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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPARG-PAX8 (FusionGDB2 ID:66926)

Fusion Gene Summary for PPARG-PAX8

Fusion gene summary

Fusion gene information	Fusion gene name: PPARG-PAX8
	Fusion gene ID: 66926
		Hgene	Tgene
	Gene symbol	PPARG	PAX8
	Gene ID	5468	7849
	Gene name	peroxisome proliferator activated receptor gamma	paired box 8
	Synonyms	CIMT1\|GLM1\|NR1C3\|PPARG1\|PPARG2\|PPARgamma	-
	Cytomap	3p25.2	2q14.1
	Type of gene	protein-coding	protein-coding
	Description	peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1	paired box protein Pax-8paired domain gene 8
	Modification date	20200329	20200313
	UniProtAcc	.	Q06710
	Ensembl transtripts involved in fusion gene	ENST00000397010, ENST00000309576, ENST00000397015, ENST00000397012, ENST00000397026, ENST00000397000, ENST00000539812, ENST00000287820,	ENST00000348715, ENST00000397647, ENST00000263335, ENST00000429538, ENST00000263334,
Fusion gene scores	* DoF score	7 X 9 X 5=315	5 X 6 X 4=120
	# samples	13	8
	** MAII score	log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPARG [Title/Abstract] AND PAX8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PAX8(113992971)-PPARG(12421203), # samples:12 PPARG(12353952)-PAX8(113984833), # samples:13
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPARG	GO:0000122	negative regulation of transcription by RNA polymerase II	12700342
Hgene	PPARG	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	18293083
Hgene	PPARG	GO:0007165	signal transduction	9568716
Hgene	PPARG	GO:0010742	macrophage derived foam cell differentiation	26504087
Hgene	PPARG	GO:0010745	negative regulation of macrophage derived foam cell differentiation	19114110
Hgene	PPARG	GO:0010871	negative regulation of receptor biosynthetic process	12700342
Hgene	PPARG	GO:0010887	negative regulation of cholesterol storage	19114110
Hgene	PPARG	GO:0010891	negative regulation of sequestering of triglyceride	12700342
Hgene	PPARG	GO:0016525	negative regulation of angiogenesis	28566713
Hgene	PPARG	GO:0030224	monocyte differentiation	9568716
Hgene	PPARG	GO:0032526	response to retinoic acid	16239304
Hgene	PPARG	GO:0042953	lipoprotein transport	9568716
Hgene	PPARG	GO:0043537	negative regulation of blood vessel endothelial cell migration	28566713
Hgene	PPARG	GO:0045713	low-density lipoprotein particle receptor biosynthetic process	9568716
Hgene	PPARG	GO:0045944	positive regulation of transcription by RNA polymerase II	9568715\|12700342\|16239304\|17611579
Hgene	PPARG	GO:0048469	cell maturation	9568716
Hgene	PPARG	GO:0048662	negative regulation of smooth muscle cell proliferation	20622039
Hgene	PPARG	GO:0051091	positive regulation of DNA-binding transcription factor activity	18293083
Hgene	PPARG	GO:0061614	pri-miRNA transcription by RNA polymerase II	28566713
Hgene	PPARG	GO:0071404	cellular response to low-density lipoprotein particle stimulus	9568716
Hgene	PPARG	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	28522568
Tgene	PAX8	GO:0006351	transcription, DNA-templated	9590296
Tgene	PAX8	GO:0045893	positive regulation of transcription, DNA-templated	9388203\|15356023\|15961562
Tgene	PAX8	GO:0045944	positive regulation of transcription by RNA polymerase II	9388203
Tgene	PAX8	GO:0071371	cellular response to gonadotropin stimulus	15961562

Fusion gene breakpoints across PPARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PAX8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-BJ-A0YZ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-

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Fusion Gene ORF analysis for PPARG-PAX8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000397010	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000309576	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397015	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000397012	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397012	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397012	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397012	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397012	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000397026	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397026	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397026	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397026	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397026	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000397000	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397000	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397000	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397000	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397000	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000539812	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000539812	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000539812	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000539812	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000539812	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000287820	ENST00000348715	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000397647	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263335	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000429538	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263334	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397010	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397010	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397010	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397010	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397010	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000309576	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000309576	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000397015	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397015	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397015	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397015	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397015	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397012	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397026	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397000	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000539812	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000287820	ENST00000348715	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000397647	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263335	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000429538	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263334	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
5UTR-3CDS	ENST00000397010	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
5UTR-intron	ENST00000397010	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000309576	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000309576	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000309576	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000309576	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000309576	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397015	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397015	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397012	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397012	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397026	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397026	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000397000	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000397000	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000539812	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000539812	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-3CDS	ENST00000287820	ENST00000348715	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000397647	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263335	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000429538	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
intron-intron	ENST00000287820	ENST00000263334	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
In-frame	ENST00000287820	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000287820	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000287820	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000287820	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000287820	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000309576	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000309576	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000309576	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000309576	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000309576	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397010	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397010	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397010	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397010	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397010	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397012	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397012	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397012	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397012	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397012	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397015	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397015	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397015	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397015	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397015	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397026	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397026	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397026	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397026	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
In-frame	ENST00000397026	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000397000	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000397000	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000397000	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000397000	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000397000	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000539812	ENST00000263334	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000539812	ENST00000263335	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000539812	ENST00000348715	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000539812	ENST00000397647	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-
intron-3CDS	ENST00000539812	ENST00000429538	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PPARG-PAX8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPARG-PAX8

