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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRCC-TMED5 (FusionGDB2 ID:67986)

Fusion Gene Summary for PRCC-TMED5

check button Fusion gene summary
Fusion gene informationFusion gene name: PRCC-TMED5
Fusion gene ID: 67986
HgeneTgene
Gene symbol

PRCC

TMED5

Gene ID

5546

50999

Gene nameproline rich mitotic checkpoint control factortransmembrane p24 trafficking protein 5
SynonymsRCCP1|TPRCCGI-100|p24g2|p28
Cytomap

1q23.1

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionproline-rich protein PRCCPRCC, proline rich mitotic checkpoint control factorpapillary renal cell carcinoma (translocation-associated)papillary renal cell carcinoma translocation-associated gene proteintransmembrane emp24 domain-containing protein 5p24 family protein gamma-2p24gamma2transmembrane emp24 protein transport domain containing 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000271526, ENST00000353233, 
ENST00000491853, 		ENST00000370282, 
ENST00000483033, ENST00000479918, 
ENST00000370280, 
Fusion gene scores* DoF score12 X 6 X 10=7205 X 3 X 3=45
# samples 145
** MAII scorelog2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRCC [Title/Abstract] AND TMED5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRCC(156738031)-TMED5(93625783), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRCC

GO:0007093

mitotic cell cycle checkpoint

11717438


check buttonFusion gene breakpoints across PRCC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMED5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A40S-01APRCCchr1

156738031

+TMED5chr1

93625783

-
ChimerDB4THCATCGA-ET-A40SPRCCchr1

156738031

+TMED5chr1

93625783

-
ChimerDB4THCATCGA-ET-A40S-01APRCCchr1

156738031

+TMED5chr1

93625783

-
ChimerDB4THCATCGA-ET-A40S-01APRCCchr1

156738031

-TMED5chr1

93625783

-


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Fusion Gene ORF analysis for PRCC-TMED5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000271526ENST00000370282PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000271526ENST00000483033PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000271526ENST00000479918PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000271526ENST00000370280PRCCchr1

156738031

+TMED5chr1

93625783

-
In-frameENST00000353233ENST00000370282PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000353233ENST00000483033PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000353233ENST00000479918PRCCchr1

156738031

+TMED5chr1

93625783

-
5CDS-5UTRENST00000353233ENST00000370280PRCCchr1

156738031

+TMED5chr1

93625783

-
intron-3CDSENST00000491853ENST00000370282PRCCchr1

156738031

+TMED5chr1

93625783

-
intron-5UTRENST00000491853ENST00000483033PRCCchr1

156738031

+TMED5chr1

93625783

-
intron-5UTRENST00000491853ENST00000479918PRCCchr1

156738031

+TMED5chr1

93625783

-
intron-5UTRENST00000491853ENST00000370280PRCCchr1

156738031

+TMED5chr1

93625783

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000271526PRCCchr1156738031+ENST00000370282TMED5chr193625783-61697402721240322
ENST00000353233PRCCchr1156738031+ENST00000370282TMED5chr193625783-61156862181186322

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000271526ENST00000370282PRCCchr1156738031+TMED5chr193625783-0.0005651850.99943477
ENST00000353233ENST00000370282PRCCchr1156738031+TMED5chr193625783-0.0005568190.9994431

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Fusion Genomic Features for PRCC-TMED5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRCC-TMED5


check button Go to

FGviewer for the breakpoints of chr1:156738031-chr1:93625783

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRCCchr1:156738031chr1:93625783ENST00000271526+1718_25156.0492.0Compositional biasNote=Poly-Glu
HgenePRCCchr1:156738031chr1:93625783ENST00000271526+1752_55156.0492.0Compositional biasNote=Poly-Pro
HgenePRCCchr1:156738031chr1:93625783ENST00000271526+1779_84156.0492.0Compositional biasNote=Poly-Pro
HgenePRCCchr1:156738031chr1:93625783ENST00000271526+1791_94156.0492.0Compositional biasNote=Poly-Pro
TgeneTMED5chr1:156738031chr1:93625783ENST0000037028204218_22963.0230.0Topological domainCytoplasmic
TgeneTMED5chr1:156738031chr1:93625783ENST0000047991805218_22963.0194.0Topological domainCytoplasmic
TgeneTMED5chr1:156738031chr1:93625783ENST0000037028204197_21763.0230.0TransmembraneHelical
TgeneTMED5chr1:156738031chr1:93625783ENST0000047991805197_21763.0194.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRCCchr1:156738031chr1:93625783ENST00000271526+17235_239156.0492.0Compositional biasNote=Poly-Thr
TgeneTMED5chr1:156738031chr1:93625783ENST000003702820445_12663.0230.0DomainGOLD
TgeneTMED5chr1:156738031chr1:93625783ENST000004799180545_12663.0194.0DomainGOLD
TgeneTMED5chr1:156738031chr1:93625783ENST000003702820428_19663.0230.0Topological domainLumenal
TgeneTMED5chr1:156738031chr1:93625783ENST000004799180528_19663.0194.0Topological domainLumenal


