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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPIB-RASA1 (FusionGDB2 ID:67104)

Fusion Gene Summary for PPIB-RASA1

Fusion gene summary

Fusion gene information	Fusion gene name: PPIB-RASA1
	Fusion gene ID: 67104
		Hgene	Tgene
	Gene symbol	PPIB	RASA1
	Gene ID	5479	8831
	Gene name	peptidylprolyl isomerase B	synaptic Ras GTPase activating protein 1
	Synonyms	B\|CYP-S1\|CYPB\|HEL-S-39\|OI9\|SCYLP	MRD5\|RASA1\|RASA5\|SYNGAP
	Cytomap	15q22.31	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	peptidyl-prolyl cis-trans isomerase BPPIase BS-cyclophilincyclophilin-like proteinepididymis secretory protein Li 39peptidylprolyl isomerase B (cyclophilin B)rotamase B	ras/Rap GTPase-activating protein SynGAPRas GTPase-activating protein SynGAPneuronal RasGAPsynaptic Ras GTPase activating protein 1 homologsynaptic Ras GTPase activating protein, 135kDa
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000300026, ENST00000558492,	ENST00000274376, ENST00000456692, ENST00000512763, ENST00000506290,
Fusion gene scores	* DoF score	11 X 10 X 5=550	3 X 3 X 2=18
	# samples	11	3
	** MAII score	log2(11/550*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PPIB [Title/Abstract] AND RASA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPIB(64454239)-RASA1(86667934), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPIB	GO:0000413	protein peptidyl-prolyl isomerization	20676357
Hgene	PPIB	GO:0061077	chaperone-mediated protein folding	22665516

Fusion gene breakpoints across PPIB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RASA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4YX	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+

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Fusion Gene ORF analysis for PPIB-RASA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000300026	ENST00000274376	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
In-frame	ENST00000300026	ENST00000456692	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
In-frame	ENST00000300026	ENST00000512763	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
In-frame	ENST00000300026	ENST00000506290	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
intron-3CDS	ENST00000558492	ENST00000274376	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
intron-3CDS	ENST00000558492	ENST00000456692	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
intron-3CDS	ENST00000558492	ENST00000512763	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+
intron-3CDS	ENST00000558492	ENST00000506290	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300026	PPIB	chr15	64454239	-	ENST00000274376	RASA1	chr5	86667934	+	1958	468	213	1913	566
ENST00000300026	PPIB	chr15	64454239	-	ENST00000456692	RASA1	chr5	86667934	+	2962	468	213	1913	566
ENST00000300026	PPIB	chr15	64454239	-	ENST00000512763	RASA1	chr5	86667934	+	2130	468	213	1913	566
ENST00000300026	PPIB	chr15	64454239	-	ENST00000506290	RASA1	chr5	86667934	+	2160	468	213	1913	566

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300026	ENST00000274376	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.001454981	0.99854505
ENST00000300026	ENST00000456692	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.000565997	0.99943393
ENST00000300026	ENST00000512763	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.001323541	0.9986765
ENST00000300026	ENST00000506290	PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.001297445	0.9987025

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Fusion Genomic Features for PPIB-RASA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.86933947	0.13066047
PPIB	chr15	64454239	-	RASA1	chr5	86667934	+	0.86933947	0.13066047

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPIB-RASA1

Go to
FGviewer for the breakpoints of chr15:64454239-chr5:86667934
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

