron | ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
5CDS-intron | ENST00000367328 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
Frame-shift | ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
5CDS-intron | ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
5CDS-intron | ENST00000358517 | ENST00000478643 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413603 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000367328 | PLEKHG1 | chr6 | 151153341 | + | ENST00000367321 | MTHFD1L | chr6 | 151277131 | + | 5010 | 3406 | 225 | 4616 | 1463 |
ENST00000358517 | PLEKHG1 | chr6 | 151153341 | + | ENST00000367321 | MTHFD1L | chr6 | 151277131 | + | 4909 | 3305 | 55 | 4515 | 1486 |
ENST00000367328 | PLEKHG1 | chr6 | 151055228 | + | ENST00000367321 | MTHFD1L | chr6 | 151198770 | + | 3741 | 723 | 225 | 3347 | 1040 |
ENST00000367328 | PLEKHG1 | chr6 | 151055228 | + | ENST00000367307 | MTHFD1L | chr6 | 151198770 | + | 1239 | 723 | 225 | 1238 | 337 |
ENST00000358517 | PLEKHG1 | chr6 | 151055228 | + | ENST00000367321 | MTHFD1L | chr6 | 151198770 | + | 3640 | 622 | 55 | 3246 | 1063 |
ENST00000358517 | PLEKHG1 | chr6 | 151055228 | + | ENST00000367307 | MTHFD1L | chr6 | 151198770 | + | 1138 | 622 | 55 | 1137 | 361 |
ENST00000367328 | PLEKHG1 | chr6 | 151107595 | + | ENST00000367321 | MTHFD1L | chr6 | 151355629 | + | 1638 | 894 | 225 | 1244 | 339 |
ENST00000358517 | PLEKHG1 | chr6 | 151107595 | + | ENST00000367321 | MTHFD1L | chr6 | 151355629 | + | 1537 | 793 | 55 | 1143 | 362 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + | 0.001014683 | 0.99898535 |
ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277131 | + | 0.000894688 | 0.9991053 |
ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + | 0.001042744 | 0.9989573 |
ENST00000367328 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + | 0.004960781 | 0.99503917 |
ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + | 0.000908163 | 0.99909186 |
ENST00000358517 | ENST00000367307 | PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198770 | + | 0.003410083 | 0.9965899 |
ENST00000367328 | ENST00000367321 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + | 0.002266289 | 0.9977337 |
ENST00000358517 | ENST00000367321 | PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355629 | + | 0.00150752 | 0.9984925 |
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Fusion Genomic Features for PLEKHG1-MTHFD1L |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277130 | + | 0.015962942 | 0.98403704 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + | 0.001048837 | 0.9989511 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + | 0.001048837 | 0.9989511 |
PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277130 | + | 3.08E-05 | 0.99996924 |
PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355628 | + | 6.03E-06 | 0.9999939 |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355628 | + | 5.80E-06 | 0.99999416 |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355628 | + | 5.80E-06 | 0.99999416 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198769 | + | 5.34E-06 | 0.99999464 |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151277130 | + | 0.015962942 | 0.98403704 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + | 0.001048837 | 0.9989511 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151413602 | + | 0.001048837 | 0.9989511 |
PLEKHG1 | chr6 | 151153341 | + | MTHFD1L | chr6 | 151277130 | + | 3.08E-05 | 0.99996924 |
PLEKHG1 | chr6 | 151107595 | + | MTHFD1L | chr6 | 151355628 | + | 6.03E-06 | 0.9999939 |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355628 | + | 5.80E-06 | 0.99999416 |
PLEKHG1 | chr6 | 150971922 | + | MTHFD1L | chr6 | 151355628 | + | 5.80E-06 | 0.99999416 |
PLEKHG1 | chr6 | 151055228 | + | MTHFD1L | chr6 | 151198769 | + | 5.34E-06 | 0.99999464 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PLEKHG1-MTHFD1L |
Go to FGviewer for the breakpoints of chr6:151153341-chr6:151277131 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | MTHFD1L |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PLEKHG1 | chr6:151153341 | chr6:151277131 | ENST00000358517 | + | 15 | 16 | 113_293 | 1031.3333333333333 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151153341 | chr6:151277131 | ENST00000358517 | + | 15 | 16 | 317_416 | 1031.3333333333333 | 1386.0 | Domain | PH |
Hgene | PLEKHG1 | chr6:151153341 | chr6:151277131 | ENST00000367328 | + | 16 | 17 | 113_293 | 1031.3333333333333 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151153341 | chr6:151277131 | ENST00000367328 | + | 16 | 17 | 317_416 | 1031.3333333333333 | 1386.0 | Domain | PH |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367307 | 0 | 8 | 34_42 | 0 | 276.0 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367307 | 0 | 8 | 34_42 | 0 | 276.0 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367307 | 1 | 8 | 423_430 | 104.0 | 276.0 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367321 | 1 | 28 | 423_430 | 104.0 | 932.6666666666666 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367307 | 0 | 8 | 423_430 | 0 | 276.0 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367307 | 0 | 8 | 423_430 | 0 | 276.0 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367307 | 1 | 8 | 349_978 | 104.0 | 276.0 | Region | Note=Formyltetrahydrofolate synthetase | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367321 | 1 | 28 | 349_978 | 104.0 | 932.6666666666666 | Region | Note=Formyltetrahydrofolate synthetase | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367307 | 0 | 8 | 31_348 | 0 | 276.0 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367307 | 0 | 8 | 349_978 | 0 | 276.0 | Region | Note=Formyltetrahydrofolate synthetase | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367307 | 0 | 8 | 31_348 | 0 | 276.0 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367307 | 0 | 8 | 349_978 | 0 | 276.0 | Region | Note=Formyltetrahydrofolate synthetase |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PLEKHG1 | chr6:151055228 | chr6:151198770 | ENST00000358517 | + | 2 | 16 | 113_293 | 137.0 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151055228 | chr6:151198770 | ENST00000358517 | + | 2 | 16 | 317_416 | 137.0 | 1386.0 | Domain | PH |
Hgene | PLEKHG1 | chr6:151055228 | chr6:151198770 | ENST00000367328 | + | 3 | 17 | 113_293 | 137.0 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151055228 | chr6:151198770 | ENST00000367328 | + | 3 | 17 | 317_416 | 137.0 | 1386.0 | Domain | PH |
Hgene | PLEKHG1 | chr6:151107595 | chr6:151355629 | ENST00000358517 | + | 4 | 16 | 113_293 | 194.0 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151107595 | chr6:151355629 | ENST00000358517 | + | 4 | 16 | 317_416 | 194.0 | 1386.0 | Domain | PH |
Hgene | PLEKHG1 | chr6:151107595 | chr6:151355629 | ENST00000367328 | + | 5 | 17 | 113_293 | 194.0 | 1386.0 | Domain | DH |
