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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP3CA-BRD2 (FusionGDB2 ID:67691)

Fusion Gene Summary for PPP3CA-BRD2

Fusion gene summary

Fusion gene information	Fusion gene name: PPP3CA-BRD2
	Fusion gene ID: 67691
		Hgene	Tgene
	Gene symbol	PPP3CA	BRD2
	Gene ID	5530	6046
	Gene name	protein phosphatase 3 catalytic subunit alpha	bromodomain containing 2
	Synonyms	ACCIID\|CALN\|CALNA\|CALNA1\|CCN1\|CNA1\|IECEE\|IECEE1\|PPP2B	BRD2-IT1\|D6S113E\|FSH\|FSRG1\|NAT\|O27.1.1\|RING3\|RNF3
	Cytomap	4q24	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 (	bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
	Modification date	20200315	20200313
	UniProtAcc	.	P25440
	Ensembl transtripts involved in fusion gene	ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292,	ENST00000374825, ENST00000496118, ENST00000580234, ENST00000374831, ENST00000395289, ENST00000443797, ENST00000395287, ENST00000449085, ENST00000438194, ENST00000466744, ENST00000383108, ENST00000547895, ENST00000549843, ENST00000442863, ENST00000552513, ENST00000442219, ENST00000498329, ENST00000488549, ENST00000425201, ENST00000399529, ENST00000399528, ENST00000550142, ENST00000548837, ENST00000399527, ENST00000549236, ENST00000482105, ENST00000414731, ENST00000449118, ENST00000550598, ENST00000479973, ENST00000546777, ENST00000450320, ENST00000547286, ENST00000552587, ENST00000549126, ENST00000553146, ENST00000448067, ENST00000436979, ENST00000466208,
Fusion gene scores	* DoF score	25 X 13 X 8=2600	10 X 15 X 3=450
	# samples	23	16
	** MAII score	log2(23/2600*10)=-3.49880585697144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/450*10)=-1.49185309632967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPP3CA [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP3CA(101945485)-BRD2(32944339), # samples:1
Anticipated loss of major functional domain due to fusion event.	PPP3CA-BRD2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. PPP3CA-BRD2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PPP3CA-BRD2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PPP3CA-BRD2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP3CA	GO:0006470	protein dephosphorylation	18815128\|19154138
Hgene	PPP3CA	GO:0033173	calcineurin-NFAT signaling cascade	19154138\|22688515
Hgene	PPP3CA	GO:0035690	cellular response to drug	11005320
Hgene	PPP3CA	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515
Hgene	PPP3CA	GO:0051592	response to calcium ion	18815128
Tgene	BRD2	GO:0006357	regulation of transcription by RNA polymerase II	18406326

Fusion gene breakpoints across PPP3CA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5790-01A	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+

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Fusion Gene ORF analysis for PPP3CA-BRD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000512215	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000394854	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000323055	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
Frame-shift	ENST00000394853	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000507176	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000523694	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000510292	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PPP3CA-BRD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PPP3CA	chr4	101945484	-	BRD2	chr6	32944338	+	0.9971661	0.002833927
PPP3CA	chr4	101945484	-	BRD2	chr6	32944338	+	0.9971661	0.002833927

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3CA-BRD2

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BRD2 P25440
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269\|PubMed:18406326}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PPP3CA-BRD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP3CA-BRD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PPP3CA-BRD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

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Related Diseases for PPP3CA-BRD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPP3CA	C4540199	EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1	2	GENOMICS_ENGLAND;UNIPROT
Hgene	PPP3CA	C0019202	Hepatolenticular Degeneration	1	CTD_human
Hgene	PPP3CA	C0030305	Pancreatitis	1	CTD_human
Hgene	PPP3CA	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	PPP3CA	C0039584	Testicular Diseases	1	CTD_human
Hgene	PPP3CA	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	PPP3CA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	PPP3CA	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	PPP3CA	C1527352	Hepatic Form of Wilson Disease	1	CTD_human
Hgene	PPP3CA	C4721610	Carcinoma, Ovarian Epithelial	1	CTD_human
Hgene	PPP3CA	C4748872	ARTHROGRYPOSIS, CLEFT PALATE, CRANIOSYNOSTOSIS, AND IMPAIRED INTELLECTUAL DEVELOPMENT	1	UNIPROT
Tgene	BRD2	C0017636	Glioblastoma	1	CTD_human
Tgene	BRD2	C0025149	Medulloblastoma	1	CTD_human
Tgene	BRD2	C0205833	Medullomyoblastoma	1	CTD_human
Tgene	BRD2	C0278510	Childhood Medulloblastoma	1	CTD_human
Tgene	BRD2	C0278876	Adult Medulloblastoma	1	CTD_human
Tgene	BRD2	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	BRD2	C0751291	Desmoplastic Medulloblastoma	1	CTD_human
Tgene	BRD2	C1275668	Melanotic medulloblastoma	1	CTD_human
Tgene	BRD2	C1621958	Glioblastoma Multiforme	1	CTD_human;UNIPROT