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Fusion Gene Sequence for PRCC-TMED5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000271526_ENST00000370282_TCGA-ET-A40S-01A_PRCC_chr1_156738031_+_TMED5_chr1_93625783_length(transcript)=6169nt_BP=740nt
ATTGGTGAGGCAAGGAGGAGGCGGAGTGACTCGGCGGCCATTAGCTGTGTGTAGTTGCCCGGGACTAGGAGCTTAAGTGAAGAGGTACGC
CTTGTTCGGTGGAAATCAGCCGTAGCCATGAGTTTCTGCCGGGGCTAGCCCTAGAGTACGGAGCAGGCGGACTTTTCGGTTCCCCGCCCC
GCCAGGTGGCGGGGCCTACTAGGCCTCCGGGCATCCCCGGTCTCAAGTAGGCCTCATCTGCCGGCAAGGGCGCCCGAAACGCGGGAGGCG
CCATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTGAGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTA
CATCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTCCGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGC
CAGCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTCAGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCT
TCCCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGACTGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCC
TCAATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGCCAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGC
CGGAGTTGCATAAGGGAGATGTTTTAGATGGAGCAGGATTAGATATTGATTTCCATCTTGCCTCTCCAGAAGGCAAAACCTTAGTTTTTG
AACAAAGAAAATCAGATGGAGTTCACACTGTAGAGACTGAAGTTGGTGATTACATGTTCTGCTTTGACAATACATTCAGCACCATTTCTG
AGAAGGTGATTTTCTTTGAATTAATCCTGGATAATATGGGAGAACAGGCACAAGAACAAGAAGATTGGAAGAAATATATTACTGGCACAG
ATATATTGGATATGAAACTGGAAGACATCCTGGAATCCATCAACAGCATCAAGTCCAGACTAAGCAAAAGTGGGCACATACAAACTCTGC
TTAGAGCATTTGAAGCTCGTGATCGAAACATACAAGAAAGCAACTTTGATAGAGTCAATTTCTGGTCTATGGTTAATTTAGTGGTCATGG
TGGTGGTGTCAGCCATTCAAGTTTATATGCTGAAGAGTCTGTTTGAAGATAAGAGGAAAAGTAGAACTTAAAACTCCAAACTAGAGTACG
TAACATTGAAAAATGAGGCATAAAAATGCAATAAACTGTTACAGTCAAGACCATTAATGGTCTTCTCCAAAATATTTTGAGATATAAAAG
TAGGAAACAGGTATAATTTTAATGTGAAAATTAAGTCTTCACTTTCTGTGCAAGTAATCCTGCTGATCCAGTTGTACTTAAGTGTGTAAC
AGGAATATTTTGCAGAATATAGGTTTAACTGAATGAAGCCATATTAATAACTGCATTTTCCTAACTTTGAAAAATTTTGCAAATGTCTTA
GGTGATTTAAATAAATGAGTATTGGGCCTAATTGCAACACCAGTCTGTTTTTAACAGGTTCTATTACCCAGAACTTTTTTGTAAATGCGG
CAGTTACAAATTAACTGTGGAAGTTTTCAGTTTTAAGTTATAAATCACCTGAGAATTACCTAATGATGGATTGAATAAATCTTTAGACTA
CAAAAGCCCAACTTTTCTCTATTTACATATGCATCTCTCCTATAATGTAAATAGAATAATAGCTTTGAAATACAATTAGGTTTTTGAGAT
