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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PNN-EIF3M (FusionGDB2 ID:66334)

Fusion Gene Summary for PNN-EIF3M

check button Fusion gene summary
Fusion gene informationFusion gene name: PNN-EIF3M
Fusion gene ID: 66334
HgeneTgene
Gene symbol

PNN

EIF3M

Gene ID

5411

10480

Gene namepinin, desmosome associated proteineukaryotic translation initiation factor 3 subunit M
SynonymsDRS|DRSP|SDK3|memAB5|GA17|PCID1|TANGO7|hfl-B5
Cytomap

14q21.1

11p13

Type of geneprotein-codingprotein-coding
Descriptionpinin140 kDa nuclear and cell adhesion-related phosphoproteinSR-like proteindesmosome-associated proteindomain-rich serine proteinmelanoma metastasis clone A proteinneutrophil proteinnuclear protein SDK3eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog
Modification date2020031320200313
UniProtAcc.

Q7L2H7

Ensembl transtripts involved in fusion geneENST00000553331, ENST00000216832, 
ENST00000556530, ENST00000557680, 
ENST00000531120, ENST00000524896, 
ENST00000532054, 
Fusion gene scores* DoF score8 X 9 X 3=21610 X 7 X 6=420
# samples 911
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PNN [Title/Abstract] AND EIF3M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPNN(39645353)-EIF3M(32616460), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PNN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF3M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A573-01APNNchr14

39645353

+EIF3Mchr11

32616460

+


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Fusion Gene ORF analysis for PNN-EIF3M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000553331ENST00000531120PNNchr14

39645353

+EIF3Mchr11

32616460

+
In-frameENST00000553331ENST00000524896PNNchr14

39645353

+EIF3Mchr11

32616460

+
5CDS-intronENST00000553331ENST00000532054PNNchr14

39645353

+EIF3Mchr11

32616460

+
In-frameENST00000216832ENST00000531120PNNchr14

39645353

+EIF3Mchr11

32616460

+
In-frameENST00000216832ENST00000524896PNNchr14

39645353

+EIF3Mchr11

32616460

+
5CDS-intronENST00000216832ENST00000532054PNNchr14

39645353

+EIF3Mchr11

32616460

+
In-frameENST00000556530ENST00000531120PNNchr14

39645353

+EIF3Mchr11

32616460

+
In-frameENST00000556530ENST00000524896PNNchr14

39645353

+EIF3Mchr11

32616460

+
5CDS-intronENST00000556530ENST00000532054PNNchr14

39645353

+EIF3Mchr11

32616460

+
intron-3CDSENST00000557680ENST00000531120PNNchr14

39645353

+EIF3Mchr11

32616460

+
intron-3CDSENST00000557680ENST00000524896PNNchr14

39645353

+EIF3Mchr11

32616460

+
intron-intronENST00000557680ENST00000532054PNNchr14

39645353

+EIF3Mchr11

32616460

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000553331PNNchr1439645353+ENST00000531120EIF3Mchr1132616460+46532821789262
ENST00000553331PNNchr1439645353+ENST00000524896EIF3Mchr1132616460+12142821789262
ENST00000216832PNNchr1439645353+ENST00000531120EIF3Mchr1132616460+462325267759230
ENST00000216832PNNchr1439645353+ENST00000524896EIF3Mchr1132616460+118425267759230
ENST00000556530PNNchr1439645353+ENST00000531120EIF3Mchr1132616460+460623550742230
ENST00000556530PNNchr1439645353+ENST00000524896EIF3Mchr1132616460+116723550742230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000553331ENST00000531120PNNchr1439645353+EIF3Mchr1132616460+0.0006321560.9993679
ENST00000553331ENST00000524896PNNchr1439645353+EIF3Mchr1132616460+0.0008513050.9991487
ENST00000216832ENST00000531120PNNchr1439645353+EIF3Mchr1132616460+0.0006241850.9993759
ENST00000216832ENST00000524896PNNchr1439645353+EIF3Mchr1132616460+0.0007912970.99920875
ENST00000556530ENST00000531120PNNchr1439645353+EIF3Mchr1132616460+0.0006254050.99937457
ENST00000556530ENST00000524896PNNchr1439645353+EIF3Mchr1132616460+0.0008893930.99911064

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Fusion Genomic Features for PNN-EIF3M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PNNchr1439645353+EIF3Mchr1132616459+0.0002452480.9997547
PNNchr1439645353+EIF3Mchr1132616459+0.0002452480.9997547