577_690

566.0

1048.0

Domain

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

748_942

566.0

1048.0

Domain

Ras-GAP

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

474_577

389.0

871.0

Domain

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

577_690

389.0

871.0

Domain

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

748_942

389.0

871.0

Domain

Ras-GAP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPIB

chr15:64454239

chr5:86667934

ENST00000300026

47_204

83.0

217.0

Domain

PPIase cyclophilin-type

Hgene

PPIB

chr15:64454239

chr5:86667934

ENST00000300026

213_216

83.0

217.0

Motif

Note=Prevents secretion from ER

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

135_141

566.0

1048.0

Compositional bias

Note=Poly-Pro

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

163_168

566.0

1048.0

Compositional bias

Note=Poly-Glu

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

17_22

566.0

1048.0

Compositional bias

Note=Poly-Gly

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

135_141

389.0

871.0

Compositional bias

Note=Poly-Pro

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

163_168

389.0

871.0

Compositional bias

Note=Poly-Glu

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

17_22

389.0

871.0

Compositional bias

Note=Poly-Gly

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

181_272

566.0

1048.0

Domain

SH2 1

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

279_341

566.0

1048.0

Domain

SH3

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

351_441

566.0

1048.0

Domain

SH2 2

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000274376

474_577

566.0

1048.0

Domain

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

181_272

389.0

871.0

Domain

SH2 1

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

279_341

389.0

871.0

Domain

SH3

Tgene

RASA1

chr15:64454239

chr5:86667934

ENST00000456692

351_441

389.0

871.0

Domain

SH2 2

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Fusion Gene Sequence for PPIB-RASA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000300026_ENST00000274376_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(transcript)=1958nt_BP=468nt
GTGGCAACCACCCACGAGCCCGCGTCGGTGCCCGCCCCGCAGGGGGACCTACTATCCGGCGCCGAGCCGGAGGGGGGAAACGGCGCCCGC
CGCCCGCCCGGAGCCCGCGAGCAACCCCAGTCCCCCCCACCCGCGCGTGGCGGCGCCGGCTCCCTAGCCACCGCGGCCCCACCCTCTTCC
GGCCTCAGCTGTCCGGGCTGCTTTCGCCTCCGCCTGTGGATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTC
ATCGCGGGGTCCGTCTTCTTCCTGCTGCTGCCGGGACCTTCTGCGGCCGATGAGAAGAAGAAGGGGCCCAAAGTCACCGTCAAGGTGTAT
TTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTGATCTTTGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTG
GCCTTAGCTACAGGAGAGGATTGGATGAAAGGTCTGCAGGCATTTTGCAATTTACGGAAAAGTAGTCCAGGGACATCCAATAAACGCCTT
CGTCAGGTCAGCAGCCTTGTTTTACATATTGAAGAAGCCCATAAACTCCCAGTAAAACATTTTACTAATCCATATTGTAACATCTACCTG
AATAGTGTCCAAGTAGCAAAAACTCATGCAAGGGAAGGGCAAAACCCAGTATGGTCAGAAGAGTTTGTCTTTGATGATCTTCCTCCTGAC
ATCAATAGATTTGAAATAACTCTTAGTAATAAAACAAAGAAAAGCAAAGATCCTGATATCTTATTTATGCGCTGCCAGTTGAGCCGATTA
CAGAAAGGGCATGCCACAGATGAATGGTTTCTGCTCAGCTCCCATATACCATTAAAAGGTATTGAACCAGGGTCCCTGCGTGTTCGAGCA
CGATACTCTATGGAAAAAATCATGCCAGAAGAAGAGTACAGTGAATTTAAAGAGCTTATACTGCAAAAGGAACTTCATGTAGTCTATGCT
TTATCACATGTATGTGGACAAGACCGAACACTACTGGCCAGCATCCTACTGAGGATTTTTCTTCACGAAAAGCTTGAATCGTTGTTGTTA
TGCACACTAAATGACAGAGAAATAAGCATGGAAGATGAAGCCACTACCCTATTTCGAGCCACAACACTTGCAAGCACCTTGATGGAGCAG
TATATGAAAGCCACTGCTACACAGTTTGTTCATCATGCTTTGAAAGACTCTATTTTAAAGATAATGGAAAGCAAGCAGTCTTGTGAGTTA
AGTCCATCAAAGTTAGAAAAAAATGAAGATGTGAACACTAATTTAACACACCTATTGAACATACTTTCAGAGCTTGTGGAGAAAATATTC
ATGGCTTCAGAAATACTTCCACCGACATTGAGATATATTTATGGGTGTTTACAGAAATCTGTTCAGCATAAGTGGCCTACAAATACCACC
ATGAGAACAAGAGTTGTTAGTGGTTTTGTTTTTCTTCGACTCATCTGTCCTGCCATCCTGAATCCACGGATGTTCAATATCATCTCAGAT
TCTCCATCTCCTATTGCTGCAAGAACACTGATATTAGTGGCTAAATCTGTGCAGAACTTAGCAAATCTTGTGGAATTTGGAGCTAAGGAG
CCCTACATGGAAGGTGTCAATCCATTCATCAAAAGCAACAAACATCGTATGATCATGTTTTTAGATGAACTTGGGAATGTACCTGAACTT
CCGGACACTACAGAGCATTCTAGAACGGACCTGTCCCGTGATTTAGCAGCATTGCATGAGATTTGCGTGGCTCATTCAGATGAACTTCGA
ACGCTCAGTAATGAGCGTGGTGCACAGCAGCACGTATTGAAAAAGCTTCTGGCTATAACAGAACTGCTTCAACAAAAACAAAACCAGTAT

>In-frame_ENST00000300026_ENST00000274376_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(amino acids)=566AA_start in transcript=213_stop in transcript=1913
MWMLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEDWMKG
LQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNK
TKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTL
LASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV
NTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLI
LVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQH

--------------------------------------------------------------
>In-frame_ENST00000300026_ENST00000456692_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(transcript)=2962nt_BP=468nt
GTGGCAACCACCCACGAGCCCGCGTCGGTGCCCGCCCCGCAGGGGGACCTACTATCCGGCGCCGAGCCGGAGGGGGGAAACGGCGCCCGC
CGCCCGCCCGGAGCCCGCGAGCAACCCCAGTCCCCCCCACCCGCGCGTGGCGGCGCCGGCTCCCTAGCCACCGCGGCCCCACCCTCTTCC
GGCCTCAGCTGTCCGGGCTGCTTTCGCCTCCGCCTGTGGATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTC
ATCGCGGGGTCCGTCTTCTTCCTGCTGCTGCCGGGACCTTCTGCGGCCGATGAGAAGAAGAAGGGGCCCAAAGTCACCGTCAAGGTGTAT
TTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTGATCTTTGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTG
GCCTTAGCTACAGGAGAGGATTGGATGAAAGGTCTGCAGGCATTTTGCAATTTACGGAAAAGTAGTCCAGGGACATCCAATAAACGCCTT
CGTCAGGTCAGCAGCCTTGTTTTACATATTGAAGAAGCCCATAAACTCCCAGTAAAACATTTTACTAATCCATATTGTAACATCTACCTG
AATAGTGTCCAAGTAGCAAAAACTCATGCAAGGGAAGGGCAAAACCCAGTATGGTCAGAAGAGTTTGTCTTTGATGATCTTCCTCCTGAC
ATCAATAGATTTGAAATAACTCTTAGTAATAAAACAAAGAAAAGCAAAGATCCTGATATCTTATTTATGCGCTGCCAGTTGAGCCGATTA
CAGAAAGGGCATGCCACAGATGAATGGTTTCTGCTCAGCTCCCATATACCATTAAAAGGTATTGAACCAGGGTCCCTGCGTGTTCGAGCA
CGATACTCTATGGAAAAAATCATGCCAGAAGAAGAGTACAGTGAATTTAAAGAGCTTATACTGCAAAAGGAACTTCATGTAGTCTATGCT
TTATCACATGTATGTGGACAAGACCGAACACTACTGGCCAGCATCCTACTGAGGATTTTTCTTCACGAAAAGCTTGAATCGTTGTTGTTA
TGCACACTAAATGACAGAGAAATAAGCATGGAAGATGAAGCCACTACCCTATTTCGAGCCACAACACTTGCAAGCACCTTGATGGAGCAG
TATATGAAAGCCACTGCTACACAGTTTGTTCATCATGCTTTGAAAGACTCTATTTTAAAGATAATGGAAAGCAAGCAGTCTTGTGAGTTA
AGTCCATCAAAGTTAGAAAAAAATGAAGATGTGAACACTAATTTAACACACCTATTGAACATACTTTCAGAGCTTGTGGAGAAAATATTC
ATGGCTTCAGAAATACTTCCACCGACATTGAGATATATTTATGGGTGTTTACAGAAATCTGTTCAGCATAAGTGGCCTACAAATACCACC
ATGAGAACAAGAGTTGTTAGTGGTTTTGTTTTTCTTCGACTCATCTGTCCTGCCATCCTGAATCCACGGATGTTCAATATCATCTCAGAT
TCTCCATCTCCTATTGCTGCAAGAACACTGATATTAGTGGCTAAATCTGTGCAGAACTTAGCAAATCTTGTGGAATTTGGAGCTAAGGAG
CCCTACATGGAAGGTGTCAATCCATTCATCAAAAGCAACAAACATCGTATGATCATGTTTTTAGATGAACTTGGGAATGTACCTGAACTT
CCGGACACTACAGAGCATTCTAGAACGGACCTGTCCCGTGATTTAGCAGCATTGCATGAGATTTGCGTGGCTCATTCAGATGAACTTCGA
ACGCTCAGTAATGAGCGTGGTGCACAGCAGCACGTATTGAAAAAGCTTCTGGCTATAACAGAACTGCTTCAACAAAAACAAAACCAGTAT
ACAAAAACCAATGATGTCAGGTAGCAGCCTTCGCCCCAGTGTTCTGCATGGATTCAGCATGTCCAACATGGTAATTCACTTCAGTTTAAT
GTCTCCTTTGCTCTTGCCAAAAAATAGCACACTTTTCCACATTCCAGTGATGTGTGAGCTATGCAAACAAAATCCAAGATTCTGCTGGTG
AATAACTATGCCAGCAACCTTGTAAGCTATCTGTGCAGGATATTTGCACTATTTCCACATGGAATCAATCTTTAACAACCTCTGAGCCTT
GGTGTACAGACCACCTTTCACAAAACGAAATGCTATGACTGTATCTTGATATCTCGAACTTTCAAAATATATTTTCAGTACACCCAGTTG
CCAAAGTTTTGCTGTCTCTTAGAGAAAGAACTATGAAATCAACTGACAAGAAACACATTCTTATTGACAATTGTGTATAACTGGATTGCA
GACTGTTCTTACTGTAACTACTTCCTGATTAGGAATATGACCATTTGACTGTTCAATGATTATTTGTATTTACAGTTTCCAGAGTTTGTC
ATTATAATAGGAACAATCTTTGCTGTATACTTTTAAAAAATACTCTGCTATTTCTCTTGCTGGAACTGTTGAAAGAAAATATATAGAATG
ATCTATTGCTCATCAGCTTTATTTTTTAAACATACGACTTATTTTGTTGAAATTGTCAAAGACTGTATTTAGATCTCATAATGCTTTGTT
AAATGTTTACAAGTAAATAGTTTGAATTCAGTAAATATTATTGGTTGTTGTATTGATCAATGCATGTTACCCATTCAACCATTTTATAGA
CTACCAATTTCTTTTATGTTAACTAGAATGCTTTTGTTAAAAGTTATTTGTTCATTATTTGTGCTACCCCTTTGATTATGCAGACAACCT
CATCAGCTGCCTAACTTATCCATCTTTGAACTTCTGACTACTTGTTGTATCTGCTGGATATTTAGTTCAACTGTATAGTTTTATTTACTT

>In-frame_ENST00000300026_ENST00000456692_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(amino acids)=566AA_start in transcript=213_stop in transcript=1913
MWMLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEDWMKG
LQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNK
TKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTL
LASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV
NTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLI
LVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQH

--------------------------------------------------------------
>In-frame_ENST00000300026_ENST00000512763_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(transcript)=2130nt_BP=468nt
GTGGCAACCACCCACGAGCCCGCGTCGGTGCCCGCCCCGCAGGGGGACCTACTATCCGGCGCCGAGCCGGAGGGGGGAAACGGCGCCCGC
CGCCCGCCCGGAGCCCGCGAGCAACCCCAGTCCCCCCCACCCGCGCGTGGCGGCGCCGGCTCCCTAGCCACCGCGGCCCCACCCTCTTCC
GGCCTCAGCTGTCCGGGCTGCTTTCGCCTCCGCCTGTGGATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTC
ATCGCGGGGTCCGTCTTCTTCCTGCTGCTGCCGGGACCTTCTGCGGCCGATGAGAAGAAGAAGGGGCCCAAAGTCACCGTCAAGGTGTAT
TTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTGATCTTTGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTG
GCCTTAGCTACAGGAGAGGATTGGATGAAAGGTCTGCAGGCATTTTGCAATTTACGGAAAAGTAGTCCAGGGACATCCAATAAACGCCTT
CGTCAGGTCAGCAGCCTTGTTTTACATATTGAAGAAGCCCATAAACTCCCAGTAAAACATTTTACTAATCCATATTGTAACATCTACCTG
AATAGTGTCCAAGTAGCAAAAACTCATGCAAGGGAAGGGCAAAACCCAGTATGGTCAGAAGAGTTTGTCTTTGATGATCTTCCTCCTGAC
ATCAATAGATTTGAAATAACTCTTAGTAATAAAACAAAGAAAAGCAAAGATCCTGATATCTTATTTATGCGCTGCCAGTTGAGCCGATTA
CAGAAAGGGCATGCCACAGATGAATGGTTTCTGCTCAGCTCCCATATACCATTAAAAGGTATTGAACCAGGGTCCCTGCGTGTTCGAGCA
CGATACTCTATGGAAAAAATCATGCCAGAAGAAGAGTACAGTGAATTTAAAGAGCTTATACTGCAAAAGGAACTTCATGTAGTCTATGCT
TTATCACATGTATGTGGACAAGACCGAACACTACTGGCCAGCATCCTACTGAGGATTTTTCTTCACGAAAAGCTTGAATCGTTGTTGTTA
TGCACACTAAATGACAGAGAAATAAGCATGGAAGATGAAGCCACTACCCTATTTCGAGCCACAACACTTGCAAGCACCTTGATGGAGCAG
TATATGAAAGCCACTGCTACACAGTTTGTTCATCATGCTTTGAAAGACTCTATTTTAAAGATAATGGAAAGCAAGCAGTCTTGTGAGTTA
AGTCCATCAAAGTTAGAAAAAAATGAAGATGTGAACACTAATTTAACACACCTATTGAACATACTTTCAGAGCTTGTGGAGAAAATATTC
ATGGCTTCAGAAATACTTCCACCGACATTGAGATATATTTATGGGTGTTTACAGAAATCTGTTCAGCATAAGTGGCCTACAAATACCACC
ATGAGAACAAGAGTTGTTAGTGGTTTTGTTTTTCTTCGACTCATCTGTCCTGCCATCCTGAATCCACGGATGTTCAATATCATCTCAGAT
TCTCCATCTCCTATTGCTGCAAGAACACTGATATTAGTGGCTAAATCTGTGCAGAACTTAGCAAATCTTGTGGAATTTGGAGCTAAGGAG
CCCTACATGGAAGGTGTCAATCCATTCATCAAAAGCAACAAACATCGTATGATCATGTTTTTAGATGAACTTGGGAATGTACCTGAACTT
CCGGACACTACAGAGCATTCTAGAACGGACCTGTCCCGTGATTTAGCAGCATTGCATGAGATTTGCGTGGCTCATTCAGATGAACTTCGA
ACGCTCAGTAATGAGCGTGGTGCACAGCAGCACGTATTGAAAAAGCTTCTGGCTATAACAGAACTGCTTCAACAAAAACAAAACCAGTAT
ACAAAAACCAATGATGTCAGGTAGCAGCCTTCGCCCCAGTGTTCTGCATGGATTCAGCATGTCCAACATGGTAATTCACTTCAGTTTAAT
GTCTCCTTTGCTCTTGCCAAAAAATAGCACACTTTTCCACATTCCAGTGATGTGTGAGCTATGCAAACAAAATCCAAGATTCTGCTGGTG

>In-frame_ENST00000300026_ENST00000512763_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(amino acids)=566AA_start in transcript=213_stop in transcript=1913
MWMLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEDWMKG
LQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNK
TKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTL
LASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV
NTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLI
LVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQH

--------------------------------------------------------------
>In-frame_ENST00000300026_ENST00000506290_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(transcript)=2160nt_BP=468nt
GTGGCAACCACCCACGAGCCCGCGTCGGTGCCCGCCCCGCAGGGGGACCTACTATCCGGCGCCGAGCCGGAGGGGGGAAACGGCGCCCGC
CGCCCGCCCGGAGCCCGCGAGCAACCCCAGTCCCCCCCACCCGCGCGTGGCGGCGCCGGCTCCCTAGCCACCGCGGCCCCACCCTCTTCC
GGCCTCAGCTGTCCGGGCTGCTTTCGCCTCCGCCTGTGGATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTC
ATCGCGGGGTCCGTCTTCTTCCTGCTGCTGCCGGGACCTTCTGCGGCCGATGAGAAGAAGAAGGGGCCCAAAGTCACCGTCAAGGTGTAT
TTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTGATCTTTGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTG
GCCTTAGCTACAGGAGAGGATTGGATGAAAGGTCTGCAGGCATTTTGCAATTTACGGAAAAGTAGTCCAGGGACATCCAATAAACGCCTT
CGTCAGGTCAGCAGCCTTGTTTTACATATTGAAGAAGCCCATAAACTCCCAGTAAAACATTTTACTAATCCATATTGTAACATCTACCTG
AATAGTGTCCAAGTAGCAAAAACTCATGCAAGGGAAGGGCAAAACCCAGTATGGTCAGAAGAGTTTGTCTTTGATGATCTTCCTCCTGAC
ATCAATAGATTTGAAATAACTCTTAGTAATAAAACAAAGAAAAGCAAAGATCCTGATATCTTATTTATGCGCTGCCAGTTGAGCCGATTA
CAGAAAGGGCATGCCACAGATGAATGGTTTCTGCTCAGCTCCCATATACCATTAAAAGGTATTGAACCAGGGTCCCTGCGTGTTCGAGCA
CGATACTCTATGGAAAAAATCATGCCAGAAGAAGAGTACAGTGAATTTAAAGAGCTTATACTGCAAAAGGAACTTCATGTAGTCTATGCT
TTATCACATGTATGTGGACAAGACCGAACACTACTGGCCAGCATCCTACTGAGGATTTTTCTTCACGAAAAGCTTGAATCGTTGTTGTTA
TGCACACTAAATGACAGAGAAATAAGCATGGAAGATGAAGCCACTACCCTATTTCGAGCCACAACACTTGCAAGCACCTTGATGGAGCAG
TATATGAAAGCCACTGCTACACAGTTTGTTCATCATGCTTTGAAAGACTCTATTTTAAAGATAATGGAAAGCAAGCAGTCTTGTGAGTTA
AGTCCATCAAAGTTAGAAAAAAATGAAGATGTGAACACTAATTTAACACACCTATTGAACATACTTTCAGAGCTTGTGGAGAAAATATTC
ATGGCTTCAGAAATACTTCCACCGACATTGAGATATATTTATGGGTGTTTACAGAAATCTGTTCAGCATAAGTGGCCTACAAATACCACC
ATGAGAACAAGAGTTGTTAGTGGTTTTGTTTTTCTTCGACTCATCTGTCCTGCCATCCTGAATCCACGGATGTTCAATATCATCTCAGAT
TCTCCATCTCCTATTGCTGCAAGAACACTGATATTAGTGGCTAAATCTGTGCAGAACTTAGCAAATCTTGTGGAATTTGGAGCTAAGGAG
CCCTACATGGAAGGTGTCAATCCATTCATCAAAAGCAACAAACATCGTATGATCATGTTTTTAGATGAACTTGGGAATGTACCTGAACTT
CCGGACACTACAGAGCATTCTAGAACGGACCTGTCCCGTGATTTAGCAGCATTGCATGAGATTTGCGTGGCTCATTCAGATGAACTTCGA
ACGCTCAGTAATGAGCGTGGTGCACAGCAGCACGTATTGAAAAAGCTTCTGGCTATAACAGAACTGCTTCAACAAAAACAAAACCAGTAT
ACAAAAACCAATGATGTCAGGTAGCAGCCTTCGCCCCAGTGTTCTGCATGGATTCAGCATGTCCAACATGGTAATTCACTTCAGTTTAAT
GTCTCCTTTGCTCTTGCCAAAAAATAGCACACTTTTCCACATTCCAGTGATGTGTGAGCTATGCAAACAAAATCCAAGATTCTGCTGGTG
AATAACTATGCCAGCAACCTTGTAAGCTATCTGTGCAGGATATTTGCACTATTTCCACATGGAATCAATCTTTAACAACCTCTGAGCCTT

>In-frame_ENST00000300026_ENST00000506290_TCGA-D7-A4YX_PPIB_chr15_64454239_-_RASA1_chr5_86667934_length(amino acids)=566AA_start in transcript=213_stop in transcript=1913
MWMLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEDWMKG
LQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNK
TKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTL
LASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV
NTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLI
LVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPIB-RASA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPIB-RASA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPIB-RASA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPIB	C1850169	OSTEOGENESIS IMPERFECTA, TYPE IX (disorder)	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PPIB	C0019693	HIV Infections	1	CTD_human
Hgene	PPIB	C0268358	Osteogenesis imperfecta, dominant perinatal lethal	1	ORPHANET
Hgene	PPIB	C0268362	Osteogenesis imperfecta type III (disorder)	1	ORPHANET
Hgene	PPIB	C0268363	Osteogenesis imperfecta type IV (disorder)	1	ORPHANET
Hgene	PPIB	C4505456	HIV Coinfection	1	CTD_human
Tgene	RASA1	C4747394	CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION 1	4	GENOMICS_ENGLAND;UNIPROT
Tgene	RASA1	C0038505	Sturge-Weber Syndrome	2	GENOMICS_ENGLAND;ORPHANET
Tgene	RASA1	C1842180	CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder)	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	RASA1	C0003857	Congenital arteriovenous malformation	1	CTD_human
Tgene	RASA1	C0007097	Carcinoma	1	CTD_human
Tgene	RASA1	C0007137	Squamous cell carcinoma	1	CTD_human
Tgene	RASA1	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	RASA1	C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene	RASA1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene	RASA1	C0028326	Noonan Syndrome	1	CLINGEN
Tgene	RASA1	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	RASA1	C0205696	Anaplastic carcinoma	1	CTD_human
Tgene	RASA1	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene	RASA1	C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene	RASA1	C0205699	Carcinomatosis	1	CTD_human
Tgene	RASA1	C0235752	Port-Wine Stain	1	CTD_human
Tgene	RASA1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	RASA1	C1257925	Mammary Carcinoma, Animal	1	CTD_human
Tgene	RASA1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	RASA1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	RASA1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	RASA1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human