FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PPP1R21-WARS2 (FusionGDB2 ID:67469)

Fusion Gene Summary for PPP1R21-WARS2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R21-WARS2
Fusion gene ID: 67469
HgeneTgene
Gene symbol

PPP1R21

WARS2

Gene ID

129285

10352

Gene nameprotein phosphatase 1 regulatory subunit 21tryptophanyl tRNA synthetase 2, mitochondrial
SynonymsCCDC128|KLRAQ1NEMMLAS|TrpRS|mtTrpRS
Cytomap

2p16.3

1p12

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 21KLRAQ motif containing 1KLRAQ motif-containing protein 1coiled-coil domain containing 128coiled-coil domain-containing protein 128tryptophan--tRNA ligase, mitochondrial(Mt)TrpRStryptophan tRNA ligase 2, mitochondrial
Modification date2020031320200313
UniProtAcc

Q6ZMI0

.
Ensembl transtripts involved in fusion geneENST00000281394, ENST00000294952, 
ENST00000449090, ENST00000476199, 
ENST00000369426, ENST00000235521, 
ENST00000537870, ENST00000497761, 
Fusion gene scores* DoF score12 X 11 X 5=6605 X 2 X 5=50
# samples 135
** MAII scorelog2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: PPP1R21 [Title/Abstract] AND WARS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R21(48725874)-WARS2(119619230), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP1R21 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B2-01APPP1R21chr2

48725874

+WARS2chr1

119619230

-
ChimerDB4BRCATCGA-BH-A0B2-01APPP1R21chr2

48725874

+WARS2chr1

119619230

-


Top

Fusion Gene ORF analysis for PPP1R21-WARS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000281394ENST00000369426PPP1R21chr2

48725874

+WARS2chr1

119619230

-
In-frameENST00000281394ENST00000235521PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-5UTRENST00000281394ENST00000537870PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-intronENST00000281394ENST00000497761PPP1R21chr2

48725874

+WARS2chr1

119619230

-
In-frameENST00000294952ENST00000369426PPP1R21chr2

48725874

+WARS2chr1

119619230

-
In-frameENST00000294952ENST00000235521PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-5UTRENST00000294952ENST00000537870PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-intronENST00000294952ENST00000497761PPP1R21chr2

48725874

+WARS2chr1

119619230

-
In-frameENST00000449090ENST00000369426PPP1R21chr2

48725874

+WARS2chr1

119619230

-
In-frameENST00000449090ENST00000235521PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-5UTRENST00000449090ENST00000537870PPP1R21chr2

48725874

+WARS2chr1

119619230

-
5CDS-intronENST00000449090ENST00000497761PPP1R21chr2

48725874

+WARS2chr1

119619230

-
intron-3CDSENST00000476199ENST00000369426PPP1R21chr2

48725874

+WARS2chr1

119619230

-
intron-3CDSENST00000476199ENST00000235521PPP1R21chr2

48725874

+WARS2chr1

119619230

-
intron-5UTRENST00000476199ENST00000537870PPP1R21chr2

48725874

+WARS2chr1

119619230

-
intron-intronENST00000476199ENST00000497761PPP1R21chr2

48725874

+WARS2chr1

119619230

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281394PPP1R21chr248725874+ENST00000369426WARS2chr1119619230-483721201642692842
ENST00000281394PPP1R21chr248725874+ENST00000235521WARS2chr1119619230-480321201643112982
ENST00000294952PPP1R21chr248725874+ENST00000369426WARS2chr1119619230-480920921362664842
ENST00000294952PPP1R21chr248725874+ENST00000235521WARS2chr1119619230-477520921363084982
ENST00000449090PPP1R21chr248725874+ENST00000369426WARS2chr1119619230-46561939762511811
ENST00000449090PPP1R21chr248725874+ENST00000235521WARS2chr1119619230-46221939762931951

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281394ENST00000369426PPP1R21chr248725874+WARS2chr1119619230-0.0021039320.9978961
ENST00000281394ENST00000235521PPP1R21chr248725874+WARS2chr1119619230-0.0011096150.99889046
ENST00000294952ENST00000369426PPP1R21chr248725874+WARS2chr1119619230-0.0021443740.9978556
ENST00000294952ENST00000235521PPP1R21chr248725874+WARS2chr1119619230-0.0011307230.99886924
ENST00000449090ENST00000369426PPP1R21chr248725874+WARS2chr1119619230-0.0022434490.99775654
ENST00000449090ENST00000235521PPP1R21chr248725874+WARS2chr1119619230-0.001122060.99887794

