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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPM1B-ABCG8 (FusionGDB2 ID:67182)

Fusion Gene Summary for PPM1B-ABCG8

check button Fusion gene summary
Fusion gene informationFusion gene name: PPM1B-ABCG8
Fusion gene ID: 67182
HgeneTgene
Gene symbol

PPM1B

ABCG8

Gene ID

5495

64241

Gene nameprotein phosphatase, Mg2+/Mn2+ dependent 1BATP binding cassette subfamily G member 8
SynonymsPP2C-beta|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAXGBD4|STSL|STSL1
Cytomap

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1BSer/Thr protein phosphatase type 2C beta 2 isoformprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoformprotein phosphatase 2C-like proteinATP-binding cassette sub-family G member 8ATP-binding cassette, sub-family G (WHITE), member 8sterolin 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000409895, ENST00000409432, 
ENST00000282412, ENST00000378551, 
ENST00000378540, ENST00000345249, 
ENST00000272286, 
Fusion gene scores* DoF score11 X 7 X 7=5392 X 5 X 3=30
# samples 135
** MAII scorelog2(13/539*10)=-2.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPM1B [Title/Abstract] AND ABCG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPM1B(44445676)-ABCG8(44071646), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPM1B

GO:0035970

peptidyl-threonine dephosphorylation

20801214


check buttonFusion gene breakpoints across PPM1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-NJ-A4YF-01APPM1Bchr2

44445676

+ABCG8chr2

44071646

+
ChimerDB4LUADTCGA-NJ-A4YFPPM1Bchr2

44445676

+ABCG8chr2

44071645

+
ChimerDB4STADTCGA-BR-8687PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
ChimerDB4LUADTCGA-NJ-A4YF-01APPM1Bchr2

44445676

+ABCG8chr2

44071646

+
ChimerDB4STADTCGA-BR-8687-01APPM1Bchr2

44396413

+ABCG8chr2

44102285

+
ChimerDB4STADTCGA-BR-8687-01APPM1Bchr2

44396413

+ABCG8chr2

44102270

+
ChimerDB4STADTCGA-BR-8687-01APPM1Bchr2

44396413

-ABCG8chr2

44102285

+
ChimerDB4LUADTCGA-NJ-A4YF-01APPM1Bchr2

44445676

-ABCG8chr2

44071646

+


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Fusion Gene ORF analysis for PPM1B-ABCG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409895ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
In-frameENST00000409432ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
In-frameENST00000282412ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
In-frameENST00000378551ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
3UTR-3CDSENST00000378540ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
In-frameENST00000345249ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071646

+
intron-3CDSENST00000409895ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
In-frameENST00000409432ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
In-frameENST00000282412ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
In-frameENST00000378551ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
3UTR-3CDSENST00000378540ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
In-frameENST00000345249ENST00000272286PPM1Bchr2

44445676

+ABCG8chr2

44071645

+
5UTR-3CDSENST00000409895ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
5UTR-3CDSENST00000409432ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
5UTR-3CDSENST00000282412ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
5UTR-3CDSENST00000378551ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
3UTR-3CDSENST00000378540ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
5UTR-3CDSENST00000345249ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102284

+
5UTR-3CDSENST00000409895ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
5UTR-3CDSENST00000409432ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
5UTR-3CDSENST00000282412ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
5UTR-3CDSENST00000378551ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
3UTR-3CDSENST00000378540ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
5UTR-3CDSENST00000345249ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102285

+
5UTR-intronENST00000409895ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+
5UTR-intronENST00000409432ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+
5UTR-intronENST00000282412ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+
5UTR-intronENST00000378551ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+
3UTR-intronENST00000378540ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+
5UTR-intronENST00000345249ENST00000272286PPM1Bchr2

44396413

+ABCG8chr2

44102270

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409432PPM1Bchr244445676+ENST00000272286ABCG8chr244071646+4058154640335041033
ENST00000282412PPM1Bchr244445676+ENST00000272286ABCG8chr244071646+4058154640335041033
ENST00000378551PPM1Bchr244445676+ENST00000272286ABCG8chr244071646+4058154640335041033
ENST00000345249PPM1Bchr244445676+ENST00000272286ABCG8chr244071646+31656533562611751
ENST00000409432PPM1Bchr244445676+ENST00000272286ABCG8chr244071645+4058154640335041033
ENST00000282412PPM1Bchr244445676+ENST00000272286ABCG8chr244071645+4058154640335041033
ENST00000378551PPM1Bchr244445676+ENST00000272286ABCG8chr244071645+4058154640335041033
ENST00000345249PPM1Bchr244445676+ENST00000272286ABCG8chr244071645+31656533562611751

