FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PLEKHM2-ECE1 (FusionGDB2 ID:65908)

Fusion Gene Summary for PLEKHM2-ECE1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHM2-ECE1
Fusion gene ID: 65908
HgeneTgene
Gene symbol

PLEKHM2

ECE1

Gene ID

23207

1889

Gene namepleckstrin homology and RUN domain containing M2endothelin converting enzyme 1
SynonymsSKIPECE
Cytomap

1p36.21

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family Mendothelin-converting enzyme 1ECE-1
Modification date2020031320200313
UniProtAcc.

P42892

Ensembl transtripts involved in fusion geneENST00000375799, ENST00000375793, 
ENST00000477849, 		ENST00000415912, 
ENST00000357071, ENST00000374893, 
ENST00000436918, ENST00000264205, 
ENST00000528294, 
Fusion gene scores* DoF score9 X 7 X 6=37810 X 12 X 6=720
# samples 914
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHM2 [Title/Abstract] AND ECE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHM2(16045120)-ECE1(21573856), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEKHM2

GO:1903527

positive regulation of membrane tubulation

18996344

TgeneECE1

GO:0010814

substance P catabolic process

18039931

TgeneECE1

GO:0010815

bradykinin catabolic process

18039931

TgeneECE1

GO:0010816

calcitonin catabolic process

18039931

TgeneECE1

GO:0016485

protein processing

7805846

TgeneECE1

GO:0016486

peptide hormone processing

7864876

TgeneECE1

GO:0034959

endothelin maturation

7805846

TgeneECE1

GO:0042447

hormone catabolic process

7864876


check buttonFusion gene breakpoints across PLEKHM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ECE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BV-01APLEKHM2chr1

16045120

+ECE1chr1

21573856

-


Top

Fusion Gene ORF analysis for PLEKHM2-ECE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375799ENST00000415912PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375799ENST00000357071PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375799ENST00000374893PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375799ENST00000436918PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375799ENST00000264205PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
5CDS-5UTRENST00000375799ENST00000528294PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375793ENST00000415912PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375793ENST00000357071PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375793ENST00000374893PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375793ENST00000436918PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
In-frameENST00000375793ENST00000264205PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
5CDS-5UTRENST00000375793ENST00000528294PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-3CDSENST00000477849ENST00000415912PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-3CDSENST00000477849ENST00000357071PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-3CDSENST00000477849ENST00000374893PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-3CDSENST00000477849ENST00000436918PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-3CDSENST00000477849ENST00000264205PLEKHM2chr1

16045120

+ECE1chr1

21573856

-
intron-5UTRENST00000477849ENST00000528294PLEKHM2chr1

16045120

+ECE1chr1

21573856

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375799PLEKHM2chr116045120+ENST00000415912ECE1chr121573856-46936921371984615
ENST00000375799PLEKHM2chr116045120+ENST00000357071ECE1chr121573856-33566921371984615
ENST00000375799PLEKHM2chr116045120+ENST00000374893ECE1chr121573856-20816921371984615
ENST00000375799PLEKHM2chr116045120+ENST00000436918ECE1chr121573856-19506921371888583
ENST00000375799PLEKHM2chr116045120+ENST00000264205ECE1chr121573856-20036921371984615
ENST00000375793PLEKHM2chr116045120+ENST00000415912ECE1chr121573856-4635634791926615
ENST00000375793PLEKHM2chr116045120+ENST00000357071ECE1chr121573856-3298634791926615
ENST00000375793PLEKHM2chr116045120+ENST00000374893ECE1chr121573856-2023634791926615
ENST00000375793PLEKHM2chr116045120+ENST00000436918ECE1chr121573856-1892634791830583
ENST00000375793PLEKHM2chr116045120+ENST00000264205ECE1chr121573856-1945634791926615