TTTTATAACCAAATACATTTCAGTGTAACATATTAGCAGAAAGCATTAGTCTTTGTACTTTGCTTACATTCCCAAAAGCTGACATTTTCA
CGATTCTTAAAAACACAAAGTTACACTTACTAAAATTAGGACATGTTTTCTCTTTGAAATGAAGAATATAGTTTAAAAGCTTCCTCCTCC
ATAGGGACACATTTTCTCTAACCCTTAACTAAAGTGTAGGATTTTAAAATTAAATGTGAGGTAAAATAAGTTTATTTTTAATAGTATCTG
TCAAGTTAATATCTGTCAACAGTTAATAATCATGTTATGTTAATTTTAACATGATTGCTGACTTGGATAATTCATTATTACCAGCAGTTA
TGAAGGAAATATTGCTAAAATGATCTGGGCCTACCATAAATAAATATCTCCTTTTCTGAGCTCTAAGAATTATCAGAAACAGGAAAGAAT
TTAGAAAAACTTGAGAAAACCTAATCCAAAATAAAATTCACTTAAGTAGAACTATAAATAAATATCTAGAATCTGACTGGCTCATCATGA
CATCCTACTCATAACATAAATCAAAGGAGATGATTAATTTCCAGTTAGCTGGAAGAAACTTTGGCTGTAGGTTTTTATTTTCTACAAGAA
TTCTGGTTTGAATTATTTTTGTAAGCAGGTACATTTTATAAAATGTAAGCCCTACTGTAAGGTTTAGCACTGGGTGTACATATTTATTAA
AAATTTTTATTATAACAACTTTTATTAAAATGGCCTTTCTGAACACTTTATTTATTGATGTTGAAGTAAGGATTAGAAACATAGACTCCC
AAGTTTTAAACACCTAAATGTGAATAACCCATATATACAACAAAGTTTCTGCCATCTAGCTTTTTGAAGTCTATGGGGGTCTTACTCAAG
TACTAGTAATTTAACTTCATCATGAATGAACTATAATTTTTAAGTTATGCCCATTTATAACGTTGTTTATGACTACATTGTGAGTTAGAA
ACAAACTTAAAATTTGGGGTATAGAACCCCTCAACAGGTTAGTAATGCTGGAATTCTTGATGAGCAATAATGATAACCAGAGAGTGATTT
CATTTACACTCATAGTAGTATAAAAAGAGATACATTTCCCTCTTAGGCCCCTGGGAGAAGAGCAGCTTAGATTTCCCTACTGGCAAGGTT
TTTAAAAATGAGGTAAATGCCGTATATGATCAATTACCTTAATTGGCCAAGAAAATGCTTCAGGTGTCTAGGGGTATCCTCTGCAACACT
TGCAGAACAAAGGTCAATAAGATCCTTGCCTATGAATACCCCTCCCTTTTGCGCTGTTAAATTTGCAATGAGAAGCAAATTTACAGTACC
ATAACTAATAAAGCAGGGTACAGATATAAACTACTGCATCTTTTCTATAAAACTGTGATTAAGAATTCTACCTCTCCTGTATGGCTGTTA
CTGTACTGTACTCTCTGACTCCTTACCTAACAATGAATTTGTTACATAATCTTCTACATGTATGATTTGTGCCACTGATCTTAAACCTAT
GATTCAGTAACTTCTTACCATATAAAAACGATAATTGCTTTATTTGGAAAAGAATTTAGGAATACTAAGGACAATTATTTTTATAGACAA
AGTAAAAAGACAGATATTTAAGAGGCATAACCAAAAAAGCAAAACTTGTAAACAGAGTAAAAATCTTTAATATTTCTAAAGACATACTGT
TTATCTGCTTCATATGCTTTTTTTAATTTCACTATTCCATTTCTAAATTAAAGTTATGCTAAATTGAGTAAGCTGTTTATCACTTAACAG
CTCATTTTGTCTTTTTCAATATACAAATTTTAAAAATACTACAATATTTAACTAAGGCCCAACCGATTTCCATAATGTAGCAGTTACCGT
GTTCACCTCACACTAAGGCCTAGAGTTTGCTCTGATATGCATTTGGATGATTAATGTTATGCTGTTCTTTCATGTGAATGTCAAGACATG
GAGGGTGTTTGTAATTTTATGGTAAAATTAATCCTTCTTACACATAATGGTGTCTTAAAATTGACAAAAAATGAGCACTTACAATTGTAT
GTCTCCTCAAATGAAAATTCTTTATCTGAAATTTTAAAAGACATTGATTCCACATGTAAGGATTTTTCATCTGAAGTACAATAATGCACA
