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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ABR-FAM101B (FusionGDB2 ID:669) |
Fusion Gene Summary for ABR-FAM101B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABR-FAM101B | Fusion gene ID: 669 | Hgene | Tgene | Gene symbol | ABR | FAM101B | Gene ID | 29 | 359845 |
| Gene name | ABR activator of RhoGEF and GTPase | refilin B | |
| Synonyms | MDB | CFM1|FAM101B | |
| Cytomap | 17p13.3 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related | refilin-Bfamily with sequence similarity 101, member Bfilamin-interacting protein FAM101Bprotein FAM101BrefilinBregulator of filamin protein B | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000302538, ENST00000544583, ENST00000572441, ENST00000574437, ENST00000291107, ENST00000543210, ENST00000536794, ENST00000573895, | ENST00000329099, | |
| Fusion gene scores | * DoF score | 23 X 15 X 14=4830 | 2 X 2 X 2=8 |
| # samples | 36 | 2 | |
| ** MAII score | log2(36/4830*10)=-3.74595437739346 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ABR [Title/Abstract] AND FAM101B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ABR(953290)-FAM101B(295730), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ABR-FAM101B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABR | GO:0090630 | activation of GTPase activity | 7479768 |
| Fusion gene breakpoints across ABR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across FAM101B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-AY-A71X-01A | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
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Fusion Gene ORF analysis for ABR-FAM101B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000302538 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| Frame-shift | ENST00000544583 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| intron-3CDS | ENST00000572441 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| In-frame | ENST00000574437 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| In-frame | ENST00000291107 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| intron-3CDS | ENST00000543210 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| In-frame | ENST00000536794 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| intron-3CDS | ENST00000573895 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000302538 | ABR | chr17 | 953290 | - | ENST00000329099 | FAM101B | chr17 | 295730 | - | 5559 | 1938 | 147 | 2372 | 741 |
| ENST00000574437 | ABR | chr17 | 953290 | - | ENST00000329099 | FAM101B | chr17 | 295730 | - | 5739 | 2118 | 123 | 2552 | 809 |
| ENST00000291107 | ABR | chr17 | 953290 | - | ENST00000329099 | FAM101B | chr17 | 295730 | - | 5333 | 1712 | 32 | 2146 | 704 |
| ENST00000536794 | ABR | chr17 | 953290 | - | ENST00000329099 | FAM101B | chr17 | 295730 | - | 5045 | 1424 | 140 | 1858 | 572 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000302538 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - | 0.000553994 | 0.999446 |
| ENST00000574437 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - | 0.000863762 | 0.99913627 |
| ENST00000291107 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - | 0.001261589 | 0.99873847 |
| ENST00000536794 | ENST00000329099 | ABR | chr17 | 953290 | - | FAM101B | chr17 | 295730 | - | 0.002803149 | 0.9971968 |
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Fusion Genomic Features for ABR-FAM101B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ABR-FAM101B |
| Go to FGviewer for the breakpoints of chr17:953290-chr17:295730 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000291107 | - | 15 | 22 | 417_420 | 560.0 | 823.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000302538 | - | 16 | 23 | 417_420 | 597.0 | 860.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000544583 | - | 16 | 23 | 417_420 | 551.0 | 814.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000574437 | - | 15 | 22 | 417_420 | 551.0 | 814.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000291107 | - | 15 | 22 | 301_459 | 560.0 | 823.0 | Domain | PH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000291107 | - | 15 | 22 | 91_284 | 560.0 | 823.0 | Domain | DH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000302538 | - | 16 | 23 | 301_459 | 597.0 | 860.0 | Domain | PH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000302538 | - | 16 | 23 | 91_284 | 597.0 | 860.0 | Domain | DH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000544583 | - | 16 | 23 | 301_459 | 551.0 | 814.0 | Domain | PH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000544583 | - | 16 | 23 | 91_284 | 551.0 | 814.0 | Domain | DH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000574437 | - | 15 | 22 | 301_459 | 551.0 | 814.0 | Domain | PH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000574437 | - | 15 | 22 | 91_284 | 551.0 | 814.0 | Domain | DH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000543210 | - | 1 | 8 | 417_420 | 0 | 311.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000291107 | - | 15 | 22 | 484_613 | 560.0 | 823.0 | Domain | C2 |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000291107 | - | 15 | 22 | 647_845 | 560.0 | 823.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000302538 | - | 16 | 23 | 484_613 | 597.0 | 860.0 | Domain | C2 |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000302538 | - | 16 | 23 | 647_845 | 597.0 | 860.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000543210 | - | 1 | 8 | 301_459 | 0 | 311.0 | Domain | PH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000543210 | - | 1 | 8 | 484_613 | 0 | 311.0 | Domain | C2 |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000543210 | - | 1 | 8 | 647_845 | 0 | 311.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000543210 | - | 1 | 8 | 91_284 | 0 | 311.0 | Domain | DH |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000544583 | - | 16 | 23 | 484_613 | 551.0 | 814.0 | Domain | C2 |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000544583 | - | 16 | 23 | 647_845 | 551.0 | 814.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000574437 | - | 15 | 22 | 484_613 | 551.0 | 814.0 | Domain | C2 |
| Hgene | ABR | chr17:953290 | chr17:295730 | ENST00000574437 | - | 15 | 22 | 647_845 | 551.0 | 814.0 | Domain | Rho-GAP |
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Fusion Gene Sequence for ABR-FAM101B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000302538_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(transcript)=5559nt_BP=1938nt GCCCCGCGCTCCTCCCGGGGACCTGGTTCCCGGCCTCCTCGCCCCTCCGCGCTCGCAACTTCGGCCTCCCCCGGCTCCCGCCCGCTCTCC CTCCTTTGTTGCGCGATGAGGGTCGGGTTTCGGATCTGACCGAGCCGCCGCCGCGGGATGGAGCCGCTCAGCCACCGGGGCCTGCCGCGC CTGTCCTGGATCGACACCCTCTACAGCAACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTAT AAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAG GACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACAC GACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATC AACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTG TCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCAC CAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCC TTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGC CGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAAT CGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGAT CTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACC AGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAAC CTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGG GATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAG GACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCCAGAGTCCAGCGTCTCTCCCCCTGGCTCCCGGCTGTGCGCTGAGG CTTTGTCCCCTGTCCTTTGGCGAAGGAGTGGAGTTTGACCCCTTACCACCAAAGGAAGTAAGGTACACCTCCTTGGTCAAGTACGACTCC GAGAGGCACTTCATCGACGACGTGCAGCTGCCCCTGGGCCTGGCGGTGGCCTCCTGCAGCCAGACGGTCACCTGTGTCCCCAATGGCACG TGGCGCAACTACAAGGCCGAGGTGCGCTTCGAGCCACGCCACAGGCCCACCCGCTTCCTCAGTACCACCATCGTGTACCCCAAGTACCCC AAGGCCGTCTACACCACCACCCTGGATTACAACTGCCGCAAGACGCTGAGGAGGTTTCTGTCCAGCGTGGAGCTCGAAGCCGCGGAGCTC CCGGGCAGCGACGACCTCTCTGATGAATGCTGACCCAGCAGGCTGGGCTGGGGTCGGACCGGCTCTCCCGCTGTCCTGCCCCCGACTGCC CTGGCCAAGCTGGGCGACCTTACCCTTCACGTCATTCCAGCCCCAGAGGAGTCTAACCTAGAGATACCTCCAAGCGCGGCCGGGGGAAGA GAAAAAAAAGAAAAAATCACTGCATCTCATAATTATTGAGATCTTTGTGTTGTAATTTTCAAGCTGTTTTTAGAGGGAATATATGTCCTG GTTTGCTGCTGTGTTGTTTCCCCAAAGTCTCAATCAGATGAGGCAACAAAAAGACCACCAGAATTGCAGGAAAGCAGCAGCAGTCTGGGA TAGGGAGGGGGGAGGAGAGCTCTCCCTCCGTGGTCAGTTTGTCAGAAGAAAAGCATGGAAAAAGTGAGATTTAAGAAATCTCAGCCACGG GTGTCTTCACTGCACAAAAGTGGTGCTAATTCAGTAAACAGTGACACCTGTGTGGGTTCAATCTGTGGAGAGTTGAGTTCCATTCCTTTG TTTTTAAATTTCCACCTCCATTTGTGTTTCCTATTAACCTAAACTCTTGTAATTCTCTAAATCTTTTTTCATGATATAAAAAAAAAAGAA AATCCCAAACCACAATTTAAGATGCCTTTTTTTTTTAAAAAAAAAGGTTCTCCGTGTTGCCACCTGCTCCGGGAAGGCCAGGCCGATGGG CGGCCAGGTTTGGGAGCAGCGGCTTCGGCTCCGATTGCTTCCTGACGGTCAGTTCCAAGCACAGGCTCTGAGAAACGCCTCGAACCCTTG GTATCTGGTGACCGTCTCCGCAGGCTTCCGTGAGTCTCCGATAGGTGTTTTGGGCTTTTGGAATACTTTCAGAATACTTTCCCATTTTTT CATAAGGCAAAACGGAGTGGACGGCCTTTTTTTGAGAGAAACAGCATTCTAAGAGTGTGCTTGGAAAACACACTTTTTGGGAGTCCACGT GGGGAGTGGACACTCAGGACAGGAAGCGGTGGCCCTAAGACCTGCGGCCACCCGGAGGAGGCAGACGCAGGCGATGACCTGGTTCATCAT GAGAGGAGCTAGAGTTGACTCAGTCTTAGGATCTCGATGGCGTCAGAATTGCAGAGGGTTTCTGCCAGTGCCTTAGGTCTAATTCAGAAA GCAAGGAAGGCTGGGCACGGTGGCTGGCGCCTGTAGTCTCAGCTACTTGGAAACTGAGGCAGGAGGATCTCTTGAGCCCAAGAATTCGAG ACCGGTCTGGCAACATAGTGAGCCTCCATCTCTAAAAAAAAGTGGCAAAGCTGAGGAAATCTGTGCCCCCATCCCCCGACACCAGACAAG CTAAGGTGCATTCAGAGTAGGGAACGATGTCAAAACCTGGCCGCCGTGGTGGCGCGCATTCCTCTCACACCACCGTACGGAGGCAGGTGA CAGTCAACTGAAATGTCCCCAAGGACCGTGTGAATTCGGCTGGCGTGGCCCAGCAGCGGGGTGGACCAGGGTGCGGTGGCTTCAGACCTG CCTCCCGCCACCCCGTCCTCCCCTAACCCCTTCTTGGGACCTCCTGCCAATCCCTGTGGTGTTTGAGTAAAGAAAGTGGCTGATGGTTTT ACTTTTTTCTTCCAATATTGGAAAGAACAAACTAGATATTCCCCTTGAACACATCCAAATTATTTCCAGTGCCTGAGGGTTACCGAGCAC TGTAAGCTCAGCTCGGCTGTAGCTCCGGGTTTCTGCCGATGGCCTCCATCTGCGCCGAAAGCTGAACTGAGCCCCGCGGTGCCCCGGAGC CACAGCAGCAGGTGCAGCGACAATCGCCGTCGTGCGCAGTCGCTGGAGTCCTGGAGAGCCACGCTGTCCTCTGCAGACAACAGCATCAGT CCGCTGTGCCCCAATGCATCGACGCCCTGTGGACGGGGCCTGCAGTCCACCCGTGGTCTGAGCTTGCCGGGCTGAAGCTCGGCTGGGACC CAGGGAGGGGCCACCCTGGGACCCACAGTCTCCTCAGTCACGTGCAGAGCAAAAAATGCTTCCTGTGTTTGGAAGAGCAAGTGACGCAGC ATTTATTGATAAAAATGGATTTTTCTGTCTGATTTCATGCTGTGGTCGTTTAAGTGGTCAATGTCTTTTTTTTTTTTTTTTTTGACATGG AGTCTCGCTCTGTTGCCCAGGCTGAGTGGAATGGCGCCAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCGACTCTCCTGCCT CAGCCTCCTGAGCAGCTGGGATTACAGGTGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTG GCCAGGCTGGTCTCGAACACCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAATAATTTGTAAGTTATGTTAGCGGGATCCTCAAGGCC TTGCTTTGCCCCGTGGAGACGCTTGCTCGGATGAGCTCAGGAAACAGTACCGGCTGCGTGGCAGGTCTGGGTGTTGTGTGCGAGGACGTG GCCTTTGAACACCGCTGTGTTCTCAGAGGTCCTTAGGAGATATTTTTTTTTGTCTTAGGGGGACTGTGTTAAGTTCAGACAAATCATGCT GGGTGTGTAGAGAGTGTGAAATACGTCAGTGAAGTAAGTAGCAGTGAGCGATTGTGAATGTGTAATGTAAATGGAAAACCGGGTTTTACC