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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PNPLA7-SNAPC4 (FusionGDB2 ID:66367) |
Fusion Gene Summary for PNPLA7-SNAPC4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PNPLA7-SNAPC4 | Fusion gene ID: 66367 | Hgene | Tgene | Gene symbol | PNPLA7 | SNAPC4 | Gene ID | 375775 | 6621 |
Gene name | patatin like phospholipase domain containing 7 | small nuclear RNA activating complex polypeptide 4 | |
Synonyms | C9orf111|NTE-R1|NTEL1 | PTFalpha|SNAP190 | |
Cytomap | 9q34.3 | 9q34.3 | |
Type of gene | protein-coding | protein-coding | |
Description | patatin-like phospholipase domain-containing protein 7 | snRNA-activating protein complex subunit 4PSE-binding factor subunit alphaPTF subunit alphaSNAPc 190 kDa subunitSNAPc subunit 4proximal sequence element-binding transcription factor subunit alphasnRNA-activating protein complex 190 kDa subunit | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000371457, ENST00000277531, ENST00000406427, ENST00000492278, | ENST00000298532, | |
Fusion gene scores | * DoF score | 8 X 9 X 7=504 | 3 X 3 X 3=27 |
# samples | 9 | 3 | |
** MAII score | log2(9/504*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PNPLA7 [Title/Abstract] AND SNAPC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PNPLA7(140379039)-SNAPC4(139283043), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | PNPLA7-SNAPC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PNPLA7-SNAPC4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. PNPLA7-SNAPC4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SNAPC4 | GO:0042795 | snRNA transcription by RNA polymerase II | 9418884 |
Tgene | SNAPC4 | GO:0042796 | snRNA transcription by RNA polymerase III | 9418884 |
Fusion gene breakpoints across PNPLA7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SNAPC4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-4B-A93V-01A | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
ChimerDB4 | LUAD | TCGA-4B-A93V-01A | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
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Fusion Gene ORF analysis for PNPLA7-SNAPC4 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000371457 | ENST00000298532 | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
Frame-shift | ENST00000277531 | ENST00000298532 | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
Frame-shift | ENST00000406427 | ENST00000298532 | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
intron-3CDS | ENST00000492278 | ENST00000298532 | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000371457 | PNPLA7 | chr9 | 140379039 | - | ENST00000298532 | SNAPC4 | chr9 | 139283043 | - | 4919 | 1253 | 1235 | 4687 | 1150 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000371457 | ENST00000298532 | PNPLA7 | chr9 | 140379039 | - | SNAPC4 | chr9 | 139283043 | - | 0.034123473 | 0.9658766 |
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Fusion Genomic Features for PNPLA7-SNAPC4 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PNPLA7-SNAPC4 |