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409432ENST00000272286PPM1Bchr244445676+ABCG8chr244071646+0.0020259610.9979741
ENST00000282412ENST00000272286PPM1Bchr244445676+ABCG8chr244071646+0.0020259610.9979741
ENST00000378551ENST00000272286PPM1Bchr244445676+ABCG8chr244071646+0.0020259610.9979741
ENST00000345249ENST00000272286PPM1Bchr244445676+ABCG8chr244071646+0.0081890370.9918109
ENST00000409432ENST00000272286PPM1Bchr244445676+ABCG8chr244071645+0.0020259610.9979741
ENST00000282412ENST00000272286PPM1Bchr244445676+ABCG8chr244071645+0.0020259610.9979741
ENST00000378551ENST00000272286PPM1Bchr244445676+ABCG8chr244071645+0.0020259610.9979741
ENST00000345249ENST00000272286PPM1Bchr244445676+ABCG8chr244071645+0.0081890370.9918109

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Fusion Genomic Features for PPM1B-ABCG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPM1Bchr244445676+ABCG8chr244071645+9.77E-080.9999999
PPM1Bchr244445676+ABCG8chr244071645+9.77E-080.9999999
PPM1Bchr244396413+ABCG8chr244102284+1.21E-081
PPM1Bchr244396413+ABCG8chr244102284+1.21E-081
PPM1Bchr244445676+ABCG8chr244071645+9.77E-080.9999999
PPM1Bchr244445676+ABCG8chr244071645+9.77E-080.9999999
PPM1Bchr244396413+ABCG8chr244102284+1.21E-081
PPM1Bchr244396413+ABCG8chr244102284+1.21E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPM1B-ABCG8


check button Go to

FGviewer for the breakpoints of chr2:44445676-chr2:44071646

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPM1Bchr2:44445676chr2:44071645ENST00000282412+5623_295378.0480.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071645ENST00000378551+5623_295378.0388.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071645ENST00000409432+5623_295378.0381.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071646ENST00000282412+5623_295378.0480.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071646ENST00000378551+5623_295378.0388.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071646ENST00000409432+5623_295378.0381.0DomainPPM-type phosphatase
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013411_66521.0674.0DomainNote=ABC transmembrane type-2
TgeneABCG8chr2:44445676chr2:44071645ENST0000027228601347_31321.0674.0DomainABC transporter
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013411_66521.0674.0DomainNote=ABC transmembrane type-2
TgeneABCG8chr2:44445676chr2:44071646ENST0000027228601347_31321.0674.0DomainABC transporter
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013438_44721.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013469_49721.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013519_52721.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013549_55521.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013577_63921.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013661_67321.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013438_44721.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013469_49721.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013519_52721.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013549_55521.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013577_63921.0674.0Topological domainExtracellular
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013661_67321.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013417_43721.0674.0TransmembraneHelical%3B Name%3D1
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013448_46821.0674.0TransmembraneHelical%3B Name%3D2
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013498_51821.0674.0TransmembraneHelical%3B Name%3D3
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013528_54821.0674.0TransmembraneHelical%3B Name%3D4
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013556_57621.0674.0TransmembraneHelical%3B Name%3D5
TgeneABCG8chr2:44445676chr2:44071645ENST00000272286013640_66021.0674.0TransmembraneHelical%3B Name%3D6
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013417_43721.0674.0TransmembraneHelical%3B Name%3D1
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013448_46821.0674.0TransmembraneHelical%3B Name%3D2
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013498_51821.0674.0TransmembraneHelical%3B Name%3D3
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013528_54821.0674.0TransmembraneHelical%3B Name%3D4
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013556_57621.0674.0TransmembraneHelical%3B Name%3D5
TgeneABCG8chr2:44445676chr2:44071646ENST00000272286013640_66021.0674.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPM1Bchr2:44445676chr2:44071645ENST00000345249+4523_29591.0193.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071645ENST00000409895+1323_2950328.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071646ENST00000345249+4523_29591.0193.0DomainPPM-type phosphatase
HgenePPM1Bchr2:44445676chr2:44071646ENST00000409895+1323_2950328.0DomainPPM-type phosphatase
TgeneABCG8chr2:44445676chr2:44071645ENST000002722860131_41621.0674.0Topological domainCytoplasmic
TgeneABCG8chr2:44445676chr2:44071646ENST000002722860131_41621.0674.0Topological domainCytoplasmic


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Fusion Gene Sequence for PPM1B-ABCG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000409432_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000409432_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

--------------------------------------------------------------
>In-frame_ENST00000282412_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000282412_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

--------------------------------------------------------------
>In-frame_ENST00000378551_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000378551_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

--------------------------------------------------------------
>In-frame_ENST00000345249_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(transcript)=3165nt_BP=653nt
AAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCTGCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGT
TCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGGCCGAATCGGCAACGGCGCTAGGGTGGAGAGAAG
GCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGGCGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGC
TGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAGCGAGGCGCCCTAGACATCTTCTCCCTCCCTTGC
CTCAGGGAAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAG
AGTTGGATAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCA
TCTTGTCTGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGA
ATCCACATAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGC
CCAACACCCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGC
CCTGGACATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCA
TAGGGAGCTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGA
TCAATGGGCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGC
GAGAGACCTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGG
AGCTGCGGCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTG
GGGTGCAGCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGA
CCTTGTCCAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCC
TCCTGATGACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCT
ACAGCAATCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGT
CACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTG
TGGAAAGCAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCC
GTCGTCAGATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCC
TCTATTTTGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCA
TTCTGGATGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCT
TTGCCAAGATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAG
GCCTCCAGCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCC
CCACCTTCCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGT
GGACAGTGCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATA
AAATGCCTCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCT
ACCTCATCGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGT
GATTCACGCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGT
GAGGACAATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGA
CAGTCGAAAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTA
TTTCCTTTTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTG
TTGGAACCTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATAC
AGAAAGTGACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAA

>In-frame_ENST00000345249_ENST00000272286_TCGA-NJ-A4YF-01A_PPM1B_chr2_44445676_+_ABCG8_chr2_44071646_length(amino acids)=751AA_start in transcript=356_stop in transcript=2611
MPQGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSR
LNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLA
IIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVI
AELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDL
VLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDT
CVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFN
VILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAAL
LPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYA

--------------------------------------------------------------
>In-frame_ENST00000409432_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000409432_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

--------------------------------------------------------------
>In-frame_ENST00000282412_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000282412_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

--------------------------------------------------------------
>In-frame_ENST00000378551_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(transcript)=4058nt_BP=1546nt
AAAAGGAGCCGAGCGGCTTCTGCTCAATGGCGGAAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCT
GCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGTTCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGG
CCGAATCGGCAACGGCGCTAGGGTGGAGAGAAGGCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGG
CGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGCTGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAG
CGAGGCGCCCTAGACATCTTCTCCCTCCCTTGCCTCAGATTTATTGCTAAACATGGGTGCATTTTTGGATAAACCCAAAACTGAAAAACA
TAATGCTCATGGTGCTGGGAATGGTTTACGTTATGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCACACACAGCTGT
TGTAGGTATTCCTCACGGCTTGGAAGACTGGTCATTTTTTGCAGTTTATGATGGTCATGCTGGATCCCGAGTGGCAAATTACTGCTCAAC
ACATTTATTAGAACACATCACTACTAACGAAGACTTTAGGGCAGCTGGAAAATCAGGATCTGCTCTTGAGCTTTCAGTGGAAAATGTTAA
GAATGGTATCAGAACTGGATTTTTGAAAATTGATGAATACATGCGTAACTTTTCAGACCTCAGAAACGGGATGGACAGGAGTGGTTCAAC
TGCAGTGGGAGTTATGATTTCACCTAAGCATATCTACTTTATCAACTGTGGTGATTCACGTGCTGTTCTGTATAGGAATGGACAAGTCTG
CTTTTCTACCCAGGATCACAAACCTTGCAATCCAAGGGAAAAGGAGCGAATCCAAAATGCAGGAGGCAGCGTGATGATACAACGTGTTAA
TGGTTCATTAGCAGTATCTCGTGCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTTTCTCCAGA
GCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTGGCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGA
GCTCTGTGAATATGTTAAATCTAGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTACACAAGGG
AAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAGAGTTGGA
TAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCATCTTGTC
TGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGAATCCACA
TAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGCCCAACAC
CCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGAC
ATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCATAGGGAG
CTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGG
GCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGCGAGAGAC
CTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCG
GCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTGGGGTGCA
GCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTC
CAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCCTCCTGAT
GACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAA
TCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGTCACTCGC
AGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAG
CAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGTCGTCA
GATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTT
TGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCATTCTGGA
TGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAA
GATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAGGCCTCCA
GCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTT
CCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGTGGACAGT
GCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCC
TCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCTACCTCAT
CGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCAC
GCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGTGAGGACA
ATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGA
AAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTATTTCCTT
TTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAAC
CTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATACAGAAAGT
GACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTG

>In-frame_ENST00000378551_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(amino acids)=1033AA_start in transcript=403_stop in transcript=3504
MLNMGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA
AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREK
ERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLA
GKRNVIEAVYSRLNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQN
LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH
QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAA
LLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKIL

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>In-frame_ENST00000345249_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(transcript)=3165nt_BP=653nt
AAAAGCCGCCGGTGCTCTGACGGCCTCGTTCCCCTAGCAGTTGCGGGGGAGTTTCCTGCCGGCGCGGCTGGAGTCTCTGATTCTCAGGGT
TCGGTGGTTGGAAGATGCTCCAGAGAGACGAGGCTGCGGCGGAGGAGGTGGCGGCGGCCGAATCGGCAACGGCGCTAGGGTGGAGAGAAG
GCGGCATCGGCGGCGGCGGCGGCGTGAGGGGCCGGGCGGTGTAAACAGCCCCGGAGGCGGCGGTCGAGACCCCGAGGGGGAAGCGGCGGC
TGAGTCAGGGTCGCGCCTCCGTTGGAAACTTGGGCTGAGTACCGCGGCGGGCGCGAGCGAGGCGCCCTAGACATCTTCTCCCTCCCTTGC
CTCAGGGAAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAGGTCTCAGATGAAGCGGTGAAAAAAGATTCAG
AGTTGGATAAGCACTTGGAATCACGGGTTGAAGAGATTATGGAGAAGTCTGGCGAGGAAGGAATGCCTGATCTTGCCCATGTCATGCGCA
TCTTGTCTGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGTAATGTTATTGAAGCTGTTTATAGTAGACTGA
ATCCACATAGAGAAAGTGATGGGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGCCAGC
CCAACACCCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCTCAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGC
CCTGGACATCTCCCAGCTGCCAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCCATCA
TAGGGAGCTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGA
TCAATGGGCAGCCCAGCTCGCCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACTGTGC
GAGAGACCTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGG
AGCTGCGGCTTAGGCAGTGCGCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGAGTCAGCATTG
GGGTGCAGCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACCTCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGA
CCTTGTCCAGGCTGGCCAAAGGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTTGATCTGGTCC
TCCTGATGACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATGGTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCT
ACAGCAATCCTGCTGACTTCTATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAGAAGGCTCAGT
CACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTG
TGGAAAGCAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCC
GTCGTCAGATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCATGGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCC
TCTATTTTGGCCATGGGAGCATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCTTTCAACGTCA
TTCTGGATGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTATGAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCT
TTGCCAAGATCCTCGGGGAGCTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAACCTGAGGCCAG
GCCTCCAGCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTCTGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCC
CCACCTTCCACATGGCCTCCTTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTGAGCAGCCTGT
GGACAGTGCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTTGAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATA
AAATGCCTCTCGGGAACCTCACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTCTACGCCATCT
ACCTCATCGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGT
GATTCACGCCAGACGTCTGCCCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCCTGGGGACAGT
GAGGACAATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGCAGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGA
CAGTCGAAAGGGATTTCTGCTCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGTTGCTAATTTA
TTTCCTTTTGATATGCATTTATATAGGCAACTCGATATAGGATGGGAGCAAACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTG
TTGGAACCTGGAGGGAACAATAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCACCATCAATAC
AGAAAGTGACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGTGGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAA

>In-frame_ENST00000345249_ENST00000272286_TCGA-NJ-A4YF_PPM1B_chr2_44445676_+_ABCG8_chr2_44071645_length(amino acids)=751AA_start in transcript=356_stop in transcript=2611
MPQGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSR
LNPHRESDGGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLA
IIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVI
AELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDL
VLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDT
CVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFN
VILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAAL
LPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYA

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Fusion Gene PPI Analysis for PPM1B-ABCG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPM1B-ABCG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPM1B-ABCG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPM1BC0151744Myocardial Ischemia1CTD_human
HgenePPM1BC1848030Hypotonia-Cystinuria Syndrome1CTD_human
HgenePPM1BC43045372p21 microdeletion syndrome1ORPHANET
TgeneABCG8C0342907Sitosterolemia5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneABCG8C0005818Blood Platelet Disorders1GENOMICS_ENGLAND
TgeneABCG8C0009438Common Bile Duct Calculi1CTD_human
TgeneABCG8C0010054Coronary Arteriosclerosis1CTD_human
TgeneABCG8C0020443Hypercholesterolemia1GENOMICS_ENGLAND
TgeneABCG8C0020445Hypercholesterolemia, Familial1GENOMICS_ENGLAND
TgeneABCG8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCG8C0242216Biliary calculi1CTD_human
TgeneABCG8C0268318Cholestasis of pregnancy1GENOMICS_ENGLAND
TgeneABCG8C0342881Familial hypercholesterolemia - homozygous1ORPHANET
TgeneABCG8C1956346Coronary Artery Disease1CTD_human
TgeneABCG8C2749759Macrothrombocytopenia-Stomatocytosis, Mediterranean1CTD_human