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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABR-CRK (FusionGDB2 ID:667)

Fusion Gene Summary for ABR-CRK

check button Fusion gene summary
Fusion gene informationFusion gene name: ABR-CRK
Fusion gene ID: 667
HgeneTgene
Gene symbol

ABR

CRK

Gene ID

29

1398

Gene nameABR activator of RhoGEF and GTPaseCRK proto-oncogene, adaptor protein
SynonymsMDBCRKII|p38
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-relatedadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein
Modification date2020031320200327
UniProtAcc.

P46109

Ensembl transtripts involved in fusion geneENST00000302538, ENST00000544583, 
ENST00000572441, ENST00000574437, 
ENST00000291107, ENST00000543210, 
ENST00000536794, ENST00000573895, 
ENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
Fusion gene scores* DoF score23 X 15 X 14=48309 X 8 X 3=216
# samples 369
** MAII scorelog2(36/4830*10)=-3.74595437739346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABR [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABR(994905)-CRK(1340449), # samples:2
CRK(1340084)-ABR(1028702), # samples:2
Anticipated loss of major functional domain due to fusion event.ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABR

GO:0090630

activation of GTPase activity

7479768

TgeneCRK

GO:0009966

regulation of signal transduction

17515907

TgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneCRK

GO:0043087

regulation of GTPase activity

11870224

TgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneCRK

GO:0061045

negative regulation of wound healing

17515907

TgeneCRK

GO:2000146

negative regulation of cell motility

17515907


check buttonFusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CRK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7662-01AABRchr17

994905

-CRKchr17

1340449

-
ChimerDB4LUADTCGA-44-7662-01AABRchr17

994905

-CRKchr17

1340449

-


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Fusion Gene ORF analysis for ABR-CRK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000302538ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000302538ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000302538ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
5CDS-5UTRENST00000302538ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
In-frameENST00000544583ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
In-frameENST00000544583ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
In-frameENST00000544583ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
5CDS-5UTRENST00000544583ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000572441ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000572441ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000572441ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
intron-5UTRENST00000572441ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000574437ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000574437ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000574437ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
5CDS-5UTRENST00000574437ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000291107ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000291107ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
Frame-shiftENST00000291107ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
5CDS-5UTRENST00000291107ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000543210ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000543210ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000543210ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
intron-5UTRENST00000543210ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000536794ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000536794ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000536794ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
intron-5UTRENST00000536794ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000573895ENST00000398970ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000573895ENST00000300574ABRchr17

994905

-CRKchr17

1340449

-
intron-3CDSENST00000573895ENST00000574295ABRchr17

994905

-CRKchr17

1340449

-
intron-5UTRENST00000573895ENST00000572145ABRchr17

994905

-CRKchr17

1340449

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544583ABRchr17994905-ENST00000398970CRKchr171340449-43219931040591149
ENST00000544583ABRchr17994905-ENST00000300574CRKchr171340449-449199310401666208
ENST00000544583ABRchr17994905-ENST00000574295CRKchr171340449-211199352938163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544583ENST00000398970ABRchr17994905-CRKchr171340449-0.01720830.9827917
ENST00000544583ENST00000300574ABRchr17994905-CRKchr171340449-0.0182898770.98171014
ENST00000544583ENST00000574295ABRchr17994905-CRKchr171340449-0.0146589990.985341

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Fusion Genomic Features for ABR-CRK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABR-CRK