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PNN-EIF3M


check button Go to

FGviewer for the breakpoints of chr14:39645353-chr11:32616460

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF3M

Q7L2H7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNNchr14:39645353chr11:32616460ENST00000216832+292_3261.666666666666664718.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29163_23461.666666666666664718.0Coiled coilOntology_term=ECO:0000255
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29287_37961.666666666666664718.0Coiled coilOntology_term=ECO:0000255
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29446_46761.666666666666664718.0Coiled coilOntology_term=ECO:0000255
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29172_47161.666666666666664718.0Compositional biasNote=Glu-rich
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29469_52061.666666666666664718.0Compositional biasNote=Gln-rich
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29552_70461.666666666666664718.0Compositional biasNote=Ser-rich
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29632_71761.666666666666664718.0Compositional biasNote=Arg-rich
HgenePNNchr14:39645353chr11:32616460ENST00000216832+29221_28461.666666666666664718.0RegionNote=Sufficient for PSAP complex assembly
HgenePNNchr14:39645353chr11:32616460ENST00000216832+292_16761.666666666666664718.0RegionNote=Necessary for mediating alternative 5' splicing
TgeneEIF3Mchr14:39645353chr11:32616460ENST00000531120511180_339205.66666666666666375.0DomainPCI


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Fusion Gene Sequence for PNN-EIF3M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000553331_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=4653nt_BP=282nt
ATTGGCTGAGCCCGGCTGTCAGTCCTTTCGCGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAG
GGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAA
GCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAG
TTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTT
GGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTT
CATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAAT
TTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTA
CTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGA
CACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTT
TGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTAT
ACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAA
AAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTA
GAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTAC
ATAATTTCACTACTGAAAGCACTTATCTACATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGT
TGTCATTTTCTAAACTTAGTAAATTTTCACTTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAG
TCGTCTTGATTGCCTGCAAATGGCTTTGTAGTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCG
AAATTATTATACAAAAGATTTTAAAGAGTCTGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCAC
TACCTTAGTAGTTCTGGCACCAGAAAAGTATACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAA
GTAAAGTGTACAAAAACTGCCTTTTACTACTTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGA
TATTTGGAAGTTGGCATGTTTTCAAGACACTGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTC
TGATGTTAAAATACTTACTGGAAATTTAGAAAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTT
GTTGACATTTTGGTATTATTTGCTGCTAGCGTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGT
GAGCAGTTTCTTAGGTCATTAAAAACAATTGTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATG
TTTGTTTCCAGTTTATCCCTACCAAAAATTAATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAA
TTTTCTCTTCAAAAGGAATACTGGGCCAGGCACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATG
AGCTCAGGAGTCGAAAACTAGCCTGAGCAACATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTC
CCAGCTCCTCGGAGGGCTGAGGTGCAAGGATCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGC
CTGGACAACAGAGTGAGACCCTCTCTCAAAAATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTG
GGCTTTCTTTTAAGATAGGGTCTCACCCTGTCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGA
TTCAGGTGATCCTCCCACCTTCACCTCCTGAGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCAT
GTTGCCCAGGCTGGTCTCTCTTAACTCTTGGGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCAT
ACTGTGTTGTGTTTTAGTTGAAAGGGATATACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCC
CAACCACCATTAAAGAGTTTGTGTAAATCTTCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATA
TGCTATGTTAAACATTTTTAGCATTTCCTCCTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTC
TGGACATTTAAATTGTAAGAAAATGGTCACTGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTA
CTGCCTTACATTAAAATCTTTTTCAATTTGACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTA
AGTTTATTTTATTTTATTTTTGAGACAGAGTCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCA
CCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTAT
TTTTAGTAGAGACAGGGTTTCACTATGTTGTCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTT
GGGATTACAGGCATGAGCCACCCTGCCCGACCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGT
TCACGGCTCCCTAAGGAGTGTTCCTTTTGGATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAG
TTTTACCTCTGATCTTTGGGGTGATTCTTTGTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAG
AACCTAGGCAAGTCATTTAATTTTTCTGGGCTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTA
GTAATGGATAAAAACCTACATAAATATTTCCTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTA
ACAGTTTCCCAAAATCCTGATTCTTTGACTTTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTA
ACTACCCACTTGCTGAGAGGGGTAGGAGCAGGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAA
ACTTGTCCTGTTTAACTTACCTGAGGGTTCTGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTC
GTTCTTTCGTCTCCTATCCTTTTTAGAAATTTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTC
CCCTAGCTTGGTACTAGTCCTTTTATTTCTGCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAA
AAAAAGTAAGTGGCTTGCTTTGCTTACTCTGGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCT
GAAAACAAGAATGAAAAACATACCATCTTTTCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATT

>In-frame_ENST00000553331_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=262AA_start in transcript=1_stop in transcript=789
LAEPGCQSFRASAARHSPARPVKQSQACRREKMAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGS
LLLRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEI

--------------------------------------------------------------
>In-frame_ENST00000553331_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=1214nt_BP=282nt
ATTGGCTGAGCCCGGCTGTCAGTCCTTTCGCGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAG
GGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAA
GCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAG
TTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTT
GGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTT
CATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAAT
TTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTA
CTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGA
CACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTT
TGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTAT
ACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAA
AAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTA
GAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTAC

>In-frame_ENST00000553331_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=262AA_start in transcript=1_stop in transcript=789
LAEPGCQSFRASAARHSPARPVKQSQACRREKMAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGS
LLLRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEI

--------------------------------------------------------------
>In-frame_ENST00000216832_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=4623nt_BP=252nt
CGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTT
GCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAG
GCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATT
GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC
CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA
GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA
GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT
AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA
CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA
GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA
GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT
AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT
AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC
ATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCAC
TTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTA
GTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTC
TGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTA
TACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTAC
TTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACAC
TGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGA
AAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGC
GTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATT
GTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATT
AATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGG
CACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAA
CATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGA
TCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAA
AATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTG
TCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTG
AGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTG
GGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATAT
ACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCT
TCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTC
CTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCAC
TGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTG
ACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAG
TCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTC
AGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTG
TCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGA
CCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGG
ATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTT
GTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGG
CTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTC
CTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACT
TTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCA
GGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTC
TGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAAT
TTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCT
GCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCT
GGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTT
TCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAA

>In-frame_ENST00000216832_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=230AA_start in transcript=67_stop in transcript=759
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG
ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK

--------------------------------------------------------------
>In-frame_ENST00000216832_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=1184nt_BP=252nt
CGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTT
GCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAG
GCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATT
GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC
CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA
GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA
GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT
AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA
CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA
GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA
GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT
AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT
AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC

>In-frame_ENST00000216832_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=230AA_start in transcript=67_stop in transcript=759
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG
ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK

--------------------------------------------------------------
>In-frame_ENST00000556530_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=4606nt_BP=235nt
ATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAA
AGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGAT
TGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCAT
TTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTA
AATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGA
GACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATG
TTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCA
CACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCC
TTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACT
AAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGG
GTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATA
CAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAAC
AGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTACATTATTTTAATCTGTTG
TTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCACTTTTATTTAGTTGATTC
GTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTAGTGGAGTTGATATCAGA
GGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTCTGTAAAGCCTCTGCAGT
TATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTATACAATGTGAATGTGTA
GGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTACTTCATGTTTCCTCCCAT
GCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACACTGTATTGGGTAATTTTA
AAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGAAAATAGAGTAAAGTAGA
AAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGCGTTTTTTTCTATTTTTA
GCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATTGTCTATGGCTGCAAAAT
ACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATTAATTCGAGTTAATTTCA
TGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGGCACTGTGACTCATACCT
GTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAACATGGCAAAACCCCATC
TCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGATCATTTGAGCCCAGGAG
GTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAAAATAAATAATAGATAAA
ACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTGTCACCTAGGCTGGAGTG
CAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTGAGTACCTTGGACTACAG
GCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTGGGCTCAAGTGATCTGAC
CATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATATACACGTGTATTTTAGAA
ATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCTTCTGGTCTCTTTTCTGT
ATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTCCTGTTCTTAAGTCTGTT
AAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCACTGTTAACTAGGCTGCAG
TGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTGACCAGTAAAAGTGGCAT
GTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAGTCTTGCACTGTCGCCCA
GGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTG
GGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGTCCAGGCTGGTCTCGAA
CGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGACCTAGTAATACTTTTTT
TTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGGATTGCTCTGTTTGGCTC
CCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTTGTTCATATTTATCTGAT
TGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGGCTTCAGTTTACTCATTA
GCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTCCTATTTTGCCATCAAAG
TGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACTTTTTTATCTTGATGATG
GAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCAGGGATTGGCTTTAGAGA
AACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTCTGCAGCCTACCGCAGTA
ATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAATTTATCACCTGTTTCTCT
TTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCTGCCTGTGATTATATTTT
AAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCTGGTTTTCCATCCTCATT
CCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTTTCAAGTTACTTTGGACC
CATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAATATGTTGAAAAATAAAA

>In-frame_ENST00000556530_ENST00000531120_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=230AA_start in transcript=50_stop in transcript=742
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG
ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK

--------------------------------------------------------------
>In-frame_ENST00000556530_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(transcript)=1167nt_BP=235nt
ATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAA
AGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGAT
TGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCAT
TTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTA
AATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGA
GACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATG
TTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCA
CACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCC
TTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACT
AAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGG
GTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATA
CAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAAC

>In-frame_ENST00000556530_ENST00000524896_TCGA-E2-A573-01A_PNN_chr14_39645353_+_EIF3M_chr11_32616460_length(amino acids)=230AA_start in transcript=50_stop in transcript=742
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG
ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PNN-EIF3M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneEIF3Mchr14:39645353chr11:32616460ENST00000531120511344_374205.66666666666666375.0HSV-1 and HSV-2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PNN-EIF3M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PNN-EIF3M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource