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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHM2-TMEM51 (FusionGDB2 ID:65913)

Fusion Gene Summary for PLEKHM2-TMEM51

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHM2-TMEM51
Fusion gene ID: 65913
HgeneTgene
Gene symbol

PLEKHM2

TMEM51

Gene ID

23207

55092

Gene namepleckstrin homology and RUN domain containing M2transmembrane protein 51
SynonymsSKIPC1orf72
Cytomap

1p36.21

1p36.21

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family Mtransmembrane protein 51
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375799, ENST00000375793, 
ENST00000477849, 		ENST00000428417, 
ENST00000376014, ENST00000400796, 
ENST00000434578, ENST00000376008, 
Fusion gene scores* DoF score9 X 7 X 6=3786 X 8 X 5=240
# samples 910
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHM2 [Title/Abstract] AND TMEM51 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHM2(16046415)-TMEM51(15536986), # samples:3
Anticipated loss of major functional domain due to fusion event.PLEKHM2-TMEM51 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEKHM2

GO:1903527

positive regulation of membrane tubulation

18996344


check buttonFusion gene breakpoints across PLEKHM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMEM51 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
ChimerDB4GBMTCGA-12-3650-01APLEKHM2chr1

16046415

-TMEM51chr1

15536986

+


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Fusion Gene ORF analysis for PLEKHM2-TMEM51

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375799ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-intronENST00000375799ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-intronENST00000375793ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-intronENST00000375793ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
intron-intronENST00000477849ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
intron-intronENST00000477849ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15541391

+
5CDS-intronENST00000375799ENST00000428417PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000376014PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-intronENST00000375799ENST00000400796PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000434578PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000376008PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-intronENST00000375793ENST00000428417PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000376014PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-intronENST00000375793ENST00000400796PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000434578PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375793ENST00000376008PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
intron-intronENST00000477849ENST00000428417PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000376014PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
intron-intronENST00000477849ENST00000400796PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000434578PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
intron-5UTRENST00000477849ENST00000376008PLEKHM2chr1

16043311

+TMEM51chr1

15536986

+
5CDS-5UTRENST00000375799ENST00000428417PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000376014PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000400796PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000434578PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375799ENST00000376008PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000428417PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000376014PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000400796PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000434578PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
5CDS-5UTRENST00000375793ENST00000376008PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000428417PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000376014PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000400796PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000434578PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
intron-5UTRENST00000477849ENST00000376008PLEKHM2chr1

16045120

+TMEM51chr1

15541391

+
In-frameENST00000375799ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375799ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375799ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
Frame-shiftENST00000375799ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375799ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375793ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375793ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375793ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
Frame-shiftENST00000375793ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
In-frameENST00000375793ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
intron-3CDSENST00000477849ENST00000428417PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
intron-3CDSENST00000477849ENST00000376014PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
intron-3CDSENST00000477849ENST00000400796PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
intron-3CDSENST00000477849ENST00000434578PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+
intron-3CDSENST00000477849ENST00000376008PLEKHM2chr1

16046415

+TMEM51chr1

15545822

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375799PLEKHM2chr116046415+ENST00000428417TMEM51chr115545822+2031879137946269
ENST00000375799PLEKHM2chr116046415+ENST00000376014TMEM51chr115545822+1893879137946269
ENST00000375799PLEKHM2chr116046415+ENST00000400796TMEM51chr115545822+1962879137946269
ENST00000375799PLEKHM2chr116046415+ENST00000376008TMEM51chr115545822+2034879137946269
ENST00000375793PLEKHM2chr116046415+ENST00000428417TMEM51chr115545822+197382179888269
ENST00000375793PLEKHM2chr116046415+ENST00000376014TMEM51chr115545822+183582179888269
ENST00000375793PLEKHM2chr116046415+ENST00000400796TMEM51chr115545822+190482179888269
ENST00000375793PLEKHM2chr116046415+ENST00000376008TMEM51chr115545822+197682179888269

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375799ENST00000428417PLEKHM2chr116046415+TMEM51chr115545822+0.0035674530.99643254
ENST00000375799ENST00000376014PLEKHM2chr116046415+TMEM51chr115545822+0.0037479940.996252
ENST00000375799ENST00000400796PLEKHM2chr116046415+TMEM51chr115545822+0.0039968330.9960032
ENST00000375799ENST00000376008PLEKHM2chr116046415+TMEM51chr115545822+0.0035414950.9964585
ENST00000375793ENST00000428417PLEKHM2chr116046415+TMEM51chr115545822+0.0029908280.9970092
ENST00000375793ENST00000376014PLEKHM2chr116046415+TMEM51chr115545822+0.0029701170.9970299
ENST00000375793ENST00000400796PLEKHM2chr116046415+TMEM51chr115545822+0.0030465240.9969535
ENST00000375793ENST00000376008PLEKHM2chr116046415+TMEM51chr115545822+0.0030131540.9969868