ATCAGTGTTGCTCAAACTGCTTTATACTTATAAACAGCCATCTTAAATAAGCAACGTATTGTGAGTACTGATATGTATATAATAAAAATT
ATCAAAGAAAATTAACTGCCAGTCATTTGTAAATGCTGTCTACTCCTGAAAGCCTTCCTTCATCTCTATTTAGTTAATAATGTGCTCTCT
CCTCCTGTTTTGAAACCCCATAGCTCTCTACACCTCTTATTGTACATCACTCTACTTTGCATTGGAGTTCTGTTTCTATATGTACTTATT
CACCTGTTGCCTAAACATGCACTGTTCCTAAAAGGTACAGTTTTTGCTCAAAATATATGAAAGGAAAGATAATCAGTTCTTAAAGTTTGG
TATGCTAAATAAGCACCCAGGGAACTTACCTGCTCCACCTCACCCCAGAAATTGATTATTCAGGTCTGGAATATGGCTCAGGATTCTTAA
TTTTCAACCAACACAATATAGAATCCTGTCAGTTATCCTTGGATCATTTGCTAAGTGATCTTGCAAAATCAAAACTCCTTTGAGACTATT
TCATTTTCAGAAATATTTTAAAACTTGTTCAGAAACATCTTAAAACTTGTTAGCATATAGGAAAAGTACAATGCTTGGTGTAGGTAGGTT
ATTATTTGGTCATTTCCCTCAAACCATCCAGACAAGCCACTCTTCTACCACAAGCTGGTAGAAATCCTTAGGCACCTTTCTGCTTCTGCA
CTGCTATCACTTTCAGGTGTCTAAGGCTTCTGGAAGGCTGTTGTCATAACCTGGAGCCATACACCTAATGTACGTCTGGGGAAAGGACAC
CAATTAAAGAATCTAGAGCTAGGATGATGTTACATAAGACAGGGCACAATGGAGATGGACTCTGGATCCCTGCATCTGAAAGAAAAAGGC
AAGAAAATGCAGGGCAGGGAAAATCCTGAAGGTCTTCACTGACCATGAATTAAAATCCTAATTGACAGTTTTACAAACAAAAACCCTCGT
TTTAGTACTTGTGTTGTTTTTGTTTCTGTTTTAACAAGCTTAGATTTATTATTGTGCCTTTTATGGAAGATGAGGAAGAAATAGGAAAGC
AGTAAAATGAACAATGAGAATCTGTTACCCAAACTGATATAAACTCCCTCAGAAAGAAAGATACTACTCCCTAATCCTGGAAGTGTTAAG
TGGCAATAATGATCAAATGTTGTAAAGGGGATTGTTACTACAGCTAATATGAAATGGGAGGCTGGACTAAATCTAACCTTTCTACCCTTG
ATTTCAATTCTAAAAGGACACGTAATACCATTGCAGAAAGAAAAGACAGTTCCAAATGATAAATTTTAGAGTTGTTTTGCTAGGATGCAA
GAGAAATTGGATAAGTGGACCACTCATACGTTGCTGGTGAGATATGAAATAGTAGAGCCACTGTGGAAAATATTCTTGGCAGTTTCTTAT
AAAACTAAACATACATTTAACATATAACTGGCATTTGTACTACTTGACAGTTATCCCTGAGAAGTTAAAACTTAACATTCACAAATGTTA
CATAGCACCTTCATTTATAATAGCCAAAACCCGGAAACAACCTGGATGTCCTTCAAAAAGAGTGAATGGTTTAGTATGTCCACACCATGG
AATACTAAATAGTAATATGAAGGAACAAACTACTGATACATGTAACAAATTGCATGGACCTCAAGGGAATTATGCTTGGGTGGTTTGGGG
GGACAATCCTAAAGTTTTACACACTGTATGATTCTGTTTTTGTAACATTCTTAAATAATAAAGCTATAGAGATGGGAAACAAGATTCGTG
GTTGCCAGGTCTTGGGACTGAAGGGAAGGAGAATGTGGCTATAAAGGGAGCCTTGTGGTGGAAAAGTTCTGTAGTTTGATTGTGGTGATT
ACATAAATATACATGTGAAATGTTAGAAGTATTTATAGCTGAAACATATTAGTATGTTGGTATATACATATTTCTGACTAATTAATTTCG
CCATGTTGCCCAGGCTGGTCTCGAACTCCTAAGCTCAAGTGATGTGCCCGCCTCAACTTCCCAAGTGCTGAGATTACAGGCGTGAGCCAC
CATGTCCGGCCTGTTTTTTCCTATGCATGCATAATTACGATCAAGTTTAATTTGTAATTAGGCACATTAAGAGATTAACAATAGCTAACA

