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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP3CA-INTS12 (FusionGDB2 ID:67696)

Fusion Gene Summary for PPP3CA-INTS12

Fusion gene summary

Fusion gene information	Fusion gene name: PPP3CA-INTS12
	Fusion gene ID: 67696
		Hgene	Tgene
	Gene symbol	PPP3CA	INTS12
	Gene ID	5530	57117
	Gene name	protein phosphatase 3 catalytic subunit alpha	integrator complex subunit 12
	Synonyms	ACCIID\|CALN\|CALNA\|CALNA1\|CCN1\|CNA1\|IECEE\|IECEE1\|PPP2B	INT12\|PHF22\|SBBI22
	Cytomap	4q24	4q24
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 (	integrator complex subunit 12PHD finger protein 22hypothetical nuclear factor SBBI22
	Modification date	20200315	20200313
	UniProtAcc	.	Q96CB8
	Ensembl transtripts involved in fusion gene	ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292,	ENST00000394735, ENST00000340139, ENST00000451321,
Fusion gene scores	* DoF score	25 X 13 X 8=2600	3 X 2 X 2=12
	# samples	23	2
	** MAII score	log2(23/2600*10)=-3.49880585697144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PPP3CA [Title/Abstract] AND INTS12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP3CA(102117073)-INTS12(106604474), # samples:3
Anticipated loss of major functional domain due to fusion event.	PPP3CA-INTS12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP3CA	GO:0006470	protein dephosphorylation	18815128\|19154138
Hgene	PPP3CA	GO:0033173	calcineurin-NFAT signaling cascade	19154138\|22688515
Hgene	PPP3CA	GO:0035690	cellular response to drug	11005320
Hgene	PPP3CA	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515
Hgene	PPP3CA	GO:0051592	response to calcium ion	18815128
Tgene	INTS12	GO:0016180	snRNA processing	16239144

Fusion gene breakpoints across PPP3CA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across INTS12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-8266-01A	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
ChimerDB4	PRAD	TCGA-HC-8266	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
ChimerDB4	PRAD	TCGA-HC-8266-01A	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-

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Fusion Gene ORF analysis for PPP3CA-INTS12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000512215	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000512215	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
Frame-shift	ENST00000512215	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000394854	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000394854	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
Frame-shift	ENST00000394854	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000323055	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000323055	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
Frame-shift	ENST00000323055	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000394853	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
In-frame	ENST00000394853	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
Frame-shift	ENST00000394853	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000507176	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000507176	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000507176	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000523694	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000523694	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000523694	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000510292	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000510292	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-
intron-3CDS	ENST00000510292	ENST00000451321	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000512215	PPP3CA	chr4	102117073	-	ENST00000394735	INTS12	chr4	106604474	-	1631	940	1550	888	220
ENST00000512215	PPP3CA	chr4	102117073	-	ENST00000340139	INTS12	chr4	106604474	-	1631	940	1550	888	220
ENST00000394854	PPP3CA	chr4	102117073	-	ENST00000394735	INTS12	chr4	106604474	-	1634	943	1553	891	220
ENST00000394854	PPP3CA	chr4	102117073	-	ENST00000340139	INTS12	chr4	106604474	-	1634	943	1553	891	220
ENST00000323055	PPP3CA	chr4	102117073	-	ENST00000394735	INTS12	chr4	106604474	-	1625	934	1544	882	220
ENST00000323055	PPP3CA	chr4	102117073	-	ENST00000340139	INTS12	chr4	106604474	-	1625	934	1544	882	220
ENST00000394853	PPP3CA	chr4	102117073	-	ENST00000394735	INTS12	chr4	106604474	-	1481	790	1400	738	220
ENST00000394853	PPP3CA	chr4	102117073	-	ENST00000340139	INTS12	chr4	106604474	-	1481	790	1400	738	220

