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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLOD2-ABCG1 (FusionGDB2 ID:65977)

Fusion Gene Summary for PLOD2-ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLOD2-ABCG1
Fusion gene ID: 65977
HgeneTgene
Gene symbol

PLOD2

ABCG1

Gene ID

5352

9619

Gene nameprocollagen-lysine,2-oxoglutarate 5-dioxygenase 2ATP binding cassette subfamily G member 1
SynonymsBRKS2|LH2|TLHABC8|WHITE1
Cytomap

3q24

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionprocollagen-lysine,2-oxoglutarate 5-dioxygenase 2lysine hydroxylase 2lysyl hydroxlase 2lysyl hydroxylase 2procollagen-lysine 5-dioxygenasetelopeptide lysyl hydroxylaseATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2020031320200329
UniProtAcc.

P45844

Ensembl transtripts involved in fusion geneENST00000461497, ENST00000282903, 
ENST00000360060, ENST00000494950, 
ENST00000398457, ENST00000462050, 
ENST00000347800, ENST00000398449, 
ENST00000361802, ENST00000343687, 
ENST00000398437, ENST00000340588, 
Fusion gene scores* DoF score7 X 6 X 4=1689 X 5 X 8=360
# samples 710
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLOD2 [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLOD2(145824319)-ABCG1(43645781), # samples:3
Anticipated loss of major functional domain due to fusion event.PLOD2-ABCG1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLOD2-ABCG1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLOD2

GO:0006493

protein O-linked glycosylation

10934207

HgenePLOD2

GO:0017185

peptidyl-lysine hydroxylation

10934207

HgenePLOD2

GO:0046947

hydroxylysine biosynthetic process

10934207

TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612

TgeneABCG1

GO:0050714

positive regulation of protein secretion

17293612

TgeneABCG1

GO:1902004

positive regulation of amyloid-beta formation

17293612


check buttonFusion gene breakpoints across PLOD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A129-01APLOD2chr3

145824319

-ABCG1chr21

43645781

+
ChimerDB4BRCATCGA-AO-A129-01APLOD2chr3

145824319

-ABCG1chr21

43645781

+
ChimerDB4BRCATCGA-AO-A129-01APLOD2chr3

145824319

-ABCG1chr21

43645781

+


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Fusion Gene ORF analysis for PLOD2-ABCG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000461497ENST00000398457PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-3UTRENST00000461497ENST00000462050PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-3UTRENST00000461497ENST00000347800PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-3UTRENST00000461497ENST00000398449PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-3UTRENST00000461497ENST00000361802PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-3UTRENST00000461497ENST00000343687PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-intronENST00000461497ENST00000398437PLOD2chr3

145824319

-ABCG1chr21

43645781

+
intron-intronENST00000461497ENST00000340588PLOD2chr3

145824319

-ABCG1chr21

43645781

+
In-frameENST00000282903ENST00000398457PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000282903ENST00000462050PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000282903ENST00000347800PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000282903ENST00000398449PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000282903ENST00000361802PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000282903ENST00000343687PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000282903ENST00000398437PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000282903ENST00000340588PLOD2chr3

145824319

-ABCG1chr21

43645781

+
In-frameENST00000360060ENST00000398457PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000360060ENST00000462050PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000360060ENST00000347800PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000360060ENST00000398449PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000360060ENST00000361802PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000360060ENST00000343687PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000360060ENST00000398437PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000360060ENST00000340588PLOD2chr3

145824319

-ABCG1chr21

43645781

+
Frame-shiftENST00000494950ENST00000398457PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000494950ENST00000462050PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000494950ENST00000347800PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000494950ENST00000398449PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000494950ENST00000361802PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-3UTRENST00000494950ENST00000343687PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000494950ENST00000398437PLOD2chr3

145824319

-ABCG1chr21

43645781

+
5CDS-intronENST00000494950ENST00000340588PLOD2chr3

145824319

-ABCG1chr21

43645781

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282903PLOD2chr3145824319-ENST00000398457ABCG1chr2143645781+36047931302751873
ENST00000360060PLOD2chr3145824319-ENST00000398457ABCG1chr2143645781+36047931302751873

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282903ENST00000398457PLOD2chr3145824319-ABCG1chr2143645781+0.0005147350.99948525
ENST00000360060ENST00000398457PLOD2chr3145824319-ABCG1chr2143645781+0.0005147350.99948525

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Fusion Genomic Features for PLOD2-ABCG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLOD2chr3145824318-ABCG1chr2143645780+5.15E-081
PLOD2chr3145824318-ABCG1chr2143645780+5.15E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLOD2-ABCG1


check button Go to

FGviewer for the breakpoints of chr3:145824319-chr21:43645781

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCG1

P45844

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015415_67325.0678.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr3:145824319chr21:43645781ENST0000034368701577_31725.0678.0DomainABC transporter
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015415_67311.0664.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr3:145824319chr21:43645781ENST0000034780001577_31711.0664.0DomainABC transporter
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015415_67314.0679.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr3:145824319chr21:43645781ENST0000036180201577_31714.0679.0DomainABC transporter
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015415_67314.0667.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr3:145824319chr21:43645781ENST0000039844901577_31714.0667.0DomainABC transporter
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116415_67316.0669.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr3:145824319chr21:43645781ENST0000039845711677_31716.0669.0DomainABC transporter
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015118_12525.0678.0Nucleotide bindingATP
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015118_12511.0664.0Nucleotide bindingATP
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015118_12514.0679.0Nucleotide bindingATP
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015118_12514.0667.0Nucleotide bindingATP
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116118_12516.0669.0Nucleotide bindingATP
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015446_45625.0678.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015478_50625.0678.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015526_53325.0678.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015556_56725.0678.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015587_64925.0678.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015670_67825.0678.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015446_45611.0664.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015478_50611.0664.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015526_53311.0664.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015556_56711.0664.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015587_64911.0664.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015670_67811.0664.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015446_45614.0679.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015478_50614.0679.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015526_53314.0679.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015556_56714.0679.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015587_64914.0679.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015670_67814.0679.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015446_45614.0667.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015478_50614.0667.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015526_53314.0667.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015556_56714.0667.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015587_64914.0667.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015670_67814.0667.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116446_45616.0669.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116478_50616.0669.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116526_53316.0669.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116556_56716.0669.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116587_64916.0669.0Topological domainExtracellular
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116670_67816.0669.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015427_44525.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015457_47725.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015507_52525.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015534_55525.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015568_58625.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000343687015650_66925.0678.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015427_44511.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015457_47711.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015507_52511.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015534_55511.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015568_58611.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000347800015650_66911.0664.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015427_44514.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015457_47714.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015507_52514.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015534_55514.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015568_58614.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000361802015650_66914.0679.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015427_44514.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015457_47714.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015507_52514.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015534_55514.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015568_58614.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398449015650_66914.0667.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116427_44516.0669.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116457_47716.0669.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116507_52516.0669.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116534_55516.0669.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116568_58616.0669.0TransmembraneHelical
TgeneABCG1chr3:145824319chr21:43645781ENST00000398457116650_66916.0669.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLOD2chr3:145824319chr21:43645781ENST00000282903-520644_737205.0759.0DomainFe2OG dioxygenase
HgenePLOD2chr3:145824319chr21:43645781ENST00000360060-519644_737205.0738.0DomainFe2OG dioxygenase
TgeneABCG1chr3:145824319chr21:43645781ENST000003436870151_42625.0678.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST000003478000151_42611.0664.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST000003618020151_42614.0679.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST000003984490151_42614.0667.0Topological domainCytoplasmic
TgeneABCG1chr3:145824319chr21:43645781ENST000003984571161_42616.0669.0Topological domainCytoplasmic


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Fusion Gene Sequence for PLOD2-ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000282903_ENST00000398457_TCGA-AO-A129-01A_PLOD2_chr3_145824319_-_ABCG1_chr21_43645781_length(transcript)=3604nt_BP=793nt
CCGACGACCTCACTCAGCTGCGTTACGCGCCGCTCCGGCTGCCGGCCGCGCGCCTTGCCCGCCGGCTCCCGCCCGCAATCGGCGGCTCAG
GGCGGACCCGGGTCTCTGCGTTCTCGCGAGAAGCGCGGCGCTGCGGGGCCGTGGGCGCCTGAGCCCGCGCGGCCCTCGAGGGCCGAATAT
GGGGGGATGCACGGTGAAGCCTCAGCTGCTGCTCCTGGCGCTCGTCCTCCACCCCTGGAATCCCTGTCTGGGTGCGGACTCGGAGAAGCC
CTCGAGCATCCCCACAGATAAATTATTAGTCATAACTGTAGCAACAAAAGAAAGTGATGGATTCCATCGATTTATGCAGTCAGCCAAATA
TTTCAATTATACTGTGAAGGTCCTTGGTCAAGGAGAAGAATGGAGAGGTGGTGATGGAATTAATAGTATTGGAGGGGGCCAGAAAGTGAG
ATTAATGAAAGAAGTCATGGAACACTATGCTGATCAAGATGATCTGGTTGTCATGTTTACTGAATGCTTTGATGTCATATTTGCTGGTGG
TCCAGAAGAAGTTCTAAAAAAATTCCAAAAGGCAAACCACAAAGTGGTCTTTGCAGCAGATGGAATTTTGTGGCCAGATAAAAGACTAGC
AGACAAGTATCCTGTTGTGCACATTGGGAAACGCTATCTGAATTCAGGAGGATTTATTGGCTATGCTCCATATGTCAACCGTATAGTTCA
ACAATGGAATCTCCAGGATAATGATGATGATCAGCTCTTTTACACTAAAGTTTACATTGATCCACTGAAAAGGAATGCCAGCAGTTACTC
TGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAGACGGACCTGCTGAA
TGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAG
GGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAG
TGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAA
GGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGATGACATGCTGCTGCC
GCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGAT
ACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGA
GCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAA
AGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCT
GAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAA
CCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGA
CTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGA
AGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCT
GACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTT
GAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGG
AGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTGCCCTTTCAGATCAT
GTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCAC
CATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGAC
AGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGT
CAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAGACGTGCCACTTCCA
GAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCT
CCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAACAGGAAGATTAGACACTG
TGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCAACCCCTAGAACCGCGTT
GGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGT
AGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCTGCAACACAGCTGGTGAT
GAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGC
ACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGT
GTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATACCTTTTTAGTACTTGCTG
AAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCTCATACATAGACAGCACT
TGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATTTTTAAAAGCTATACAAA
AAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTTTAAGCGAAATATATTGTTTGTTTCTTC

>In-frame_ENST00000282903_ENST00000398457_TCGA-AO-A129-01A_PLOD2_chr3_145824319_-_ABCG1_chr21_43645781_length(amino acids)=873AA_start in transcript=130_stop in transcript=2751
MRGRGRLSPRGPRGPNMGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEE
WRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYL
NSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKRNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEA
QRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR
CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP
TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEY
GDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGL
LIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMT
SQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYG

--------------------------------------------------------------
>In-frame_ENST00000360060_ENST00000398457_TCGA-AO-A129-01A_PLOD2_chr3_145824319_-_ABCG1_chr21_43645781_length(transcript)=3604nt_BP=793nt
CCGACGACCTCACTCAGCTGCGTTACGCGCCGCTCCGGCTGCCGGCCGCGCGCCTTGCCCGCCGGCTCCCGCCCGCAATCGGCGGCTCAG
GGCGGACCCGGGTCTCTGCGTTCTCGCGAGAAGCGCGGCGCTGCGGGGCCGTGGGCGCCTGAGCCCGCGCGGCCCTCGAGGGCCGAATAT
GGGGGGATGCACGGTGAAGCCTCAGCTGCTGCTCCTGGCGCTCGTCCTCCACCCCTGGAATCCCTGTCTGGGTGCGGACTCGGAGAAGCC
CTCGAGCATCCCCACAGATAAATTATTAGTCATAACTGTAGCAACAAAAGAAAGTGATGGATTCCATCGATTTATGCAGTCAGCCAAATA
TTTCAATTATACTGTGAAGGTCCTTGGTCAAGGAGAAGAATGGAGAGGTGGTGATGGAATTAATAGTATTGGAGGGGGCCAGAAAGTGAG
ATTAATGAAAGAAGTCATGGAACACTATGCTGATCAAGATGATCTGGTTGTCATGTTTACTGAATGCTTTGATGTCATATTTGCTGGTGG
TCCAGAAGAAGTTCTAAAAAAATTCCAAAAGGCAAACCACAAAGTGGTCTTTGCAGCAGATGGAATTTTGTGGCCAGATAAAAGACTAGC
AGACAAGTATCCTGTTGTGCACATTGGGAAACGCTATCTGAATTCAGGAGGATTTATTGGCTATGCTCCATATGTCAACCGTATAGTTCA
ACAATGGAATCTCCAGGATAATGATGATGATCAGCTCTTTTACACTAAAGTTTACATTGATCCACTGAAAAGGAATGCCAGCAGTTACTC
TGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAGACGGACCTGCTGAA
TGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAG
GGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAG
TGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAA
GGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGATGACATGCTGCTGCC
GCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGAT
ACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGA
GCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAA
AGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCT
GAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAA
CCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGA
CTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGA
AGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCT
GACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTT
GAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGG
AGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTGCCCTTTCAGATCAT
GTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCAC
CATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGAC
AGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGT
CAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAGACGTGCCACTTCCA
GAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCT
CCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAACAGGAAGATTAGACACTG
TGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCAACCCCTAGAACCGCGTT
GGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGT
AGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCTGCAACACAGCTGGTGAT
GAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGC
ACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGT
GTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATACCTTTTTAGTACTTGCTG
AAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCTCATACATAGACAGCACT
TGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATTTTTAAAAGCTATACAAA
AAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTTTAAGCGAAATATATTGTTTGTTTCTTC

>In-frame_ENST00000360060_ENST00000398457_TCGA-AO-A129-01A_PLOD2_chr3_145824319_-_ABCG1_chr21_43645781_length(amino acids)=873AA_start in transcript=130_stop in transcript=2751
MRGRGRLSPRGPRGPNMGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEE
WRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYL
NSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKRNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEA
QRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR
CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP
TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEY
GDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGL
LIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMT
SQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLOD2-ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLOD2-ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLOD2-ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLOD2C1836602Bruck syndrome 23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgenePLOD2C0432253Bruck syndrome2GENOMICS_ENGLAND;ORPHANET
HgenePLOD2C1850168Bruck syndrome 12ORPHANET
HgenePLOD2C0005967Bone neoplasms1CTD_human
HgenePLOD2C0023890Liver Cirrhosis1CTD_human
HgenePLOD2C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePLOD2C0029408Degenerative polyarthritis1CTD_human
HgenePLOD2C0029434Osteogenesis Imperfecta1GENOMICS_ENGLAND
HgenePLOD2C0086743Osteoarthrosis Deformans1CTD_human
HgenePLOD2C0087031Juvenile-Onset Still Disease1CTD_human
HgenePLOD2C0239946Fibrosis, Liver1CTD_human
HgenePLOD2C0279530Malignant Bone Neoplasm1CTD_human
HgenePLOD2C3495559Juvenile arthritis1CTD_human
HgenePLOD2C3714758Juvenile psoriatic arthritis1CTD_human
HgenePLOD2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgenePLOD2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneABCG1C0009402Colorectal Carcinoma1CTD_human
TgeneABCG1C0009404Colorectal Neoplasms1CTD_human
TgeneABCG1C0022661Kidney Failure, Chronic1CTD_human
TgeneABCG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCG1C0043094Weight Gain1CTD_human