Top

Fusion Genomic Features for PPP1R21-WARS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PPP1R21-WARS2


check button Go to

FGviewer for the breakpoints of chr2:48725874-chr1:119619230

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R21

Q6ZMI0

.
FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000305|PubMed:19389623}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R21chr2:48725874chr1:119619230ENST00000281394+17211_207645.0770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000281394+1721556_607645.0770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000294952+17221_207645.0781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000294952+1722556_607645.0781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000449090+16201_207614.0739.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000449090+1620556_607614.0739.0Coiled coilOntology_term=ECO:0000255
TgeneWARS2chr2:48725874chr1:119619230ENST0000023552106179_18130.0361.0Nucleotide bindingATP
TgeneWARS2chr2:48725874chr1:119619230ENST0000023552106226_23030.0361.0Nucleotide bindingATP
TgeneWARS2chr2:48725874chr1:119619230ENST000002355210648_5130.0361.0Nucleotide bindingATP
TgeneWARS2chr2:48725874chr1:119619230ENST0000036942606179_18130.0221.0Nucleotide bindingATP
TgeneWARS2chr2:48725874chr1:119619230ENST0000036942606226_23030.0221.0Nucleotide bindingATP
TgeneWARS2chr2:48725874chr1:119619230ENST000003694260648_5130.0221.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R21chr2:48725874chr1:119619230ENST00000281394+1721693_742645.0770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000294952+1722693_742645.0781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48725874chr1:119619230ENST00000449090+1620693_742614.0739.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for PPP1R21-WARS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000281394_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4837nt_BP=2120nt
CCACCTTCCTCCCACCCCGGGAACCCGGAAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATA
CTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGG
AGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAA
AAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAA
TGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGA
AAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGA
ATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGA
CAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAAC
TAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATG
AAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTC
TGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGG
CTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGA
AGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATA
CTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCT
ATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGA
AAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAA
ACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAG
CTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATG
GAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCA
TTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTG
TGCCTTATGAAGAAGCACTGGCAAACCGCCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTT
TGGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGC
GAATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGG
ATGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTA
CAGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTG
TTGACCTCCACTCCATTACTGTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCA
TAAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTAC
CTCGATTACAACATTTACATCAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCC
AGGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCAC
AAGGTTTCAACAAGAAGTATGGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCAGTATGTGTGTGTTGGTGTTTTTAACCTAGCATCCAT
GAAGAAGGTAAAATCCCTACGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATAACAGACAGCCC
AGAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCGGAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAA
CATAGTGGCGGTGCATGCCGCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCTCGCTACAAGCT
GGCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAAATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGT
TTTACAAATTGGATCAGCAAAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTATAGGAAGTTTC
AACGAATCACAGCAAGGCTTTTGTGCCTTGCACTCCATGCATTCTGATAACGGCAGCTTTCCTAAAAAGAAAAAGTTATAGTTTTGGGAC
ATTTAATTTGGTATAGCTGATTATTGGCTTTATTTGATGAATATTGCTTTGTAGCTTTGAAATACGACAGTGTTCCAAATCCCATCAACA
AAATGCTGTGAACAACAACAACAAAAAATAAATCAAGAAGGCATAGCTGTCTGAATCCCCAATTATTGAGGCACACTCCTTGGCCTGCAG
AAATGTGATTGAAGTAAGGAGTAATTTGGGAAATGGAGTATCATTTGTGCTTCTCTCTGGAGTACTTACTGTAACAGATGCACACGTTAT
CTACTTCAACCCTTTTATAAAGCAATATATAGAGGTCTTAGATGTATAATCCTTGAGATGCCATTTGATCAGATGCCAATTTGTATTCAG
AGCTCATAAAAACAAGTCCATTCTTATAGTTTGTTTGTCACTGAGACGGTGCCTGATTTAATATATTTAAGCTGCTTAACTTGTTTTCCA
AGAGATAACACCAACTGTTCCAGCAATAATTTGTTTTTTAATTCAGAGATATGGGATATGATCTTCTAAGGAGGTTGCATTATTTTGACC
TGATTTATTTATTGTACAAGAGCCCAAGTCCCTGAATTATATTCTTAATAAGTGCTTTCTTGCATTCATTTCAGTTTAGTCTCACCAACC
CCCTATGAATTAGGAGAATTATTGTCATTTTACACATGAGGAAAGTGAGGCTGAGAGAATCCAATTAGCTTGTACGATATCACTCCATAA
GAGAAGCAAATCTGAGAGTAAAACCCTTACCCCTTATTCTTAAGAATAGTGCTTGTTTATTCAGTACAAAAAAAATGCTGAAAGGCAGCG
TTTTTTAGACTCTAAACATTCTGATTTTGAAGGTGGGTGTTGGAACGACTGATGATGTTTTTTATATCATCAATTCAGCCAATGGATGCG
AACTTAAAATCTGGATTCACAGAACCGTGGTCACATTTCCCCATCAAAATCCCCAAGGCGGGTCCCAAGTTCTCTCCTCTACGCTCATTG
CAGAAATACTTTGAAATAGGTTCTGCCAGTCTACAATAGCAGTGAAGACTGACAAATCAGATATTCCCAATGACTGACAGCTTCTCATCT
TGCCTCTACCTCAGTTAAGTAATGTCACCCTGAAACCTAGCTTTTCTGCACTTCCATTTCTGACACCTGAAAATGAAAATGATAATCCTA
ACTTATACACCAAGACCTGTTAGCAAGATCGATTTTGTAACAGAAATTGCTTATAAGTTTTTTATCAGTAAGGACCATGATCACCATTTG
TACATACATAACTAGGTTGTTGAGCAAAGCATTTTTGCTCATGTTTCTTAAGGAAGTAGAGTAGTCCTTGTGTCAGAACACATGTTAATC
CACAAAACGCCCCATCCCAGATTCCAAATTAAAACATCGTTTTTAGGATTCTTGGAGCTAGCCTGGATCATGGGTAAAGGAAACATTTTG
CCTTTTGTATCTTATACTGGAATGGGATGTCTGTAAGTCCTAGAACCTCTTTGAGCATATTTCTTACAAGCCTCTGTTTTTTCCCCTTTA