GTGTTAAGTTATTCACTAGGGAGCCAGTCGTAGTTCTTTGTAATCCTCTTTCTTCCAAACCTGCTTTGCTGAAAGTTGCAGAAAAGGAAG TGTGTGGAGAGAAACAGAACCCTTCAGGGTGGGTCAGAGGACGCCATCCACAGTGGATTCGTGTTCGTTTGCAGGTGGAAGCAGTGATTT TTAGGACCCACTGATTAAAAACAAACATTCCCAAGTGTCTCTGAGAGATGCTGTTTATTTGTTAATTAAAAAGCTTTTTTCTCTGTCTTT TAAATTATGGCTTTCATGTAATAAGGATATTTTTAGTGAAAAATTGTTTTCCTTTCAAATTACAGACCTTTTAAAAAAACTTAATTTGAG CGAGTACCTTTTCATTTGACACTTTTCCTGTTTCTAACCTTAGGAAACCAGAATAGCGTTTGGCAGACACGACGTTTTCAGTTTACCTTT >In-frame_ENST00000302538_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(amino acids)=741AA_start in transcript=147_stop in transcript=2372 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA LRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQSPASLPLAPGCALRLCPLSFGEGVEFDPLPPKE VRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCVPNGTWRNYKAEVRFEPRHRPTRFLSTTIVYPKYPKAVYTTTLDYNCRKTLRRF -------------------------------------------------------------- >In-frame_ENST00000574437_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(transcript)=5739nt_BP=2118nt ATAAAAAGCAAAATGGTGACTCAGAGAGGAGAGTTGGAAGCGTCCTGCCTCTTGCTCCCACTGTTAATTTTTACACTTGGAATTAGGCAG AAGGCAAAGAAAACAGCAGCTTGAAATACGCGGCTGACATGCTCTTCATCGGGTAGCAACAGCAGAGCCGCTCCTCCCCGCCTCCCAGCA GCCCCGGAGCGGGCAGGGCCCGGTGCCTGCTGGCTCTCCCCCGCCCCTCACCAGGCCCAGGCCCCCGCACAGCCCCCGCCCGGGCCAGGC GTGGATGGTGCGGCCGGGGCCATGGCTGCCGGGGGCCGCCGCCGGCGCCCACTACGCTACCAGTCCCTGGCAGCTCTGGTGGAGGATTCT CAGTGGCCTTTCTTGTTCCTTGTCTCAGACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTAT AAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAG GACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACAC GACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATC AACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTG TCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCAC CAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCC TTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGC CGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAAT CGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGAT CTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACC AGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAAC CTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGG GATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAG GACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCCAGAGTCCAGCGTCTCTCCCCCTGGCTCCCGGCTGTGCGCTGAGG CTTTGTCCCCTGTCCTTTGGCGAAGGAGTGGAGTTTGACCCCTTACCACCAAAGGAAGTAAGGTACACCTCCTTGGTCAAGTACGACTCC GAGAGGCACTTCATCGACGACGTGCAGCTGCCCCTGGGCCTGGCGGTGGCCTCCTGCAGCCAGACGGTCACCTGTGTCCCCAATGGCACG TGGCGCAACTACAAGGCCGAGGTGCGCTTCGAGCCACGCCACAGGCCCACCCGCTTCCTCAGTACCACCATCGTGTACCCCAAGTACCCC AAGGCCGTCTACACCACCACCCTGGATTACAACTGCCGCAAGACGCTGAGGAGGTTTCTGTCCAGCGTGGAGCTCGAAGCCGCGGAGCTC CCGGGCAGCGACGACCTCTCTGATGAATGCTGACCCAGCAGGCTGGGCTGGGGTCGGACCGGCTCTCCCGCTGTCCTGCCCCCGACTGCC CTGGCCAAGCTGGGCGACCTTACCCTTCACGTCATTCCAGCCCCAGAGGAGTCTAACCTAGAGATACCTCCAAGCGCGGCCGGGGGAAGA GAAAAAAAAGAAAAAATCACTGCATCTCATAATTATTGAGATCTTTGTGTTGTAATTTTCAAGCTGTTTTTAGAGGGAATATATGTCCTG GTTTGCTGCTGTGTTGTTTCCCCAAAGTCTCAATCAGATGAGGCAACAAAAAGACCACCAGAATTGCAGGAAAGCAGCAGCAGTCTGGGA TAGGGAGGGGGGAGGAGAGCTCTCCCTCCGTGGTCAGTTTGTCAGAAGAAAAGCATGGAAAAAGTGAGATTTAAGAAATCTCAGCCACGG GTGTCTTCACTGCACAAAAGTGGTGCTAATTCAGTAAACAGTGACACCTGTGTGGGTTCAATCTGTGGAGAGTTGAGTTCCATTCCTTTG TTTTTAAATTTCCACCTCCATTTGTGTTTCCTATTAACCTAAACTCTTGTAATTCTCTAAATCTTTTTTCATGATATAAAAAAAAAAGAA AATCCCAAACCACAATTTAAGATGCCTTTTTTTTTTAAAAAAAAAGGTTCTCCGTGTTGCCACCTGCTCCGGGAAGGCCAGGCCGATGGG CGGCCAGGTTTGGGAGCAGCGGCTTCGGCTCCGATTGCTTCCTGACGGTCAGTTCCAAGCACAGGCTCTGAGAAACGCCTCGAACCCTTG GTATCTGGTGACCGTCTCCGCAGGCTTCCGTGAGTCTCCGATAGGTGTTTTGGGCTTTTGGAATACTTTCAGAATACTTTCCCATTTTTT