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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POU5F1-POU5F1B (FusionGDB2 ID:66832)

Fusion Gene Summary for POU5F1-POU5F1B

check button Fusion gene summary
Fusion gene informationFusion gene name: POU5F1-POU5F1B
Fusion gene ID: 66832
HgeneTgene
Gene symbol

POU5F1

POU5F1B

Gene ID

5460

5462

Gene namePOU class 5 homeobox 1POU class 5 homeobox 1B
SynonymsOCT3|OCT4|OTF-3|OTF3|OTF4|Oct-3|Oct-4OCT4-PG1|OCT4PG1|OTF3C|OTF3P1|POU5F1P1|POU5F1P4|POU5FLC20|POU5FLC8
Cytomap

6p21.33

8q24.21

Type of geneprotein-codingprotein-coding
DescriptionPOU domain, class 5, transcription factor 1POU class 5 homeobox 1 transcript variant OCT4B1POU class 5 homeobox 1 transcript variant OCT4B2POU class 5 homeobox 1 transcript variant OCT4B3POU class 5 homeobox 1 transcript variant OCT4B4POU class 5 homputative POU domain, class 5, transcription factor 1BPOU 5 domain proteinPOU class 5 homeobox 1 pseudogene 1POU domain transcription factor OCT4-pg1POU domain transcription factor Oct-4POU domain, class 5, transcription factor 1 pseudogene 1octamer
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000441888, ENST00000259915, 
ENST00000512818, ENST00000606567, 
ENST00000513407, ENST00000471529, 
ENST00000547658, ENST00000496130, 
ENST00000451077, ENST00000429603, 
ENST00000547234, ENST00000553069, 
ENST00000463773, ENST00000412166, 
ENST00000434616, ENST00000550521, 
ENST00000550059, ENST00000483880, 
ENST00000419095, ENST00000433063, 
ENST00000548682, ENST00000553206, 
ENST00000497087, ENST00000376243, 
ENST00000383524, ENST00000550572, 
ENST00000546505, ENST00000497367, 
ENST00000433348, ENST00000454714, 
ENST00000549294, ENST00000547981, 
ENST00000495227, ENST00000429314, 
ENST00000437747, ENST00000548685, 
ENST00000465342, ENST00000391675, 
Fusion gene scores* DoF score2 X 1 X 1=23 X 3 X 3=27
# samples 34
** MAII scorelog2(3/2*10)=3.90689059560852log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: POU5F1 [Title/Abstract] AND POU5F1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOU5F1(31132114)-POU5F1B(128428517), # samples:1
Anticipated loss of major functional domain due to fusion event.POU5F1-POU5F1B seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
POU5F1-POU5F1B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
POU5F1-POU5F1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
POU5F1-POU5F1B seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOU5F1

GO:0000122

negative regulation of transcription by RNA polymerase II

19409607

HgenePOU5F1

GO:0001714

endodermal cell fate specification

20713518

HgenePOU5F1

GO:0006355

regulation of transcription, DNA-templated

16153702

HgenePOU5F1

GO:0035019

somatic stem cell population maintenance

19409607

HgenePOU5F1

GO:0045944

positive regulation of transcription by RNA polymerase II

20713518


check buttonFusion gene breakpoints across POU5F1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across POU5F1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ANM_001173531POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+


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Fusion Gene ORF analysis for POU5F1-POU5F1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000441888ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
In-frameENST00000441888ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
In-frameENST00000259915ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
Frame-shiftENST00000259915ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000512818ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000512818ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000606567ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000606567ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000513407ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000513407ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000471529ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000471529ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547658ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547658ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000496130ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000496130ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000451077ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000451077ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000429603ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000429603ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547234ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547234ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000553069ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000553069ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000463773ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000463773ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000412166ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000412166ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000434616ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000434616ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550521ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550521ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550059ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550059ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000483880ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000483880ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000419095ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000419095ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000433063ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000433063ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000548682ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000548682ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000553206ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000553206ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000497087ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000497087ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000376243ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000376243ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000383524ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000383524ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550572ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000550572ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000546505ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000546505ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000497367ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000497367ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000433348ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000433348ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000454714ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000454714ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000549294ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000549294ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547981ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000547981ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000495227ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000495227ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000429314ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000429314ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000437747ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000437747ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000548685ENST00000465342POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+
intron-3CDSENST00000548685ENST00000391675POU5F1chr6

31132114

-POU5F1Bchr8

128428517

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441888POU5F1chr631132114-ENST00000391675POU5F1Bchr8128428517+1972105065790241
ENST00000259915POU5F1chr631132114-ENST00000465342POU5F1Bchr8128428517+52081414731155360

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for POU5F1-POU5F1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POU5F1-POU5F1B


check button Go to

FGviewer for the breakpoints of chr6:31132114-chr8:128428517

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOU5F1chr6:31132114chr8:128428517ENST00000259915-55230_289447.0361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000259915-55138_212447.0361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000259915-55180_186447.0361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000259915-55193_196447.0361.0RegionDNA binding
TgenePOU5F1Bchr6:31132114chr8:128428517ENST0000039167501229_2880360.0DNA bindingHomeobox
TgenePOU5F1Bchr6:31132114chr8:128428517ENST0000046534202229_2880360.0DNA bindingHomeobox
TgenePOU5F1Bchr6:31132114chr8:128428517ENST0000039167501138_2120360.0DomainPOU-specific
TgenePOU5F1Bchr6:31132114chr8:128428517ENST0000046534202138_2120360.0DomainPOU-specific

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOU5F1chr6:31132114chr8:128428517ENST00000376243-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000383524-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000412166-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000419095-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429314-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429603-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433063-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433348-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000434616-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000437747-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000451077-14230_2890266.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000454714-15230_2890361.0DNA bindingHomeobox
HgenePOU5F1chr6:31132114chr8:128428517ENST00000376243-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000383524-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000412166-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000419095-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429314-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429603-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433063-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433348-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000434616-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000437747-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000451077-14138_2120266.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000454714-15138_2120361.0DomainPOU-specific
HgenePOU5F1chr6:31132114chr8:128428517ENST00000376243-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000376243-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000383524-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000383524-15193_1960361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000412166-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000412166-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000419095-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000419095-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429314-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429314-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429603-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000429603-15193_1960361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433063-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433063-15193_1960361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433348-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000433348-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000434616-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000434616-15193_1960361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000437747-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000437747-15193_1960361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000451077-14180_1860266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000451077-14193_1960266.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000454714-15180_1860361.0RegionDNA binding
HgenePOU5F1chr6:31132114chr8:128428517ENST00000454714-15193_1960361.0RegionDNA binding


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Fusion Gene Sequence for POU5F1-POU5F1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000441888_ENST00000391675_NM_001173531_POU5F1_chr6_31132114_-_POU5F1B_chr8_128428517_length(transcript)=1972nt_BP=1050nt
GGTTGCCGGGAATCTGGACCTGAGCGAGAAGCACGATCCCCGGCCGCCCCCGCTCTTGCATCCCCCTGGTCCTACTGCTGTGCTTGCTGG
CGACGGTTCGTTCCGGAAGTCAGTCCCAGGACATCAAAGCTCTGCAGAAAGAACTCGAGCAATTTGCCAAGCTCCTGAAGCAGAAGAGGA
TCACCCTGGGATATACACAGGCCGATGTGGGGCTCACCCTGGGGGTTCTATTTGGGAAGGTATTCAGCCAAACGACCATCTGCCGCTTTG
AGGCTCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTGCGGCCCTTGCTGCAGAAGTGGGTGGAGGAAGCTGACAACAATGAAAATCTTC
AGGAGATATGCAAAGCAGAAACCCTCGTGCAGGCCCGAAAGAGAAAGCGAACCAGTATCGAGAACCGAGTGAGAGGCAACCTGGAGAATT
TGTTCCTGCAGTGCCCGAAACCCACACTGCAGCAGATCAGCCACATCGCCCAGCAGCTTGGGCTCGAGAAGGATGTGGTCCGAGTGTGGT
TCTGTAACCGGCGCCAGAAGGGCAAGCGATCAAGCAGCGACTATGCACAACGAGAGGATTTTGAGGCTGCTGGGTCTCCTTTCTCAGGGG
GACCAGTGTCCTTTCCTCTGGCCCCAGGGCCCCATTTTGGTACCCCAGGCTATGGGAGCCCTCACTTCACTGCACTGTACTCCTCGGTCC
CTTTCCCTGAGGGGGAAGCCTTTCCCCCTGTCTCCGTCACCACTCTGGGCTCTCCCATGCATTCAAACTGAGGTGCCTGCCCTTCTAGGA
ATGGGGGACAGGGGGAGGGGAGGAGCTAGGGAAAGAAAACCTGGAGTTTGTGCCAGGGTTTTTGGGATTAAGTTCTTCATTCACTAAGGA
AGGAATTGGGAACACAAAGGGTGGGGGCAGGGGAGTTTGGGGCAACTGGTTGGAGGGAAGGTGAAGTTCAATGATGCTCTTGATTTTAAT
CCCACATCATGTATCACTTTTTTCTTAAATAAAGAAGCCTGGGACACAGTAGATAGACACCCCAGGACATCAAAGCTCTGCAGAAAGAAC
TCGAGCAATTTGCCAAGCTCCTGAAGCAGAAGAGGATCACCCTGGGATATACACAGGCCGATGTGGGGCTCATCCTGGGGGTTCTATTTG
GGAAGGTGTTCAGCCAAAAGACCATCTGCCGCTTTGAGGCTCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTGCGGCCCTTGCTGCAGA
AGTGGGTGGAGGAAGCTGACAACAATGAAAATCTTCAGGAGATATGCAAAGCAGAAACCCTCATGCAGGCCCGAAAGAGAAAGCGAACCA
GTATCGAGAACCGAGTGAGAGGCAACCTGGAGAATTTGTTCCTGCAGTGCCCGAAACCCACACTGCAGATCAGCCACATCGCCCAGCAGC
TTGGGCTCGAGAAGGATGTGGTCCGAGTGTGGTTCTGTAACCGGCGCCAGAAGGGCAAGCGATCAAGCAGCGACTATGCACAACGAGAGG
ATTTTGAGGCTGCTGGGTCTCCTTTCTCAGGGGGACCAGTGTCCTTTCCTCCGGCCCCAGGGCCCCATTTTGGTACCCCAGGCTATGGGA
GCCCTCACTTCACTGCACTGTACTCCTCAGTCCCTTTCCCTGAGGGGGAAGTCTTTCCCCCAGTCTCCGTCATCACTCTGGGCTCTCCCA
TGCATTCAAACTGAGGTGCCTGCCCTTCTAGGAATGGGGAACAGGGGAGGGGAGGAGCTAGGGAAAGAGAACCTGGAGTTTGTGGCAGGG
CTTTTGGGATTAAGTTCTTCATTCACTAAGGAAGGAATTGGGAACACTAAGGGTGGGGGCAGGGGAGTTTGGGGCAACTGGTTGGAGGGA

>In-frame_ENST00000441888_ENST00000391675_NM_001173531_POU5F1_chr6_31132114_-_POU5F1B_chr8_128428517_length(amino acids)=241AA_start in transcript=65_stop in transcript=790
MVLLLCLLATVRSGSQSQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVE
EADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFE

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>In-frame_ENST00000259915_ENST00000465342_NM_001173531_POU5F1_chr6_31132114_-_POU5F1B_chr8_128428517_length(transcript)=5208nt_BP=1414nt
AGAGAGGGGTTGAGTAGTCCCTTCGCAAGCCCTCATTTCACCAGGCCCCCGGCTTGGGGCGCCTTCCTTCCCCATGGCGGGACACCTGGC
TTCGGATTTCGCCTTCTCGCCCCCTCCAGGTGGTGGAGGTGATGGGCCAGGGGGGCCGGAGCCGGGCTGGGTTGATCCTCGGACCTGGCT
AAGCTTCCAAGGCCCTCCTGGAGGGCCAGGAATCGGGCCGGGGGTTGGGCCAGGCTCTGAGGTGTGGGGGATTCCCCCATGCCCCCCGCC
GTATGAGTTCTGTGGGGGGATGGCGTACTGTGGGCCCCAGGTTGGAGTGGGGCTAGTGCCCCAAGGCGGCTTGGAGACCTCTCAGCCTGA
GGGCGAAGCAGGAGTCGGGGTGGAGAGCAACTCCGATGGGGCCTCCCCGGAGCCCTGCACCGTCACCCCTGGTGCCGTGAAGCTGGAGAA
GGAGAAGCTGGAGCAAAACCCGGAGGAGTCCCAGGACATCAAAGCTCTGCAGAAAGAACTCGAGCAATTTGCCAAGCTCCTGAAGCAGAA
GAGGATCACCCTGGGATATACACAGGCCGATGTGGGGCTCACCCTGGGGGTTCTATTTGGGAAGGTATTCAGCCAAACGACCATCTGCCG
CTTTGAGGCTCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTGCGGCCCTTGCTGCAGAAGTGGGTGGAGGAAGCTGACAACAATGAAAA
TCTTCAGGAGATATGCAAAGCAGAAACCCTCGTGCAGGCCCGAAAGAGAAAGCGAACCAGTATCGAGAACCGAGTGAGAGGCAACCTGGA
GAATTTGTTCCTGCAGTGCCCGAAACCCACACTGCAGCAGATCAGCCACATCGCCCAGCAGCTTGGGCTCGAGAAGGATGTGGTCCGAGT
GTGGTTCTGTAACCGGCGCCAGAAGGGCAAGCGATCAAGCAGCGACTATGCACAACGAGAGGATTTTGAGGCTGCTGGGTCTCCTTTCTC
AGGGGGACCAGTGTCCTTTCCTCTGGCCCCAGGGCCCCATTTTGGTACCCCAGGCTATGGGAGCCCTCACTTCACTGCACTGTACTCCTC
GGTCCCTTTCCCTGAGGGGGAAGCCTTTCCCCCTGTCTCCGTCACCACTCTGGGCTCTCCCATGCATTCAAACTGAGGTGCCTGCCCTTC
TAGGAATGGGGGACAGGGGGAGGGGAGGAGCTAGGGAAAGAAAACCTGGAGTTTGTGCCAGGGTTTTTGGGATTAAGTTCTTCATTCACT
AAGGAAGGAATTGGGAACACAAAGGGTGGGGGCAGGGGAGTTTGGGGCAACTGGTTGGAGGGAAGGTGAAGTTCAATGATGCTCTTGATT
TTAATCCCACATCATGTATCACTTTTTTCTTAAATAAAGAAGCCTGGGACACAGTAGATAGACACCCAGGACATCAAAGCTCTGCAGAAA
GAACTCGAGCAATTTGCCAAGCTCCTGAAGCAGAAGAGGATCACCCTGGGATATACACAGGCCGATGTGGGGCTCATCCTGGGGGTTCTA
TTTGGGAAGGTGTTCAGCCAAAAGACCATCTGCCGCTTTGAGGCTCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTGCGGCCCTTGCTG
CAGAAGTGGGTGGAGGAAGCTGACAACAATGAAAATCTTCAGGAGATATGCAAAGCAGAAACCCTCATGCAGGCCCGAAAGAGAAAGCGA
ACCAGTATCGAGAACCGAGTGAGAGGCAACCTGGAGAATTTGTTCCTGCAGTGCCCGAAACCCACACTGCAGATCAGCCACATCGCCCAG
CAGCTTGGGCTCGAGAAGGATGTGGTCCGAGTGTGGTTCTGTAACCGGCGCCAGAAGGGCAAGCGATCAAGCAGCGACTATGCACAACGA
GAGGATTTTGAGGCTGCTGGGTCTCCTTTCTCAGGGGGACCAGTGTCCTTTCCTCCGGCCCCAGGGCCCCATTTTGGTACCCCAGGCTAT
GGGAGCCCTCACTTCACTGCACTGTACTCCTCAGTCCCTTTCCCTGAGGGGGAAGTCTTTCCCCCAGTCTCCGTCATCACTCTGGGCTCT
CCCATGCATTCAAACTGAGGTGCCTGCCCTTCTAGGAATGGGGAACAGGGGAGGGGAGGAGCTAGGGAAAGAGAACCTGGAGTTTGTGGC
AGGGCTTTTGGGATTAAGTTCTTCATTCACTAAGGAAGGAATTGGGAACACTAAGGGTGGGGGCAGGGGAGTTTGGGGCAACTGGTTGGA
GGGAAGGTGAAGTTCAATGATGCTCTTGATTTTAATCCCACATCATGTATCACTTTTTTCTTAAATAAAGAAGCCTGGGACACAGTAAAA
AAAAAAAAAAAAGAAAGAAAAGAAAAGTAACATAATTGAGTAATAATTTTTTAAGTGTGGTAAAATGTGTGGCACGTAGTAGGTATTCAA
TAAATACTTGCTTTTTTCCTCCTTTTTACCTTTTCCTAGAGTGCTACTTGATGGTAGCTGTAGTTTTTCTTCAAGACATCCTATTTGTCC
TGATACAAAACCTCTTTTGACCGCTAACGGCATAGTTCGGCCCTCACCATTCCCTCACATATTCCACAAAAATGTGAGCATTAACCATTC
CCCATGATACAGATAATTCATTTTTTAATTTAATTTTTTAAAATTTTATTTATTTACTTATTTATTTTGAGACCAGGTTATGAGACTGGC
TAATTTTTGTATTTTTGGTGGAGATGGGGTTTTGCCATATTGTCTAGGCTGGTCTCAAACTCCTGAGCTCAAGGGATCCTCCTGCCTGGG
CCTCCCAAAGTACTGGGATTACAGGCATGAGCCATTGCACCTGGCCCGGATAATTTTTTTTCTTTTTTTGAGGTAGTGCCTTCCTTTATA
GCTCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAACCTCCTGAGT
AGCTGGGATTACAGGCGCCCACTACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCT
CGAACTCTTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTATTGGGATTGTAGGCGTGAACCACCACGCCCGGCCCTGAAAATT
CATTTTTAAAAGAACATCATATCTACCTTAAATGCATTAAGATTTCACATTAGACTCATTATTCATAGTGAACATTAGGAACTTAAGTCC
ACTCAGTAATAATGCACCTATTCATGACTCTTGATTCAAAGATGTGCACCTATTTACCCTGGACCAGCTCCTTGGAAGGACATGAAATAG
AGGGTAATAATCACATCTTTCCAAATTTGCTATGAAACTGCATCGCCAAAAACTGAGACTCATTTTCCGATTGATGAATCAAATGACAAC
AAAATCTCCAGGGCATTCTGAAACCCAACAGGGATTAATGATTAGGCATACCAGTGGTAGTTAGGAGACTTGCCCAAATTTCCAGTTTTC
TGCAGATGGCATCTAAGTTAGAAGACTGTCATAAATTTATTCATGGCTTGGCTTTCTGCTATTTGCTCATTGGTGACACTTTTATATACA
ATGGTGTTTCTATGGCTAGGAAATCCCAGTGGAGATCAAGAAACCTGGGTTCTACAAACTAATGGGGTGACCTTTGATTAGTCCTAACTC
CCTTCCTAAGCCTCAGTTTCTTTAGACATGAAATGAAAGCAATGGATTACATTGCCTTAGACTTTTTCCTAGATCGAAAATGTGATAATT
GTGCCTTTCCAACAATAATTGATACCACTAGTGAACATTCTTTCTTAAGCACATCTATTAAGGACTTCATTTATATTATTTTTCTAATCT
TTAAGCAAACTCTGAGATAAGTGACTATGATGTTTATTCCATAGGTGCAAAAGATTTGTCAAGTAACTCTCCAAAGTAAAAGAGAGGGCT
GGAGTTTAGACTCATGACTGTTCTGCTCTAACCCAAGTGATTCTGGATCCCAGACTCCCCAAATGACAAGTTATTCCAGAAATACTCAGA
AAAAGGAGGGTGCCGTATGTCGCACATGGAAAAATAGAAAAAGTAACAGAATCCAGCCAAAGGATTCCCAGAAATTGAGGCTCTTCTGTT
CTTGGCATTTGCATCTTTGGATGTGTGTTTTTTACATTGCTCTATGCAAAAGGTATGTTTCAATGTGATTTTTTTTTTCTCCTCCCATCC
TACCACTGAGGAATCACAGGGAATAGACTCGACACCTGTGAACTCAATTTACCCTAGAAAAATGTTTCAGTCACACTTAAAATAAAAAGG
GCATCAATTAGAATAAGAAGGACACTTTGTTGCCTAGGAGGACTGAACTTTTTTGGACCTGGGGCACCTTATCAGCTTCATTTTTAGCTC
TAGTATAATCAAAAGGTCAGGATCTCCACTGGACCTTAGAAATTTTTTATTTTTCGATAAGATTTTCTGAATGCCTGCCATGTGTGAAGG
GAAATGCCTGGACTTCTATGCATATGTATTTCATTGTCTCCCCACATCTACCCAGGAAGACAGGCACAGTGAGCCTTGCATGTTGTAGAT
AAGGAAGCTAAGTCTCAAAGACAGAGAAGGAATTTCTCAAGGTCACACTGTAAGTAAAAGGCAAAGGAGGGATTAGAACCCTGGATCCTC
TTTATTACACCAAGCCTGCCTCACAAGGATGCCAATCTCTCATCACTTACTGGGAAAGACCCACTCCTCCCATTCATGATAAGGTAATGC
TATCCAATAAAAACCCCAAAGCAGGCATAAAATATGAAGTAGCGAAACTCAGGCAGGCAGAAAGCAGAGTGGTTTAGACATGGCTGCTGT
CTGCAGCAGGGAGAAGTTCCTGGCAACATGACCCTGAAAATAACAATGAGTGACTGAAGCTAAGAAGGAAGAATCTTCCAAGGACTCTGA
AACTAGATATTTTCTCAAGCCCCACCTATGGACAAACACAAATCATGGAGAAATAAAGATGCCAGTCTCCAGGAAGCACCAGAGTTAAAT
TCATTCTGGAATTTAACTCCTGGCATTAACAGTTAGCTGGGAGATTAAAACAAACCAACACACAAACACAAAAAAATAATCAGTGGAAAA

>In-frame_ENST00000259915_ENST00000465342_NM_001173531_POU5F1_chr6_31132114_-_POU5F1B_chr8_128428517_length(amino acids)=360AA_start in transcript=73_stop in transcript=1155
MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGL
ETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS
QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLE
KDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN

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Fusion Gene PPI Analysis for POU5F1-POU5F1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POU5F1-POU5F1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POU5F1-POU5F1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOU5F1C0018798Congenital Heart Defects1CTD_human
HgenePOU5F1C0027654Embryonal Neoplasm1CTD_human
HgenePOU5F1C0027658Neoplasms, Germ Cell and Embryonal1CTD_human
HgenePOU5F1C0085215Ovarian Failure, Premature1GENOMICS_ENGLAND
HgenePOU5F1C0205851Germ cell tumor1CTD_human
HgenePOU5F1C0205852Neoplasms, Embryonal and Mixed1CTD_human
HgenePOU5F1C0236733Amphetamine-Related Disorders1CTD_human
HgenePOU5F1C0236804Amphetamine Addiction1CTD_human
HgenePOU5F1C0236807Amphetamine Abuse1CTD_human
HgenePOU5F1C0740345Germ Cell Cancer1CTD_human
HgenePOU5F1C0751364Cancer, Embryonal1CTD_human
HgenePOU5F1C0751365Cancer, Embryonal and Mixed1CTD_human
HgenePOU5F1C1135868Gestational Trophoblastic Neoplasms1CTD_human
HgenePOU5F1C2931618Gestational trophoblastic disease1CTD_human