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375799ENST00000415912PLEKHM2chr116045120+ECE1chr121573856-0.0090913330.9909087
ENST00000375799ENST00000357071PLEKHM2chr116045120+ECE1chr121573856-0.0089805260.9910194
ENST00000375799ENST00000374893PLEKHM2chr116045120+ECE1chr121573856-0.0141171370.9858828
ENST00000375799ENST00000436918PLEKHM2chr116045120+ECE1chr121573856-0.0112809030.98871905
ENST00000375799ENST00000264205PLEKHM2chr116045120+ECE1chr121573856-0.0132626270.98673743
ENST00000375793ENST00000415912PLEKHM2chr116045120+ECE1chr121573856-0.0092338030.99076617
ENST00000375793ENST00000357071PLEKHM2chr116045120+ECE1chr121573856-0.0092177110.9907823
ENST00000375793ENST00000374893PLEKHM2chr116045120+ECE1chr121573856-0.0135141660.98648584
ENST00000375793ENST00000436918PLEKHM2chr116045120+ECE1chr121573856-0.010751030.989249
ENST00000375793ENST00000264205PLEKHM2chr116045120+ECE1chr121573856-0.0126423130.98735774

Top

Fusion Genomic Features for PLEKHM2-ECE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PLEKHM2-ECE1