check button Go to

FGviewer for the breakpoints of chr17:994905-chr17:1340449

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CRK

P46109

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May mediate the transduction of intracellular signals.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCRKchr17:994905chr17:1340449ENST0000030057403132_19280.33333333333333305.0DomainSH3 1
TgeneCRKchr17:994905chr17:1340449ENST0000030057403235_29680.33333333333333305.0DomainSH3 2
TgeneCRKchr17:994905chr17:1340449ENST0000039897003132_19280.33333333333333205.0DomainSH3 1
TgeneCRKchr17:994905chr17:1340449ENST0000039897003235_29680.33333333333333205.0DomainSH3 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABRchr17:994905chr17:1340449ENST00000291107-322417_420140.0823.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr17:1340449ENST00000302538-423417_420177.0860.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr17:1340449ENST00000543210-18417_4200311.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr17:1340449ENST00000544583-423417_420131.0814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr17:1340449ENST00000574437-322417_420131.0814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr17:1340449ENST00000291107-322301_459140.0823.0DomainPH
HgeneABRchr17:994905chr17:1340449ENST00000291107-322484_613140.0823.0DomainC2
HgeneABRchr17:994905chr17:1340449ENST00000291107-322647_845140.0823.0DomainRho-GAP
HgeneABRchr17:994905chr17:1340449ENST00000291107-32291_284140.0823.0DomainDH
HgeneABRchr17:994905chr17:1340449ENST00000302538-423301_459177.0860.0DomainPH
HgeneABRchr17:994905chr17:1340449ENST00000302538-423484_613177.0860.0DomainC2
HgeneABRchr17:994905chr17:1340449ENST00000302538-423647_845177.0860.0DomainRho-GAP
HgeneABRchr17:994905chr17:1340449ENST00000302538-42391_284177.0860.0DomainDH
HgeneABRchr17:994905chr17:1340449ENST00000543210-18301_4590311.0DomainPH
HgeneABRchr17:994905chr17:1340449ENST00000543210-18484_6130311.0DomainC2
HgeneABRchr17:994905chr17:1340449ENST00000543210-18647_8450311.0DomainRho-GAP
HgeneABRchr17:994905chr17:1340449ENST00000543210-1891_2840311.0DomainDH
HgeneABRchr17:994905chr17:1340449ENST00000544583-423301_459131.0814.0DomainPH
HgeneABRchr17:994905chr17:1340449ENST00000544583-423484_613131.0814.0DomainC2
HgeneABRchr17:994905chr17:1340449ENST00000544583-423647_845131.0814.0DomainRho-GAP
HgeneABRchr17:994905chr17:1340449ENST00000544583-42391_284131.0814.0DomainDH
HgeneABRchr17:994905chr17:1340449ENST00000574437-322301_459131.0814.0DomainPH
HgeneABRchr17:994905chr17:1340449ENST00000574437-322484_613131.0814.0DomainC2
HgeneABRchr17:994905chr17:1340449ENST00000574437-322647_845131.0814.0DomainRho-GAP
HgeneABRchr17:994905chr17:1340449ENST00000574437-32291_284131.0814.0DomainDH
TgeneCRKchr17:994905chr17:1340449ENST000003005740313_11880.33333333333333305.0DomainSH2
TgeneCRKchr17:994905chr17:1340449ENST000003989700313_11880.33333333333333205.0DomainSH2