CATAAGGCAAAACGGAGTGGACGGCCTTTTTTTGAGAGAAACAGCATTCTAAGAGTGTGCTTGGAAAACACACTTTTTGGGAGTCCACGT GGGGAGTGGACACTCAGGACAGGAAGCGGTGGCCCTAAGACCTGCGGCCACCCGGAGGAGGCAGACGCAGGCGATGACCTGGTTCATCAT GAGAGGAGCTAGAGTTGACTCAGTCTTAGGATCTCGATGGCGTCAGAATTGCAGAGGGTTTCTGCCAGTGCCTTAGGTCTAATTCAGAAA GCAAGGAAGGCTGGGCACGGTGGCTGGCGCCTGTAGTCTCAGCTACTTGGAAACTGAGGCAGGAGGATCTCTTGAGCCCAAGAATTCGAG ACCGGTCTGGCAACATAGTGAGCCTCCATCTCTAAAAAAAAGTGGCAAAGCTGAGGAAATCTGTGCCCCCATCCCCCGACACCAGACAAG CTAAGGTGCATTCAGAGTAGGGAACGATGTCAAAACCTGGCCGCCGTGGTGGCGCGCATTCCTCTCACACCACCGTACGGAGGCAGGTGA CAGTCAACTGAAATGTCCCCAAGGACCGTGTGAATTCGGCTGGCGTGGCCCAGCAGCGGGGTGGACCAGGGTGCGGTGGCTTCAGACCTG CCTCCCGCCACCCCGTCCTCCCCTAACCCCTTCTTGGGACCTCCTGCCAATCCCTGTGGTGTTTGAGTAAAGAAAGTGGCTGATGGTTTT ACTTTTTTCTTCCAATATTGGAAAGAACAAACTAGATATTCCCCTTGAACACATCCAAATTATTTCCAGTGCCTGAGGGTTACCGAGCAC TGTAAGCTCAGCTCGGCTGTAGCTCCGGGTTTCTGCCGATGGCCTCCATCTGCGCCGAAAGCTGAACTGAGCCCCGCGGTGCCCCGGAGC CACAGCAGCAGGTGCAGCGACAATCGCCGTCGTGCGCAGTCGCTGGAGTCCTGGAGAGCCACGCTGTCCTCTGCAGACAACAGCATCAGT CCGCTGTGCCCCAATGCATCGACGCCCTGTGGACGGGGCCTGCAGTCCACCCGTGGTCTGAGCTTGCCGGGCTGAAGCTCGGCTGGGACC CAGGGAGGGGCCACCCTGGGACCCACAGTCTCCTCAGTCACGTGCAGAGCAAAAAATGCTTCCTGTGTTTGGAAGAGCAAGTGACGCAGC ATTTATTGATAAAAATGGATTTTTCTGTCTGATTTCATGCTGTGGTCGTTTAAGTGGTCAATGTCTTTTTTTTTTTTTTTTTTGACATGG AGTCTCGCTCTGTTGCCCAGGCTGAGTGGAATGGCGCCAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCGACTCTCCTGCCT CAGCCTCCTGAGCAGCTGGGATTACAGGTGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTG GCCAGGCTGGTCTCGAACACCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAATAATTTGTAAGTTATGTTAGCGGGATCCTCAAGGCC TTGCTTTGCCCCGTGGAGACGCTTGCTCGGATGAGCTCAGGAAACAGTACCGGCTGCGTGGCAGGTCTGGGTGTTGTGTGCGAGGACGTG GCCTTTGAACACCGCTGTGTTCTCAGAGGTCCTTAGGAGATATTTTTTTTTGTCTTAGGGGGACTGTGTTAAGTTCAGACAAATCATGCT GGGTGTGTAGAGAGTGTGAAATACGTCAGTGAAGTAAGTAGCAGTGAGCGATTGTGAATGTGTAATGTAAATGGAAAACCGGGTTTTACC GTGTTAAGTTATTCACTAGGGAGCCAGTCGTAGTTCTTTGTAATCCTCTTTCTTCCAAACCTGCTTTGCTGAAAGTTGCAGAAAAGGAAG TGTGTGGAGAGAAACAGAACCCTTCAGGGTGGGTCAGAGGACGCCATCCACAGTGGATTCGTGTTCGTTTGCAGGTGGAAGCAGTGATTT TTAGGACCCACTGATTAAAAACAAACATTCCCAAGTGTCTCTGAGAGATGCTGTTTATTTGTTAATTAAAAAGCTTTTTTCTCTGTCTTT TAAATTATGGCTTTCATGTAATAAGGATATTTTTAGTGAAAAATTGTTTTCCTTTCAAATTACAGACCTTTTAAAAAAACTTAATTTGAG CGAGTACCTTTTCATTTGACACTTTTCCTGTTTCTAACCTTAGGAAACCAGAATAGCGTTTGGCAGACACGACGTTTTCAGTTTACCTTT >In-frame_ENST00000574437_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(amino acids)=809AA_start in transcript=123_stop in transcript=2552 MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCS QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAV TTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKM KISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVEL QVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGS QSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQSPASLPLAPGCALRLCPLSFGEGVEFDPLPPKEVRYTSLVKYDSERHFIDDVQLP -------------------------------------------------------------- >In-frame_ENST00000291107_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(transcript)=5333nt_BP=1712nt TTCCTGTCTGCCCTCCGCGGGCTCCGGCTGCCATGGAGGAGGAAGAGGAGGCGATAGGCTTGCTGGACAAGGTTCTGGAGGACGAAGATG TGTTTCTCCTGGAGGAGTGCGAGCTGGGAACCCCGACCAGCCCCGGCTCAGGGTCCCCCTTCCTGGTGGCTGTGAAGGTGGAAGCAGGGA AAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCA TGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCT ATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGC TGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAACC AGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTCT ACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGC TGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGG GGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATG TCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGT TTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCC TCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCC TGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGA GGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAG GATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTC ATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCA AAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGA TCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCC AGAGTCCAGCGTCTCTCCCCCTGGCTCCCGGCTGTGCGCTGAGGCTTTGTCCCCTGTCCTTTGGCGAAGGAGTGGAGTTTGACCCCTTAC CACCAAAGGAAGTAAGGTACACCTCCTTGGTCAAGTACGACTCCGAGAGGCACTTCATCGACGACGTGCAGCTGCCCCTGGGCCTGGCGG TGGCCTCCTGCAGCCAGACGGTCACCTGTGTCCCCAATGGCACGTGGCGCAACTACAAGGCCGAGGTGCGCTTCGAGCCACGCCACAGGC CCACCCGCTTCCTCAGTACCACCATCGTGTACCCCAAGTACCCCAAGGCCGTCTACACCACCACCCTGGATTACAACTGCCGCAAGACGC TGAGGAGGTTTCTGTCCAGCGTGGAGCTCGAAGCCGCGGAGCTCCCGGGCAGCGACGACCTCTCTGATGAATGCTGACCCAGCAGGCTGG GCTGGGGTCGGACCGGCTCTCCCGCTGTCCTGCCCCCGACTGCCCTGGCCAAGCTGGGCGACCTTACCCTTCACGTCATTCCAGCCCCAG AGGAGTCTAACCTAGAGATACCTCCAAGCGCGGCCGGGGGAAGAGAAAAAAAAGAAAAAATCACTGCATCTCATAATTATTGAGATCTTT GTGTTGTAATTTTCAAGCTGTTTTTAGAGGGAATATATGTCCTGGTTTGCTGCTGTGTTGTTTCCCCAAAGTCTCAATCAGATGAGGCAA CAAAAAGACCACCAGAATTGCAGGAAAGCAGCAGCAGTCTGGGATAGGGAGGGGGGAGGAGAGCTCTCCCTCCGTGGTCAGTTTGTCAGA AGAAAAGCATGGAAAAAGTGAGATTTAAGAAATCTCAGCCACGGGTGTCTTCACTGCACAAAAGTGGTGCTAATTCAGTAAACAGTGACA CCTGTGTGGGTTCAATCTGTGGAGAGTTGAGTTCCATTCCTTTGTTTTTAAATTTCCACCTCCATTTGTGTTTCCTATTAACCTAAACTC TTGTAATTCTCTAAATCTTTTTTCATGATATAAAAAAAAAAGAAAATCCCAAACCACAATTTAAGATGCCTTTTTTTTTTAAAAAAAAAG GTTCTCCGTGTTGCCACCTGCTCCGGGAAGGCCAGGCCGATGGGCGGCCAGGTTTGGGAGCAGCGGCTTCGGCTCCGATTGCTTCCTGAC GGTCAGTTCCAAGCACAGGCTCTGAGAAACGCCTCGAACCCTTGGTATCTGGTGACCGTCTCCGCAGGCTTCCGTGAGTCTCCGATAGGT GTTTTGGGCTTTTGGAATACTTTCAGAATACTTTCCCATTTTTTCATAAGGCAAAACGGAGTGGACGGCCTTTTTTTGAGAGAAACAGCA TTCTAAGAGTGTGCTTGGAAAACACACTTTTTGGGAGTCCACGTGGGGAGTGGACACTCAGGACAGGAAGCGGTGGCCCTAAGACCTGCG GCCACCCGGAGGAGGCAGACGCAGGCGATGACCTGGTTCATCATGAGAGGAGCTAGAGTTGACTCAGTCTTAGGATCTCGATGGCGTCAG AATTGCAGAGGGTTTCTGCCAGTGCCTTAGGTCTAATTCAGAAAGCAAGGAAGGCTGGGCACGGTGGCTGGCGCCTGTAGTCTCAGCTAC TTGGAAACTGAGGCAGGAGGATCTCTTGAGCCCAAGAATTCGAGACCGGTCTGGCAACATAGTGAGCCTCCATCTCTAAAAAAAAGTGGC AAAGCTGAGGAAATCTGTGCCCCCATCCCCCGACACCAGACAAGCTAAGGTGCATTCAGAGTAGGGAACGATGTCAAAACCTGGCCGCCG TGGTGGCGCGCATTCCTCTCACACCACCGTACGGAGGCAGGTGACAGTCAACTGAAATGTCCCCAAGGACCGTGTGAATTCGGCTGGCGT GGCCCAGCAGCGGGGTGGACCAGGGTGCGGTGGCTTCAGACCTGCCTCCCGCCACCCCGTCCTCCCCTAACCCCTTCTTGGGACCTCCTG CCAATCCCTGTGGTGTTTGAGTAAAGAAAGTGGCTGATGGTTTTACTTTTTTCTTCCAATATTGGAAAGAACAAACTAGATATTCCCCTT GAACACATCCAAATTATTTCCAGTGCCTGAGGGTTACCGAGCACTGTAAGCTCAGCTCGGCTGTAGCTCCGGGTTTCTGCCGATGGCCTC CATCTGCGCCGAAAGCTGAACTGAGCCCCGCGGTGCCCCGGAGCCACAGCAGCAGGTGCAGCGACAATCGCCGTCGTGCGCAGTCGCTGG AGTCCTGGAGAGCCACGCTGTCCTCTGCAGACAACAGCATCAGTCCGCTGTGCCCCAATGCATCGACGCCCTGTGGACGGGGCCTGCAGT CCACCCGTGGTCTGAGCTTGCCGGGCTGAAGCTCGGCTGGGACCCAGGGAGGGGCCACCCTGGGACCCACAGTCTCCTCAGTCACGTGCA GAGCAAAAAATGCTTCCTGTGTTTGGAAGAGCAAGTGACGCAGCATTTATTGATAAAAATGGATTTTTCTGTCTGATTTCATGCTGTGGT CGTTTAAGTGGTCAATGTCTTTTTTTTTTTTTTTTTTGACATGGAGTCTCGCTCTGTTGCCCAGGCTGAGTGGAATGGCGCCAACTCAGC TCACTGCAACCTTCACCTCCCAGGCTCAAGCGACTCTCCTGCCTCAGCCTCCTGAGCAGCTGGGATTACAGGTGCCCACCACCACGCCCA GCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACACCTGACCTTGTGATCCACCCGCCTCGG CCTCCCAATAATTTGTAAGTTATGTTAGCGGGATCCTCAAGGCCTTGCTTTGCCCCGTGGAGACGCTTGCTCGGATGAGCTCAGGAAACA GTACCGGCTGCGTGGCAGGTCTGGGTGTTGTGTGCGAGGACGTGGCCTTTGAACACCGCTGTGTTCTCAGAGGTCCTTAGGAGATATTTT TTTTTGTCTTAGGGGGACTGTGTTAAGTTCAGACAAATCATGCTGGGTGTGTAGAGAGTGTGAAATACGTCAGTGAAGTAAGTAGCAGTG AGCGATTGTGAATGTGTAATGTAAATGGAAAACCGGGTTTTACCGTGTTAAGTTATTCACTAGGGAGCCAGTCGTAGTTCTTTGTAATCC TCTTTCTTCCAAACCTGCTTTGCTGAAAGTTGCAGAAAAGGAAGTGTGTGGAGAGAAACAGAACCCTTCAGGGTGGGTCAGAGGACGCCA TCCACAGTGGATTCGTGTTCGTTTGCAGGTGGAAGCAGTGATTTTTAGGACCCACTGATTAAAAACAAACATTCCCAAGTGTCTCTGAGA GATGCTGTTTATTTGTTAATTAAAAAGCTTTTTTCTCTGTCTTTTAAATTATGGCTTTCATGTAATAAGGATATTTTTAGTGAAAAATTG TTTTCCTTTCAAATTACAGACCTTTTAAAAAAACTTAATTTGAGCGAGTACCTTTTCATTTGACACTTTTCCTGTTTCTAACCTTAGGAA ACCAGAATAGCGTTTGGCAGACACGACGTTTTCAGTTTACCTTTGACACCTGCCCCACTCCATTTTGCTTTGTGATGTCTTCATTTAACA >In-frame_ENST00000291107_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(amino acids)=704AA_start in transcript=32_stop in transcript=2146 MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKV KGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGF LVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKAN KGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHN IPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKT KVNKDNNEIVDKIMGKGQIQSPASLPLAPGCALRLCPLSFGEGVEFDPLPPKEVRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCV -------------------------------------------------------------- >In-frame_ENST00000536794_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(transcript)=5045nt_BP=1424nt AGCCTCGTGCCCAGGCAGCCAGCCAGCTACAAACGTGCTCCTCTTTAGGATGCCAGCAGGCTGCTGGCTCCCTCCCTCCCTACCCCTCCT CCCCTTCCCCTTCCCTCCTCTCCTCGCCACGCGCCTCCCTCCCCTCCCCCTTGCTGGAAGAGCACTCCGGAGCGGCTGCCCGATGCTGGA GTCCGTGCGGCAGCATCAGCAAGGTGGCTGAGTGGCCGGGCTGCTGGTGGGCGCCGGGGAGCCTGGAGCGATGGCTGCACGCTCCCGCCG CGGGGACAGAGGCTGCCATGGAGATTCTCCTCATTATTCGCTTCTGCTGTAACTGCACCTATGCTCTGCTCTACAAGCCCATTGACCGGG TCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGCTGCAGGATGCCCTCCGCA TCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAGACGCGACAGCTGG TGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTACTGTGTGCCAAGC TGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCATCCCCCGAGGAGT CTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAGAGTGAAATCCAGA AGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTGCTGCTCAACTCCC CCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCAGAGTGGAGAGAAG CAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCCTGTTTCAAGCTTA GGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTCATCGTCCACTCTG CCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCCAAAACCAGGGTGT TCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTGTGCTATGAGAAGT GCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCCAGAGTCCAGCGTCTCTCC CCCTGGCTCCCGGCTGTGCGCTGAGGCTTTGTCCCCTGTCCTTTGGCGAAGGAGTGGAGTTTGACCCCTTACCACCAAAGGAAGTAAGGT ACACCTCCTTGGTCAAGTACGACTCCGAGAGGCACTTCATCGACGACGTGCAGCTGCCCCTGGGCCTGGCGGTGGCCTCCTGCAGCCAGA CGGTCACCTGTGTCCCCAATGGCACGTGGCGCAACTACAAGGCCGAGGTGCGCTTCGAGCCACGCCACAGGCCCACCCGCTTCCTCAGTA CCACCATCGTGTACCCCAAGTACCCCAAGGCCGTCTACACCACCACCCTGGATTACAACTGCCGCAAGACGCTGAGGAGGTTTCTGTCCA GCGTGGAGCTCGAAGCCGCGGAGCTCCCGGGCAGCGACGACCTCTCTGATGAATGCTGACCCAGCAGGCTGGGCTGGGGTCGGACCGGCT CTCCCGCTGTCCTGCCCCCGACTGCCCTGGCCAAGCTGGGCGACCTTACCCTTCACGTCATTCCAGCCCCAGAGGAGTCTAACCTAGAGA TACCTCCAAGCGCGGCCGGGGGAAGAGAAAAAAAAGAAAAAATCACTGCATCTCATAATTATTGAGATCTTTGTGTTGTAATTTTCAAGC TGTTTTTAGAGGGAATATATGTCCTGGTTTGCTGCTGTGTTGTTTCCCCAAAGTCTCAATCAGATGAGGCAACAAAAAGACCACCAGAAT TGCAGGAAAGCAGCAGCAGTCTGGGATAGGGAGGGGGGAGGAGAGCTCTCCCTCCGTGGTCAGTTTGTCAGAAGAAAAGCATGGAAAAAG TGAGATTTAAGAAATCTCAGCCACGGGTGTCTTCACTGCACAAAAGTGGTGCTAATTCAGTAAACAGTGACACCTGTGTGGGTTCAATCT GTGGAGAGTTGAGTTCCATTCCTTTGTTTTTAAATTTCCACCTCCATTTGTGTTTCCTATTAACCTAAACTCTTGTAATTCTCTAAATCT TTTTTCATGATATAAAAAAAAAAGAAAATCCCAAACCACAATTTAAGATGCCTTTTTTTTTTAAAAAAAAAGGTTCTCCGTGTTGCCACC