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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPFIBP1-VIM (FusionGDB2 ID:67048)

Fusion Gene Summary for PPFIBP1-VIM

check button Fusion gene summary
Fusion gene informationFusion gene name: PPFIBP1-VIM
Fusion gene ID: 67048
HgeneTgene
Gene symbol

PPFIBP1

VIM

Gene ID

8496

7431

Gene namePPFIA binding protein 1vimentin
SynonymsL2|SGT2|hSGT2|hSgt2p-
Cytomap

12p11.23-p11.22

10p13

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1vimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc.

VMAC

Ensembl transtripts involved in fusion geneENST00000545334, ENST00000537927, 
ENST00000318304, ENST00000535047, 
ENST00000542629, ENST00000228425, 
ENST00000541633, 		ENST00000544301, 
ENST00000224237, ENST00000485947, 
Fusion gene scores* DoF score20 X 14 X 13=364042 X 25 X 11=11550
# samples 2641
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPFIBP1 [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPFIBP1(27807747)-VIM(17277167), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1690PPFIBP1chr12

27807747

+VIMchr10

17277167

+


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Fusion Gene ORF analysis for PPFIBP1-VIM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000545334ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-3CDSENST00000545334ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-intronENST00000545334ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000537927ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000537927ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
5CDS-intronENST00000537927ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000318304ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000318304ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
5CDS-intronENST00000318304ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-3CDSENST00000535047ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-3CDSENST00000535047ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-intronENST00000535047ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000542629ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000542629ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
5CDS-intronENST00000542629ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000228425ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
In-frameENST00000228425ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
5CDS-intronENST00000228425ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-3CDSENST00000541633ENST00000544301PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-3CDSENST00000541633ENST00000224237PPFIBP1chr12

27807747

+VIMchr10

17277167

+
intron-intronENST00000541633ENST00000485947PPFIBP1chr12

27807747

+VIMchr10

17277167

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537927PPFIBP1chr1227807747+ENST00000544301VIMchr1017277167+14056982571090277
ENST00000537927PPFIBP1chr1227807747+ENST00000224237VIMchr1017277167+14136982571090277
ENST00000318304PPFIBP1chr1227807747+ENST00000544301VIMchr1017277167+16869792501371373
ENST00000318304PPFIBP1chr1227807747+ENST00000224237VIMchr1017277167+16949792501371373
ENST00000542629PPFIBP1chr1227807747+ENST00000544301VIMchr1017277167+16689612321353373
ENST00000542629PPFIBP1chr1227807747+ENST00000224237VIMchr1017277167+16769612321353373
ENST00000228425PPFIBP1chr1227807747+ENST00000544301VIMchr1017277167+16369292001321373
ENST00000228425PPFIBP1chr1227807747+ENST00000224237VIMchr1017277167+16449292001321373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537927ENST00000544301PPFIBP1chr1227807747+VIMchr1017277167+0.0014617030.99853826
ENST00000537927ENST00000224237PPFIBP1chr1227807747+VIMchr1017277167+0.0014642360.99853575
ENST00000318304ENST00000544301PPFIBP1chr1227807747+VIMchr1017277167+0.0013523170.99864775
ENST00000318304ENST00000224237PPFIBP1chr1227807747+VIMchr1017277167+0.0013225950.99867743
ENST00000542629ENST00000544301PPFIBP1chr1227807747+VIMchr1017277167+0.0014390780.99856097
ENST00000542629ENST00000224237PPFIBP1chr1227807747+VIMchr1017277167+0.0014043820.99859565
ENST00000228425ENST00000544301PPFIBP1chr1227807747+VIMchr1017277167+0.0014568660.99854314
ENST00000228425ENST00000224237PPFIBP1chr1227807747+VIMchr1017277167+0.0014258690.99857414

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Fusion Genomic Features for PPFIBP1-VIM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPFIBP1chr1227807747+VIMchr1017277167+3.47E-050.9999653
PPFIBP1chr1227807747+VIMchr1017277167+3.47E-050.9999653

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPFIBP1-VIM


check button Go to

FGviewer for the breakpoints of chr12:27807747-chr10:17277167

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.VIM

VMAC

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749408_466336.0467.0RegionNote=Tail
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510408_466336.0467.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000228425+830156_405232.01006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000318304+829156_405232.01012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000535047+16156_4050171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000537927+627156_40579.0859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000542629+828156_405232.0981.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000228425+830647_711232.01006.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000228425+830719_782232.01006.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000228425+830804_876232.01006.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000318304+829647_711232.01012.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000318304+829719_782232.01012.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000318304+829804_876232.01012.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000535047+16647_7110171.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000535047+16719_7820171.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000535047+16804_8760171.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000537927+627647_71179.0859.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000537927+627719_78279.0859.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000537927+627804_87679.0859.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000542629+828647_711232.0981.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000542629+828719_782232.0981.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr10:17277167ENST00000542629+828804_876232.0981.0DomainSAM 3
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749154_245336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749303_407336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST000002242374996_131336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510154_245336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510303_407336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST0000054430151096_131336.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749103_411336.0467.0DomainIF rod
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510103_411336.0467.0DomainIF rod
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749326_329336.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510326_329336.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749132_153336.0467.0RegionNote=Linker 1
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749246_268336.0467.0RegionNote=Linker 12
TgeneVIMchr12:27807747chr10:17277167ENST0000022423749269_407336.0467.0RegionNote=Coil 2
TgeneVIMchr12:27807747chr10:17277167ENST00000224237492_95336.0467.0RegionNote=Head
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510132_153336.0467.0RegionNote=Linker 1
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510246_268336.0467.0RegionNote=Linker 12
TgeneVIMchr12:27807747chr10:17277167ENST00000544301510269_407336.0467.0RegionNote=Coil 2
TgeneVIMchr12:27807747chr10:17277167ENST000005443015102_95336.0467.0RegionNote=Head


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Fusion Gene Sequence for PPFIBP1-VIM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000537927_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1405nt_BP=698nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGA
TGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGG
AGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGC
TGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGG
TTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATG
ACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCA
AGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTT
AGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCT

>In-frame_ENST00000537927_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=277AA_start in transcript=257_stop in transcript=1090
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIGRLQDEI
QNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETS

--------------------------------------------------------------
>In-frame_ENST00000537927_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1413nt_BP=698nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGA
TGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGG
AGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGC
TGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGG
TTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATG
ACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCA
AGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTT
AGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCT

>In-frame_ENST00000537927_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=277AA_start in transcript=257_stop in transcript=1090
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIGRLQDEI
QNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETS

--------------------------------------------------------------
>In-frame_ENST00000318304_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1686nt_BP=979nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCT
GGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCA
GAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTA
CAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTC
ACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCA
GCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGA
AACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTC
CTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCA

>In-frame_ENST00000318304_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=250_stop in transcript=1371
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------
>In-frame_ENST00000318304_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1694nt_BP=979nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCT
GGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCA
GAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTA
CAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTC
ACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCA
GCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGA
AACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTC
CTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCA

>In-frame_ENST00000318304_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=250_stop in transcript=1371
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------
>In-frame_ENST00000542629_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1668nt_BP=961nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGATGCGTGA
AATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAAT
GGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGG
CGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATAC
CCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGA
ATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCT
TTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAA
AGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTT

>In-frame_ENST00000542629_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=232_stop in transcript=1353
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------
>In-frame_ENST00000542629_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1676nt_BP=961nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGATGCGTGA
AATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAAT
GGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGG
CGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATAC
CCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGA
ATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCT
TTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAA
AGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTT

>In-frame_ENST00000542629_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=232_stop in transcript=1353
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------
>In-frame_ENST00000228425_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1636nt_BP=929nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTA
ACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGC
TCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAA
ACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGG
TTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATAT
ATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATT
TGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAAT
CTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGC

>In-frame_ENST00000228425_ENST00000544301_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=200_stop in transcript=1321
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------
>In-frame_ENST00000228425_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(transcript)=1644nt_BP=929nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTA
ACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGC
TCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAA
ACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGG
TTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATAT
ATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATT
TGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAAT
CTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGC

>In-frame_ENST00000228425_ENST00000224237_TCGA-29-1690_PPFIBP1_chr12_27807747_+_VIM_chr10_17277167_length(amino acids)=373AA_start in transcript=200_stop in transcript=1321
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKNESLERQMREMEENFAVEAANYQDTIG
RLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPFIBP1-VIM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPFIBP1-VIM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPFIBP1-VIM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPFIBP1C0085269Plasma Cell Granuloma, Pulmonary1CTD_human
TgeneVIMC0006142Malignant neoplasm of breast4CTD_human
TgeneVIMC0678222Breast Carcinoma4CTD_human
TgeneVIMC1257931Mammary Neoplasms, Human4CTD_human
TgeneVIMC1458155Mammary Neoplasms4CTD_human
TgeneVIMC3805411CATARACT 304GENOMICS_ENGLAND;UNIPROT
TgeneVIMC4704874Mammary Carcinoma, Human4CTD_human
TgeneVIMC0023890Liver Cirrhosis2CTD_human
TgeneVIMC0029408Degenerative polyarthritis2CTD_human
TgeneVIMC0033578Prostatic Neoplasms2CTD_human
TgeneVIMC0086743Osteoarthrosis Deformans2CTD_human
TgeneVIMC0239946Fibrosis, Liver2CTD_human
TgeneVIMC0376358Malignant neoplasm of prostate2CTD_human
TgeneVIMC0007140Carcinosarcoma1CTD_human
TgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
TgeneVIMC0019193Hepatitis, Toxic1CTD_human
TgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC0027626Neoplasm Invasiveness1CTD_human
TgeneVIMC0027627Neoplasm Metastasis1CTD_human
TgeneVIMC0027720Nephrosis1CTD_human
TgeneVIMC0031149Peritoneal Neoplasms1CTD_human
TgeneVIMC0035126Reperfusion Injury1CTD_human
TgeneVIMC0035309Retinal Diseases1CTD_human
TgeneVIMC0039101synovial sarcoma1CTD_human
TgeneVIMC0043094Weight Gain1CTD_human
TgeneVIMC0085084Motor Neuron Disease1CTD_human
TgeneVIMC0086543Cataract1CTD_human
TgeneVIMC0154681Anterior Horn Cell Disease1CTD_human
TgeneVIMC0154682Lateral Sclerosis1CTD_human
TgeneVIMC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneVIMC0270763Familial Motor Neuron Disease1CTD_human
TgeneVIMC0270764Motor Neuron Disease, Lower1CTD_human
TgeneVIMC0345967Malignant mesothelioma1CTD_human
TgeneVIMC0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneVIMC0521659Motor Neuron Disease, Upper1CTD_human
TgeneVIMC0524524Pseudoaphakia1CTD_human
TgeneVIMC0524851Neurodegenerative Disorders1CTD_human
TgeneVIMC0543858Motor Neuron Disease, Secondary1CTD_human
TgeneVIMC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneVIMC0860207Drug-Induced Liver Disease1CTD_human
TgeneVIMC0948089Acute Coronary Syndrome1CTD_human
TgeneVIMC1262760Hepatitis, Drug-Induced1CTD_human
TgeneVIMC1510497Lens Opacities1CTD_human
TgeneVIMC1833118Cataract, Pulverulent1ORPHANET
TgeneVIMC1852438CATARACT, COPPOCK-LIKE1ORPHANET
TgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneVIMC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneVIMC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneVIMC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneVIMC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human