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000512215	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.024850965	0.975149
ENST00000512215	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.024850965	0.975149
ENST00000394854	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.027533596	0.9724664
ENST00000394854	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.027533596	0.9724664
ENST00000323055	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.02141134	0.9785887
ENST00000323055	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.02141134	0.9785887
ENST00000394853	ENST00000394735	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.027635556	0.97236437
ENST00000394853	ENST00000340139	PPP3CA	chr4	102117073	-	INTS12	chr4	106604474	-	0.027635556	0.97236437

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Fusion Genomic Features for PPP3CA-INTS12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3CA-INTS12

Go to
FGviewer for the breakpoints of chr4:102117073-chr4:106604474
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	INTS12 Q96CB8
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269\|PubMed:16239144, ECO:0000269\|PubMed:23904267}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000340139

270_440

268.0

463.0

Compositional bias

Note=Ser-rich

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000394735

270_440

268.0

463.0

Compositional bias

Note=Ser-rich

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000451321

270_440

268.0

463.0

Compositional bias

Note=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

307_311

86.33333333333333

470.0

Motif

SAPNY motif

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

307_311

86.33333333333333

512.0

Motif

SAPNY motif

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

307_311

86.33333333333333

522.0

Motif

SAPNY motif

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

307_311

86.33333333333333

290.0

Motif

SAPNY motif

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

341_369

86.33333333333333

470.0

Region

Calcineurin B binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

392_406

86.33333333333333

470.0

Region

Calmodulin-binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

407_414

86.33333333333333

470.0

Region

Autoinhibitory segment

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

465_487

86.33333333333333

470.0

Region

Autoinhibitory domain

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000323055

56_340

86.33333333333333

470.0

Region

Catalytic

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

341_369

86.33333333333333

512.0

Region

Calcineurin B binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

392_406

86.33333333333333

512.0

Region

Calmodulin-binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

407_414

86.33333333333333

512.0

Region

Autoinhibitory segment

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

465_487

86.33333333333333

512.0

Region

Autoinhibitory domain

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394853

56_340

86.33333333333333

512.0

Region

Catalytic

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

341_369

86.33333333333333

522.0

Region

Calcineurin B binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

392_406

86.33333333333333

522.0

Region

Calmodulin-binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

407_414

86.33333333333333

522.0

Region

Autoinhibitory segment

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

465_487

86.33333333333333

522.0

Region

Autoinhibitory domain

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000394854

56_340

86.33333333333333

522.0

Region

Catalytic

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

341_369

86.33333333333333

290.0

Region

Calcineurin B binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

392_406

86.33333333333333

290.0

Region

Calmodulin-binding

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

407_414

86.33333333333333

290.0

Region

Autoinhibitory segment

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

465_487

86.33333333333333

290.0

Region

Autoinhibitory domain

Hgene

PPP3CA

chr4:102117073

chr4:106604474

ENST00000512215

56_340

86.33333333333333

290.0

Region

Catalytic

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000340139

159_215

268.0

463.0

Zinc finger

PHD-type

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000394735

159_215

268.0

463.0

Zinc finger

PHD-type

Tgene

INTS12

chr4:102117073

chr4:106604474

ENST00000451321

159_215

268.0

463.0

Zinc finger

PHD-type

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Fusion Gene Sequence for PPP3CA-INTS12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000512215_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1631nt_BP=940nt
GAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGC
TCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGG
GACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCC
TGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATC
CCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCG
GCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTC
AGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGG
GTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACG
ACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGTGTG
GATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGA
CAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTCGTC
AGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAACACA
AAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAATAGG
TTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAGTCG
CTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAATGG
AAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGGCCC
AACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATGTGG
CCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAGTCT

>In-frame_ENST00000512215_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1550_stop in transcript=888
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000512215_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1631nt_BP=940nt
GAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGC
TCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGG
GACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCC
TGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATC
CCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCG
GCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTC
AGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGG
GTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACG
ACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGTGTG
GATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGA
CAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTCGTC
AGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAACACA
AAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAATAGG
TTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAGTCG
CTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAATGG
AAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGGCCC
AACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATGTGG
CCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAGTCT

>In-frame_ENST00000512215_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1550_stop in transcript=888
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000394854_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1634nt_BP=943nt
GGTGAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGG
CGCTCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCC
GGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAA
TCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCC
ATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAG
TCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAG
CTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTC
GGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCG
ACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGT
GTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTT
CGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTC
GTCAGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAAC
ACAAAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAAT
AGGTTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAG
TCGCTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAA
TGGAAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGG
CCCAACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATG
TGGCCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAG

>In-frame_ENST00000394854_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1553_stop in transcript=891
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000394854_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1634nt_BP=943nt
GGTGAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGG
CGCTCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCC
GGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAA
TCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCC
ATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAG
TCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAG
CTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTC
GGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCG
ACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGT
GTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTT
CGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTC
GTCAGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAAC
ACAAAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAAT
AGGTTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAG
TCGCTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAA
TGGAAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGG
CCCAACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATG
TGGCCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAG

>In-frame_ENST00000394854_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1553_stop in transcript=891
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000323055_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1625nt_BP=934nt
AGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGCTCTGTG
TGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCC
AAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCG
TGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTT
CCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGG
CTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCC
TAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGC
AGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGAC
AGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGTGTGGATATC
TTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAA
AAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTCGTCAGTAAC
TAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAACACAAAACAA
TACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAATAGGTTCCAA
AATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAGTCGCTCAGT
TAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAATGGAAATAG
TGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGGCCCAACTTC
ACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATGTGGCCAAGT
AGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAGTCTTCATAA

>In-frame_ENST00000323055_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1544_stop in transcript=882
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000323055_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1625nt_BP=934nt
AGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGCTCTGTG
TGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCC
AAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCG
TGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTT
CCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGG
CTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCC
TAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGC
AGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGAC
AGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGTGTGGATATC
TTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAA
AAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGGAAATTCTTCTAGTGCCAGCGTTTCCTCGTCAGTAAC
TAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCCTTCAACAGCAAAATTGAGTTCAACAACACAAAACAA
TACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGGTCTGGCAACATCATCCAAAGGTGGAATAGGTTCCAA
AATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACCTCTAACCTTGGGTAAAACTGGCCTTAGTCGCTCAGT
TAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCCAGGAAGCAGCAGCCAACTAAGTGGGAATGGAAATAG
TGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAGCAGCTCTCCCTCAGCATCCCTTAAAGGCCCAACTTC
ACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGCTGCCCAAAAGAAACTCAAGAAGTAATGTGGCCAAGT
AGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAATCTGTAATACACTGTAATTTAATAAAAGTCTTCATAA

>In-frame_ENST00000323055_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1544_stop in transcript=882
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000394853_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1481nt_BP=790nt
AGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCC
CGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGG
GTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAAC
CACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCG
CGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCG
TTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAG
CCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAA
GTGTTTGATAATGATGGAAAACCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGA
ATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGG
AAATTCTTCTAGTGCCAGCGTTTCCTCGTCAGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCC
TTCAACAGCAAAATTGAGTTCAACAACACAAAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGG
TCTGGCAACATCATCCAAAGGTGGAATAGGTTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACC
TCTAACCTTGGGTAAAACTGGCCTTAGTCGCTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCC
AGGAAGCAGCAGCCAACTAAGTGGGAATGGAAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAG
CAGCTCTCCCTCAGCATCCCTTAAAGGCCCAACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGC
TGCCCAAAAGAAACTCAAGAAGTAATGTGGCCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAAT

>In-frame_ENST00000394853_ENST00000394735_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1400_stop in transcript=738
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------
>In-frame_ENST00000394853_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(transcript)=1481nt_BP=790nt
AGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCC
CGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGG
GTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAAC
CACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCG
CGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCG
TTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAG
CCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAA
GTGTTTGATAATGATGGAAAACCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGA
ATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGACATCCACAGTTATTTCAGG
AAATTCTTCTAGTGCCAGCGTTTCCTCGTCAGTAACTAGTGGCTTAACTGGATGGGCAGCTTTTGCAGCCAAAACTTCCTCTGCTGGTCC
TTCAACAGCAAAATTGAGTTCAACAACACAAAACAATACTGGGAAACCTGCTACTTCGTCAGCTAACCAGAAACCTGTGGGTTTGACTGG
TCTGGCAACATCATCCAAAGGTGGAATAGGTTCCAAAATAGGTTCCAATAACAGCACTACGCCCACTGTACCTTTAAAACCACCTCCACC
TCTAACCTTGGGTAAAACTGGCCTTAGTCGCTCAGTTAGTTGTGACAATGTCAGCAAAGTAGGTCTTCCTAGTCCAAGTAGTTTAGTTCC
AGGAAGCAGCAGCCAACTAAGTGGGAATGGAAATAGTGGAACATCAGGACCTAGTGGAAGTACTACCAGCAAAACTACTTCAGAATCCAG
CAGCTCTCCCTCAGCATCCCTTAAAGGCCCAACTTCACAAGAATCACAGCTCAATGCTATGAAGCGATTACAGATGGTCAAGAAGAAAGC
TGCCCAAAAGAAACTCAAGAAGTAATGTGGCCAAGTAGGTTTTTGTATCATATTAGCCTAAAGATGAAAGGCTTATTATTATGATATAAT

>In-frame_ENST00000394853_ENST00000340139_TCGA-HC-8266-01A_PPP3CA_chr4_102117073_-_INTS12_chr4_106604474_length(amino acids)=220AA_start in transcript=1400_stop in transcript=738
MIQKPTWPHYFLSFFWAAFFLTICNRFIALSCDSCEVGPLRDAEGELLDSEVVLLVVLPLGPDVPLFPFPLSWLLLPGTKLLGLGRPTLL
TLSQLTERLRPVLPKVRGGGGFKGTVGVVLLLEPILEPIPPLDDVARPVKPTGFWLADEVAGFPVLFCVVELNFAVEGPAEEVLAAKAAH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP3CA-INTS12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PPP3CA	chr4:102117073	chr4:106604474	ENST00000323055	-	2	12	327_336	86.33333333333333	470.0	PxIxIF motif in substrate
Hgene	PPP3CA	chr4:102117073	chr4:106604474	ENST00000394853	-	2	13	327_336	86.33333333333333	512.0	PxIxIF motif in substrate
Hgene	PPP3CA	chr4:102117073	chr4:106604474	ENST00000394854	-	2	14	327_336	86.33333333333333	522.0	PxIxIF motif in substrate
Hgene	PPP3CA	chr4:102117073	chr4:106604474	ENST00000512215	-	2	8	327_336	86.33333333333333	290.0	PxIxIF motif in substrate

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PPP3CA-INTS12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PPP3CA-INTS12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPP3CA	C4540199	EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1	2	GENOMICS_ENGLAND;UNIPROT
Hgene	PPP3CA	C0019202	Hepatolenticular Degeneration	1	CTD_human
Hgene	PPP3CA	C0030305	Pancreatitis	1	CTD_human
Hgene	PPP3CA	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	PPP3CA	C0039584	Testicular Diseases	1	CTD_human
Hgene	PPP3CA	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	PPP3CA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	PPP3CA	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	PPP3CA	C1527352	Hepatic Form of Wilson Disease	1	CTD_human
Hgene	PPP3CA	C4721610	Carcinoma, Ovarian Epithelial	1	CTD_human
Hgene	PPP3CA	C4748872	ARTHROGRYPOSIS, CLEFT PALATE, CRANIOSYNOSTOSIS, AND IMPAIRED INTELLECTUAL DEVELOPMENT	1	UNIPROT