Hgene | PLEKHG1 | chr6:151107595 | chr6:151355629 | ENST00000367328 | + | 5 | 17 | 317_416 | 194.0 | 1386.0 | Domain | PH |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367307 | 1 | 8 | 34_42 | 104.0 | 276.0 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367321 | 1 | 28 | 34_42 | 104.0 | 932.6666666666666 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367321 | 23 | 28 | 34_42 | 862.0 | 932.6666666666666 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367321 | 15 | 28 | 34_42 | 575.3333333333334 | 932.6666666666666 | Compositional bias | Note=Poly-Gly | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367321 | 23 | 28 | 423_430 | 862.0 | 932.6666666666666 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367321 | 15 | 28 | 423_430 | 575.3333333333334 | 932.6666666666666 | Nucleotide binding | ATP | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367307 | 1 | 8 | 31_348 | 104.0 | 276.0 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151055228 | chr6:151198770 | ENST00000367321 | 1 | 28 | 31_348 | 104.0 | 932.6666666666666 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367321 | 23 | 28 | 31_348 | 862.0 | 932.6666666666666 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151107595 | chr6:151355629 | ENST00000367321 | 23 | 28 | 349_978 | 862.0 | 932.6666666666666 | Region | Note=Formyltetrahydrofolate synthetase | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367321 | 15 | 28 | 31_348 | 575.3333333333334 | 932.6666666666666 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase | |
Tgene | MTHFD1L | chr6:151153341 | chr6:151277131 | ENST00000367321 | 15 | 28 | 349_978 | 575.3333333333334 | 932.6666666666666 | Region | Note=Formyltetrahydrofolate synthetase |
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Fusion Gene Sequence for PLEKHG1-MTHFD1L |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000367328_ENST00000367321_TCGA-BT-A20W-01A_PLEKHG1_chr6_151153341_+_MTHFD1L_chr6_151277131_length(transcript)=5010nt_BP=3406nt GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA GAGGATTACCTTGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATC TACCACTTCAATAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGAGTGAA GAGTTCCACATTTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACAAGATACTGGCCAAA TTCTTCAGGGAGCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGATTCTCAAGTATCAT CTCCTTCTGCATGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACACAATGCAGCGAGTC GCCTGGCATATCAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTAACTGGAAGGGGCCA GACCTGACCAGCTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCTTCCTCTTCGACAAG CTGCTGCTCATCACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTGTGGAGGTGATTCCA AAAGAGCCGCTCAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGCAAGACAAACGCCTC TGGGTTCTGCACCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCCTTGAAATGGATGCC ATTCATCATCCAGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTCCATATCGGCTGAGA AGAAAATCTGAACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTTCTAGAGAGGAAGGA TCTCCCCAGCTGTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCGTGCTTCGAGCGGGT GGAGCTCTCAGAAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGAATGAGGATGATGAA GATGATTATCAGATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTTCTAGTCGCCCTTGC AGCTGGCATATGGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTGCTGGGGAGAGCAAC ACATGCCCTCCTGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGGAGATGACTCCCTTT GGGTCATCCATAGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAATGGTTGCTAAGCGG GAAGAAGCTGAATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCACAAAGAGGCAAGCT GGCCACAGTAAGGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGCATGAACTCCAAGCG GTTGAGGAGAACATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGCGTGCAAAGCGGAGC ACCTTTTTGGGTCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGCTCAGTGAGGACGAA GCCCCTTACCATCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTATGCCTCATAAGCCT GTATCTGATAAACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACAAGGCCAGAGACCGT CTCCTGGCAGCGTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCCGGGACGTGGGGCGC TCTGTGTCCACGCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCCGCGCCAACTGCCCC TTTGAGGAAGACCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCCTCATGGACAATCCC TACGACCTGGCCAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGACAAAAAGCAGGGTG TTTATGATGGCTCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGGAGCAGCCGCCGGCC AGTCAGCATCAGAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTGTATTGGATACAAAT GACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGC GAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGG CAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTG GAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAA CTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCT TCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTT CCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTC TTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCT GGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGT AAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAA GATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACC CACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCT GGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAA ACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTG CTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTC AAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGG AGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTC >In-frame_ENST00000367328_ENST00000367321_TCGA-BT-A20W-01A_PLEKHG1_chr6_151153341_+_MTHFD1L_chr6_151277131_length(amino acids)=1463AA_start in transcript=225_stop in transcript=4616 MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPL GTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPL GSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFR IQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAA KIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRN SQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSS GHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSV RPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSL RPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDR LHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPEN PDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIVLDTNDRFLRKITIGQGNTE KGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANI AHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVA DGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPI VDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPG -------------------------------------------------------------- >In-frame_ENST00000358517_ENST00000367321_TCGA-BT-A20W-01A_PLEKHG1_chr6_151153341_+_MTHFD1L_chr6_151277131_length(transcript)=4909nt_BP=3305nt AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGATTACCT TGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATCTACCACTTCAA TAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGAGTGAAGAGTTCCACAT TTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACAAGATACTGGCCAAATTCTTCAGGGA GCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGATTCTCAAGTATCATCTCCTTCTGCA TGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACACAATGCAGCGAGTCGCCTGGCATAT CAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTAACTGGAAGGGGCCAGACCTGACCAG CTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCTTCCTCTTCGACAAGCTGCTGCTCAT CACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTGTGGAGGTGATTCCAAAAGAGCCGCT CAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGCAAGACAAACGCCTCTGGGTTCTGCA CCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCCTTGAAATGGATGCCATTCATCATCC AGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTCCATATCGGCTGAGAAGAAAATCTGA ACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTTCTAGAGAGGAAGGATCTCCCCAGCT GTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCGTGCTTCGAGCGGGTGGAGCTCTCAG AAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGAATGAGGATGATGAAGATGATTATCA GATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTTCTAGTCGCCCTTGCAGCTGGCATAT GGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTGCTGGGGAGAGCAACACATGCCCTCC TGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGGAGATGACTCCCTTTGGGTCATCCAT AGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAATGGTTGCTAAGCGGGAAGAAGCTGA ATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCACAAAGAGGCAAGCTGGCCACAGTAA GGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGCATGAACTCCAAGCGGTTGAGGAGAA CATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGCGTGCAAAGCGGAGCACCTTTTTGGG TCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGCTCAGTGAGGACGAAGCCCCTTACCA TCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTATGCCTCATAAGCCTGTATCTGATAA ACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACAAGGCCAGAGACCGTCTCCTGGCAGC GTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCCGGGACGTGGGGCGCTCTGTGTCCAC GCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCCGCGCCAACTGCCCCTTTGAGGAAGA CCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCCTCATGGACAATCCCTACGACCTGGC CAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGACAAAAAGCAGGGTGTTTATGATGGC TCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGGAGCAGCCGCCGGCCAGTCAGCATCA GAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTGTATTGGATACAAATGACCGATTTCT ACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGC GGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGAC AGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACC TGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGA AGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGT GCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAA AGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCC CGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGA TGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCG ATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACT CTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCT ATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTA CCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGT TAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGA GAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTC TGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTA TTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGT >In-frame_ENST00000358517_ENST00000367321_TCGA-BT-A20W-01A_PLEKHG1_chr6_151153341_+_MTHFD1L_chr6_151277131_length(amino acids)=1486AA_start in transcript=55_stop in transcript=4515 MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY VQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTEC MRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS LLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQA KSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDI QKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCE DSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYED LKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCS SLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKK NEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLAS EMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGG PAIVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAI KPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGG GPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLA RAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPIS -------------------------------------------------------------- >In-frame_ENST00000367328_ENST00000367321_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(transcript)=3741nt_BP=723nt GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA GAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCA GATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAAC TTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGG GATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATT TTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAA ACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAA CCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATT GAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCAC AGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCT GTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTA GAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACC ATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTG AAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACC GCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTT CCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTG ACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTT CTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATG GCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTG ACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACA CCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGT GAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA GTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTG GAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAAT TCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCAT TATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAA >In-frame_ENST00000367328_ENST00000367321_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(amino acids)=1040AA_start in transcript=225_stop in transcript=3347 MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEAGDDNLMQEINQNL AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVI ELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSG KVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEI EIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPM EEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDIDP STITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLM KDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALK MHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGS VDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFI -------------------------------------------------------------- >In-frame_ENST00000367328_ENST00000367307_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(transcript)=1239nt_BP=723nt GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA GAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCA GATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAAC TTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGG GATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATT TTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAA >In-frame_ENST00000367328_ENST00000367307_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(amino acids)=337AA_start in transcript=225_stop in transcript=1238 MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEAGDDNLMQEINQNL AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVI -------------------------------------------------------------- >In-frame_ENST00000358517_ENST00000367321_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(transcript)=3640nt_BP=622nt AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGCAGGTGA CGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGA AGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAA CAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGA ATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGG GGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCT TCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTAC TGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGA TGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAG ACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCT TGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAA GGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGT GCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGC CGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAA CTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAA TGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGA AGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAAT AACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGC CCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGA TTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGT GCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATT TGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGT GGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATAC AGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGT GGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCC CTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTT CCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGA GGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCA ACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGT CGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTT GTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACT GAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAG TGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTG CTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTT >In-frame_ENST00000358517_ENST00000367321_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(amino acids)=1063AA_start in transcript=55_stop in transcript=3246 MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY VQDLKSIVEAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDI NLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPE EIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEI SRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQP SQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGI NKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVA SDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFN IKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCE LAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPI -------------------------------------------------------------- >In-frame_ENST00000358517_ENST00000367307_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(transcript)=1138nt_BP=622nt AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGCAGGTGA CGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGA AGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAA CAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGA ATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGG GGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCT >In-frame_ENST00000358517_ENST00000367307_TCGA-E1-A7YN_PLEKHG1_chr6_151055228_+_MTHFD1L_chr6_151198770_length(amino acids)=361AA_start in transcript=55_stop in transcript=1137 MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY VQDLKSIVEAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDI NLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKTESRSVTRLECRRVI -------------------------------------------------------------- >In-frame_ENST00000367328_ENST00000367321_TCGA-44-2656-01A_PLEKHG1_chr6_151107595_+_MTHFD1L_chr6_151355629_length(transcript)=1638nt_BP=894nt GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA GAGGATTACCTTGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATC TACCACTTCAATAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGGTTCCA ATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGT TACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCA AGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCA GGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTC ACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTAT GCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAA GGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATT TTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGAAAATAAAC >In-frame_ENST00000367328_ENST00000367321_TCGA-44-2656-01A_PLEKHG1_chr6_151107595_+_MTHFD1L_chr6_151355629_length(amino acids)=339AA_start in transcript=225_stop in transcript=1244 MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPL GTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAK -------------------------------------------------------------- >In-frame_ENST00000358517_ENST00000367321_TCGA-44-2656-01A_PLEKHG1_chr6_151107595_+_MTHFD1L_chr6_151355629_length(transcript)=1537nt_BP=793nt AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGATTACCT TGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATCTACCACTTCAA TAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGGTTCCAATTGTGGACAA GATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACA GGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCAT CTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCAC CCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGA TGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGA GACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACC AAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACT AAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGAAAATAAACATGGATCTAGA >In-frame_ENST00000358517_ENST00000367321_TCGA-44-2656-01A_PLEKHG1_chr6_151107595_+_MTHFD1L_chr6_151355629_length(amino acids)=362AA_start in transcript=55_stop in transcript=1143 MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY VQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKVPIVDKIRTIAQAVYGAKDIELSP EAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PLEKHG1-MTHFD1L |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PLEKHG1-MTHFD1L |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PLEKHG1-MTHFD1L |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLEKHG1 | C0028043 | Nicotine Dependence | 1 | CTD_human |
Hgene | PLEKHG1 | C0040332 | Tobacco Dependence | 1 | CTD_human |
Hgene | PLEKHG1 | C0376384 | Nicotine Use Disorder | 1 | CTD_human |