Go to
FGviewer for the breakpoints of chr3:12458653-chr2:113999303
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	PAX8 Q06710
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PPARG-PAX8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPARG-PAX8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PPARG-PAX8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PPARG-PAX8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPARG	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	6	CTD_human;GENOMICS_ENGLAND
Hgene	PPARG	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Hgene	PPARG	C0002152	Alloxan Diabetes	3	CTD_human
Hgene	PPARG	C0002395	Alzheimer's Disease	3	CTD_human
Hgene	PPARG	C0011265	Presenile dementia	3	CTD_human
Hgene	PPARG	C0011853	Diabetes Mellitus, Experimental	3	CTD_human
Hgene	PPARG	C0020538	Hypertensive disease	3	CTD_human
Hgene	PPARG	C0021655	Insulin Resistance	3	CTD_human
Hgene	PPARG	C0022660	Kidney Failure, Acute	3	CTD_human
Hgene	PPARG	C0028754	Obesity	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PPARG	C0035126	Reperfusion Injury	3	CTD_human
Hgene	PPARG	C0038433	Streptozotocin Diabetes	3	CTD_human
Hgene	PPARG	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Hgene	PPARG	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Hgene	PPARG	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Hgene	PPARG	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Hgene	PPARG	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Hgene	PPARG	C0920563	Insulin Sensitivity	3	CTD_human
Hgene	PPARG	C1565662	Acute Kidney Insufficiency	3	CTD_human
Hgene	PPARG	C1720861	Familial Partial Lipodystrophy, Type 3	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	PPARG	C2609414	Acute kidney injury	3	CTD_human
Hgene	PPARG	C0021368	Inflammation	2	CTD_human
Hgene	PPARG	C0022116	Ischemia	2	CTD_human
Hgene	PPARG	C0024623	Malignant neoplasm of stomach	2	CTD_human
Hgene	PPARG	C0025202	melanoma	2	CTD_human
Hgene	PPARG	C0030297	Pancreatic Neoplasm	2	CTD_human
Hgene	PPARG	C0038356	Stomach Neoplasms	2	CTD_human
Hgene	PPARG	C0346647	Malignant neoplasm of pancreas	2	CTD_human
Hgene	PPARG	C1708349	Hereditary Diffuse Gastric Cancer	2	CTD_human
Hgene	PPARG	C0001418	Adenocarcinoma	1	CTD_human
Hgene	PPARG	C0004153	Atherosclerosis	1	CTD_human
Hgene	PPARG	C0004763	Barrett Esophagus	1	CTD_human
Hgene	PPARG	C0007102	Malignant tumor of colon	1	CTD_human;UNIPROT
Hgene	PPARG	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	PPARG	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	PPARG	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	PPARG	C0010346	Crohn Disease	1	CTD_human
Hgene	PPARG	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	PPARG	C0011859	Lipoatrophic Diabetes Mellitus	1	ORPHANET
Hgene	PPARG	C0011881	Diabetic Nephropathy	1	CTD_human
Hgene	PPARG	C0017658	Glomerulonephritis	1	CTD_human
Hgene	PPARG	C0017667	Nodular glomerulosclerosis	1	CTD_human
Hgene	PPARG	C0018801	Heart failure	1	CTD_human
Hgene	PPARG	C0018802	Congestive heart failure	1	CTD_human
Hgene	PPARG	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	PPARG	C0023645	Lichen planus follicularis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0023794	Lipoidosis	1	CTD_human
Hgene	PPARG	C0023903	Liver neoplasms	1	CTD_human
Hgene	PPARG	C0025517	Metabolic Diseases	1	CTD_human
Hgene	PPARG	C0027746	Nerve Degeneration	1	CTD_human
Hgene	PPARG	C0029408	Degenerative polyarthritis	1	CTD_human
Hgene	PPARG	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Hgene	PPARG	C0030625	Passive Cutaneous Anaphylaxis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0033860	Psoriasis	1	CTD_human
Hgene	PPARG	C0035078	Kidney Failure	1	CTD_human
Hgene	PPARG	C0038525	Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	PPARG	C0079772	T-Cell Lymphoma	1	CTD_human
Hgene	PPARG	C0085278	Antiphospholipid Syndrome	1	CTD_human
Hgene	PPARG	C0085413	Polycystic Kidney, Autosomal Dominant	1	CTD_human
Hgene	PPARG	C0086743	Osteoarthrosis Deformans	1	CTD_human
Hgene	PPARG	C0086873	Pseudopelade	1	GENOMICS_ENGLAND
Hgene	PPARG	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Hgene	PPARG	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	PPARG	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	PPARG	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	PPARG	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	PPARG	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	PPARG	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	PPARG	C0206726	gliosarcoma	1	ORPHANET
Hgene	PPARG	C0221032	Familial generalized lipodystrophy	1	ORPHANET
Hgene	PPARG	C0221406	Pituitary-dependent Cushing's disease	1	CTD_human
Hgene	PPARG	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	PPARG	C0236811	Chronobiology Disorders	1	CTD_human
Hgene	PPARG	C0242339	Dyslipidemias	1	CTD_human
Hgene	PPARG	C0242488	Acute Lung Injury	1	CTD_human
Hgene	PPARG	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	PPARG	C0270192	Perinatal Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0271694	Familial partial lipodystrophy	1	CTD_human
Hgene	PPARG	C0282548	Leukostasis	1	CTD_human
Hgene	PPARG	C0334588	Giant Cell Glioblastoma	1	ORPHANET
Hgene	PPARG	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	PPARG	C0472383	Subarachnoid Hemorrhage, Spontaneous	1	CTD_human
Hgene	PPARG	C0525045	Mood Disorders	1	PSYGENET
Hgene	PPARG	C0549473	Thyroid carcinoma	1	CTD_human
Hgene	PPARG	C0598784	Dyslipoproteinemias	1	CTD_human
Hgene	PPARG	C0678202	Regional enteritis	1	CTD_human
Hgene	PPARG	C0751220	Inappropriate ACTH Secretion Syndrome	1	CTD_human
Hgene	PPARG	C0751530	Subarachnoid Hemorrhage, Aneurysmal	1	CTD_human
Hgene	PPARG	C0795688	Subarachnoid Hemorrhage, Intracranial	1	CTD_human
Hgene	PPARG	C0813142	Circadian Rhythm Disorders	1	CTD_human
Hgene	PPARG	C0887800	Psychogenic Inversion of Circadian Rhythm	1	CTD_human
Hgene	PPARG	C0887850	Polycystic Kidney, Type 1 Autosomal Dominant Disease	1	CTD_human
Hgene	PPARG	C0949272	IIeocolitis	1	CTD_human
Hgene	PPARG	C1258085	Barrett Epithelium	1	CTD_human
Hgene	PPARG	C1563937	Atherogenesis	1	CTD_human
Hgene	PPARG	C1565489	Renal Insufficiency	1	CTD_human
Hgene	PPARG	C1704377	Bright Disease	1	CTD_human
Hgene	PPARG	C1720859	Familial Partial Lipodystrophy, Type 1	1	CTD_human
Hgene	PPARG	C1720860	Familial Partial Lipodystrophy, Type 2	1	CTD_human
Hgene	PPARG	C1959583	Myocardial Failure	1	CTD_human
Hgene	PPARG	C1961112	Heart Decompensation	1	CTD_human
Hgene	PPARG	C2239176	Liver carcinoma	1	CTD_human
Hgene	PPARG	C2751306	Polycystic kidney disease, type 2	1	CTD_human
Hgene	PPARG	C2931367	Thyroid cancer, follicular	1	CTD_human
Hgene	PPARG	C2936846	Scarring alopecia	1	GENOMICS_ENGLAND
Tgene	PAX8	C0151516	Thyroid Hypoplasia	4	GENOMICS_ENGLAND;ORPHANET
Tgene	PAX8	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Tgene	PAX8	C1869118	HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	PAX8	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	PAX8	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	PAX8	C0010308	Congenital Hypothyroidism	1	GENOMICS_ENGLAND
Tgene	PAX8	C0266283	Ectopic thyroid tissue (disorder)	1	ORPHANET
Tgene	PAX8	C1563716	Thyroid Dysgenesis	1	GENOMICS_ENGLAND
Tgene	PAX8	C2931367	Thyroid cancer, follicular	1	CTD_human