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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARMC7-NUP85 (FusionGDB2 ID:6766)

Fusion Gene Summary for ARMC7-NUP85

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7-NUP85
Fusion gene ID: 6766
HgeneTgene
Gene symbol

ARMC7

NUP85

Gene ID

79637

79902

Gene namearmadillo repeat containing 7nucleoporin 85
Synonyms-FROUNT|NPHS17|Nup75
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 7nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000581078, ENST00000582136, 
ENST00000245543, ENST00000584947, 
ENST00000579096, 		ENST00000245544, 
ENST00000541827, ENST00000579324, 
ENST00000449421, ENST00000579298, 
ENST00000447371, ENST00000540768, 
Fusion gene scores* DoF score9 X 3 X 5=1359 X 9 X 6=486
# samples 910
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC7(73106701)-NUP85(73221198), # samples:2
Anticipated loss of major functional domain due to fusion event.ARMC7-NUP85 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARMC7-NUP85 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ARMC7-NUP85 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARMC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUP85 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-62-A46U-01AARMC7chr17

73106701

+NUP85chr17

73221198

+
ChimerDB4LUADTCGA-62-A46U-01AARMC7chr17

73106701

+NUP85chr17

73221198

+


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Fusion Gene ORF analysis for ARMC7-NUP85

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000581078ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000581078ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000581078ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3UTRENST00000581078ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000582136ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000245543ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000584947ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3UTRENST00000579096ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARMC7-NUP85


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARMC7chr1773106701+NUP85chr1773221197+1.41E-101
ARMC7chr1773106701+NUP85chr1773221197+1.41E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARMC7-NUP85


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARMC7-NUP85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARMC7-NUP85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARMC7-NUP85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARMC7-NUP85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP85C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneNUP85C4748545NEPHROTIC SYNDROME, TYPE 171GENOMICS_ENGLAND;UNIPROT