TGCTCCGGGAAGGCCAGGCCGATGGGCGGCCAGGTTTGGGAGCAGCGGCTTCGGCTCCGATTGCTTCCTGACGGTCAGTTCCAAGCACAG GCTCTGAGAAACGCCTCGAACCCTTGGTATCTGGTGACCGTCTCCGCAGGCTTCCGTGAGTCTCCGATAGGTGTTTTGGGCTTTTGGAAT ACTTTCAGAATACTTTCCCATTTTTTCATAAGGCAAAACGGAGTGGACGGCCTTTTTTTGAGAGAAACAGCATTCTAAGAGTGTGCTTGG AAAACACACTTTTTGGGAGTCCACGTGGGGAGTGGACACTCAGGACAGGAAGCGGTGGCCCTAAGACCTGCGGCCACCCGGAGGAGGCAG ACGCAGGCGATGACCTGGTTCATCATGAGAGGAGCTAGAGTTGACTCAGTCTTAGGATCTCGATGGCGTCAGAATTGCAGAGGGTTTCTG CCAGTGCCTTAGGTCTAATTCAGAAAGCAAGGAAGGCTGGGCACGGTGGCTGGCGCCTGTAGTCTCAGCTACTTGGAAACTGAGGCAGGA GGATCTCTTGAGCCCAAGAATTCGAGACCGGTCTGGCAACATAGTGAGCCTCCATCTCTAAAAAAAAGTGGCAAAGCTGAGGAAATCTGT GCCCCCATCCCCCGACACCAGACAAGCTAAGGTGCATTCAGAGTAGGGAACGATGTCAAAACCTGGCCGCCGTGGTGGCGCGCATTCCTC TCACACCACCGTACGGAGGCAGGTGACAGTCAACTGAAATGTCCCCAAGGACCGTGTGAATTCGGCTGGCGTGGCCCAGCAGCGGGGTGG ACCAGGGTGCGGTGGCTTCAGACCTGCCTCCCGCCACCCCGTCCTCCCCTAACCCCTTCTTGGGACCTCCTGCCAATCCCTGTGGTGTTT GAGTAAAGAAAGTGGCTGATGGTTTTACTTTTTTCTTCCAATATTGGAAAGAACAAACTAGATATTCCCCTTGAACACATCCAAATTATT TCCAGTGCCTGAGGGTTACCGAGCACTGTAAGCTCAGCTCGGCTGTAGCTCCGGGTTTCTGCCGATGGCCTCCATCTGCGCCGAAAGCTG AACTGAGCCCCGCGGTGCCCCGGAGCCACAGCAGCAGGTGCAGCGACAATCGCCGTCGTGCGCAGTCGCTGGAGTCCTGGAGAGCCACGC TGTCCTCTGCAGACAACAGCATCAGTCCGCTGTGCCCCAATGCATCGACGCCCTGTGGACGGGGCCTGCAGTCCACCCGTGGTCTGAGCT TGCCGGGCTGAAGCTCGGCTGGGACCCAGGGAGGGGCCACCCTGGGACCCACAGTCTCCTCAGTCACGTGCAGAGCAAAAAATGCTTCCT GTGTTTGGAAGAGCAAGTGACGCAGCATTTATTGATAAAAATGGATTTTTCTGTCTGATTTCATGCTGTGGTCGTTTAAGTGGTCAATGT CTTTTTTTTTTTTTTTTTTGACATGGAGTCTCGCTCTGTTGCCCAGGCTGAGTGGAATGGCGCCAACTCAGCTCACTGCAACCTTCACCT CCCAGGCTCAAGCGACTCTCCTGCCTCAGCCTCCTGAGCAGCTGGGATTACAGGTGCCCACCACCACGCCCAGCTAATTTTTGTATTTTT AGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACACCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAATAATTTGTAA GTTATGTTAGCGGGATCCTCAAGGCCTTGCTTTGCCCCGTGGAGACGCTTGCTCGGATGAGCTCAGGAAACAGTACCGGCTGCGTGGCAG GTCTGGGTGTTGTGTGCGAGGACGTGGCCTTTGAACACCGCTGTGTTCTCAGAGGTCCTTAGGAGATATTTTTTTTTGTCTTAGGGGGAC TGTGTTAAGTTCAGACAAATCATGCTGGGTGTGTAGAGAGTGTGAAATACGTCAGTGAAGTAAGTAGCAGTGAGCGATTGTGAATGTGTA ATGTAAATGGAAAACCGGGTTTTACCGTGTTAAGTTATTCACTAGGGAGCCAGTCGTAGTTCTTTGTAATCCTCTTTCTTCCAAACCTGC TTTGCTGAAAGTTGCAGAAAAGGAAGTGTGTGGAGAGAAACAGAACCCTTCAGGGTGGGTCAGAGGACGCCATCCACAGTGGATTCGTGT TCGTTTGCAGGTGGAAGCAGTGATTTTTAGGACCCACTGATTAAAAACAAACATTCCCAAGTGTCTCTGAGAGATGCTGTTTATTTGTTA ATTAAAAAGCTTTTTTCTCTGTCTTTTAAATTATGGCTTTCATGTAATAAGGATATTTTTAGTGAAAAATTGTTTTCCTTTCAAATTACA GACCTTTTAAAAAAACTTAATTTGAGCGAGTACCTTTTCATTTGACACTTTTCCTGTTTCTAACCTTAGGAAACCAGAATAGCGTTTGGC AGACACGACGTTTTCAGTTTACCTTTGACACCTGCCCCACTCCATTTTGCTTTGTGATGTCTTCATTTAACAATAAATTATCTGAAAAAA >In-frame_ENST00000536794_ENST00000329099_TCGA-AY-A71X-01A_ABR_chr17_953290_-_FAM101B_chr17_295730_length(amino acids)=572AA_start in transcript=140_stop in transcript=1858 MLEEHSGAAARCWSPCGSISKVAEWPGCWWAPGSLERWLHAPAAGTEAAMEILLIIRFCCNCTYALLYKPIDRVTRSTLVLHDLLKHTPV DHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY IPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLF LLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVD SFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQSPASLPLAPGCALRLCPLSFGE GVEFDPLPPKEVRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCVPNGTWRNYKAEVRFEPRHRPTRFLSTTIVYPKYPKAVYTTTL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ABR-FAM101B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABR-FAM101B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABR-FAM101B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ABR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ABR | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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