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Fusion Gene Sequence for ABR-CRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000544583_ENST00000398970_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(transcript)=4321nt_BP=993nt
GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC
CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC
CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA
GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC
AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT
GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG
GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG
TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG
AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC
ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC
TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG
CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG
ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCC
TCTTTGACTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGT
GGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTC
TGATTGGAGGTCGGTGAGCTGGTAAAGGTTACGAAGATTAATGTGAGTGGTCAGTGGGAAGGGGAGTGTAATGGCAAACGAGGTCACTTC
CCATTCACACATGTCCGTCTGCTGGATCAACAGAATCCCGATGAGGACTTCAGCTGAGTATAGTTCAACAGTTTTGCTGACAGATGGGAA
CAATCTTTTTTTTTTTTTTCCAACTGCCATCTATACAATTTTCTTACAGATGTCAAAAGCAGTCTAGTTTATATAAGCATTCTGTTACCT
GTGATATTTTTTAGACTGAACTGCTCCATTCCTAGTCTTAATTACCATATTCAGGGTACGAACTGGAGGGCTTGTGTGTTAGCTTCTGAA
TTGGCAATTGGAGGCGGTAGTGGTCGTGCCTGTGTGTATCAGAAGGGATAGGTATCTTGCCTCCTTTCTCTCAGGCAGTGCAAATCACCC
TGTGGAAAACCGATGGACAGGAAGGAGTGTTACACACTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATC
AAATGGCGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATCATGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAG
CATGACCAGCGTGTGACTCATTCTGACATTTCAGATCCTAAGAATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCT
TCATACTTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTGTCCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTT
CATTCCAGGTGAAAAGCAGGATGTACCGAGCACTTTATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCT
CCCAGCTCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCCTTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGC
CATTTCTCCAGAGGGCCAGTATCCTATTAGGAGACTCTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATT
CTGTGGAAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTGTGCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGG
GTTAGTGCTTTGAAAAAATGTTGAACCGGCTGGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCA
TGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCA
CGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGTGAGCCGAGATCGCACCAC
TGCGTTCCAGCCTGAGCGACAGGGCAAGACTCAGTCTCAAAAAAAAAAAAAAGGAAAAAAAAAAGAAAAAAAAATGTTGAACCAATTGTG
AATTACTTATGTATTATTCATTTCTCATGGGGAGAGTAATGCTGTTGAAGAACATTACATTGTAAACTGCCTTCATTTTTGGCTCTTTGT
TTATGTTCAGGTTTAGTTTACAAACCCATTTAAGTATGGAATGATTTATATGGGGTCAGGTGCTCCACAAAATAGACCTATGAGACCAAA
AATGACCTAGGCTATTTAGACGACAGCATGAAACTTCCACGTTAGTTCTCAGTCTATAAAGGCACTTACCGGTCTCTGGTGTGGTATGAC
CAATAGAAACACCTTATAGTTTGCTTTGGACCTCATTTTGGAAAAATAATCTGCCTTTCTAATTGTTCTGCATAGGTTAAAATGATAAAT
TTACATTCTTTGAACCTATACCAGATTGTGGTGTCCGAGTGACCGGCACACTGTCTGACACACAGTCAGTGTGCACGTATTTGTCTGAGT
GAATGAGGAGACCTGAGAAACCGGTGACGTGGCACAGGGAAGCCAGCTGGCCCAGGATTCCGTACATGGCCGCAAGCAGACTAACGCGTT
GACGCTAATTTAATGTATTTTACCTCACACTAAGGTCATGCTTGATAAAGACGTTAAACTCAACTTGTAAAATGGTAGCCCAGTGCTATG
CACAGAGTGGGTGCTCATTAGTGTTGAATGAACACATTTGTAATACTACATGTAATTCCATCTGACTGCTTTGTTAAATTTTCAGTTAGA
ACGTAGATACTGTAAAGTCCACACACACATTAAATCTTGTTTTCCTGAAAGTATGGCATCAAAAATACTTGTAGAAAAACCTTGTCACAA
CTGATTTGAATGTTCCTATTTTCTTTTCCTTTGACTTTGATATTGGCTTGTAATGTCTCTTTTCATCATATGTAATATCAGTGGAACAGG
CAGCGCTACTCAAGTCCTAAGGATTCCTCAGTGATCAGTGATCCAGGGCCGTTCATGAACCACTGGGCTGGATTTGACTGTTGAGTGTGG
CAGTTAATGCCCCTCAAGAAATCAAAGGATGTCTTATAAGTGTCTTCCAAAAAAAAGCAAATGCTGAAATCCTATTGGCAAAGTAAACTG
AAATTGGCTGCTATATTTTATATAATCATTTCTGCAAATCCCATTTTTTGAATACTAATATTTGACATGGTTAATTCTTATTAATTTGTT
GGAATTGTTTATTGTTAATAATGCAAATAGATAATTTTTAATTATCCACAAGTAACATTTCACTGTTAATGGTTTGAAATAGGTGATAAG
CAAACCAATTTGAAATAAAATATAAACATGTGCCATTGTATTATAACACTATACACTTTCTTGACAGTTAAATTTAAAAAAAAATTTTTT
TTGGTAGCATGTATTGTATATGTTTATAGTATATGTAGTAAATAAAAATATGGCCAAATGTTTGGCTTGGTGATCTTTTGCAAAAAAGTA

>In-frame_ENST00000544583_ENST00000398970_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(amino acids)=149AA_start in transcript=1040_stop in transcript=591
MNQTLDLLFGVWRGSPQLLEEVAHGDLAVPLLHLGAQVVIELLVDLIDVLDLVEDGLDLLDGEHGLGGGGGGLQGFHGQQQGFQLVNVDL

--------------------------------------------------------------
>In-frame_ENST00000544583_ENST00000300574_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(transcript)=4491nt_BP=993nt
GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC
CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC
CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA
GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC
AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT
GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG
GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG
TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG
AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC
ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC
TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG
CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG
ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCC
TCTTTGACTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGT
GGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTC
TGATTGGAGGTAACCAGGAGGGTTCCCACCCACAGCCACTGGGTGGGCCGGAGCCTGGGCCCTATGCCCAACCCAGCGTCAACACTCCGC
TCCCTAACCTCCAGAATGGGCCCATATATGCCAGGGTTATCCAGAAGCGAGTCCCCAATGCCTACGACAAGACAGCCTTGGCTTTGGAGG
TCGGTGAGCTGGTAAAGGTTACGAAGATTAATGTGAGTGGTCAGTGGGAAGGGGAGTGTAATGGCAAACGAGGTCACTTCCCATTCACAC
ATGTCCGTCTGCTGGATCAACAGAATCCCGATGAGGACTTCAGCTGAGTATAGTTCAACAGTTTTGCTGACAGATGGGAACAATCTTTTT
TTTTTTTTTCCAACTGCCATCTATACAATTTTCTTACAGATGTCAAAAGCAGTCTAGTTTATATAAGCATTCTGTTACCTGTGATATTTT
TTAGACTGAACTGCTCCATTCCTAGTCTTAATTACCATATTCAGGGTACGAACTGGAGGGCTTGTGTGTTAGCTTCTGAATTGGCAATTG
GAGGCGGTAGTGGTCGTGCCTGTGTGTATCAGAAGGGATAGGTATCTTGCCTCCTTTCTCTCAGGCAGTGCAAATCACCCTGTGGAAAAC
CGATGGACAGGAAGGAGTGTTACACACTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATCAAATGGCGAC
AGACTGTTCCGTTCCACCCCCGTGAAGTAATCATGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAGCATGACCAGC
GTGTGACTCATTCTGACATTTCAGATCCTAAGAATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCTTCATACTTTT
TCTTGGGATTCTTTTAGCCCTTGACATTCTTGTCCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTTCATTCCAGGT
GAAAAGCAGGATGTACCGAGCACTTTATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCTCCCAGCTCTC
TGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCCTTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGCCATTTCTCCA
GAGGGCCAGTATCCTATTAGGAGACTCTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATTCTGTGGAAGG
TTTTGGGGTCAAATTCTGCCCTCTGCATTCTGTGCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGGGTTAGTGCTT
TGAAAAAATGTTGAACCGGCTGGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGG
AGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCACGCCTGTAAT
CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGTGAGCCGAGATCGCACCACTGCGTTCCAG
CCTGAGCGACAGGGCAAGACTCAGTCTCAAAAAAAAAAAAAAGGAAAAAAAAAAGAAAAAAAAATGTTGAACCAATTGTGAATTACTTAT
GTATTATTCATTTCTCATGGGGAGAGTAATGCTGTTGAAGAACATTACATTGTAAACTGCCTTCATTTTTGGCTCTTTGTTTATGTTCAG
GTTTAGTTTACAAACCCATTTAAGTATGGAATGATTTATATGGGGTCAGGTGCTCCACAAAATAGACCTATGAGACCAAAAATGACCTAG
GCTATTTAGACGACAGCATGAAACTTCCACGTTAGTTCTCAGTCTATAAAGGCACTTACCGGTCTCTGGTGTGGTATGACCAATAGAAAC
ACCTTATAGTTTGCTTTGGACCTCATTTTGGAAAAATAATCTGCCTTTCTAATTGTTCTGCATAGGTTAAAATGATAAATTTACATTCTT
TGAACCTATACCAGATTGTGGTGTCCGAGTGACCGGCACACTGTCTGACACACAGTCAGTGTGCACGTATTTGTCTGAGTGAATGAGGAG
ACCTGAGAAACCGGTGACGTGGCACAGGGAAGCCAGCTGGCCCAGGATTCCGTACATGGCCGCAAGCAGACTAACGCGTTGACGCTAATT
TAATGTATTTTACCTCACACTAAGGTCATGCTTGATAAAGACGTTAAACTCAACTTGTAAAATGGTAGCCCAGTGCTATGCACAGAGTGG
GTGCTCATTAGTGTTGAATGAACACATTTGTAATACTACATGTAATTCCATCTGACTGCTTTGTTAAATTTTCAGTTAGAACGTAGATAC
TGTAAAGTCCACACACACATTAAATCTTGTTTTCCTGAAAGTATGGCATCAAAAATACTTGTAGAAAAACCTTGTCACAACTGATTTGAA
TGTTCCTATTTTCTTTTCCTTTGACTTTGATATTGGCTTGTAATGTCTCTTTTCATCATATGTAATATCAGTGGAACAGGCAGCGCTACT
CAAGTCCTAAGGATTCCTCAGTGATCAGTGATCCAGGGCCGTTCATGAACCACTGGGCTGGATTTGACTGTTGAGTGTGGCAGTTAATGC
CCCTCAAGAAATCAAAGGATGTCTTATAAGTGTCTTCCAAAAAAAAGCAAATGCTGAAATCCTATTGGCAAAGTAAACTGAAATTGGCTG
CTATATTTTATATAATCATTTCTGCAAATCCCATTTTTTGAATACTAATATTTGACATGGTTAATTCTTATTAATTTGTTGGAATTGTTT
ATTGTTAATAATGCAAATAGATAATTTTTAATTATCCACAAGTAACATTTCACTGTTAATGGTTTGAAATAGGTGATAAGCAAACCAATT
TGAAATAAAATATAAACATGTGCCATTGTATTATAACACTATACACTTTCTTGACAGTTAAATTTAAAAAAAAATTTTTTTTGGTAGCAT

>In-frame_ENST00000544583_ENST00000300574_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(amino acids)=208AA_start in transcript=1040_stop in transcript=1666
MPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPY
VEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWE

--------------------------------------------------------------
>In-frame_ENST00000544583_ENST00000574295_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(transcript)=2111nt_BP=993nt
GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC
CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC
CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA
GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC
AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT
GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG
GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG
TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG
AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC
ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC
TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG
CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG
ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGAGTGTTACACACTGCTTA
CCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATCAAATGGCGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATCA
TGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAGCATGACCAGCGTGTGACTCATTCTGACATTTCAGATCCTAAGA
ATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCTTCATACTTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTGT
CCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTTCATTCCAGGTGAAAAGCAGGATGTACCGAGCACTTTATTCAGT
GCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCTCCCAGCTCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCC
TTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGCCATTTCTCCAGAGGGCCAGTATCCTATTAGGAGACTCTTGGAA
TTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATTCTGTGGAAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTGT
GCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGGGTTAGTGCTTTGAAAAAATGTTGAACCGGCTGGGCGCGGTGGC
TCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAAC
CCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATT

>In-frame_ENST00000544583_ENST00000574295_TCGA-44-7662-01A_ABR_chr17_994905_-_CRK_chr17_1340449_length(amino acids)=163AA_start in transcript=529_stop in transcript=38
MKSPSPHQHSERRQQKSPMDSLSLQNPEIQFSGSNLLSPKGNKSTSSWGQSSRAGPLPSCGHDGPEAGRAPRSFSQNSADASQAYAALPG

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Fusion Gene PPI Analysis for ABR-CRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABR-CRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABR-CRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABRC0033578Prostatic Neoplasms1CTD_human
HgeneABRC0376358Malignant neoplasm of prostate1CTD_human
TgeneCRKC0151744Myocardial Ischemia1CTD_human