check button Go to

FGviewer for the breakpoints of chr1:16045120-chr1:21573856

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ECE1

P42892

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:9396733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+52036_158155.01020.0DomainRUN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520317_320155.01020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520323_326155.01020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520506_511155.01020.0Compositional biasNote=Poly-Gly
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520593_596155.01020.0Compositional biasNote=Poly-Leu
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520771_873155.01020.0DomainPH
TgeneECE1chr1:16045120chr1:21573856ENST0000026420561898_770337.0768.0DomainPeptidase M13
TgeneECE1chr1:16045120chr1:21573856ENST0000035707151798_770328.0759.0DomainPeptidase M13
TgeneECE1chr1:16045120chr1:21573856ENST0000037489371998_770340.0771.0DomainPeptidase M13
TgeneECE1chr1:16045120chr1:21573856ENST0000041591271998_770324.0755.0DomainPeptidase M13
TgeneECE1chr1:16045120chr1:21573856ENST000002642056181_68337.0768.0Topological domainCytoplasmic
TgeneECE1chr1:16045120chr1:21573856ENST0000026420561890_770337.0768.0Topological domainExtracellular
TgeneECE1chr1:16045120chr1:21573856ENST000003570715171_68328.0759.0Topological domainCytoplasmic
TgeneECE1chr1:16045120chr1:21573856ENST0000035707151790_770328.0759.0Topological domainExtracellular
TgeneECE1chr1:16045120chr1:21573856ENST000003748937191_68340.0771.0Topological domainCytoplasmic
TgeneECE1chr1:16045120chr1:21573856ENST0000037489371990_770340.0771.0Topological domainExtracellular
TgeneECE1chr1:16045120chr1:21573856ENST000004159127191_68324.0755.0Topological domainCytoplasmic
TgeneECE1chr1:16045120chr1:21573856ENST0000041591271990_770324.0755.0Topological domainExtracellular
TgeneECE1chr1:16045120chr1:21573856ENST0000026420561869_89337.0768.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneECE1chr1:16045120chr1:21573856ENST0000035707151769_89328.0759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneECE1chr1:16045120chr1:21573856ENST0000037489371969_89340.0771.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneECE1chr1:16045120chr1:21573856ENST0000041591271969_89324.0755.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Gene Sequence for PLEKHM2-ECE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375799_ENST00000415912_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=4693nt_BP=692nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGACCTTGGCACCCGCCATCAACTGGTTGC
CTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCA
CTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCT
TTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGGAAGTTTTGCGTGAGTGACACAG
AAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGG
AGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCAGCCAAGGAAAAGGCCGATGCCA
TCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCT
ACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCCCCCAACAGAGATCAGTGGAGCA
TGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACAC
GCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCTTTTGATGATCAAGGACGGGAGT
ATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACA
GCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAACGGGGGTCTCAAGGCGGCCTATC
GGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGGCCTCACCAATAACCAGCTCTTCTTCCTGGGCT
TTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCACAGCCCCTCTCGCTTCCGGGTCA
TCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCT
GGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGACCCCCATCCAGCCTCCAGGGCATTGCTCAGCCC
GCTTGGCCACCCGGGGCCCTGCTTCCTCACACTGGCGGGTTTTCAGCCGGAACCGAGCCCATGGTGTTGGCTCTCAACGTGACCCGCAGT
CTGATCCCCTGTGAAGAGCCGGACATCCCAGGCACACGTGTGCGCCACCTTCAGCAGGCATTCGGGTGCTGGGCTGGTGGCTCATCAGGC
CTGGGCCCCACACTGACAAGCGCCAGATACGCCACAAATACCACTGTGTCAAATGCTTTCAAGATATATTTTTGGGGAAACTATTTTTTA
AACACTGTGGAATACACTGGAAATCTTCAGGGAAAAACACATTTAAACACTTTTTTTTTTAAGGAAAGAATTGGTATATTTATTATGTTC
TGTTTTTCTAAATAACCTGTGGACAAGGGAAGCCCCACTGATTTACTCCCTCTCTTCCCCACTCCCTGTGAGGCTGGGCTGAGGCACGGA
TCCCTGGGCCACAGAGCAAGTCTCCAAATCAGACAGCTGCCTCAGCCCCTGGGATGTGTGATTTCAGCTCCTGTCACCTCATGCAAGGGC
GTGGAGACCAGTAGAGGTGTGGAGGCCAGGCAGAGAGAGGAGCCTGCTCTGCGGGGGGCCCAGCTCATGGGCACTGCCCCTTCAGCTAGC
CTGCCTCCGTCCCCTGAGTCCAACAGTGGGAGCCCTAGCTGGGAAGTTCTGATCCCCAAAGCCACAGCAGGGGACTGATGGCTATAGCAG
AATGAGGTCGGGTCAGGACCCTCAAACACCATCTGGGAACACCAAGCACCCTGAATCGAGACTGCAGGAGCCCTGCGGGGTGAGACTGTG
TCAGAGATACACTGCTGGCCACAAGTGTCCCCTCTCAGTCCCACCTTTTCGGGCTGTCCCATGTCTATCTCAGGGGCCCGTTACCTCTCT
GCAGCAGTCCCCCATCCCAGCCACACCAGGGTCTGTCCGGCCAACCCTCTTCCCCAGGGAAAGGAGAAAAGAGAAAACAGGCTGGGCCCG
GTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTG
GTGAAACCCCATCTCTACTAAAAAAAATTACAAAAATTAGCCGGGAGTGGTGGTGGGCACCTGTAATCCCAGTTACTCGGGAGGCTGAGG
CAAGAGAATCTCTTGAGCTCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGGGAGACTCC
GTCCCAAAAAAAAGAAAAGAGAAACAGCTGTCACCTCCCGCAGGACCCAAATCCTCTCTCTGAGCACCGTCATCCACCACATGGCTGGGC
CTGGCTCCCAGGACCAGTCCAGTCCTCTAGTGCCTTATCTGAGGCTGCAGCCGCCAGTCTCCACCCCAAGGAGACAGCCCCTGCTCCTAG
ATGCCCTTGGCCTCCGCAGTGCAGCCCCCAGGTGTCCTGACTGAAGCACAGGCCATAGCCCCATTTCCCCGGTGCCTGCAGGGCTAACCT
CCACGGGAGCCCAGGAGCTCTGGCCGGCAGGTCCATGGCACAGGGCATCGGAAGACTGCAAAACTGCTGGACTTACCCTGGGCTGCAGTC
CATTGTCGGCCCCTGGGTTGAATCAAGATAGTACTTGCAGCTAGATGGATGCTTTTAGCCAGGGGACATTGTGAGGGGAAGATTCCTCCA
CCCAGTCTGGCCTGTGGTGTCTGTCTCCTCCCTGAGACCACAGCTTCTCCAGTAGCAGACTCATGGGCGCCACCAAGTGGAAGCACCTGG
AGCGGCCTCTGCCATCCAGTGGGGAAGCCAGGCCCCGAGACGGAGGTGGGGGCAGCACGTGCCCTCCACAGCCACCGCTTTCCCGCCTCA
GCAGCCCAGGCCTCCTGGCCCAGCCCTGCCTGGACAGTGCTCTCCCCTCACCCGGGAAGCTGGAATCCTCCTGCCCGAGAGGAAGCAGAC
GGCACAGGGACACCCCTGCCACCTTGGGATCTGCCTCCAAGCTGGTGCAGGGTATCGAGAGTGGATTCCAGATGGAGGTCCTGGTCCCAG
CACGCAGCAGTCCTGGTAGCTCTGCAGAGGAGACAGGAACCCGAGAAGTAGCTGAAGCAGAAGCCAGCCGCAGTCCCCTTGCCACATAGA
GGCGGGCTTCTCCCAGCCATGGTGTCCCCTCTGCCTCCCCTCCCCCGACCCTCCTGCCTTCCGCGTGGAGGGTGGTGGTCCTGTAGTGTC
AGCACCAGCACCATGGGCTTGGACCCCCTCCCTGGACACAGGCAGGTGTCCTAGGGCTGGGGGTGCAGCCCGAGGGAATGGAGACCACAC
TCATGGCTCAGGTCTGCCGGGGCCGGCAGGGGGTTGGGGAAGAAGAGGGCTCAGGCCCAGCAGGGGTGGAAGCCCCTGCCACTGCCACTA
CCCGCTCCAGAGCTTTAAGGAAAATGAAGTGAGACCCCTCCCCTTAGGCCTGGGGAGCCATAGGGCTGGCTTCTCTGTGGGTGCGTGGAC
GTGGGGTTGGGAGCTGGGAATCTATTTTTTGTATTATGTTTTGAGCTACTGTAGTTTTGGCGTGGCACTATTGTAATGGAAATAAAATAC

>In-frame_ENST00000375799_ENST00000415912_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=137_stop in transcript=1984
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000357071_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=3356nt_BP=692nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGACCTTGGCACCCGCCATCAACTGGTTGC
CTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCA
CTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCT
TTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGGAAGTTTTGCGTGAGTGACACAG
AAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGG
AGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCAGCCAAGGAAAAGGCCGATGCCA
TCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCT
ACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCCCCCAACAGAGATCAGTGGAGCA
TGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACAC
GCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCTTTTGATGATCAAGGACGGGAGT
ATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACA
GCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAACGGGGGTCTCAAGGCGGCCTATC
GGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGGCCTCACCAATAACCAGCTCTTCTTCCTGGGCT
TTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCACAGCCCCTCTCGCTTCCGGGTCA
TCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCT
GGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGACCCCCATCCAGCCTCCAGGGCATTGCTCAGCCC
GCTTGGCCACCCGGGGCCCTGCTTCCTCACACTGGCGGGTTTTCAGCCGGAACCGAGCCCATGGTGTTGGCTCTCAACGTGACCCGCAGT
CTGATCCCCTGTGAAGAGCCGGACATCCCAGGCACACGTGTGCGCCACCTTCAGCAGGCATTCGGGTGCTGGGCTGGTGGCTCATCAGGC
CTGGGCCCCACACTGACAAGCGCCAGATACGCCACAAATACCACTGTGTCAAATGCTTTCAAGATATATTTTTGGGGAAACTATTTTTTA
AACACTGTGGAATACACTGGAAATCTTCAGGGAAAAACACATTTAAACACTTTTTTTTTTAAGGAAAGAATTGGTATATTTATTATGTTC
TGTTTTTCTAAATAACCTGTGGACAAGGGAAGCCCCACTGATTTACTCCCTCTCTTCCCCACTCCCTGTGAGGCTGGGCTGAGGCACGGA
TCCCTGGGCCACAGAGCAAGTCTCCAAATCAGACAGCTGCCTCAGCCCCTGGGATGTGTGATTTCAGCTCCTGTCACCTCATGCAAGGGC
GTGGAGACCAGTAGAGGTGTGGAGGCCAGGCAGAGAGAGGAGCCTGCTCTGCGGGGGGCCCAGCTCATGGGCACTGCCCCTTCAGCTAGC
CTGCCTCCGTCCCCTGAGTCCAACAGTGGGAGCCCTAGCTGGGAAGTTCTGATCCCCAAAGCCACAGCAGGGGACTGATGGCTATAGCAG
AATGAGGTCGGGTCAGGACCCTCAAACACCATCTGGGAACACCAAGCACCCTGAATCGAGACTGCAGGAGCCCTGCGGGGTGAGACTGTG
TCAGAGATACACTGCTGGCCACAAGTGTCCCCTCTCAGTCCCACCTTTTCGGGCTGTCCCATGTCTATCTCAGGGGCCCGTTACCTCTCT
GCAGCAGTCCCCCATCCCAGCCACACCAGGGTCTGTCCGGCCAACCCTCTTCCCCAGGGAAAGGAGAAAAGAGAAAACAGGCTGGGCCCG
GTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTG
GTGAAACCCCATCTCTACTAAAAAAAATTACAAAAATTAGCCGGGAGTGGTGGTGGGCACCTGTAATCCCAGTTACTCGGGAGGCTGAGG
CAAGAGAATCTCTTGAGCTCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGGGAGACTCC

>In-frame_ENST00000375799_ENST00000357071_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=137_stop in transcript=1984
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000374893_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=2081nt_BP=692nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGACCTTGGCACCCGCCATCAACTGGTTGC
CTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCA
CTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCT
TTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGGAAGTTTTGCGTGAGTGACACAG
AAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGG
AGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCAGCCAAGGAAAAGGCCGATGCCA
TCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCT
ACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCCCCCAACAGAGATCAGTGGAGCA
TGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACAC
GCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCTTTTGATGATCAAGGACGGGAGT
ATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACA
GCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAACGGGGGTCTCAAGGCGGCCTATC
GGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGGCCTCACCAATAACCAGCTCTTCTTCCTGGGCT
TTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCACAGCCCCTCTCGCTTCCGGGTCA
TCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCT
GGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGACCCCCATCCAGCCTCCAGGGCATTGCTCAGCCC

>In-frame_ENST00000375799_ENST00000374893_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=137_stop in transcript=1984
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000436918_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=1950nt_BP=692nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGACCTTGGCACCCGCCATCAACTGGTTGC
CTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCA
CTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCT
TTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGGAAGTTTTGCGTGAGTGACACAG
AAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGG
AGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCAGCCAAGGAAAAGGCCGATGCCA
TCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCT
ACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCCCCCAACAGAGATCAGTGGAGCA
TGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACAC
GCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCTTTTGATGATCAAGGACGGGAGT
ATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACA
GCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAACGGGGGTCTCAAGGCGGCCTATC
GGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCACAGCCCCTCTCGCTTCCGGGTCATCGGCT
CCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCTGGTAAG

>In-frame_ENST00000375799_ENST00000436918_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=583AA_start in transcript=137_stop in transcript=1888
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRVWCSVRTPESSHEGL

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000264205_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=2003nt_BP=692nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGACCTTGGCACCCGCCATCAACTGGTTGC
CTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCA
CTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCT
TTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGGAAGTTTTGCGTGAGTGACACAG
AAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGG
AGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCAGCCAAGGAAAAGGCCGATGCCA
TCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCT
ACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCCCCCAACAGAGATCAGTGGAGCA
TGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACAC
GCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCTTTTGATGATCAAGGACGGGAGT
ATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACA
GCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAACGGGGGTCTCAAGGCGGCCTATC
GGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGGCCTCACCAATAACCAGCTCTTCTTCCTGGGCT
TTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCACAGCCCCTCTCGCTTCCGGGTCA
TCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCT

>In-frame_ENST00000375799_ENST00000264205_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=137_stop in transcript=1984
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000415912_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=4635nt_BP=634nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGT
CTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGT
GCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCT
TCCTCGCTGGAAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGA
CAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAAC
CCGAAAATCAGCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGT
GTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCT
CAGGAAAGCCCCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCC
GGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCT
GACTCATGCTTTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAA
GCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACAT
CGCCGACAACGGGGGTCTCAAGGCGGCCTATCGGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGG
CCTCACCAATAACCAGCTCTTCTTCCTGGGCTTTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCAC
CGATCCCCACAGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTC
ACCCATGAACCCGCCTCACAAGTGCGAAGTCTGGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGAC
CCCCATCCAGCCTCCAGGGCATTGCTCAGCCCGCTTGGCCACCCGGGGCCCTGCTTCCTCACACTGGCGGGTTTTCAGCCGGAACCGAGC
CCATGGTGTTGGCTCTCAACGTGACCCGCAGTCTGATCCCCTGTGAAGAGCCGGACATCCCAGGCACACGTGTGCGCCACCTTCAGCAGG
CATTCGGGTGCTGGGCTGGTGGCTCATCAGGCCTGGGCCCCACACTGACAAGCGCCAGATACGCCACAAATACCACTGTGTCAAATGCTT
TCAAGATATATTTTTGGGGAAACTATTTTTTAAACACTGTGGAATACACTGGAAATCTTCAGGGAAAAACACATTTAAACACTTTTTTTT
TTAAGGAAAGAATTGGTATATTTATTATGTTCTGTTTTTCTAAATAACCTGTGGACAAGGGAAGCCCCACTGATTTACTCCCTCTCTTCC
CCACTCCCTGTGAGGCTGGGCTGAGGCACGGATCCCTGGGCCACAGAGCAAGTCTCCAAATCAGACAGCTGCCTCAGCCCCTGGGATGTG
TGATTTCAGCTCCTGTCACCTCATGCAAGGGCGTGGAGACCAGTAGAGGTGTGGAGGCCAGGCAGAGAGAGGAGCCTGCTCTGCGGGGGG
CCCAGCTCATGGGCACTGCCCCTTCAGCTAGCCTGCCTCCGTCCCCTGAGTCCAACAGTGGGAGCCCTAGCTGGGAAGTTCTGATCCCCA
AAGCCACAGCAGGGGACTGATGGCTATAGCAGAATGAGGTCGGGTCAGGACCCTCAAACACCATCTGGGAACACCAAGCACCCTGAATCG
AGACTGCAGGAGCCCTGCGGGGTGAGACTGTGTCAGAGATACACTGCTGGCCACAAGTGTCCCCTCTCAGTCCCACCTTTTCGGGCTGTC
CCATGTCTATCTCAGGGGCCCGTTACCTCTCTGCAGCAGTCCCCCATCCCAGCCACACCAGGGTCTGTCCGGCCAACCCTCTTCCCCAGG
GAAAGGAGAAAAGAGAAAACAGGCTGGGCCCGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGCGGATCACCTGAG
GTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGTGAAACCCCATCTCTACTAAAAAAAATTACAAAAATTAGCCGGGAGTGGTGGTGGGC
ACCTGTAATCCCAGTTACTCGGGAGGCTGAGGCAAGAGAATCTCTTGAGCTCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACT
GCACTCCAGCCTGGGTGACAGAGGGAGACTCCGTCCCAAAAAAAAGAAAAGAGAAACAGCTGTCACCTCCCGCAGGACCCAAATCCTCTC
TCTGAGCACCGTCATCCACCACATGGCTGGGCCTGGCTCCCAGGACCAGTCCAGTCCTCTAGTGCCTTATCTGAGGCTGCAGCCGCCAGT
CTCCACCCCAAGGAGACAGCCCCTGCTCCTAGATGCCCTTGGCCTCCGCAGTGCAGCCCCCAGGTGTCCTGACTGAAGCACAGGCCATAG
CCCCATTTCCCCGGTGCCTGCAGGGCTAACCTCCACGGGAGCCCAGGAGCTCTGGCCGGCAGGTCCATGGCACAGGGCATCGGAAGACTG
CAAAACTGCTGGACTTACCCTGGGCTGCAGTCCATTGTCGGCCCCTGGGTTGAATCAAGATAGTACTTGCAGCTAGATGGATGCTTTTAG
CCAGGGGACATTGTGAGGGGAAGATTCCTCCACCCAGTCTGGCCTGTGGTGTCTGTCTCCTCCCTGAGACCACAGCTTCTCCAGTAGCAG
ACTCATGGGCGCCACCAAGTGGAAGCACCTGGAGCGGCCTCTGCCATCCAGTGGGGAAGCCAGGCCCCGAGACGGAGGTGGGGGCAGCAC
GTGCCCTCCACAGCCACCGCTTTCCCGCCTCAGCAGCCCAGGCCTCCTGGCCCAGCCCTGCCTGGACAGTGCTCTCCCCTCACCCGGGAA
GCTGGAATCCTCCTGCCCGAGAGGAAGCAGACGGCACAGGGACACCCCTGCCACCTTGGGATCTGCCTCCAAGCTGGTGCAGGGTATCGA
GAGTGGATTCCAGATGGAGGTCCTGGTCCCAGCACGCAGCAGTCCTGGTAGCTCTGCAGAGGAGACAGGAACCCGAGAAGTAGCTGAAGC
AGAAGCCAGCCGCAGTCCCCTTGCCACATAGAGGCGGGCTTCTCCCAGCCATGGTGTCCCCTCTGCCTCCCCTCCCCCGACCCTCCTGCC
TTCCGCGTGGAGGGTGGTGGTCCTGTAGTGTCAGCACCAGCACCATGGGCTTGGACCCCCTCCCTGGACACAGGCAGGTGTCCTAGGGCT
GGGGGTGCAGCCCGAGGGAATGGAGACCACACTCATGGCTCAGGTCTGCCGGGGCCGGCAGGGGGTTGGGGAAGAAGAGGGCTCAGGCCC
AGCAGGGGTGGAAGCCCCTGCCACTGCCACTACCCGCTCCAGAGCTTTAAGGAAAATGAAGTGAGACCCCTCCCCTTAGGCCTGGGGAGC
CATAGGGCTGGCTTCTCTGTGGGTGCGTGGACGTGGGGTTGGGAGCTGGGAATCTATTTTTTGTATTATGTTTTGAGCTACTGTAGTTTT

>In-frame_ENST00000375793_ENST00000415912_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=79_stop in transcript=1926
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000357071_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=3298nt_BP=634nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGT
CTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGT
GCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCT
TCCTCGCTGGAAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGA
CAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAAC
CCGAAAATCAGCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGT
GTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCT
CAGGAAAGCCCCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCC
GGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCT
GACTCATGCTTTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAA
GCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACAT
CGCCGACAACGGGGGTCTCAAGGCGGCCTATCGGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGG
CCTCACCAATAACCAGCTCTTCTTCCTGGGCTTTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCAC
CGATCCCCACAGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTC
ACCCATGAACCCGCCTCACAAGTGCGAAGTCTGGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGAC
CCCCATCCAGCCTCCAGGGCATTGCTCAGCCCGCTTGGCCACCCGGGGCCCTGCTTCCTCACACTGGCGGGTTTTCAGCCGGAACCGAGC
CCATGGTGTTGGCTCTCAACGTGACCCGCAGTCTGATCCCCTGTGAAGAGCCGGACATCCCAGGCACACGTGTGCGCCACCTTCAGCAGG
CATTCGGGTGCTGGGCTGGTGGCTCATCAGGCCTGGGCCCCACACTGACAAGCGCCAGATACGCCACAAATACCACTGTGTCAAATGCTT
TCAAGATATATTTTTGGGGAAACTATTTTTTAAACACTGTGGAATACACTGGAAATCTTCAGGGAAAAACACATTTAAACACTTTTTTTT
TTAAGGAAAGAATTGGTATATTTATTATGTTCTGTTTTTCTAAATAACCTGTGGACAAGGGAAGCCCCACTGATTTACTCCCTCTCTTCC
CCACTCCCTGTGAGGCTGGGCTGAGGCACGGATCCCTGGGCCACAGAGCAAGTCTCCAAATCAGACAGCTGCCTCAGCCCCTGGGATGTG
TGATTTCAGCTCCTGTCACCTCATGCAAGGGCGTGGAGACCAGTAGAGGTGTGGAGGCCAGGCAGAGAGAGGAGCCTGCTCTGCGGGGGG
CCCAGCTCATGGGCACTGCCCCTTCAGCTAGCCTGCCTCCGTCCCCTGAGTCCAACAGTGGGAGCCCTAGCTGGGAAGTTCTGATCCCCA
AAGCCACAGCAGGGGACTGATGGCTATAGCAGAATGAGGTCGGGTCAGGACCCTCAAACACCATCTGGGAACACCAAGCACCCTGAATCG
AGACTGCAGGAGCCCTGCGGGGTGAGACTGTGTCAGAGATACACTGCTGGCCACAAGTGTCCCCTCTCAGTCCCACCTTTTCGGGCTGTC
CCATGTCTATCTCAGGGGCCCGTTACCTCTCTGCAGCAGTCCCCCATCCCAGCCACACCAGGGTCTGTCCGGCCAACCCTCTTCCCCAGG
GAAAGGAGAAAAGAGAAAACAGGCTGGGCCCGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGCGGATCACCTGAG
GTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGTGAAACCCCATCTCTACTAAAAAAAATTACAAAAATTAGCCGGGAGTGGTGGTGGGC
ACCTGTAATCCCAGTTACTCGGGAGGCTGAGGCAAGAGAATCTCTTGAGCTCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACT

>In-frame_ENST00000375793_ENST00000357071_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=79_stop in transcript=1926
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000374893_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=2023nt_BP=634nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGT
CTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGT
GCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCT
TCCTCGCTGGAAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGA
CAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAAC
CCGAAAATCAGCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGT
GTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCT
CAGGAAAGCCCCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCC
GGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCT
GACTCATGCTTTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAA
GCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACAT
CGCCGACAACGGGGGTCTCAAGGCGGCCTATCGGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGG
CCTCACCAATAACCAGCTCTTCTTCCTGGGCTTTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCAC
CGATCCCCACAGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTC
ACCCATGAACCCGCCTCACAAGTGCGAAGTCTGGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGAC

>In-frame_ENST00000375793_ENST00000374893_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=79_stop in transcript=1926
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000436918_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=1892nt_BP=634nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGT
CTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGT
GCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCT
TCCTCGCTGGAAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGA
CAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAAC
CCGAAAATCAGCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGT
GTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCT
CAGGAAAGCCCCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCC
GGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCT
GACTCATGCTTTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAA
GCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACAT
CGCCGACAACGGGGGTCTCAAGGCGGCCTATCGGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCC
CCACAGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTCACCCAT
GAACCCGCCTCACAAGTGCGAAGTCTGGTAAGGACGAAGCGGAGAGAGCCAAGACGGAGGAGGGGAAGGGGCTGAGGACGAGACCCCCAT

>In-frame_ENST00000375793_ENST00000436918_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=583AA_start in transcript=79_stop in transcript=1830
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRVWCSVRTPESSHEGL

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000264205_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(transcript)=1945nt_BP=634nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGT
CTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGT
GCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCT
TCCTCGCTGGAAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTCAAAGCAACCTTCGCCGAGGA
CAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAGAAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAAC
CCGAAAATCAGCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGATCCCAAGGAGCTGGACAAAGT
GTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAAAATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCT
CAGGAAAGCCCCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACCAAGAATGAGATTGTGTTTCC
GGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCACCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCT
GACTCATGCTTTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAACTCATCCGTGGAGGCCTTCAA
GCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTACAGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACAT
CGCCGACAACGGGGGTCTCAAGGCGGCCTATCGGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAGCACTCGCTCCCCACCCTGGG
CCTCACCAATAACCAGCTCTTCTTCCTGGGCTTTGCACAGGTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCAC
CGATCCCCACAGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACACTTCCGCTGCCCACCTGGCTC

>In-frame_ENST00000375793_ENST00000264205_TCGA-DX-A8BV-01A_PLEKHM2_chr1_16045120_+_ECE1_chr1_21573856_length(amino acids)=615AA_start in transcript=79_stop in transcript=1926
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK
KTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKE
LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVV
GHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLEKHM2-ECE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+5201_310155.01020.0KIF5B
HgenePLEKHM2chr1:16045120chr1:21573856ENST00000375799+520762_885155.01020.0sifA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PLEKHM2-ECE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PLEKHM2-ECE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLEKHM2C1960469Left ventricular noncompaction1ORPHANET
TgeneECE1C0018798Congenital Heart Defects2CTD_human
TgeneECE1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneECE1C0019569Hirschsprung Disease1CTD_human
TgeneECE1C0020538Hypertensive disease1CTD_human
TgeneECE1C0085758Aganglionosis, Colonic1CTD_human
TgeneECE1C0376634Craniofacial Abnormalities1CTD_human
TgeneECE1C0393912Segmental Autonomic Dysfunction1CTD_human
TgeneECE1C0750944Peripheral Autonomic Nervous System Diseases1CTD_human
TgeneECE1C0750945Nervous System Diseases, Parasympathetic1CTD_human
TgeneECE1C0750946Nervous System Diseases, Sympathetic1CTD_human
TgeneECE1C1145628Autonomic nervous system disorders1CTD_human
TgeneECE1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
TgeneECE1C3151237Hirschsprung Disease, Cardiac Defects, and Autonomic Dysfunction1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneECE1C3661523Congenital Intestinal Aganglionosis1CTD_human