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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLOD1-TUBB (FusionGDB2 ID:65976)

Fusion Gene Summary for PLOD1-TUBB

Fusion gene summary

Fusion gene information	Fusion gene name: PLOD1-TUBB
	Fusion gene ID: 65976
		Hgene	Tgene
	Gene symbol	PLOD1	TUBB
	Gene ID	5351	203068
	Gene name	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	tubulin beta class I
	Synonyms	EDS6\|EDSKCL1\|LH\|LH1\|LLH\|PLOD	CDCBM6\|CSCSC1\|M40\|OK/SW-cl.56\|TUBB1\|TUBB5
	Cytomap	1p36.22	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1lysine hydroxylaselysyl hydroxlase 1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	tubulin beta chainbeta Ib tubulinepididymis secretory sperm binding proteintubulin beta-1 chaintubulin beta-5 chaintubulin, beta polypeptide
	Modification date	20200313	20200327
	UniProtAcc	.	TULP4
	Ensembl transtripts involved in fusion gene	ENST00000485046, ENST00000376369, ENST00000196061,	ENST00000327892, ENST00000435534, ENST00000330914, ENST00000396389, ENST00000396384, ENST00000421473, ENST00000549614, ENST00000413547, ENST00000419551, ENST00000454620, ENST00000422674, ENST00000548023, ENST00000435546, ENST00000420400, ENST00000453350, ENST00000419792, ENST00000547690, ENST00000436335, ENST00000425136, ENST00000444441, ENST00000422650, ENST00000547695, ENST00000454454, ENST00000412136, ENST00000446385, ENST00000383564, ENST00000551208, ENST00000400531, ENST00000400534, ENST00000400530, ENST00000436628, ENST00000549902, ENST00000437490, ENST00000426754, ENST00000425102, ENST00000432462, ENST00000549654, ENST00000427480, ENST00000424734, ENST00000420618,
Fusion gene scores	* DoF score	4 X 4 X 4=64	12 X 12 X 3=432
	# samples	4	12
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLOD1 [Title/Abstract] AND TUBB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLOD1(12035371)-TUBB(30691647), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLOD1	GO:0006493	protein O-linked glycosylation	10934207
Hgene	PLOD1	GO:0017185	peptidyl-lysine hydroxylation	8621606\|9724729\|10934207
Tgene	TUBB	GO:0009987	cellular process	19567321

Fusion gene breakpoints across PLOD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TUBB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA948311	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-

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Fusion Gene ORF analysis for PLOD1-TUBB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000485046	ENST00000327892	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000435534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000330914	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000396389	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000396384	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000421473	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000549614	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000413547	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000419551	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000454620	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000422674	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000548023	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000435546	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000420400	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000453350	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000419792	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000547690	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000436335	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000425136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000444441	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000422650	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000547695	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000454454	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000412136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000446385	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000383564	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000551208	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000400531	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000400534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000400530	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000436628	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000549902	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000437490	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000426754	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000425102	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000432462	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000549654	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000427480	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000424734	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000485046	ENST00000420618	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-3CDS	ENST00000376369	ENST00000327892	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000435534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000330914	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000396389	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000396384	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000421473	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000549614	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000413547	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000419551	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000454620	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000422674	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000548023	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000435546	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000420400	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000453350	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000419792	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000547690	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000436335	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000425136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000444441	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000422650	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000547695	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000454454	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000412136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000446385	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000383564	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000551208	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000400531	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000400534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000400530	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000436628	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000549902	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000437490	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000426754	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000425102	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000432462	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000549654	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000427480	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000424734	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
intron-intron	ENST00000376369	ENST00000420618	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-3CDS	ENST00000196061	ENST00000327892	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000435534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000330914	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000396389	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000396384	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000421473	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000549614	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000413547	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000419551	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000454620	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000422674	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000548023	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000435546	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000420400	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000453350	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000419792	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000547690	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000436335	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000425136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000444441	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000422650	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000547695	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000454454	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000412136	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000446385	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000383564	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000551208	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000400531	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000400534	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000400530	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000436628	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000549902	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000437490	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000426754	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000425102	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000432462	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000549654	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000427480	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000424734	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-
3UTR-intron	ENST00000196061	ENST00000420618	PLOD1	chr1	12035371	-	TUBB	chr6	30691647	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PLOD1-TUBB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLOD1-TUBB

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	TUBB TULP4
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	1543

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PLOD1-TUBB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PLOD1-TUBB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PLOD1-TUBB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PLOD1-TUBB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PLOD1	C0268342	Ehlers-Danlos syndrome type 6	8	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	PLOD1	C0022821	Kyphosis deformity of spine	1	CTD_human
Hgene	PLOD1	C2936777	Nevo syndrome (disorder)	1	CTD_human
Hgene	PLOD1	C4551497	Ehlers-Danlos syndrome kyphoscoliotic type	1	CTD_human
Tgene	TUBB	C4014283	CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 6	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TUBB	C0473586	Michelin tire baby syndrome	1	ORPHANET
Tgene	TUBB	C4551592	SKIN CREASES, CONGENITAL SYMMETRIC CIRCUMFERENTIAL, 1	1	GENOMICS_ENGLAND;UNIPROT