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Fusion Genomic Features for PLEKHM2-TMEM51


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHM2chr116046415+TMEM51chr115541390+0.0001498540.99985015
PLEKHM2chr116045120+TMEM51chr115541390+0.0001330920.99986684
PLEKHM2chr116046415+TMEM51chr115536985+2.20E-050.99997807
PLEKHM2chr116043311+TMEM51chr115536985+1.56E-050.9999844
PLEKHM2chr116046415+TMEM51chr115545825+1.15E-070.9999999
PLEKHM2chr116046415+TMEM51chr115541390+0.0001498540.99985015
PLEKHM2chr116045120+TMEM51chr115541390+0.0001330920.99986684
PLEKHM2chr116046415+TMEM51chr115536985+2.20E-050.99997807
PLEKHM2chr116043311+TMEM51chr115536985+1.56E-050.9999844
PLEKHM2chr116046415+TMEM51chr115545825+1.15E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHM2-TMEM51


check button Go to

FGviewer for the breakpoints of chr1:16046415-chr1:15545822

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+62036_158217.333333333333341020.0DomainRUN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620317_320217.333333333333341020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620323_326217.333333333333341020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620506_511217.333333333333341020.0Compositional biasNote=Poly-Gly
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620593_596217.333333333333341020.0Compositional biasNote=Poly-Leu
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620771_873217.333333333333341020.0DomainPH
TgeneTMEM51chr1:16046415chr1:15545822ENST000003760082417_37114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000003760082465_85114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000003760142417_37114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000003760142465_85114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000004007961317_37114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000004007961365_85114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000004284171317_37114.66666666666667254.0TransmembraneHelical
TgeneTMEM51chr1:16046415chr1:15545822ENST000004284171365_85114.66666666666667254.0TransmembraneHelical


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Fusion Gene Sequence for PLEKHM2-TMEM51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375799_ENST00000428417_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=2031nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGA
TGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAACTACTCAGAAGCAAGGGGAGAGGAGCAGAACCC
GAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACCCCCACATCCACCAGGGCTGACGTGGAGGCCAG
CCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTGAAAGTTCGAAGGATTAAATCTGAAAAGCTTCA
CCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAGCCTTTGACTCCTCCACCGCAGTATGATGAAGT
CCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGCTCCCTCCTGTCTCTCACACCTTTCACCCCCAA
GACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGGAGCCATTTGGATGGCGGCGGGCGGGGGGGGAT
TCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGGAAAGAGATGCTGCCTTGGAGCTGGTGAATCTG
TGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGCTGGCGACACATTCTCCTTTCCAGCTAGGAAAG
GGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTTTGTTTCAAAAAGGAAACAAGTTTTGTGTTTGC
TGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGGACACAGGGCTGTTTTATGAACTAAGCGGTGAG
GCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGCCTGATGAACGTAGGCACGTGATGCATAATAGT
CTTCAATGGTACACTTAACTAGTCTCTTCTGTGTAACAGCAAAAAAAAAAAAAAAAAGAAGAAGAAAGAAAACTGTAGGAAATGTTCTTT

>In-frame_ENST00000375799_ENST00000428417_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=137_stop in transcript=946
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000376014_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1893nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGA
TGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAACTACTCAGAAGCAAGGGGAGAGGAGCAGAACCC
GAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACCCCCACATCCACCAGGGCTGACGTGGAGGCCAG
CCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTGAAAGTTCGAAGGATTAAATCTGAAAAGCTTCA
CCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAGCCTTTGACTCCTCCACCGCAGTATGATGAAGT
CCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGCTCCCTCCTGTCTCTCACACCTTTCACCCCCAA
GACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGGAGCCATTTGGATGGCGGCGGGCGGGGGGGGAT
TCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGGAAAGAGATGCTGCCTTGGAGCTGGTGAATCTG
TGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGCTGGCGACACATTCTCCTTTCCAGCTAGGAAAG
GGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTTTGTTTCAAAAAGGAAACAAGTTTTGTGTTTGC
TGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGGACACAGGGCTGTTTTATGAACTAAGCGGTGAG
GCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGCCTGATGAACGTAGGCACGTGATGCATAATAGT

>In-frame_ENST00000375799_ENST00000376014_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=137_stop in transcript=946
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000400796_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1962nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGA
TGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAACTACTCAGAAGCAAGGGGAGAGGAGCAGAACCC
GAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACCCCCACATCCACCAGGGCTGACGTGGAGGCCAG
CCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTGAAAGTTCGAAGGATTAAATCTGAAAAGCTTCA
CCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAGCCTTTGACTCCTCCACCGCAGTATGATGAAGT
CCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGCTCCCTCCTGTCTCTCACACCTTTCACCCCCAA
GACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGGAGCCATTTGGATGGCGGCGGGCGGGGGGGGAT
TCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGGAAAGAGATGCTGCCTTGGAGCTGGTGAATCTG
TGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGCTGGCGACACATTCTCCTTTCCAGCTAGGAAAG
GGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTTTGTTTCAAAAAGGAAACAAGTTTTGTGTTTGC
TGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGGACACAGGGCTGTTTTATGAACTAAGCGGTGAG
GCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGCCTGATGAACGTAGGCACGTGATGCATAATAGT

>In-frame_ENST00000375799_ENST00000400796_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=137_stop in transcript=946
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375799_ENST00000376008_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=2034nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGA
TGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAACTACTCAGAAGCAAGGGGAGAGGAGCAGAACCC
GAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACCCCCACATCCACCAGGGCTGACGTGGAGGCCAG
CCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTGAAAGTTCGAAGGATTAAATCTGAAAAGCTTCA
CCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAGCCTTTGACTCCTCCACCGCAGTATGATGAAGT
CCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGCTCCCTCCTGTCTCTCACACCTTTCACCCCCAA
GACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGGAGCCATTTGGATGGCGGCGGGCGGGGGGGGAT
TCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGGAAAGAGATGCTGCCTTGGAGCTGGTGAATCTG
TGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGCTGGCGACACATTCTCCTTTCCAGCTAGGAAAG
GGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTTTGTTTCAAAAAGGAAACAAGTTTTGTGTTTGC
TGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGGACACAGGGCTGTTTTATGAACTAAGCGGTGAG
GCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGCCTGATGAACGTAGGCACGTGATGCATAATAGT
CTTCAATGGTACACTTAACTAGTCTCTTCTGTGTAACAGCAAAAAAAAAAAAAAAAAGAAGAAGAAAGAAAACTGTAGGAAATGTTCTTT

>In-frame_ENST00000375799_ENST00000376008_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=137_stop in transcript=946
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000428417_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1973nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGATGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAAC
TACTCAGAAGCAAGGGGAGAGGAGCAGAACCCGAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACC
CCCACATCCACCAGGGCTGACGTGGAGGCCAGCCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTG
AAAGTTCGAAGGATTAAATCTGAAAAGCTTCACCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAG
CCTTTGACTCCTCCACCGCAGTATGATGAAGTCCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGC
TCCCTCCTGTCTCTCACACCTTTCACCCCCAAGACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGG
AGCCATTTGGATGGCGGCGGGCGGGGGGGGATTCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGG
AAAGAGATGCTGCCTTGGAGCTGGTGAATCTGTGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGC
TGGCGACACATTCTCCTTTCCAGCTAGGAAAGGGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTT
TGTTTCAAAAAGGAAACAAGTTTTGTGTTTGCTGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGG
ACACAGGGCTGTTTTATGAACTAAGCGGTGAGGCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGC
CTGATGAACGTAGGCACGTGATGCATAATAGTCTTCAATGGTACACTTAACTAGTCTCTTCTGTGTAACAGCAAAAAAAAAAAAAAAAAG

>In-frame_ENST00000375793_ENST00000428417_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=79_stop in transcript=888
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000376014_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1835nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGATGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAAC
TACTCAGAAGCAAGGGGAGAGGAGCAGAACCCGAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACC
CCCACATCCACCAGGGCTGACGTGGAGGCCAGCCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTG
AAAGTTCGAAGGATTAAATCTGAAAAGCTTCACCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAG
CCTTTGACTCCTCCACCGCAGTATGATGAAGTCCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGC
TCCCTCCTGTCTCTCACACCTTTCACCCCCAAGACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGG
AGCCATTTGGATGGCGGCGGGCGGGGGGGGATTCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGG
AAAGAGATGCTGCCTTGGAGCTGGTGAATCTGTGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGC
TGGCGACACATTCTCCTTTCCAGCTAGGAAAGGGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTT
TGTTTCAAAAAGGAAACAAGTTTTGTGTTTGCTGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGG
ACACAGGGCTGTTTTATGAACTAAGCGGTGAGGCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGC

>In-frame_ENST00000375793_ENST00000376014_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=79_stop in transcript=888
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000400796_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1904nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGATGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAAC
TACTCAGAAGCAAGGGGAGAGGAGCAGAACCCGAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACC
CCCACATCCACCAGGGCTGACGTGGAGGCCAGCCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTG
AAAGTTCGAAGGATTAAATCTGAAAAGCTTCACCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAG
CCTTTGACTCCTCCACCGCAGTATGATGAAGTCCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGC
TCCCTCCTGTCTCTCACACCTTTCACCCCCAAGACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGG
AGCCATTTGGATGGCGGCGGGCGGGGGGGGATTCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGG
AAAGAGATGCTGCCTTGGAGCTGGTGAATCTGTGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGC
TGGCGACACATTCTCCTTTCCAGCTAGGAAAGGGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTT
TGTTTCAAAAAGGAAACAAGTTTTGTGTTTGCTGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGG
ACACAGGGCTGTTTTATGAACTAAGCGGTGAGGCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGC
CTGATGAACGTAGGCACGTGATGCATAATAGTCTTCAATGGTACACTTAACTAGTCTCTTCTGTGTAACAGCAAAAAAAAAAAAAAAAAG

>In-frame_ENST00000375793_ENST00000400796_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=79_stop in transcript=888
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

--------------------------------------------------------------
>In-frame_ENST00000375793_ENST00000376008_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(transcript)=1976nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGCCAGGAGGAAGAAGAGGAGGATGAGGAGGCTGCCTCAAGGTACTATGTTCCCAGCTACGAGGAAGTGATGAACACAAAC
TACTCAGAAGCAAGGGGAGAGGAGCAGAACCCGAGGTTGAGCATCTCTCTCCCGTCCTATGAGTCACTGACGGGGCTCGACGAGACCACC
CCCACATCCACCAGGGCTGACGTGGAGGCCAGCCCTGGGAACCCCCCTGACAGGCAGAACTCTAAGTTGGCCAAACGACTGAAACCGCTG
AAAGTTCGAAGGATTAAATCTGAAAAGCTTCACCTCAAAGACTTTAGGATCAACCTCCCAGACAAAAACGTCCCTCCTCCCTCGATAGAG
CCTTTGACTCCTCCACCGCAGTATGATGAAGTCCAGGAGAAGGCCCCCGACACCCGGCCGCCCGACTGAATGGCCCCACTTGAGCCACGC
TCCCTCCTGTCTCTCACACCTTTCACCCCCAAGACTCTAACAAAGCCACATGAGCCACAGTTGAGAAGCGGAGGGGCCAGCTGTGCATGG
AGCCATTTGGATGGCGGCGGGCGGGGGGGGATTCTCTGTATCAGGAGTGACTTTGTTGCCCCACACAGCCTCCTGCTGCAGGTGCTTTGG
AAAGAGATGCTGCCTTGGAGCTGGTGAATCTGTGGACCACATTCAAGGGTGTGGCACAGGCATCTTCCCATCCTTTTCACTCCGAATCGC
TGGCGACACATTCTCCTTTCCAGCTAGGAAAGGGTTCCTCGCGGCTGGTTTAGATTGTGGTTGTTTGTTTTGCTTCTACTAAGACTGTTT
TGTTTCAAAAAGGAAACAAGTTTTGTGTTTGCTGTCTACGCTGGAGTCCTGAACTGTGGGTAGAAAACACGACCTGGCTTTGTAGAAAGG
ACACAGGGCTGTTTTATGAACTAAGCGGTGAGGCTCAGGTGGCGGCTCTCGCAGAGCCCCTGATGCTGTTGTTCTTTGAGGGCTTAAGGC
CTGATGAACGTAGGCACGTGATGCATAATAGTCTTCAATGGTACACTTAACTAGTCTCTTCTGTGTAACAGCAAAAAAAAAAAAAAAAAG

>In-frame_ENST00000375793_ENST00000376008_TCGA-12-3650-01A_PLEKHM2_chr1_16046415_+_TMEM51_chr1_15545822_length(amino acids)=269AA_start in transcript=79_stop in transcript=888
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR

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Fusion Gene PPI Analysis for PLEKHM2-TMEM51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+6201_310217.333333333333341020.0KIF5B
HgenePLEKHM2chr1:16046415chr1:15545822ENST00000375799+620762_885217.333333333333341020.0sifA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHM2-TMEM51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHM2-TMEM51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLEKHM2C1960469Left ventricular noncompaction1ORPHANET