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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP6R3-DPP3 (FusionGDB2 ID:67872)

Fusion Gene Summary for PPP6R3-DPP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R3-DPP3
Fusion gene ID: 67872
HgeneTgene
Gene symbol

PPP6R3

DPP3

Gene ID

55291

10072

Gene nameprotein phosphatase 6 regulatory subunit 3dipeptidyl peptidase 3
SynonymsC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3DPPIII
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPLdipeptidyl peptidase 3DPP IIIdipeptidyl aminopeptidase IIIdipeptidyl arylamidase IIIdipeptidyl peptidase IIIenkephalinase B
Modification date2020031320200313
UniProtAcc.

Q9NY33

Ensembl transtripts involved in fusion geneENST00000393799, ENST00000530427, 
ENST00000393800, ENST00000534534, 
ENST00000524845, ENST00000265637, 
ENST00000524904, ENST00000393801, 
ENST00000265636, ENST00000529710, 
ENST00000527403, 		ENST00000531863, 
ENST00000532677, ENST00000453114, 
ENST00000360510, ENST00000541961, 
ENST00000530165, ENST00000533799, 
Fusion gene scores* DoF score34 X 21 X 15=1071010 X 9 X 4=360
# samples 4310
** MAII scorelog2(43/10710*10)=-4.63847801004816
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP6R3 [Title/Abstract] AND DPP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP6R3(68228297)-DPP3(66272080), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191

TgeneDPP3

GO:0006508

proteolysis

9425109|10387075


check buttonFusion gene breakpoints across PPP6R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DPP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA723279PPP6R3chr11

68228297

+DPP3chr11

66272080

+
ChiTaRS5.0N/ADC369559PPP6R3chr11

68228297

+DPP3chr11

66272080

+


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Fusion Gene ORF analysis for PPP6R3-DPP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000393799ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393799ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393799ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393799ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393799ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393799ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000393799ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-3CDSENST00000530427ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
3UTR-intronENST00000530427ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393800ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000393800ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000534534ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000534534ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524845ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000524845ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265637ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000265637ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000524904ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000524904ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000393801ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000393801ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000265636ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000265636ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-3CDSENST00000529710ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
5UTR-intronENST00000529710ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000531863PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000532677PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000453114PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000360510PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000541961PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-3CDSENST00000527403ENST00000530165PPP6R3chr11

68228297

+DPP3chr11

66272080

+
intron-intronENST00000527403ENST00000533799PPP6R3chr11

68228297

+DPP3chr11

66272080

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP6R3-DPP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP6R3chr1168228295+DPP3chr1166272082+2.76E-081
PPP6R3chr1168228295+DPP3chr1166272082+2.76E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP6R3-DPP3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPP3

Q9NY33

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP6R3-DPP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP6R3-DPP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP6R3-DPP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP6R3-DPP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource