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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPME1-TENM4 (FusionGDB2 ID:67268)

Fusion Gene Summary for PPME1-TENM4

check button Fusion gene summary
Fusion gene informationFusion gene name: PPME1-TENM4
Fusion gene ID: 67268
HgeneTgene
Gene symbol

PPME1

TENM4

Gene ID

51400

26011

Gene nameprotein phosphatase methylesterase 1teneurin transmembrane protein 4
SynonymsABDH19|PME-1Doc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4
Cytomap

11q13.4

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase methylesterase 1testicular secretory protein Li 39teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000328257, ENST00000398427, 
ENST00000542710, ENST00000543525, 
ENST00000278550, ENST00000533038, 
Fusion gene scores* DoF score8 X 3 X 5=12017 X 17 X 9=2601
# samples 818
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2601*10)=-3.85299758761332
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPME1 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPME1(73915490)-TENM4(78383374), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPME1

GO:0006482

protein demethylation

10318862


check buttonFusion gene breakpoints across PPME1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TENM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A4SB-01APPME1chr11

73915490

+TENM4chr11

78383374

-
ChimerDB4BRCATCGA-A7-A4SB-01APPME1chr11

73915490

+TENM4chr11

78383374

-


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Fusion Gene ORF analysis for PPME1-TENM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328257ENST00000278550PPME1chr11

73915490

+TENM4chr11

78383374

-
5CDS-intronENST00000328257ENST00000533038PPME1chr11

73915490

+TENM4chr11

78383374

-
In-frameENST00000398427ENST00000278550PPME1chr11

73915490

+TENM4chr11

78383374

-
5CDS-intronENST00000398427ENST00000533038PPME1chr11

73915490

+TENM4chr11

78383374

-
3UTR-3CDSENST00000542710ENST00000278550PPME1chr11

73915490

+TENM4chr11

78383374

-
3UTR-intronENST00000542710ENST00000533038PPME1chr11

73915490

+TENM4chr11

78383374

-
intron-3CDSENST00000543525ENST00000278550PPME1chr11

73915490

+TENM4chr11

78383374

-
intron-intronENST00000543525ENST00000533038PPME1chr11

73915490

+TENM4chr11

78383374

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328257PPME1chr1173915490+ENST00000278550TENM4chr1178383374-865261132334241033
ENST00000398427PPME1chr1173915490+ENST00000278550TENM4chr1178383374-842938810032011033

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328257ENST00000278550PPME1chr1173915490+TENM4chr1178383374-0.0005018120.9994981
ENST00000398427ENST00000278550PPME1chr1173915490+TENM4chr1178383374-0.0004296990.9995703

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Fusion Genomic Features for PPME1-TENM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPME1-TENM4


check button Go to

FGviewer for the breakpoints of chr11:73915490-chr11:78383374

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341887_19061832.02770.0RepeatNote=YD 5
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341928_19461832.02770.0RepeatNote=YD 6
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341947_19671832.02770.0RepeatNote=YD 7
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341974_19911832.02770.0RepeatNote=YD 8
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341992_20131832.02770.0RepeatNote=YD 9
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342014_20311832.02770.0RepeatNote=YD 10
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342034_20541832.02770.0RepeatNote=YD 11
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342057_20771832.02770.0RepeatNote=YD 12
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342085_21041832.02770.0RepeatNote=YD 13
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342110_21271832.02770.0RepeatNote=YD 14
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342128_21541832.02770.0RepeatNote=YD 15
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342156_21691832.02770.0RepeatNote=YD 16
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342170_21931832.02770.0RepeatNote=YD 17
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342196_22161832.02770.0RepeatNote=YD 18
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342217_22371832.02770.0RepeatNote=YD 19
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342239_22591832.02770.0RepeatNote=YD 20
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342271_22911832.02770.0RepeatNote=YD 21
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342293_23131832.02770.0RepeatNote=YD 22
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029342339_23801832.02770.0RepeatNote=YD 23

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPME1chr11:73915490chr11:78383374ENST00000328257+314256_26396.0387.0Compositional biasNote=Poly-Glu
HgenePPME1chr11:73915490chr11:78383374ENST00000543525+18256_2630200.0Compositional biasNote=Poly-Glu
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934179_1821832.02770.0Compositional biasNote=Poly-Pro
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341_3411832.02770.0DomainTeneurin N-terminal
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934562_5931832.02770.0DomainEGF-like 1
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934594_6241832.02770.0DomainEGF-like 2
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934626_6581832.02770.0DomainEGF-like 3
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934659_6901832.02770.0DomainEGF-like 4
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934692_7251832.02770.0DomainEGF-like 5
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934726_7571832.02770.0DomainEGF-like 6
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934758_7871832.02770.0DomainEGF-like 7
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934788_8311832.02770.0DomainEGF-like 8
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341216_12591832.02770.0RepeatNote=NHL 1
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341264_13081832.02770.0RepeatNote=NHL 2
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341334_13781832.02770.0RepeatNote=NHL 3
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341393_14441832.02770.0RepeatNote=NHL 4
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341523_15661832.02770.0RepeatNote=NHL 5
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341576_15951832.02770.0RepeatNote=YD 1
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341612_16321832.02770.0RepeatNote=YD 2
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341675_16941832.02770.0RepeatNote=YD 3
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341695_17171832.02770.0RepeatNote=YD 4
TgeneTENM4chr11:73915490chr11:78383374ENST0000027855029341_3451832.02770.0Topological domainCytoplasmic
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934367_27691832.02770.0Topological domainExtracellular
TgeneTENM4chr11:73915490chr11:78383374ENST000002785502934346_3661832.02770.0TransmembraneHelical


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Fusion Gene Sequence for PPME1-TENM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000328257_ENST00000278550_TCGA-A7-A4SB-01A_PPME1_chr11_73915490_+_TENM4_chr11_78383374_length(transcript)=8652nt_BP=611nt
ATTGCGCAGGGTGCATTGCCCTGAAGAGCGCTCCTCCTTCCGGTGAAAGTCGTCGGGTTCCCAGCCGGGAGTCTGCGGAGTTCTCATACT
CTGTTACCCAGCTTCCTTTGTATGAGTGCTGTTGCGCACTTCCGGTGGAAGCGCTGAAGCGAGTGGGTGGAGTTTACGGAGCCGGTGGGC
GGTAGGCGGTGCTACGGGTAGCTGGGTGCTGTCCAAAGGCGACAGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAA
CGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAGCCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCC
TTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAGCGGAGCCAAGATGCGAATGGGCCCTGGAAGAAAGCGGGACTTTTCCC
CTGTTCCTTGGAGTCAGTATTTTGAGTCCATGGAAGATGTAGAAGTAGAGAATGAAACTGGCAAGGATACTTTTCGAGTCTACAAGAGTG
GTTCAGAGGGTCCAGTCCTGCTCCTTCTGCATGGAGGAGGTCATTCTGCCCTTTCTTGGGCTGTGTTCACGGTTCACAACCGAAATCTCC
TATCTCTGGACTTTGATCGCGTAACACGCACAGAGAAGATCTATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGG
GGCGGCCCAGCCTCTGGTCACCCAGCAGCAGGCTGAATGGTGTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGG
GCATCATGTCTGAAAGAATGGAATACGACCAGGCGGGCCGCATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACT
TAGAGAAGTCCATGGTGCTGCTACTACACAGCCAGAGGCAGTATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGC
CCAACGTGGCGCGGCAGACACTAGAGACCATCCGCTCAGTGGGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCA
TACAGGACTTCACTGAGGATGGGCACCTCCTTCACACCTTCTACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAA
AGCTGGCAGAGACGCTCTATGACACCACCAAGGTCAGTTTCACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATG
AGGGCTTCACCTGCACCATCCGCTACCGTCAGATTGGGCCCCTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACG
CCCGTTTTGACTACAACTATGACAACAGCTTCCGGGTGACCAGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATC
GCTATGATGATGTGTCAGGCAAGACAGAGCAGTTTGGGAAGTTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCA
TGACCCACACCAAGCATTTTGATGCATATGGCAGGATGAAGGAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCC
AGTATGATAACATGGGGCGAGTAGTGAAGAAGGAGCTGAAGGTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTG
ACGGCCAGCTGCAGACAGTCTCCATCAATGACAAGCCACTCTGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTG
GGAACAGTGCACGGCTCACACCACTACGGTATGACATCCGCGACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATG
GCTTCCTGAGGCAGCGGGGCGGTGATATCTTTGAGTACAACTCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTG
TCAGGTACCGCTACGATGGCCTGGGGCGGCGCGTGTCCAGCAAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCA
ACCCCACCAAGGTCACCCACCTGTACAACCACTCCAGCTCTGAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGG
AGCTGAGCAGTGGTGATGAGTTTTACATAGCTTGTGACAACATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGC
AAATCCTGTACACAGCCTATGGGGAGATCTACATGGATACCAACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATC
CACTCACCAAGCTTGTCCACATGGGCCGGCGAGATTATGATGTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACC
TTAGTAGCAGCAACGTCATGCCTTTTAATCTCTATATGTTCAAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGA
CAGATGTTAACAGCTGGCTGCTCACCTTTGGATTCCAGCTACACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAAC
CCTCCTACGAGCTCATCCACACACAGATGAAAACGCAGGAGTGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGC
AGCTCAAGGCCTTTGTCACCTTAGAACGGTTTGACCAGCTCTATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGT
TTGCATCCAGCGGCTCAGTCTTTGGCAAGGGGGTCAAGTTTGCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATG
AGGATGGGCGAAGGGTTGCTGCCATCTTGAACCATGCCCACTACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACT
TTGTGAAACCAGGACCTTCAGAAGGTGACCTGGCCATCCTGGGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTG
TGTCCCAGATCAACACAGTACTTAATGGCAGGACTAGACGCTACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCT
ACGGGACAACGTTGGATGAGGAGAAGGCACGGGTCCTGGAGCTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGA
GACTGCGGGAAGGGGAGGAAGGCCTGCGGGCCTGGACAGAGGGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACG
GCTTTTTCGTGATCTCTGTCGAGCAGTACCCAGAACTGTCAGACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGA
GGTGACAGAGAGGACCAAGGACTTCTTGCCAAAGACAGCTACTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGAT
TTTTTAACAAGTGCAGAAACAAAAAGATACTGGTTGCATTGTAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGC
CTTCGCACATTTTTTGCAAAGAACAGAAGGTATTTTTTTCTGTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCT
TGAGGATTTTTCCCTTGTCGTTTGGGGTATGTATCTCCTCTCTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAG
TGTGATGTGGGACATGAATGTCTGTGCTAACTTGTCTCATGTGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGA
TGGGCCAGTACAACACCCCTTCCAAGGGGGCCTGGGAGGAGGGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGT
GGATTTCTTCTCACCTTGTTCTCTGCCTCCAGAGGATCATAGATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTT
TTTTAAGCTGCCCCAAACTCCTGTTCAAGCTTTCTATTTTGATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCG
GTGCCACCCCCATGCTGGGATAGAGAAAGTGTCTCCCAGGTCCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCC
TCCCGGGAGGGAAAGCACCCAGGATGCCTGTGATTGGTTGGTCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATG
TGAGAACGAGCACTGCACAGCAAGCCTTCAATGTGGGCACCATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGG
CGAGGGCACCAGCCTGCCTTCCGAGGCAAAGCCCTCTCTCTATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACG
TAGGAATGTGGAGGGAGGTGCTTGGTGGCCTTTGATTCTGGAAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTA
AGCATCCTTCTAACCAGTTCCCAAAGTCCCATCTGCCTCCATGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGA
AATTCCTGAAGTTCTGAAACAGCTTCCCCTCTAGAGAAGCCCACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATG
TGGTGTGGCCTGCCCATATCATACAACCCCACCAGGAGCAGGGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCAT
GATTCCTGTGAAGAACTGTGCCTGTGTCGTCAGGGAGAGGCCTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCA
AGCTGAGGCAGCAGCCAGCAGGCTGGGGGAGCAGTGAGGGCAGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATT
CCTGGTTCATCCGCCTAATTACCATTGTCATTACCACTCACAGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCT
GGGCTTCTTAGAAAATGGAACTTTTATGGGTTACATTTACATTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACC
TTGTTGGACTGATAAGCTCATGGCACCTCTATAGCCTTACTCACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTG
ACTGCATGAGGATCGGAGCAGCATGTAGTCTGGGTTCTGCCTGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTT
AACGTCATCCCACTGGGATTAGAGGATGTGTTTCGCTAAGTGCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTT
TGGCCTGCTTGTCCACTGGTTGCCCATTGCCCCTGGATCCAGAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGC
ATGAGCTGGAGATGGGGGCTCCCATCTGGCAGGATCATTCTTGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTC
CAGAAGGGACTTACGCCTCTCAAAATGTACTCTTCATACCAAGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGG
CTGCCTGACATCAGTGAAGACCTGCTGGGGATGTCTGCTCAGAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCC
CCCACGCCCTGTCCCTCCTCCACAGCCCCCTCCCCAAAGGAATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATT
TATTTTTTTCTTTCTTTCTTTTTTTTTTCATAGAGATGGGGTCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATC
CACCTTGGCCTCCTGAAGTGCTGGGGTTACAGGTGTGAGCCACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTC
CTGTGCTACATACCACCACAGCAGCCCAGCTTCTGTGGGGAGAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGC
ACAGGCAGTGTTATGCGCCTCACTGCCACATTGGTGCTGTTGTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCAT
TTGGGCTGCAGGTGACTCAGTGACTCCCTCCTCAAGCTGTCCTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAA
GGCCTAACCCTGTGCCTATGTAATAGGCTCCAAGCATCGACTCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGT
TCATTCGATAGAGTGACCAGGCCTCCCTCACCTGCCCAGGTGTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAA
CTGGTCCTACATCCTCAGCCCCTCTGCCACCACCTTAAATAGGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCT
TTTTATCCCACCCCCCCACACCCCAAACAGACATTGCTGGAGGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTC
AGCCTCTGACCCTCATCTCTCAGAATTGTTGGCTGAGAATTAACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATT
GGAAACGATCCCTAAGAAACTGACTGAGGGTGAGAATGGCCAGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCA
AGGCAGACTGGGCAGTGTTTTGTAGACACAGAACAAAGAATCAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAA
AGTATCACCTTTATAGATGGCAGGGATTTCCATTATGCAAATGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTT
GCAGTCTTGTATTTGTGGTGGCCATGTGGTGAGGGCGGTGATGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGG
TGTCAGGCTTGGGGATTTGAGCATCCACTGCTCAAAGTCCAGGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCT
GGCCCGGGGACACATCTCCTGAGGGATCCCAGAAAGAACCCAGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATT
TAAGGCACATCATTCCCAGCTAGGTTTATACACTTGTCTATATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCC
CTTTCATTTAACCTTCCAAAAACAGCAAACTCATTTTAAAGACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCAC
ATTCACAAAAACCATCCTTGTGTACTTGACTGCCCTAGACAGTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGA
AGGCCCAGGCGAGGGCCAATGTTGTGTTTCTTACCCCCTCTGGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAAT
GTGATTTATTCTGAGGGCGAACAGCCAAGGGAGGACTAGTCTGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGC
GGTGCCCCAGCAGCCCTGGATTCACCCAACACCAGAATCCCACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTT
CGGCAAAAGGAGTCTGTACCAAGCTGCTTCTGGATGACCAACACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTG
GAACTAATTTTGAGAAGTTTTTTTCTCAACACTTTTGTGTTTCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAA
TGCAGATGTAGATACCTTCTAGAAAAAAAAAAGCATAAAAACAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTAT
TTTGTGTTTACAGGTGTCTGGTGGCCTTTGCTTGGAGATAAAGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACT
TCCCTGCTGGCTGCTATCAGGATGACCTGGGAGAGGACTCAGTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTC
AAGAGGGATGTCCAGAGGGTCTCTAAGACCCTGAAGCTTGACTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCAC
TAGTGCAGCGTGGCTCCCCATCCCACTGCTGCCCTCGTTCAGGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGC
CTTGCTCCACCACTGGGCACACAGAGTCATCCACCATGCCACTGCCTTCCACAAGGGATGTGAGCCGTTGCACTTTAAAAATAAATGACT

>In-frame_ENST00000328257_ENST00000278550_TCGA-A7-A4SB-01A_PPME1_chr11_73915490_+_TENM4_chr11_78383374_length(amino acids)=1033AA_start in transcript=323_stop in transcript=3424
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSAL
SWAVFTVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSR
IFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGT
GRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQA
VINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPY
ANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGL
LIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTP
LAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNN
PISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGST
ITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSG
GRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQ

--------------------------------------------------------------
>In-frame_ENST00000398427_ENST00000278550_TCGA-A7-A4SB-01A_PPME1_chr11_73915490_+_TENM4_chr11_78383374_length(transcript)=8429nt_BP=388nt
AGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAACGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAG
CCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCCTTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAG
CGGAGCCAAGATGCGAATGGGCCCTGGAAGAAAGCGGGACTTTTCCCCTGTTCCTTGGAGTCAGTATTTTGAGTCCATGGAAGATGTAGA
AGTAGAGAATGAAACTGGCAAGGATACTTTTCGAGTCTACAAGAGTGGTTCAGAGGGTCCAGTCCTGCTCCTTCTGCATGGAGGAGGTCA
TTCTGCCCTTTCTTGGGCTGTGTTCACGGTTCACAACCGAAATCTCCTATCTCTGGACTTTGATCGCGTAACACGCACAGAGAAGATCTA
TGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTCTGGTCACCCAGCAGCAGGCTGAATGGTGT
CAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAAAGAATGGAATACGACCAGGCGGGCCGCAT
CACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATGGTGCTGCTACTACACAGCCAGAGGCAGTA
TATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGGCAGACACTAGAGACCATCCGCTCAGTGGG
CTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACTGAGGATGGGCACCTCCTTCACACCTTCTA
CCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACGCTCTATGACACCACCAAGGTCAGTTTCAC
CTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGCACCATCCGCTACCGTCAGATTGGGCCCCT
GATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTACAACTATGACAACAGCTTCCGGGTGACCAG
CATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTGTCAGGCAAGACAGAGCAGTTTGGGAAGTT
TGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAGCATTTTGATGCATATGGCAGGATGAAGGA
AGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATGGGGCGAGTAGTGAAGAAGGAGCTGAAGGT
AGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAGACAGTCTCCATCAATGACAAGCCACTCTG
GCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGGCTCACACCACTACGGTATGACATCCGCGA
CCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAGCGGGGCGGTGATATCTTTGAGTACAACTC
AGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTACGATGGCCTGGGGCGGCGCGTGTCCAGCAA
GAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTCACCCACCTGTACAACCACTCCAGCTCTGA
GATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGTGATGAGTTTTACATAGCTTGTGACAACAT
CGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACAGCCTATGGGGAGATCTACATGGATACCAA
CCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTTGTCCACATGGGCCGGCGAGATTATGATGT
GCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAACGTCATGCCTTTTAATCTCTATATGTTCAA
AAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGCTGGCTGCTCACCTTTGGATTCCAGCTACA
CAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTCATCCACACACAGATGAAAACGCAGGAGTG
GGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTTGTCACCTTAGAACGGTTTGACCAGCTCTA
TGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGCTCAGTCTTTGGCAAGGGGGTCAAGTTTGC
CTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGGGTTGCTGCCATCTTGAACCATGCCCACTA
CCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGACCTTCAGAAGGTGACCTGGCCATCCTGGG
CCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAACACAGTACTTAATGGCAGGACTAGACGCTA
CACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTGGATGAGGAGAAGGCACGGGTCCTGGAGCT
GGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGGGAGGAAGGCCTGCGGGCCTGGACAGAGGG
GGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATCTCTGTCGAGCAGTACCCAGAACTGTCAGA
CAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGACCAAGGACTTCTTGCCAAAGACAGCTACT
CTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGCAGAAACAAAAAGATACTGGTTGCATTGTA
ACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTTTGCAAAGAACAGAAGGTATTTTTTTCTGT
AGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCCTTGTCGTTTGGGGTATGTATCTCCTCTCT
GAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACATGAATGTCTGTGCTAACTTGTCTCATGTG
CAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAACACCCCTTCCAAGGGGGCCTGGGAGGAGGG
TCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCACCTTGTTCTCTGCCTCCAGAGGATCATAGA
TGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCCAAACTCCTGTTCAAGCTTTCTATTTTGAT
GCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATGCTGGGATAGAGAAAGTGTCTCCCAGGTCC
TTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAAGCACCCAGGATGCCTGTGATTGGTTGGTC
CTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACTGCACAGCAAGCCTTCAATGTGGGCACCAT
GTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCCTGCCTTCCGAGGCAAAGCCCTCTCTCTAT
GACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGGGAGGTGCTTGGTGGCCTTTGATTCTGGAA
AAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAACCAGTTCCCAAAGTCCCATCTGCCTCCATG
TACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTCTGAAACAGCTTCCCCTCTAGAGAAGCCCA
CCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCCCATATCATACAACCCCACCAGGAGCAGGG
CAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGAACTGTGCCTGTGTCGTCAGGGAGAGGCCT
GAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAGCCAGCAGGCTGGGGGAGCAGTGAGGGCAG
GGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGCCTAATTACCATTGTCATTACCACTCACAG
GAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAAATGGAACTTTTATGGGTTACATTTACATT
AAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATAAGCTCATGGCACCTCTATAGCCTTACTCA
CATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATCGGAGCAGCATGTAGTCTGGGTTCTGCCTG
GCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACTGGGATTAGAGGATGTGTTTCGCTAAGTGC
TCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCCACTGGTTGCCCATTGCCCCTGGATCCAGA
GCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATGGGGGCTCCCATCTGGCAGGATCATTCTTG
GATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTACGCCTCTCAAAATGTACTCTTCATACCAAG
GGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAGTGAAGACCTGCTGGGGATGTCTGCTCAGA
GGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCCCTCCTCCACAGCCCCCTCCCCAAAGGAAT
AGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTCTTTCTTTTTTTTTTCATAGAGATGGGGTC
TCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCTGAAGTGCTGGGGTTACAGGTGTGAGCCAC
TGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACCACCACAGCAGCCCAGCTTCTGTGGGGAGA
GAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTATGCGCCTCACTGCCACATTGGTGCTGTTGT
ATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTGACTCAGTGACTCCCTCCTCAAGCTGTCCT
CCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTGCCTATGTAATAGGCTCCAAGCATCGACTC
CCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGTGACCAGGCCTCCCTCACCTGCCCAGGTGT
ATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCCTCAGCCCCTCTGCCACCACCTTAAATAGG
ACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCCCCCACACCCCAAACAGACATTGCTGGAGG
GCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTCATCTCTCAGAATTGTTGGCTGAGAATTAA
CCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTAAGAAACTGACTGAGGGTGAGAATGGCCAG
GAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCAGTGTTTTGTAGACACAGAACAAAGAATCA
GAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTATAGATGGCAGGGATTTCCATTATGCAAATG
GAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTTGTGGTGGCCATGTGGTGAGGGCGGTGATG
CTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGGATTTGAGCATCCACTGCTCAAAGTCCAGG
CTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACATCTCCTGAGGGATCCCAGAAAGAACCCAG
TCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATTCCCAGCTAGGTTTATACACTTGTCTATAT
TTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCTTCCAAAAACAGCAAACTCATTTTAAAGAC
TCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCATCCTTGTGTACTTGACTGCCCTAGACAGT
GGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGGGCCAATGTTGTGTTTCTTACCCCCTCTGG
AATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGAGGGCGAACAGCCAAGGGAGGACTAGTCTG
GAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGCCCTGGATTCACCCAACACCAGAATCCCAC
TTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTCTGTACCAAGCTGCTTCTGGATGACCAACA
CTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAGAAGTTTTTTTCTCAACACTTTTGTGTTTC
TAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATACCTTCTAGAAAAAAAAAAGCATAAAAACA
AAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGGTGTCTGGTGGCCTTTGCTTGGAGATAAAG
GCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGCTATCAGGATGACCTGGGAGAGGACTCAGT
CCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCAGAGGGTCTCTAAGACCCTGAAGCTTGACT
TTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGCTCCCCATCCCACTGCTGCCCTCGTTCAGG
GACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACTGGGCACACAGAGTCATCCACCATGCCACT

>In-frame_ENST00000398427_ENST00000278550_TCGA-A7-A4SB-01A_PPME1_chr11_73915490_+_TENM4_chr11_78383374_length(amino acids)=1033AA_start in transcript=100_stop in transcript=3201
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSAL
SWAVFTVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSR
IFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGT
GRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQA
VINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPY
ANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGL
LIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTP
LAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNN
PISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGST
ITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSG
GRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPME1-TENM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPME1-TENM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPME1-TENM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTENM4C0005586Bipolar Disorder1CTD_human
TgeneTENM4C0005587Depression, Bipolar1CTD_human
TgeneTENM4C0024713Manic Disorder1CTD_human
TgeneTENM4C0033975Psychotic Disorders1PSYGENET
TgeneTENM4C0036341Schizophrenia1PSYGENET
TgeneTENM4C0338831Manic1CTD_human
TgeneTENM4C0349204Nonorganic psychosis1PSYGENET
TgeneTENM4C4225223TREMOR, HEREDITARY ESSENTIAL, 51CTD_human;UNIPROT