Go to FGviewer for the breakpoints of chr9:140379039-chr9:139283043 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 145_272 | 757.3333333333334 | 1318.0 | Nucleotide binding | cNMP 1 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 458_563 | 757.3333333333334 | 1318.0 | Nucleotide binding | cNMP 2 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 591_696 | 757.3333333333334 | 1318.0 | Nucleotide binding | cNMP 3 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 145_272 | 782.3333333333334 | 1343.0 | Nucleotide binding | cNMP 1 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 458_563 | 782.3333333333334 | 1343.0 | Nucleotide binding | cNMP 2 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 591_696 | 782.3333333333334 | 1343.0 | Nucleotide binding | cNMP 3 |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 1_12 | 757.3333333333334 | 1318.0 | Topological domain | Lumenal |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 1_12 | 782.3333333333334 | 1343.0 | Topological domain | Lumenal |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 13_33 | 757.3333333333334 | 1318.0 | Transmembrane | Helical |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 13_33 | 782.3333333333334 | 1343.0 | Transmembrane | Helical |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 931_1264 | 325.0 | 1407.0 | Compositional bias | Pro-rich | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 424_447 | 325.0 | 1407.0 | DNA binding | H-T-H motif | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 476_499 | 325.0 | 1407.0 | DNA binding | H-T-H motif | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 344_395 | 325.0 | 1407.0 | Domain | Myb-like 2 | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 396_451 | 325.0 | 1407.0 | Domain | HTH myb-type 2 | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 452_503 | 325.0 | 1407.0 | Domain | HTH myb-type 3 | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 1281_1393 | 325.0 | 1407.0 | Region | SNAPC2-binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 928_1094 | 757.3333333333334 | 1318.0 | Domain | PNPLA |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 928_1094 | 782.3333333333334 | 1343.0 | Domain | PNPLA |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 1081_1083 | 757.3333333333334 | 1318.0 | Motif | DGA/G |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 932_937 | 757.3333333333334 | 1318.0 | Motif | GXGXXG |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 959_963 | 757.3333333333334 | 1318.0 | Motif | GXSXG |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 1081_1083 | 782.3333333333334 | 1343.0 | Motif | DGA/G |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 932_937 | 782.3333333333334 | 1343.0 | Motif | GXGXXG |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 959_963 | 782.3333333333334 | 1343.0 | Motif | GXSXG |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 659_945 | 757.3333333333334 | 1318.0 | Region | Involved in the binding to lipid droplets |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 659_945 | 782.3333333333334 | 1343.0 | Region | Involved in the binding to lipid droplets |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000277531 | - | 20 | 34 | 34_1317 | 757.3333333333334 | 1318.0 | Topological domain | Cytoplasmic |
Hgene | PNPLA7 | chr9:140379039 | chr9:139283043 | ENST00000406427 | - | 21 | 35 | 34_1317 | 782.3333333333334 | 1343.0 | Topological domain | Cytoplasmic |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 317_341 | 325.0 | 1407.0 | DNA binding | H-T-H motif | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 250_288 | 325.0 | 1407.0 | Domain | Myb-like 1 | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 289_343 | 325.0 | 1407.0 | Domain | HTH myb-type 1 | |
