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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPA2-SORCS2 (FusionGDB2 ID:66863)

Fusion Gene Summary for PPA2-SORCS2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPA2-SORCS2
Fusion gene ID: 66863
HgeneTgene
Gene symbol

PPA2

SORCS2

Gene ID

27068

57537

Gene nameinorganic pyrophosphatase 2sortilin related VPS10 domain containing receptor 2
SynonymsHSPC124|SCFAI|SCFI|SID6-306-
Cytomap

4q24

4p16.1

Type of geneprotein-codingprotein-coding
Descriptioninorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000341695, ENST00000348706, 
ENST00000432483, ENST00000354147, 
ENST00000380004, ENST00000357415, 
ENST00000509426, ENST00000310267, 
ENST00000507866, ENST00000511199, 
ENST00000329016, 
Fusion gene scores* DoF score10 X 9 X 7=6306 X 5 X 6=180
# samples 118
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPA2 [Title/Abstract] AND SORCS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPA2(106377838)-SORCS2(7398015), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SORCS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9LZ-01APPA2chr4

106377838

-SORCS2chr4

7398015

+
ChimerDB4PRADTCGA-ZG-A9LZ-01APPA2chr4

106377838

-SORCS2chr4

7398015

+


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Fusion Gene ORF analysis for PPA2-SORCS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341695ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-3UTRENST00000341695ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-5UTRENST00000341695ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
In-frameENST00000348706ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-3UTRENST00000348706ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-5UTRENST00000348706ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
In-frameENST00000432483ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-3UTRENST00000432483ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-5UTRENST00000432483ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-3CDSENST00000354147ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-3UTRENST00000354147ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-5UTRENST00000354147ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
In-frameENST00000380004ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-3UTRENST00000380004ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-5UTRENST00000380004ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
In-frameENST00000357415ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-3UTRENST00000357415ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5CDS-5UTRENST00000357415ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
5UTR-3CDSENST00000509426ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
5UTR-3UTRENST00000509426ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
5UTR-5UTRENST00000509426ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-3CDSENST00000310267ENST00000507866PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-3UTRENST00000310267ENST00000511199PPA2chr4

106377838

-SORCS2chr4

7398015

+
intron-5UTRENST00000310267ENST00000329016PPA2chr4

106377838

-SORCS2chr4

7398015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341695PPA2chr4106377838-ENST00000507866SORCS2chr47398015+58162533132521073
ENST00000348706PPA2chr4106377838-ENST00000507866SORCS2chr47398015+57992361432351073
ENST00000432483PPA2chr4106377838-ENST00000507866SORCS2chr47398015+5785222032211073
ENST00000380004PPA2chr4106377838-ENST00000507866SORCS2chr47398015+57992361432351073
ENST00000357415PPA2chr4106377838-ENST00000507866SORCS2chr47398015+57992361432351073

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341695ENST00000507866PPA2chr4106377838-SORCS2chr47398015+0.0004889360.999511
ENST00000348706ENST00000507866PPA2chr4106377838-SORCS2chr47398015+0.0004771240.9995229
ENST00000432483ENST00000507866PPA2chr4106377838-SORCS2chr47398015+0.0004663230.99953365
ENST00000380004ENST00000507866PPA2chr4106377838-SORCS2chr47398015+0.0004771240.9995229
ENST00000357415ENST00000507866PPA2chr4106377838-SORCS2chr47398015+0.0004771240.9995229

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Fusion Genomic Features for PPA2-SORCS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPA2chr4106377837-SORCS2chr47398014+6.62E-060.9999933
PPA2chr4106377837-SORCS2chr47398014+6.62E-060.9999933

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPA2-SORCS2


check button Go to

FGviewer for the breakpoints of chr4:106377838-chr4:7398015

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027786_876160.01160.0DomainPKD
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027182_193160.01160.0RepeatNote=BNR 1
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027232_243160.01160.0RepeatNote=BNR 2
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027273_284160.01160.0RepeatNote=BNR 3
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027468_479160.01160.0RepeatNote=BNR 4
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027545_556160.01160.0RepeatNote=BNR 5
TgeneSORCS2chr4:106377838chr4:7398015ENST00000507866027587_598160.01160.0RepeatNote=BNR 6
TgeneSORCS2chr4:106377838chr4:7398015ENST000005078660271100_1159160.01160.0Topological domainCytoplasmic
TgeneSORCS2chr4:106377838chr4:7398015ENST000005078660271079_1099160.01160.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSORCS2chr4:106377838chr4:7398015ENST0000050786602713_104160.01160.0Compositional biasNote=Pro-rich
TgeneSORCS2chr4:106377838chr4:7398015ENST0000050786602751_1078160.01160.0Topological domainExtracellular


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Fusion Gene Sequence for PPA2-SORCS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000341695_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(transcript)=5816nt_BP=253nt
CCGCGCGCACAGCAGGACCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTT
GGGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCT
CTTCTTTAAGAATGTAACTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGTGATCTTGATCCTGAC
GAAGTACTACCACGCAGACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCT
CCAGCCTGGTGTCACCACCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGA
CCGGGACCAGAGCCTATTCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCA
CCCTAAGGAGGAGGACAAGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCA
AGAGCGAGTGACCAAAGACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGG
TGGAGATTTTCGGTACGTCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTC
TCTGACCGTGCAGGACGATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGT
CCTGATGAAGCTGCCGAAGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTG
GTACCAGATGGACACCTACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCA
GGCGGAGGAGAGCGTGCTCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGAT
GACGCTTATAACCTACAACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCC
TCCAGACTGCCACCTGCACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCT
CATCATGGGTGCAGGTAACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCA
GGTGTTTGAGGAAGAGCATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCT
CAAGTTCAGTGTGGACGAGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGG
GGACGAGACGCTGGTCATGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTC
CAGGCAGTGCGGCGAGGAGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCG
GAAAAGAAAGTCCACGTCCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTT
CCTGTGCGACTACGGATTTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCC
GCCTGACGACTGTGCCCTGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACAT
GCAGCAGAGTCAGGTGCAGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCC
TGGAGAGGACGTCCTGTTTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGC
CATGTACGTGAACCTTACACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAA
CACGGCAGGCCACGATGAGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCT
CAACCAGGAGGTGAACCTCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCC
CCTCCTTTCCCTGGATAATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGT
GCTGCAGGACTCCAGGGTCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAA
CACCCCTGAGTGGAGGGAAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGT
GGTGAAGCCGGGGCTGCCCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAA
GAGGCTCGCCGCCATCCAGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGA
CACAGGCACAGGTGCTGAGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGC
CTTCATCCTCTACAAGTTCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCC
TGTGAGTCACAGTGAGGACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTA
CCTGGTGAGCTGATGCCACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCC
TCAGAGACCTGCGGAAAGCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGC
CCACGGGGGGCCCACGGGACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCC
CCAGACCCCACACACGGCCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCC
AGTACCTCGGGCTGCAAGAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCT
TCTTCACTCCCACCTGTGCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCC
TGCCCTCCGGCTGGAAACTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGC
CGGCGGTAGCCACCGGGGTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGG
GCAGCAGCTCTCCCTGGTTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGC
AGCACCATCCCGCAGGCTTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGG
TGGTGGAGACGGCACCAGATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGA
TGGCAGGGCTGGAAGGGCCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCA
CGGTCACAGCAGAGGTGGCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGT
TAGTGTAAGTCTATAGGAATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCC
TCCCCCTCCTCTCTGGCAGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGC
TGGGGGTGAATCCCAATGAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATG
AGGGTCCCTCTCAGAAAGGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCC
CATCCACCATGTCTGAGCTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCT
TCACGCCCCAAACAGTGCCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGG
TCGGGGGGTGTTCAAGGCCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGA
CCCAAAGCTCTCTCCCCACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGG
TCATCCTGGAGATGGGATCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGAC
ACCTTTGCAGGGATTCTTGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGAC
AGACATGGCGAGCACAGTGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGT
AGCCACTCTAGGTCGTTGGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGT
TTCCTGTATTTTATGTTAATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCT
GATACGTTCCCGTCTGTGCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGT
TCAGGTAGACCTGGGCGCCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTA

>In-frame_ENST00000341695_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(amino acids)=1073AA_start in transcript=31_stop in transcript=3252
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEVILILTKYYHADMGKV
LESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAY
TKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFF
KATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDIL
EVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQ
LVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFG
HISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSS
SSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQ
EQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVL
LPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGL
VVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGG

--------------------------------------------------------------
>In-frame_ENST00000348706_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(transcript)=5799nt_BP=236nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGTGATCTTGATCCTGACGAAGTACTACCACGCAG
ACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGGTGTCACCA
CCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCAGAGCCTAT
TCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGAGGAGGACA
AGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGTGACCAAAG
ACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTTTCGGTACG
TCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGTGCAGGACG
ATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAAGCTGCCGA
AGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGATGGACACCT
ACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGAGAGCGTGC
TCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTATAACCTACA
ACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTGCCACCTGC
ACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGGTGCAGGTA
ACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGAGGAAGAGC
ATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAGTGTGGACG
AGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGACGCTGGTCA
TGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTGCGGCGAGG
AGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAAGTCCACGT
CCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGACTACGGAT
TTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGACTGTGCCC
TGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAGTCAGGTGC
AGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGACGTCCTGT
TTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGTGAACCTTA
CACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGGCCACGATG
AGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGAGGTGAACC
TCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTCCCTGGATA
ATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGACTCCAGGG
TCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGAGTGGAGGG
AAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCCGGGGCTGC
CCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGCCGCCATCC
AGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCACAGGTGCTG
AGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCTCTACAAGT
TCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCACAGTGAGG
ACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAGCTGATGCC
ACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACCTGCGGAAA
GCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGGGCCCACGG
GACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCCACACACGG
CCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCGGGCTGCAA
GAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTCCCACCTGT
GCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCGGCTGGAAA
CTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAGCCACCGGG
GTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCTCTCCCTGG
TTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATCCCGCAGGC
TTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGACGGCACCA
GATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGCTGGAAGGG
CCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAGCAGAGGTG
GCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAGTCTATAGG
AATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCCTCTCTGGC
AGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGAATCCCAAT
GAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCTCTCAGAAA
GGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCATGTCTGAG
CTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCCAAACAGTG
CCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGTGTTCAAGG
CCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCTCTCTCCCC
ACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGGAGATGGGA
TCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCAGGGATTCT
TGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGCGAGCACAG
TGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCTAGGTCGTT
GGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTATTTTATGTT
AATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTCCCGTCTGT
GCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGACCTGGGCG
CCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGATGAATCATT

>In-frame_ENST00000348706_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(amino acids)=1073AA_start in transcript=14_stop in transcript=3235
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEVILILTKYYHADMGKV
LESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAY
TKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFF
KATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDIL
EVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQ
LVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFG
HISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSS
SSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQ
EQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVL
LPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGL
VVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGG

--------------------------------------------------------------
>In-frame_ENST00000432483_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(transcript)=5785nt_BP=222nt
ATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGACCGGGTCGCGCCGT
GCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAACTGGTCACTACATT
TCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGTGATCTTGATCCTGACGAAGTACTACCACGCAGACATGGGGAAGGTT
CTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGGTGTCACCACCGTCATCGACAAT
TTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCAGAGCCTATTCCTCAGCGCAGAC
GAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGAGGAGGACAAGGTCCTCGCCTAC
ACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGTGACCAAAGACCACGTGTTCTGG
TCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTTTCGGTACGTCACCTGCGCAATC
CACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGTGCAGGACGATTACATCTTCTTT
AAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAAGCTGCCGAAGTATGCATTGCCA
AAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGATGGACACCTACAACCTGTACCAG
TCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGAGAGCGTGCTCATCGACATCCTG
GAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTATAACCTACAACAAGGGCCGCGAC
TGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTGCCACCTGCACCTGCACCTGCGC
TGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGGTGCAGGTAACCTGGGCTCACAG
CTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGAGGAAGAGCATCACATCCTGTAC
CTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAGTGTGGACGAGGGCCTCACCTGG
AGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGACGCTGGTCATGACGGTCTTTGGC
CACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTGCGGCGAGGAGGACTACAGCTCC
TGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAAGTCCACGTCCTGGTGCATCAAG
GGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGACTACGGATTTGAGCGCTCCTCC
TCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGACTGTGCCCTGGGCCAGACCTAC
ACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAGTCAGGTGCAGCTGCAGTGCCCC
CTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGACGTCCTGTTTGTGGTGCGGCAG
GAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGTGAACCTTACACTGACCGGGGAG
CCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGGCCACGATGAGGCGGTGCTCTTT
GTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGAGGTGAACCTCACAGCTGTGCTG
CTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTCCCTGGATAATTCTGTGACAACG
CGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGACTCCAGGGTCCTCCGTGTGCTG
GATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGAGTGGAGGGAAGACGTGGGCCTG
GTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCCGGGGCTGCCCACTTTGGCCGAT
CTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGCCGCCATCCAGCAGGTGCTGAAC
GCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCACAGGTGCTGAGCAGCTGGGCGGC
GGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCTCTACAAGTTCAAAAGGAAACGG
CCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCACAGTGAGGACGTCCAGGGCGCT
GTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAGCTGATGCCACCCCAGCATCTGT
CTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACCTGCGGAAAGCCCCCTCCCTGAG
TCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGGGCCCACGGGACCCCCCGGGACT
CCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCCACACACGGCCGCCCCACGTGCT
GTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCGGGCTGCAAGAGCTGCAGACCCG
TTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTCCCACCTGTGCGGCCACCCAGTC
CCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCGGCTGGAAACTGCAGCTCTGTAA
ATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAGCCACCGGGGTGGCTCTGTCAGA
GTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCTCTCCCTGGTTCTCCCCAGGGCA
GACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATCCCGCAGGCTTCTCCCACCTGAT
GGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGACGGCACCAGATGTACCAGTTTT
CTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGCTGGAAGGGCCATCAGCGTGACC
CTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAGCAGAGGTGGCCGAACCCAGCCC
TCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAGTCTATAGGAATATAGGGGGGTG
GGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCCTCTCTGGCAGGGATCTCAGATG
ACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCTCTCA
GAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCTCTCAGAAAGGGAGAACGCCAGA
GCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCATGTCTGAGCTTGGGGGAATTGC
CTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCCAAACAGTGCCCGGTGGGGAGGA
GGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGTGTTCAAGGCCACAGGACAAGGG
GAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCTCTCTCCCCACCCTACCTGCCCA
CCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGGAGATGGGATCCAGGACGTGGGG
CCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCAGGGATTCTTGTCCTGCTGGCCA
CCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGCGAGCACAGTGCAGGCCCGGGGC
CCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCTAGGTCGTTGGCCTTCCTTGACC
ACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTATTTTATGTTAATATTTCTATTAA
GAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTCCCGTCTGTGCACCCATGGAGAT
CCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGACCTGGGCGCCTGGGAACGAGGC
CATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGATGAATCATTTGTGATGCTTTTAA

>In-frame_ENST00000432483_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(amino acids)=1073AA_start in transcript=0_stop in transcript=3221
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEVILILTKYYHADMGKV
LESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAY
TKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFF
KATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDIL
EVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQ
LVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFG
HISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSS
SSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQ
EQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVL
LPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGL
VVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGG

--------------------------------------------------------------
>In-frame_ENST00000380004_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(transcript)=5799nt_BP=236nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGTGATCTTGATCCTGACGAAGTACTACCACGCAG
ACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGGTGTCACCA
CCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCAGAGCCTAT
TCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGAGGAGGACA
AGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGTGACCAAAG
ACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTTTCGGTACG
TCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGTGCAGGACG
ATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAAGCTGCCGA
AGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGATGGACACCT
ACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGAGAGCGTGC
TCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTATAACCTACA
ACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTGCCACCTGC
ACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGGTGCAGGTA
ACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGAGGAAGAGC
ATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAGTGTGGACG
AGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGACGCTGGTCA
TGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTGCGGCGAGG
AGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAAGTCCACGT
CCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGACTACGGAT
TTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGACTGTGCCC
TGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAGTCAGGTGC
AGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGACGTCCTGT
TTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGTGAACCTTA
CACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGGCCACGATG
AGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGAGGTGAACC
TCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTCCCTGGATA
ATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGACTCCAGGG
TCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGAGTGGAGGG
AAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCCGGGGCTGC
CCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGCCGCCATCC
AGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCACAGGTGCTG
AGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCTCTACAAGT
TCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCACAGTGAGG
ACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAGCTGATGCC
ACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACCTGCGGAAA
GCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGGGCCCACGG
GACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCCACACACGG
CCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCGGGCTGCAA
GAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTCCCACCTGT
GCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCGGCTGGAAA
CTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAGCCACCGGG
GTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCTCTCCCTGG
TTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATCCCGCAGGC
TTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGACGGCACCA
GATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGCTGGAAGGG
CCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAGCAGAGGTG
GCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAGTCTATAGG
AATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCCTCTCTGGC
AGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGAATCCCAAT
GAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCTCTCAGAAA
GGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCATGTCTGAG
CTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCCAAACAGTG
CCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGTGTTCAAGG
CCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCTCTCTCCCC
ACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGGAGATGGGA
TCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCAGGGATTCT
TGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGCGAGCACAG
TGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCTAGGTCGTT
GGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTATTTTATGTT
AATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTCCCGTCTGT
GCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGACCTGGGCG
CCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGATGAATCATT

>In-frame_ENST00000380004_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(amino acids)=1073AA_start in transcript=14_stop in transcript=3235
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEVILILTKYYHADMGKV
LESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAY
TKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFF
KATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDIL
EVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQ
LVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFG
HISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSS
SSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQ
EQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVL
LPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGL
VVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGG

--------------------------------------------------------------
>In-frame_ENST00000357415_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(transcript)=5799nt_BP=236nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGTGATCTTGATCCTGACGAAGTACTACCACGCAG
ACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGGTGTCACCA
CCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCAGAGCCTAT
TCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGAGGAGGACA
AGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGTGACCAAAG
ACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTTTCGGTACG
TCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGTGCAGGACG
ATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAAGCTGCCGA
AGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGATGGACACCT
ACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGAGAGCGTGC
TCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTATAACCTACA
ACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTGCCACCTGC
ACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGGTGCAGGTA
ACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGAGGAAGAGC
ATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAGTGTGGACG
AGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGACGCTGGTCA
TGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTGCGGCGAGG
AGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAAGTCCACGT
CCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGACTACGGAT
TTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGACTGTGCCC
TGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAGTCAGGTGC
AGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGACGTCCTGT
TTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGTGAACCTTA
CACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGGCCACGATG
AGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGAGGTGAACC
TCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTCCCTGGATA
ATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGACTCCAGGG
TCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGAGTGGAGGG
AAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCCGGGGCTGC
CCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGCCGCCATCC
AGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCACAGGTGCTG
AGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCTCTACAAGT
TCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCACAGTGAGG
ACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAGCTGATGCC
ACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACCTGCGGAAA
GCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGGGCCCACGG
GACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCCACACACGG
CCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCGGGCTGCAA
GAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTCCCACCTGT
GCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCGGCTGGAAA
CTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAGCCACCGGG
GTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCTCTCCCTGG
TTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATCCCGCAGGC
TTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGACGGCACCA
GATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGCTGGAAGGG
CCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAGCAGAGGTG
GCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAGTCTATAGG
AATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCCTCTCTGGC
AGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGAATCCCAAT
GAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCTCTCAGAAA
GGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCATGTCTGAG
CTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCCAAACAGTG
CCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGTGTTCAAGG
CCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCTCTCTCCCC
ACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGGAGATGGGA
TCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCAGGGATTCT
TGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGCGAGCACAG
TGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCTAGGTCGTT
GGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTATTTTATGTT
AATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTCCCGTCTGT
GCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGACCTGGGCG
CCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGATGAATCATT

>In-frame_ENST00000357415_ENST00000507866_TCGA-ZG-A9LZ-01A_PPA2_chr4_106377838_-_SORCS2_chr4_7398015_length(amino acids)=1073AA_start in transcript=14_stop in transcript=3235
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEVILILTKYYHADMGKV
LESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAY
TKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFF
KATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDIL
EVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQ
LVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFG
HISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSS
SSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQ
EQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVL
LPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGL
VVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPA2-SORCS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPA2-SORCS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPA2-SORCS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPA2C4310663SUDDEN CARDIAC FAILURE, ALCOHOL-INDUCED2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePPA2C4310664SUDDEN CARDIAC FAILURE, INFANTILE2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneSORCS2C0005586Bipolar Disorder1PSYGENET