>In-frame_ENST00000281394_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=842AA_start in transcript=164_stop in transcript=2692
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAV
LLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMEL

--------------------------------------------------------------
>In-frame_ENST00000281394_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4803nt_BP=2120nt
CCACCTTCCTCCCACCCCGGGAACCCGGAAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATA
CTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGG
AGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAA
AAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAA
TGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGA
AAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGA
ATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGA
CAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAAC
TAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATG
AAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTC
TGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGG
CTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGA
AGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATA
CTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCT
ATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGA
AAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAA
ACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAG
CTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATG
GAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCA
TTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTG
TGCCTTATGAAGAAGCACTGGCAAACCGCCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTT
TGGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGC
GAATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGG
ATGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTA
CAGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTG
TTGACCTCCACTCCATTACTGTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCA
TAAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTAC
CTCGATTACAACATTTACATCAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCC
AGGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCAC
AAGGTTTCAACAAGAAGTATGGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCACATCCATGAAGAAGGTAAAATCCCTACGTGATCCTT
CTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATAACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGG
CTGTGACAGACTTCACCTCGGAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCCGCGGTGACGG
GGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCTCGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGT
TTGCCCCAATTAAGCGTGAAATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCAAAAGCCAAAG
AATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTATAGGAAGTTTCAACGAATCACAGCAAGGCTTTTGTGCCTT
GCACTCCATGCATTCTGATAACGGCAGCTTTCCTAAAAAGAAAAAGTTATAGTTTTGGGACATTTAATTTGGTATAGCTGATTATTGGCT
TTATTTGATGAATATTGCTTTGTAGCTTTGAAATACGACAGTGTTCCAAATCCCATCAACAAAATGCTGTGAACAACAACAACAAAAAAT
AAATCAAGAAGGCATAGCTGTCTGAATCCCCAATTATTGAGGCACACTCCTTGGCCTGCAGAAATGTGATTGAAGTAAGGAGTAATTTGG
GAAATGGAGTATCATTTGTGCTTCTCTCTGGAGTACTTACTGTAACAGATGCACACGTTATCTACTTCAACCCTTTTATAAAGCAATATA
TAGAGGTCTTAGATGTATAATCCTTGAGATGCCATTTGATCAGATGCCAATTTGTATTCAGAGCTCATAAAAACAAGTCCATTCTTATAG
TTTGTTTGTCACTGAGACGGTGCCTGATTTAATATATTTAAGCTGCTTAACTTGTTTTCCAAGAGATAACACCAACTGTTCCAGCAATAA
TTTGTTTTTTAATTCAGAGATATGGGATATGATCTTCTAAGGAGGTTGCATTATTTTGACCTGATTTATTTATTGTACAAGAGCCCAAGT
CCCTGAATTATATTCTTAATAAGTGCTTTCTTGCATTCATTTCAGTTTAGTCTCACCAACCCCCTATGAATTAGGAGAATTATTGTCATT
TTACACATGAGGAAAGTGAGGCTGAGAGAATCCAATTAGCTTGTACGATATCACTCCATAAGAGAAGCAAATCTGAGAGTAAAACCCTTA
CCCCTTATTCTTAAGAATAGTGCTTGTTTATTCAGTACAAAAAAAATGCTGAAAGGCAGCGTTTTTTAGACTCTAAACATTCTGATTTTG
AAGGTGGGTGTTGGAACGACTGATGATGTTTTTTATATCATCAATTCAGCCAATGGATGCGAACTTAAAATCTGGATTCACAGAACCGTG
GTCACATTTCCCCATCAAAATCCCCAAGGCGGGTCCCAAGTTCTCTCCTCTACGCTCATTGCAGAAATACTTTGAAATAGGTTCTGCCAG
TCTACAATAGCAGTGAAGACTGACAAATCAGATATTCCCAATGACTGACAGCTTCTCATCTTGCCTCTACCTCAGTTAAGTAATGTCACC
CTGAAACCTAGCTTTTCTGCACTTCCATTTCTGACACCTGAAAATGAAAATGATAATCCTAACTTATACACCAAGACCTGTTAGCAAGAT
CGATTTTGTAACAGAAATTGCTTATAAGTTTTTTATCAGTAAGGACCATGATCACCATTTGTACATACATAACTAGGTTGTTGAGCAAAG
CATTTTTGCTCATGTTTCTTAAGGAAGTAGAGTAGTCCTTGTGTCAGAACACATGTTAATCCACAAAACGCCCCATCCCAGATTCCAAAT
TAAAACATCGTTTTTAGGATTCTTGGAGCTAGCCTGGATCATGGGTAAAGGAAACATTTTGCCTTTTGTATCTTATACTGGAATGGGATG
TCTGTAAGTCCTAGAACCTCTTTGAGCATATTTCTTACAAGCCTCTGTTTTTTCCCCTTTAAAGGAAACTTTGAAAGGATTGTGAATACT

>In-frame_ENST00000281394_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=982AA_start in transcript=164_stop in transcript=3112
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAV
LLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMEL
VQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV

--------------------------------------------------------------
>In-frame_ENST00000294952_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4809nt_BP=2092nt
AAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATACTGCCTGACCCGTTCCCGGGAGCGTGTC
TGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGGAGGCCATGGCCTCGGCTGAGTTGCAGGG
GAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAAAAGGTGTTGTGGATGAACAAGCAAATTC
TGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAATGGACAGTTTGACATTTCGAAATCTGCA
GCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGAAAAACAAGAAAAGTGGAGAATCTTCTTC
TCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGAATGAACGGTTGCATATACAATTTTTTGA
AGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGACAGAAGCAGCCCAGCACCAAGCTGTGGT
TGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAACTAGAAGTGAAATCTCAGACTCTAGAAAA
GGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATGAAGATTTGTCAGGTAGATTAGAGGAATC
CTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTCTGAACGTTCCACTCCACAATAGGAGACA
CCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGGCTCTTCTAAACTTTCATACCTACACAGA
ACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGAAGTTCTCACAATACCTTCATGAAAATGC
GTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATACTGTGACTGTCTTGGAGACAACTGTGAA
ATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCTATCAGTTAAAAAGTTTAGAAGAAGAATG
TGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGAAAAAAATGACAGCTGTGTTTGAGAAGCT
GCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAAACTACAGTTCTGTGTTAACAAATGTTGG
TGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAGCTGCAATAGAGCATGAACTTCCAACAGC
AACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATGGAGCAGGAAAGATTGCATCCTTCTTCAG
CAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCATTAGTCCTCTTTCAGCTGAATGCATGCT
ACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTGTGCCTTATGAAGAAGCACTGGCAAACCG
CCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTTTGGAAAAGATTTCTAAACTGGAGCAGGA
AAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCGAATTGCAGATAAGCTGAAGAATACAGG
TAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGATGAAGCCACAGCTAAGGCTGTGTTGGA
GCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTACAGGAATCCTCCACCTGGGCAATTACCT
GGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGTTGACCTCCACTCCATTACTGTCCCCCA
AGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCATAAACCCGGAAAAAAGCATCCTTTTCCA
ACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACCTCGATTACAACATTTACATCAGTGGAA
GGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCCAGGCAGCCGACATTCTGTTGTACAAGTC
CACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACAAGGTTTCAACAAGAAGTATGGGGAGTT
CTTTCCAGTGCCCGAGTCCATTCTCAGTATGTGTGTGTTGGTGTTTTTAACCTAGCATCCATGAAGAAGGTAAAATCCCTACGTGATCCT
TCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATAACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAG
GCTGTGACAGACTTCACCTCGGAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCCGCGGTGACG
GGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCTCGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAG
TTTGCCCCAATTAAGCGTGAAATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCAAAAGCCAAA
GAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTATAGGAAGTTTCAACGAATCACAGCAAGGCTTTTGTGCCT
TGCACTCCATGCATTCTGATAACGGCAGCTTTCCTAAAAAGAAAAAGTTATAGTTTTGGGACATTTAATTTGGTATAGCTGATTATTGGC
TTTATTTGATGAATATTGCTTTGTAGCTTTGAAATACGACAGTGTTCCAAATCCCATCAACAAAATGCTGTGAACAACAACAACAAAAAA
TAAATCAAGAAGGCATAGCTGTCTGAATCCCCAATTATTGAGGCACACTCCTTGGCCTGCAGAAATGTGATTGAAGTAAGGAGTAATTTG
GGAAATGGAGTATCATTTGTGCTTCTCTCTGGAGTACTTACTGTAACAGATGCACACGTTATCTACTTCAACCCTTTTATAAAGCAATAT
ATAGAGGTCTTAGATGTATAATCCTTGAGATGCCATTTGATCAGATGCCAATTTGTATTCAGAGCTCATAAAAACAAGTCCATTCTTATA
GTTTGTTTGTCACTGAGACGGTGCCTGATTTAATATATTTAAGCTGCTTAACTTGTTTTCCAAGAGATAACACCAACTGTTCCAGCAATA
ATTTGTTTTTTAATTCAGAGATATGGGATATGATCTTCTAAGGAGGTTGCATTATTTTGACCTGATTTATTTATTGTACAAGAGCCCAAG
TCCCTGAATTATATTCTTAATAAGTGCTTTCTTGCATTCATTTCAGTTTAGTCTCACCAACCCCCTATGAATTAGGAGAATTATTGTCAT
TTTACACATGAGGAAAGTGAGGCTGAGAGAATCCAATTAGCTTGTACGATATCACTCCATAAGAGAAGCAAATCTGAGAGTAAAACCCTT
ACCCCTTATTCTTAAGAATAGTGCTTGTTTATTCAGTACAAAAAAAATGCTGAAAGGCAGCGTTTTTTAGACTCTAAACATTCTGATTTT
GAAGGTGGGTGTTGGAACGACTGATGATGTTTTTTATATCATCAATTCAGCCAATGGATGCGAACTTAAAATCTGGATTCACAGAACCGT
GGTCACATTTCCCCATCAAAATCCCCAAGGCGGGTCCCAAGTTCTCTCCTCTACGCTCATTGCAGAAATACTTTGAAATAGGTTCTGCCA
GTCTACAATAGCAGTGAAGACTGACAAATCAGATATTCCCAATGACTGACAGCTTCTCATCTTGCCTCTACCTCAGTTAAGTAATGTCAC
CCTGAAACCTAGCTTTTCTGCACTTCCATTTCTGACACCTGAAAATGAAAATGATAATCCTAACTTATACACCAAGACCTGTTAGCAAGA
TCGATTTTGTAACAGAAATTGCTTATAAGTTTTTTATCAGTAAGGACCATGATCACCATTTGTACATACATAACTAGGTTGTTGAGCAAA
GCATTTTTGCTCATGTTTCTTAAGGAAGTAGAGTAGTCCTTGTGTCAGAACACATGTTAATCCACAAAACGCCCCATCCCAGATTCCAAA
TTAAAACATCGTTTTTAGGATTCTTGGAGCTAGCCTGGATCATGGGTAAAGGAAACATTTTGCCTTTTGTATCTTATACTGGAATGGGAT
GTCTGTAAGTCCTAGAACCTCTTTGAGCATATTTCTTACAAGCCTCTGTTTTTTCCCCTTTAAAGGAAACTTTGAAAGGATTGTGAATAC

>In-frame_ENST00000294952_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=842AA_start in transcript=136_stop in transcript=2664
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAV
LLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMEL

--------------------------------------------------------------
>In-frame_ENST00000294952_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4775nt_BP=2092nt
AAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATACTGCCTGACCCGTTCCCGGGAGCGTGTC
TGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGGAGGCCATGGCCTCGGCTGAGTTGCAGGG
GAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAAAAGGTGTTGTGGATGAACAAGCAAATTC
TGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAATGGACAGTTTGACATTTCGAAATCTGCA
GCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGAAAAACAAGAAAAGTGGAGAATCTTCTTC
TCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGAATGAACGGTTGCATATACAATTTTTTGA
AGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGACAGAAGCAGCCCAGCACCAAGCTGTGGT
TGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAACTAGAAGTGAAATCTCAGACTCTAGAAAA
GGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATGAAGATTTGTCAGGTAGATTAGAGGAATC
CTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTCTGAACGTTCCACTCCACAATAGGAGACA
CCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGGCTCTTCTAAACTTTCATACCTACACAGA
ACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGAAGTTCTCACAATACCTTCATGAAAATGC
GTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATACTGTGACTGTCTTGGAGACAACTGTGAA
ATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCTATCAGTTAAAAAGTTTAGAAGAAGAATG
TGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGAAAAAAATGACAGCTGTGTTTGAGAAGCT
GCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAAACTACAGTTCTGTGTTAACAAATGTTGG
TGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAGCTGCAATAGAGCATGAACTTCCAACAGC
AACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATGGAGCAGGAAAGATTGCATCCTTCTTCAG
CAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCATTAGTCCTCTTTCAGCTGAATGCATGCT
ACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTGTGCCTTATGAAGAAGCACTGGCAAACCG
CCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTTTGGAAAAGATTTCTAAACTGGAGCAGGA
AAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCGAATTGCAGATAAGCTGAAGAATACAGG
TAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGATGAAGCCACAGCTAAGGCTGTGTTGGA
GCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTACAGGAATCCTCCACCTGGGCAATTACCT
GGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGTTGACCTCCACTCCATTACTGTCCCCCA
AGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCATAAACCCGGAAAAAAGCATCCTTTTCCA
ACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACCTCGATTACAACATTTACATCAGTGGAA
GGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCCAGGCAGCCGACATTCTGTTGTACAAGTC
CACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACAAGGTTTCAACAAGAAGTATGGGGAGTT
CTTTCCAGTGCCCGAGTCCATTCTCACATCCATGAAGAAGGTAAAATCCCTACGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGA
CAAACTGGCCACCGTCCGAATAACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCGGAGGTCAC
CTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCCGCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCG
CAGCGCGGGCATGAACACTGCTCGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAAATTGAAAA
ACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCAAAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGT
GAAGAAATTGGTGGGTTTTCTATAGGAAGTTTCAACGAATCACAGCAAGGCTTTTGTGCCTTGCACTCCATGCATTCTGATAACGGCAGC
TTTCCTAAAAAGAAAAAGTTATAGTTTTGGGACATTTAATTTGGTATAGCTGATTATTGGCTTTATTTGATGAATATTGCTTTGTAGCTT
TGAAATACGACAGTGTTCCAAATCCCATCAACAAAATGCTGTGAACAACAACAACAAAAAATAAATCAAGAAGGCATAGCTGTCTGAATC
CCCAATTATTGAGGCACACTCCTTGGCCTGCAGAAATGTGATTGAAGTAAGGAGTAATTTGGGAAATGGAGTATCATTTGTGCTTCTCTC
TGGAGTACTTACTGTAACAGATGCACACGTTATCTACTTCAACCCTTTTATAAAGCAATATATAGAGGTCTTAGATGTATAATCCTTGAG
ATGCCATTTGATCAGATGCCAATTTGTATTCAGAGCTCATAAAAACAAGTCCATTCTTATAGTTTGTTTGTCACTGAGACGGTGCCTGAT
TTAATATATTTAAGCTGCTTAACTTGTTTTCCAAGAGATAACACCAACTGTTCCAGCAATAATTTGTTTTTTAATTCAGAGATATGGGAT
ATGATCTTCTAAGGAGGTTGCATTATTTTGACCTGATTTATTTATTGTACAAGAGCCCAAGTCCCTGAATTATATTCTTAATAAGTGCTT
TCTTGCATTCATTTCAGTTTAGTCTCACCAACCCCCTATGAATTAGGAGAATTATTGTCATTTTACACATGAGGAAAGTGAGGCTGAGAG
AATCCAATTAGCTTGTACGATATCACTCCATAAGAGAAGCAAATCTGAGAGTAAAACCCTTACCCCTTATTCTTAAGAATAGTGCTTGTT
TATTCAGTACAAAAAAAATGCTGAAAGGCAGCGTTTTTTAGACTCTAAACATTCTGATTTTGAAGGTGGGTGTTGGAACGACTGATGATG
TTTTTTATATCATCAATTCAGCCAATGGATGCGAACTTAAAATCTGGATTCACAGAACCGTGGTCACATTTCCCCATCAAAATCCCCAAG
GCGGGTCCCAAGTTCTCTCCTCTACGCTCATTGCAGAAATACTTTGAAATAGGTTCTGCCAGTCTACAATAGCAGTGAAGACTGACAAAT
CAGATATTCCCAATGACTGACAGCTTCTCATCTTGCCTCTACCTCAGTTAAGTAATGTCACCCTGAAACCTAGCTTTTCTGCACTTCCAT
TTCTGACACCTGAAAATGAAAATGATAATCCTAACTTATACACCAAGACCTGTTAGCAAGATCGATTTTGTAACAGAAATTGCTTATAAG
TTTTTTATCAGTAAGGACCATGATCACCATTTGTACATACATAACTAGGTTGTTGAGCAAAGCATTTTTGCTCATGTTTCTTAAGGAAGT
AGAGTAGTCCTTGTGTCAGAACACATGTTAATCCACAAAACGCCCCATCCCAGATTCCAAATTAAAACATCGTTTTTAGGATTCTTGGAG
CTAGCCTGGATCATGGGTAAAGGAAACATTTTGCCTTTTGTATCTTATACTGGAATGGGATGTCTGTAAGTCCTAGAACCTCTTTGAGCA
TATTTCTTACAAGCCTCTGTTTTTTCCCCTTTAAAGGAAACTTTGAAAGGATTGTGAATACTGGAAAATGACAAAACTAAAGGTAGATCT

>In-frame_ENST00000294952_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=982AA_start in transcript=136_stop in transcript=3084
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAV
LLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMEL
VQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV

--------------------------------------------------------------
>In-frame_ENST00000449090_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4656nt_BP=1939nt
TACTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGG
GGAGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAA
AAAAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGA
AATGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAA
GAAAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGA
GAATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGA
GACAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAA
ACTAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCA
TGAAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGC
TCTGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGAC
GGCTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCA
GAAGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGA
TACTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCC
CTATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACAT
GAAAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGAC
AAACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAA
AGCTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAA
TGGAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATT
CATTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGGTTCAACAGAGTTT
GGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCG
AATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGA
TGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTAC
AGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGT
TGACCTCCACTCCATTACTGTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCAT
AAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACC
TCGATTACAACATTTACATCAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCCA
GGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACA
AGGTTTCAACAAGAAGTATGGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCAGTATGTGTGTGTTGGTGTTTTTAACCTAGCATCCATG
AAGAAGGTAAAATCCCTACGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATAACAGACAGCCCA
GAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCGGAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAAC
ATAGTGGCGGTGCATGCCGCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCTCGCTACAAGCTG
GCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAAATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTT
TTACAAATTGGATCAGCAAAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTATAGGAAGTTTCA
ACGAATCACAGCAAGGCTTTTGTGCCTTGCACTCCATGCATTCTGATAACGGCAGCTTTCCTAAAAAGAAAAAGTTATAGTTTTGGGACA
TTTAATTTGGTATAGCTGATTATTGGCTTTATTTGATGAATATTGCTTTGTAGCTTTGAAATACGACAGTGTTCCAAATCCCATCAACAA
AATGCTGTGAACAACAACAACAAAAAATAAATCAAGAAGGCATAGCTGTCTGAATCCCCAATTATTGAGGCACACTCCTTGGCCTGCAGA
AATGTGATTGAAGTAAGGAGTAATTTGGGAAATGGAGTATCATTTGTGCTTCTCTCTGGAGTACTTACTGTAACAGATGCACACGTTATC
TACTTCAACCCTTTTATAAAGCAATATATAGAGGTCTTAGATGTATAATCCTTGAGATGCCATTTGATCAGATGCCAATTTGTATTCAGA
GCTCATAAAAACAAGTCCATTCTTATAGTTTGTTTGTCACTGAGACGGTGCCTGATTTAATATATTTAAGCTGCTTAACTTGTTTTCCAA
GAGATAACACCAACTGTTCCAGCAATAATTTGTTTTTTAATTCAGAGATATGGGATATGATCTTCTAAGGAGGTTGCATTATTTTGACCT
GATTTATTTATTGTACAAGAGCCCAAGTCCCTGAATTATATTCTTAATAAGTGCTTTCTTGCATTCATTTCAGTTTAGTCTCACCAACCC
CCTATGAATTAGGAGAATTATTGTCATTTTACACATGAGGAAAGTGAGGCTGAGAGAATCCAATTAGCTTGTACGATATCACTCCATAAG
AGAAGCAAATCTGAGAGTAAAACCCTTACCCCTTATTCTTAAGAATAGTGCTTGTTTATTCAGTACAAAAAAAATGCTGAAAGGCAGCGT
TTTTTAGACTCTAAACATTCTGATTTTGAAGGTGGGTGTTGGAACGACTGATGATGTTTTTTATATCATCAATTCAGCCAATGGATGCGA
ACTTAAAATCTGGATTCACAGAACCGTGGTCACATTTCCCCATCAAAATCCCCAAGGCGGGTCCCAAGTTCTCTCCTCTACGCTCATTGC
AGAAATACTTTGAAATAGGTTCTGCCAGTCTACAATAGCAGTGAAGACTGACAAATCAGATATTCCCAATGACTGACAGCTTCTCATCTT
GCCTCTACCTCAGTTAAGTAATGTCACCCTGAAACCTAGCTTTTCTGCACTTCCATTTCTGACACCTGAAAATGAAAATGATAATCCTAA
CTTATACACCAAGACCTGTTAGCAAGATCGATTTTGTAACAGAAATTGCTTATAAGTTTTTTATCAGTAAGGACCATGATCACCATTTGT
ACATACATAACTAGGTTGTTGAGCAAAGCATTTTTGCTCATGTTTCTTAAGGAAGTAGAGTAGTCCTTGTGTCAGAACACATGTTAATCC
ACAAAACGCCCCATCCCAGATTCCAAATTAAAACATCGTTTTTAGGATTCTTGGAGCTAGCCTGGATCATGGGTAAAGGAAACATTTTGC
CTTTTGTATCTTATACTGGAATGGGATGTCTGTAAGTCCTAGAACCTCTTTGAGCATATTTCTTACAAGCCTCTGTTTTTTCCCCTTTAA

>In-frame_ENST00000449090_ENST00000369426_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=811AA_start in transcript=76_stop in transcript=2511
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLKDSKKRVFS
GIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSC
MVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILSMCVLVFL

--------------------------------------------------------------
>In-frame_ENST00000449090_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(transcript)=4622nt_BP=1939nt
TACTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGG
GGAGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAA
AAAAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGA
AATGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAA
GAAAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGA
GAATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGA
GACAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAA
ACTAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCA
TGAAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGC
TCTGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGAC
GGCTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCA
GAAGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGA
TACTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCC
CTATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACAT
GAAAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGAC
AAACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAA
AGCTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAA
TGGAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATT
CATTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGGTTCAACAGAGTTT
GGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCG
AATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGA
TGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAAAAGACAGCAAGAAGCGAGTATTTTCCGGCATTCAACCTAC
AGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTGAGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGT
TGACCTCCACTCCATTACTGTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTTGCCTGTGGCAT
AAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACACACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACC
TCGATTACAACATTTACATCAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATACCCAGTACTCCA
GGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAGGATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACA
AGGTTTCAACAAGAAGTATGGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCACATCCATGAAGAAGGTAAAATCCCTACGTGATCCTTC
TGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATAACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGGC
TGTGACAGACTTCACCTCGGAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCCGCGGTGACGGG
GCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCTCGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGTT
TGCCCCAATTAAGCGTGAAATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCAAAAGCCAAAGA
ATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTATAGGAAGTTTCAACGAATCACAGCAAGGCTTTTGTGCCTTG
CACTCCATGCATTCTGATAACGGCAGCTTTCCTAAAAAGAAAAAGTTATAGTTTTGGGACATTTAATTTGGTATAGCTGATTATTGGCTT
TATTTGATGAATATTGCTTTGTAGCTTTGAAATACGACAGTGTTCCAAATCCCATCAACAAAATGCTGTGAACAACAACAACAAAAAATA
AATCAAGAAGGCATAGCTGTCTGAATCCCCAATTATTGAGGCACACTCCTTGGCCTGCAGAAATGTGATTGAAGTAAGGAGTAATTTGGG
AAATGGAGTATCATTTGTGCTTCTCTCTGGAGTACTTACTGTAACAGATGCACACGTTATCTACTTCAACCCTTTTATAAAGCAATATAT
AGAGGTCTTAGATGTATAATCCTTGAGATGCCATTTGATCAGATGCCAATTTGTATTCAGAGCTCATAAAAACAAGTCCATTCTTATAGT
TTGTTTGTCACTGAGACGGTGCCTGATTTAATATATTTAAGCTGCTTAACTTGTTTTCCAAGAGATAACACCAACTGTTCCAGCAATAAT
TTGTTTTTTAATTCAGAGATATGGGATATGATCTTCTAAGGAGGTTGCATTATTTTGACCTGATTTATTTATTGTACAAGAGCCCAAGTC
CCTGAATTATATTCTTAATAAGTGCTTTCTTGCATTCATTTCAGTTTAGTCTCACCAACCCCCTATGAATTAGGAGAATTATTGTCATTT
TACACATGAGGAAAGTGAGGCTGAGAGAATCCAATTAGCTTGTACGATATCACTCCATAAGAGAAGCAAATCTGAGAGTAAAACCCTTAC
CCCTTATTCTTAAGAATAGTGCTTGTTTATTCAGTACAAAAAAAATGCTGAAAGGCAGCGTTTTTTAGACTCTAAACATTCTGATTTTGA
AGGTGGGTGTTGGAACGACTGATGATGTTTTTTATATCATCAATTCAGCCAATGGATGCGAACTTAAAATCTGGATTCACAGAACCGTGG
TCACATTTCCCCATCAAAATCCCCAAGGCGGGTCCCAAGTTCTCTCCTCTACGCTCATTGCAGAAATACTTTGAAATAGGTTCTGCCAGT
CTACAATAGCAGTGAAGACTGACAAATCAGATATTCCCAATGACTGACAGCTTCTCATCTTGCCTCTACCTCAGTTAAGTAATGTCACCC
TGAAACCTAGCTTTTCTGCACTTCCATTTCTGACACCTGAAAATGAAAATGATAATCCTAACTTATACACCAAGACCTGTTAGCAAGATC
GATTTTGTAACAGAAATTGCTTATAAGTTTTTTATCAGTAAGGACCATGATCACCATTTGTACATACATAACTAGGTTGTTGAGCAAAGC
ATTTTTGCTCATGTTTCTTAAGGAAGTAGAGTAGTCCTTGTGTCAGAACACATGTTAATCCACAAAACGCCCCATCCCAGATTCCAAATT
AAAACATCGTTTTTAGGATTCTTGGAGCTAGCCTGGATCATGGGTAAAGGAAACATTTTGCCTTTTGTATCTTATACTGGAATGGGATGT
CTGTAAGTCCTAGAACCTCTTTGAGCATATTTCTTACAAGCCTCTGTTTTTTCCCCTTTAAAGGAAACTTTGAAAGGATTGTGAATACTG

>In-frame_ENST00000449090_ENST00000235521_TCGA-BH-A0B2-01A_PPP1R21_chr2_48725874_+_WARS2_chr1_119619230_length(amino acids)=951AA_start in transcript=76_stop in transcript=2931
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLKDSKKRVFS
GIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSC
MVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKS
LRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP1R21-WARS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PPP1R21-WARS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PPP1R21-WARS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP1R21C0019214Hepatosplenomegaly1GENOMICS_ENGLAND
HgenePPP1R21C4018871Abnormality of the respiratory system1GENOMICS_ENGLAND
TgeneWARS2C4540192NEURODEVELOPMENTAL DISORDER, MITOCHONDRIAL, WITH ABNORMAL MOVEMENTS AND LACTIC ACIDOSIS, WITH OR WITHOUT SEIZURES3GENOMICS_ENGLAND;UNIPROT