Tgene | SNAPC4 | chr9:140379039 | chr9:139283043 | ENST00000298532 | 8 | 23 | 84_133 | 325.0 | 1407.0 | Region | SNAPC5-binding |
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Fusion Gene Sequence for PNPLA7-SNAPC4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000371457_ENST00000298532_TCGA-4B-A93V-01A_PNPLA7_chr9_140379039_-_SNAPC4_chr9_139283043_length(transcript)=4919nt_BP=1253nt CGGCCGCCCGGCAGCTGCTGGGCCCCTGCTGAAGAGGAGCCACTCCGTCCCCGCGCCTTCCATTCGCAAACAGATCTTGGAGGAGCTGGA GAAGCCCGGGGCAGGTGACCCTGACCCTTCGGCCCCACAAGGGGGCCCAGGCAGTGCCACTTCTGATCTGGGGATGGCATGTGACCGTGC CAGGGTCTTCCTGCACTCGGACGAGCACCCCGGGAGCTCCGTGGCCAGCAAGTCCAGGAAAAGCGTGATGGTTGCAGAGATACCCTCCAC GGTCTCCCAGCACTCAGAGAGTCACACGGATGAGACCCTGGCCAGCAGGAAGTCGGATGCCATCTTCAGAGCTGCCAAGAAGGACCTGCT CACCCTGATGAAGCTGGAAGACTCATCTCTGTTGGATGGCCGGGTGGCGCTTCTGCACGTTCCTGCAGGCACGGTGGTGTCAAGGCAGGG AGACCAGGACGCCAGCATCCTGTTCGTGGTCTCGGGGCTGCTGCACGTGTACCAGCGGAAGATCGGCAGCCAGGAGGACACCTGCTTGTT CCTCACGCGCCCCGGGGAGATGGTGGGCCAGCTGGCCGTGCTCACCGGGGAGCCTCTCATCTTCACCGTCAAGGCCAACAGGGACTGCAG CTTCCTGTCCATCTCCAAGGCCCACTTCTATGAAATCATGCGGAAGCAGCCGACCGTCGTCCTGGGTGTGGCGCACACTGTGGTGAAGAG GATGTCGTCCTTCGTGCGGCAAATCGACTTTGCCCTGGACTGGGTGGAGGTGGAGGCCGGGCGAGCAATATACAGGCAGGGGGACAAGTC CGACTGCACGTACATCATGCTCAGCGGCCGGCTGCGCTCTGTGATCCGGAAGGATGATGGGAAGAAGCGCCTGGCCGGGGAGTACGGCCG AGGAGACCTCGTCGGCGTGGTGGAGACACTGACCCACCAGGCCCGGGCGACCACGGTGCATGCCGTTCGGGACTCAGAATTGGCCAAGCT GCCGGCAGGAGCCCTCACGTCCATCAAGCGCAGGTACCCACAGGTGGTGACTCGGCTGATTCATCTCTTGGGTGAGAAGATCCTGGGCAG CCTCCAGCAGGGACCTGTGACAGGCCACCAGCTTGGGCTCCCCACGGAGGGCAGCAAGTGGGACTTGGGGAACCCGGCTGTCAACCTGTC CACGGTGGCAGTGATGCCCGTGTCAGAGGAAGTGCCCCTCACCGCCTTCGCCCTGGAGCTGGAGCATGCCCTCAGCGCCATCGACCAGCC GCAGCGCCTTCCAGTGCCTGCAGAAATTCCAGCAGCACAACAAAGCTCTGAAACGCAAGGAGTGGACAGAGGAGGAGGACCGCATGCTCA CGCAGCTGGTGCAGGAGATGCGCGTCGGCAGCCACATCCCCTACCGCAGAATTGTCTACTATATGGAAGGGAGAGACTCCATGCAGCTGA TCTACCGATGGACCAAGAGCTTGGATCCTGGTCTGAAGAAGGGTTACTGGGCCCCGGAGGAAGATGCTAAGTTGCTTCAAGCTGTTGCCA AATACGGGGAGCAGGATTGGTTTAAAATCCGGGAAGAGGTGCCAGGTAGGAGCGATGCCCAGTGCCGAGATCGGTATCTCAGGAGATTAC ATTTCAGCTTGAAAAAGGGTCGGTGGAATTTAAAAGAAGAGGAACAGTTAATTGAATTAATAGAAAAATATGGTGTCGGTCACTGGGCAA AAATAGCTTCTGAGCTGCCCCATCGGTCTGGCTCCCAGTGTCTGAGCAAGTGGAAGATCATGATGGGGAAGAAGCAGGGTCTCCGGAGGC GGCGGCGGAGGGCCCGTCACAGCGTCCGGTGGAGCTCTACCAGCAGCAGCGGCAGCAGCAGTGGCAGCAGTGGAGGGAGCAGCAGCAGCA GCAGCAGCAGCAGCGAGGAGGACGAGCCAGAGCAGGCGCAGGCCGGGGAGGGTGACAGAGCGCTGCTGTCCCCACAGTACATGGTCCCGG ACATGGACCTGTGGGTTCCTGCCAGGCAGAGCACCAGCCAGCCATGGAGAGGAGGGGCAGGGGCCTGGCTGGGAGGCCCCGCTGCCTCCC TCAGCCCTCCCAAGGGGTCCAGTGCCAGCCAGGGCGGCAGCAAGGAAGCTTCCACCACAGCCGCGGCTCCTGGAGAGGAGACGAGTCCGG TGCAGGTCCCTGCCAGGGCCCACGGCCCTGTCCCGAGGTCTGCCCAGGCCTCCCACTCAGCAGACACTCGCCCGGCGGGCGCAGAGAAGC AGGCCCTGGAGGGTGGGAGGCGTCTGCTGACAGTGCCTGTGGAGACCGTGCTGAGGGTGCTCAGGGCCAACACGGCTGCTCGGAGCTGCA CACAGAAAGAGCAGCTGAGGCAGCCACCCCTGCCCACCTCATCCCCAGGGGTCAGCTCTGGTGACAGCGTGGCCCGATCCCATGTGCAGT GGCTACGGCACAGAGCCACCCAGAGTGGGCAGCGGCGCTGGAGACACGCTCTGCACCGGAGGCTCCTGAACCGCAGGCTGCTGCTGGCTG TGACCCCTTGGGTAGGGGACGTTGTCGTGCCCTGCACACAGGCTTCCCAGAGACCCGCCGTAGTGCAGACTCAAGCGGATGGCCTCAGGG AGCAGCTGCAGCAGGCCCGCCTGGCCAGCACCCCTGTGTTTACCCTGTTTACCCAGCTGTTCCACATCGATACTGCCGGCTGCTTGGAGG TCGTCCGAGAGAGGAAGGCCCTGCCACCCAGGCTGCCCCAGGCTGGTGCTCGGGACCCACCAGTTCATCTTCTGCAGGCATCCTCAAGTG CCCAGAGCACCCCAGGCCACCTCTTCCCAAACGTGCCGGCTCAAGAAGCCTCAAAGAGTGCCAGCCACAAAGGGAGCCGAAGACTGGCGT CCAGCCGGGTGGAGCGCACCCTACCCCAGGCGTCCCTGCTGGCTTCAACCGGCCCCCGGCCCAAGCCCAAGACTGTGTCGGAGCTGCTTC AGGAGAAGCGGCTTCAGGAGGCCCGTGCCAGGGAGGCCACCCGGGGCCCGGTGGTGCTCCCGTCCCAGCTGCTGGTCTCCTCGTCTGTGA TCCTCCAGCCCCCTCTACCACACACCCCACACGGCCGCCCAGCCCCGGGTCCCACCGTCTTAAATGTACCGCTCTCTGGGCCTGGGGCCC CCGCGGCAGCCAAACCTGGCACTTCTGGCTCCTGGCAGGAGGCTGGGACTTCAGCCAAGGACAAGAGACTCTCCACCATGCAAGCCCTGC CCCTCGCTCCTGTCTTCTCAGAGGCCGAGGGCACAGCCCCTGCTGCTTCCCAAGCCCCTGCCCTGGGCCCCGGCCAGATCTCTGTGAGCT GCCCCGAGAGTGGTCTCGGACAGTCTCAGGCCCCCGCTGCATCCCGGAAGCAGGGCCTGCCTGAGGCGCCACCCTTTCTCCCCGCAGCCC CCAGCCCCACCCCACTGCCCGTCCAGCCCCTCAGCCTGACGCACATAGGAGGGCCACATGTGGCGACCAGTGTCCCCCTGCCTGTCACCT GGGTGCTCACAGCCCAGGGGCTTCTCCCTGTTCCTGTACCAGCTGTGGTGAGCCTTCCCAGGCCAGCAGGGACCCCTGGCCCCGCAGGGC TGCTGGCCACTCTGCTGCCTCCCCTGACTGAGACTCGGGCGGCCCAGGGCCCCAGGGCCCCAGCGTTGAGCAGCTCTTGGCAGCCCCCAG CCAATATGAACAGGGAACCGGAGCCTTCCTGCAGGACAGACACCCCAGCTCCTCCCACACACGCCCTCTCCCAAAGTCCTGCAGAAGCGG ATGGCAGTGTGGCCTTTGTCCCTGGAGAGGCCCAGGTGGCCAGGGAGATACCTGAGCCCAGGACGTCCTCCCACGCTGACCCTCCTGAAG CAGAACCCCCTTGGTCCGGGAGGCTGCCAGCCTTCGGTGGTGTCATCCCAGCAACTGAGCCAAGGGGGACGCCGGGGTCCCCCTCAGGGA CACAGGAGCCCAGGGGGCCTCTGGGCCTGGAGAAGCTGCCCCTGCGCCAGCCTGGGCCTGAGAAGGGGGCCCTGGACCTGGAGAAGCCGC CCCTACCCCAGCCTGGGCCTGAGAAGGGGGCCCTGGACCTGGGCCTGCTGTCCCAGGAGGGCGAGGCGGCCACACAGCAGTGGCTGGGGG GCCAGCGGGGGGTGCGTGTGCCTCTTCTGGGCAGCAGACTGCCCTATCAGCCCCCAGCCCTGTGCAGCCTGCGAGCTCTGTCCGGTCTCC TACTCCACAAGAAGGCCCTGGAGCACAAGGCCACCTCCCTGGTGGTGGGGGGCGAGGCTGAGCGGCCGGCCGGAGCACTGCAAGCCTCAC TGGGGCTGGTGCGGGGGCAGCTCCAGGACAACCCGGCCTACCTCCTGTTGCGGGCGCGGTTCCTGGCAGCCTTCACCCTCCCTGCGCTCC TGGCCACCCTGGCCCCCCAAGGCGTCCGCACCACCCTCTCAGTACCTTCGAGGGTGGGCTCTGAGAGTGAGGATGAAGACCTCCTGAGTG AGCTGGAACTTGCAGACAGGGACGGGCAGCCGGGCTGCACGACAGCCACATGCCCCATTCAGGGAGCCCCAGACTCTGGTAAATGCTCTG CTTCCTCCTGCCTGGATACTTCTAATGACCCTGACGACCTGGACGTGCTCAGAACCCGGCATGCCAGGCACACCCGGAAGCGGAGGCGGC TGGTGTGAGCAGCAGGACAAGCACTTTCTCAGAAGCCCGTGGCCCTGCTGACGAGAGACAGCCCACCCCCAGCCTGCAAGAGAGGCAGCC AGAGGCCAGGTATCTGCTGGCCGCTGACTGACCAGGTCCGCAGTGAACAGAGGCGGGCCTGCCGACTGACTGTGTGGCATGGAGCATGGC >In-frame_ENST00000371457_ENST00000298532_TCGA-4B-A93V-01A_PNPLA7_chr9_140379039_-_SNAPC4_chr9_139283043_length(amino acids)=1150AA_start in transcript=1235_stop in transcript=4687 MPSAPSTSRSAFQCLQKFQQHNKALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEED AKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMM GKKQGLRRRRRRARHSVRWSSTSSSGSSSGSSGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGA WLGGPAASLSPPKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRRLLTVPVETVLRVLR ANTAARSCTQKEQLRQPPLPTSSPGVSSGDSVARSHVQWLRHRATQSGQRRWRHALHRRLLNRRLLLAVTPWVGDVVVPCTQASQRPAVV QTQADGLREQLQQARLASTPVFTLFTQLFHIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSAS HKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLN VPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPAASRKQGLPE APPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPA LSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPR GTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGPEKGALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSRLPYQPPALC SLRALSGLLLHKKALEHKATSLVVGGEAERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFTLPALLATLAPQGVRTTLSVPSRVGSE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PNPLA7-SNAPC4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PNPLA7-SNAPC4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PNPLA7-SNAPC4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |