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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R13B-L2HGDH (FusionGDB2 ID:67388)

Fusion Gene Summary for PPP1R13B-L2HGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R13B-L2HGDH
Fusion gene ID: 67388
HgeneTgene
Gene symbol

PPP1R13B

L2HGDH

Gene ID

23368

79944

Gene nameprotein phosphatase 1 regulatory subunit 13BL-2-hydroxyglutarate dehydrogenase
SynonymsASPP1|p53BP2-like|p85C14orf160|L2HGA
Cytomap

14q32.33

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionapoptosis-stimulating of p53 protein 1apoptosis-stimulating protein of p53, 1protein phosphatase 1, regulatory (inhibitor) subunit 13BL-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin
Modification date2020031320200313
UniProtAcc.

Q9H9P8

Ensembl transtripts involved in fusion geneENST00000202556, ENST00000423488, 
ENST00000555391, 		ENST00000261699, 
ENST00000267436, ENST00000421284, 
ENST00000555423, ENST00000555610, 
ENST00000556393, 
Fusion gene scores* DoF score16 X 10 X 10=160011 X 9 X 6=594
# samples 2213
** MAII scorelog2(22/1600*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R13B [Title/Abstract] AND L2HGDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R13B(104313636)-L2HGDH(50750751), # samples:3
Anticipated loss of major functional domain due to fusion event.PPP1R13B-L2HGDH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP1R13B-L2HGDH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R13B

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11684014

TgeneL2HGDH

GO:0044267

cellular protein metabolic process

16005139


check buttonFusion gene breakpoints across PPP1R13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across L2HGDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FH-01APPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
ChimerDB4ESCATCGA-JY-A6FHPPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
ChimerDB4ESCATCGA-JY-A6FHPPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
ChimerDB4ESCATCGA-JY-A6FHPPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
ChimerDB4ESCATCGA-JY-A6FH-01APPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-


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Fusion Gene ORF analysis for PPP1R13B-L2HGDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000202556ENST00000261699PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000267436PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000421284PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000555423PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
Frame-shiftENST00000202556ENST00000555610PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
5CDS-intronENST00000202556ENST00000556393PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000261699PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000267436PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000421284PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000555423PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000555610PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-intronENST00000423488ENST00000556393PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000261699PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000267436PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000421284PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000555423PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000555610PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
intron-intronENST00000555391ENST00000556393PPP1R13Bchr14

104313636

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000261699PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000267436PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000421284PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
In-frameENST00000202556ENST00000555423PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
Frame-shiftENST00000202556ENST00000555610PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
5CDS-intronENST00000202556ENST00000556393PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000261699PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000267436PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000421284PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000555423PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000423488ENST00000555610PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-intronENST00000423488ENST00000556393PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000261699PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000267436PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000421284PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000555423PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-3CDSENST00000555391ENST00000555610PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-
intron-intronENST00000555391ENST00000556393PPP1R13Bchr14

104313635

-L2HGDHchr14

50750751

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000202556PPP1R13Bchr14104313636-ENST00000261699L2HGDHchr1450750751-11112922831077264
ENST00000202556PPP1R13Bchr14104313636-ENST00000267436L2HGDHchr1450750751-28002922831143286
ENST00000202556PPP1R13Bchr14104313636-ENST00000421284L2HGDHchr1450750751-16312922831143286
ENST00000202556PPP1R13Bchr14104313636-ENST00000555423L2HGDHchr1450750751-5172923260109
ENST00000202556PPP1R13Bchr14104313635-ENST00000261699L2HGDHchr1450750751-11112922831077264
ENST00000202556PPP1R13Bchr14104313635-ENST00000267436L2HGDHchr1450750751-28002922831143286
ENST00000202556PPP1R13Bchr14104313635-ENST00000421284L2HGDHchr1450750751-16312922831143286
ENST00000202556PPP1R13Bchr14104313635-ENST00000555423L2HGDHchr1450750751-5172923260109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000202556ENST00000261699PPP1R13Bchr14104313636-L2HGDHchr1450750751-0.0015898020.9984102
ENST00000202556ENST00000267436PPP1R13Bchr14104313636-L2HGDHchr1450750751-0.0003606990.9996393
ENST00000202556ENST00000421284PPP1R13Bchr14104313636-L2HGDHchr1450750751-0.0008153770.99918467
ENST00000202556ENST00000555423PPP1R13Bchr14104313636-L2HGDHchr1450750751-0.160159810.83984023
ENST00000202556ENST00000261699PPP1R13Bchr14104313635-L2HGDHchr1450750751-0.0015898020.9984102
ENST00000202556ENST00000267436PPP1R13Bchr14104313635-L2HGDHchr1450750751-0.0003606990.9996393
ENST00000202556ENST00000421284PPP1R13Bchr14104313635-L2HGDHchr1450750751-0.0008153770.99918467
ENST00000202556ENST00000555423PPP1R13Bchr14104313635-L2HGDHchr1450750751-0.160159810.83984023

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Fusion Genomic Features for PPP1R13B-L2HGDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R13B-L2HGDH


check button Go to

FGviewer for the breakpoints of chr14:104313636-chr14:50750751

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.L2HGDH

Q9H9P8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R13Bchr14:104313635chr14:50750751ENST00000202556-117132_2923.01091.0Compositional biasNote=Gln-rich
HgenePPP1R13Bchr14:104313635chr14:50750751ENST00000202556-117428_8603.01091.0Compositional biasNote=Pro-rich
HgenePPP1R13Bchr14:104313636chr14:50750751ENST00000202556-117132_2923.01091.0Compositional biasNote=Gln-rich
HgenePPP1R13Bchr14:104313636chr14:50750751ENST00000202556-117428_8603.01091.0Compositional biasNote=Pro-rich
HgenePPP1R13Bchr14:104313635chr14:50750751ENST00000202556-1171019_10813.01091.0DomainSH3
HgenePPP1R13Bchr14:104313636chr14:50750751ENST00000202556-1171019_10813.01091.0DomainSH3
HgenePPP1R13Bchr14:104313635chr14:50750751ENST00000202556-117920_9523.01091.0RepeatNote=ANK 1
HgenePPP1R13Bchr14:104313635chr14:50750751ENST00000202556-117953_9853.01091.0RepeatNote=ANK 2
HgenePPP1R13Bchr14:104313636chr14:50750751ENST00000202556-117920_9523.01091.0RepeatNote=ANK 1
HgenePPP1R13Bchr14:104313636chr14:50750751ENST00000202556-117953_9853.01091.0RepeatNote=ANK 2


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Fusion Gene Sequence for PPP1R13B-L2HGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000202556_ENST00000261699_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(transcript)=1111nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGCTATGGCAGCAACC
CATGAAAGTGAGTGATAACAACATTTATTGTTTCCTGTGGCGTTGCTTTGCTTTGCTATTGACTGGTAGCGCTTGTAGCTTTAAATAAAT

>In-frame_ENST00000202556_ENST00000261699_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(amino acids)=264AA_start in transcript=283_stop in transcript=1077
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000267436_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(transcript)=2800nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGG
AAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGC
TACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAGCTAGGTATGCACT
GTAATCTTCATGTCAGCAACAAGAATGTACTAATTGCATTCTTTAATTTAAAAAATGGTTTTTAAACTTTAGTTTTTAGGTCAAAGATAA
CCACTGCATTGTTAAAATGATGTAACATAGAAATAATAATTTTCTACAAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAATCTCAGCT
ACTCAGGAGGCTGAGGCAGGAGAATCAATTGAACCGAGCAGACGGAGGTGAGCTGAGAGCTGAGATTGCACCACTGCACTCCAGCCTGGG
TGACAGAGCAAGAAAATAATAATAATAATAATTTTCAAAATGTTAGGCTGGGGGCCGTGGCCAGCACTTTGGGAAGCCAAGGCAGGTAGA
TTGTAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATGGCAAAACCCTGTTTCTACACAAAGTTAGCTGGGTCTGGTGCCTCTGTAGTTC
CAGCTCCTCAGTAGGCTGAGGTGAGAGGATCACTTGAGCCCAGGAGGTCTAGGCTGCAGTGAGCTTATGTTCATGACACTGCATTCCAGG
CTGGATGATAGAGCAAGATCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGGGCAACATAGTGAATGAAACCCCATCTC
TACAAAAAATACAAAAATTAGCTGGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGGATCGCTTGAGCCC
GGGAGATCAAGGCTACAGTGAGCTGTGTTCATGCCACTATACCCCAGCCTGGGCAACAAAGTGAGTCCCTGACTCAAAAAATAAAAACAA
CAACAAAAAATAAATTCCATGCTTATTTACTTTGCGAATAAAGAGGCAAGGTACAGTTTTATCTGTCCGAATCCCTGACTTTTATTTATT
TTTTTTTTCAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTC
CAGCGATTCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGA
CGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAG
GTGCGAGCCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAA
GAGTTTTGGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATA
GACAAGAAAATACATTATATTGTAGGTTACATTCTTTTAATTTTGAAGAGTCACAAAACTCACATTATTTAGAGCAACAATATTTGTATT
TGGAAATTAAAAATTCATGATTTCAAGAAAATACATAAAATTTACATTTTTGAGTAGTTTGAATAAGTTTCTATCTTAATTATAATATTT
GTAGGAAATAACAAAACAAACTCAAAGCCTTTATTATTTCCAGTCTCTTTGTAACTGATGTGGTATGGTATCATCATGAAATCTAAACAG

>In-frame_ENST00000202556_ENST00000267436_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(amino acids)=286AA_start in transcript=283_stop in transcript=1143
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL
IKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSI

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000421284_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(transcript)=1631nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGG
AAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGC
TACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAGCTAGACGGAGTTT
CACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCCAGCGATTCTCTTGCCTCAA
CCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTTGCCATGTTGGC
CAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGTGCGAGCCATCATGCTCAG
CCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAAGAGTTTTGGAGAAAGATGGC
ATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATAGACAAGAAAATACATTATAT

>In-frame_ENST00000202556_ENST00000421284_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(amino acids)=286AA_start in transcript=283_stop in transcript=1143
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL
IKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSI

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000555423_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(transcript)=517nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT

>In-frame_ENST00000202556_ENST00000555423_TCGA-JY-A6FH-01A_PPP1R13B_chr14_104313636_-_L2HGDH_chr14_50750751_length(amino acids)=109AA_start in transcript=326_stop in transcript=0
MPVCGQSIAIRPGIIAGRVRDALGRRLTGRSAPSCAHRSGRLLRPRSRRRALRPGRGEAAAAAGCGALAGPVAAAGALRRCPGHPAAAAA

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000261699_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(transcript)=1111nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGCTATGGCAGCAACC
CATGAAAGTGAGTGATAACAACATTTATTGTTTCCTGTGGCGTTGCTTTGCTTTGCTATTGACTGGTAGCGCTTGTAGCTTTAAATAAAT

>In-frame_ENST00000202556_ENST00000261699_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(amino acids)=264AA_start in transcript=283_stop in transcript=1077
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000267436_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(transcript)=2800nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGG
AAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGC
TACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAGCTAGGTATGCACT
GTAATCTTCATGTCAGCAACAAGAATGTACTAATTGCATTCTTTAATTTAAAAAATGGTTTTTAAACTTTAGTTTTTAGGTCAAAGATAA
CCACTGCATTGTTAAAATGATGTAACATAGAAATAATAATTTTCTACAAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAATCTCAGCT
ACTCAGGAGGCTGAGGCAGGAGAATCAATTGAACCGAGCAGACGGAGGTGAGCTGAGAGCTGAGATTGCACCACTGCACTCCAGCCTGGG
TGACAGAGCAAGAAAATAATAATAATAATAATTTTCAAAATGTTAGGCTGGGGGCCGTGGCCAGCACTTTGGGAAGCCAAGGCAGGTAGA
TTGTAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATGGCAAAACCCTGTTTCTACACAAAGTTAGCTGGGTCTGGTGCCTCTGTAGTTC
CAGCTCCTCAGTAGGCTGAGGTGAGAGGATCACTTGAGCCCAGGAGGTCTAGGCTGCAGTGAGCTTATGTTCATGACACTGCATTCCAGG
CTGGATGATAGAGCAAGATCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGGGCAACATAGTGAATGAAACCCCATCTC
TACAAAAAATACAAAAATTAGCTGGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGGATCGCTTGAGCCC
GGGAGATCAAGGCTACAGTGAGCTGTGTTCATGCCACTATACCCCAGCCTGGGCAACAAAGTGAGTCCCTGACTCAAAAAATAAAAACAA
CAACAAAAAATAAATTCCATGCTTATTTACTTTGCGAATAAAGAGGCAAGGTACAGTTTTATCTGTCCGAATCCCTGACTTTTATTTATT
TTTTTTTTCAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTC
CAGCGATTCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGA
CGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAG
GTGCGAGCCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAA
GAGTTTTGGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATA
GACAAGAAAATACATTATATTGTAGGTTACATTCTTTTAATTTTGAAGAGTCACAAAACTCACATTATTTAGAGCAACAATATTTGTATT
TGGAAATTAAAAATTCATGATTTCAAGAAAATACATAAAATTTACATTTTTGAGTAGTTTGAATAAGTTTCTATCTTAATTATAATATTT
GTAGGAAATAACAAAACAAACTCAAAGCCTTTATTATTTCCAGTCTCTTTGTAACTGATGTGGTATGGTATCATCATGAAATCTAAACAG

>In-frame_ENST00000202556_ENST00000267436_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(amino acids)=286AA_start in transcript=283_stop in transcript=1143
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL
IKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSI

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000421284_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(transcript)=1631nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT
AGATGGAATGCAATATCCAATTGTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTC
AGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATG
TTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTAT
TTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTAT
CAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAA
GTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGG
AAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGC
TACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAGCTAGACGGAGTTT
CACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCCAGCGATTCTCTTGCCTCAA
CCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTTGCCATGTTGGC
CAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGTGCGAGCCATCATGCTCAG
CCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAAGAGTTTTGGAGAAAGATGGC
ATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATAGACAAGAAAATACATTATAT

>In-frame_ENST00000202556_ENST00000421284_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(amino acids)=286AA_start in transcript=283_stop in transcript=1143
MMPGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRIS
ELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGL
IKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSI

--------------------------------------------------------------
>In-frame_ENST00000202556_ENST00000555423_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(transcript)=517nt_BP=292nt
GGGCGGGCGGGCCGCAGGCTGTCGGGCTGGGGCTGAGGCTGAGGCTGAGGTTGAGGCGGCGGCGGCGGCGGCCGGGTGCCCGGGACAGCG
ACGCAGCGCGCCGGCGGCCGCGACAGGGCCAGCGAGAGCCCCGCAGCCCGCCGCAGCTGCCGCCTCGCCGCGGCCGGGCCGGAGAGCACG
GCGGCGGGAGCGCGGCCTTAGGAGGCGGCCGGAGCGGTGGGCACAGCTCGGCGCGGAGCGTCCTGTCAGGCGGCGGCCGAGGGCGTCGCG
GACTCTCCCCGCGATGATGCCGGGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTGTCATTTGC
CCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAAGGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTAT

>In-frame_ENST00000202556_ENST00000555423_TCGA-JY-A6FH_PPP1R13B_chr14_104313635_-_L2HGDH_chr14_50750751_length(amino acids)=109AA_start in transcript=326_stop in transcript=0
MPVCGQSIAIRPGIIAGRVRDALGRRLTGRSAPSCAHRSGRLLRPRSRRRALRPGRGEAAAAAGCGALAGPVAAAGALRRCPGHPAAAAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP1R13B-L2HGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R13B-L2HGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R13B-L2HGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneL2HGDHC1855995L-2-HYDROXYGLUTARIC ACIDURIA8GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneL2HGDHC2746066Combined D-2- and L-2-hydroxyglutaric aciduria3CTD_human;GENOMICS_ENGLAND
TgeneL2HGDHC0013421Dystonia1GENOMICS_ENGLAND
TgeneL2HGDHC0014544Epilepsy1CTD_human
TgeneL2HGDHC0020796Profound Mental Retardation1CTD_human
TgeneL2HGDHC0025363Mental Retardation, Psychosocial1CTD_human
TgeneL2HGDHC0086237Epilepsy, Cryptogenic1CTD_human
TgeneL2HGDHC0236018Aura1CTD_human
TgeneL2HGDHC0265541Cranioschisis1CTD_human
TgeneL2HGDHC0497552Congenital neurologic anomalies1CTD_human
TgeneL2HGDHC0751111Awakening Epilepsy1CTD_human
TgeneL2HGDHC0917816Mental deficiency1CTD_human
TgeneL2HGDHC3714756Intellectual Disability1CTD_human
TgeneL2HGDHC3888081L-2-hydroxyglutaric acidemia1ORPHANET