>In-frame_ENST00000271526_ENST00000370282_TCGA-ET-A40S-01A_PRCC_chr1_156738031_+_TMED5_chr1_93625783_length(amino acids)=322AA_start in transcript=272_stop in transcript=1240
MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGF
PPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDVLDGAGLDIDFHLASPEGKTLVFE
QRKSDGVHTVETEVGDYMFCFDNTFSTISEKVIFFELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSGHIQTLL

--------------------------------------------------------------
>In-frame_ENST00000353233_ENST00000370282_TCGA-ET-A40S-01A_PRCC_chr1_156738031_+_TMED5_chr1_93625783_length(transcript)=6115nt_BP=686nt
TTGCCCGGGACTAGGAGCTTAAGTGAAGAGGTACGCCTTGTTCGGTGGAAATCAGCCGTAGCCATGAGTTTCTGCCGGGGCTAGCCCTAG
AGTACGGAGCAGGCGGACTTTTCGGTTCCCCGCCCCGCCAGGTGGCGGGGCCTACTAGGCCTCCGGGCATCCCCGGTCTCAAGTAGGCCT
CATCTGCCGGCAAGGGCGCCCGAAACGCGGGAGGCGCCATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTG
AGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTACATCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTC
CGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGCCAGCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTC
AGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCTTCCCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGAC
TGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCCTCAATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGC
CAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGCCGGAGTTGCATAAGGGAGATGTTTTAGATGGAGCAGGATTAGATATTGATTTCC
ATCTTGCCTCTCCAGAAGGCAAAACCTTAGTTTTTGAACAAAGAAAATCAGATGGAGTTCACACTGTAGAGACTGAAGTTGGTGATTACA
TGTTCTGCTTTGACAATACATTCAGCACCATTTCTGAGAAGGTGATTTTCTTTGAATTAATCCTGGATAATATGGGAGAACAGGCACAAG
AACAAGAAGATTGGAAGAAATATATTACTGGCACAGATATATTGGATATGAAACTGGAAGACATCCTGGAATCCATCAACAGCATCAAGT
CCAGACTAAGCAAAAGTGGGCACATACAAACTCTGCTTAGAGCATTTGAAGCTCGTGATCGAAACATACAAGAAAGCAACTTTGATAGAG
TCAATTTCTGGTCTATGGTTAATTTAGTGGTCATGGTGGTGGTGTCAGCCATTCAAGTTTATATGCTGAAGAGTCTGTTTGAAGATAAGA
GGAAAAGTAGAACTTAAAACTCCAAACTAGAGTACGTAACATTGAAAAATGAGGCATAAAAATGCAATAAACTGTTACAGTCAAGACCAT
TAATGGTCTTCTCCAAAATATTTTGAGATATAAAAGTAGGAAACAGGTATAATTTTAATGTGAAAATTAAGTCTTCACTTTCTGTGCAAG
TAATCCTGCTGATCCAGTTGTACTTAAGTGTGTAACAGGAATATTTTGCAGAATATAGGTTTAACTGAATGAAGCCATATTAATAACTGC
ATTTTCCTAACTTTGAAAAATTTTGCAAATGTCTTAGGTGATTTAAATAAATGAGTATTGGGCCTAATTGCAACACCAGTCTGTTTTTAA
CAGGTTCTATTACCCAGAACTTTTTTGTAAATGCGGCAGTTACAAATTAACTGTGGAAGTTTTCAGTTTTAAGTTATAAATCACCTGAGA
ATTACCTAATGATGGATTGAATAAATCTTTAGACTACAAAAGCCCAACTTTTCTCTATTTACATATGCATCTCTCCTATAATGTAAATAG
AATAATAGCTTTGAAATACAATTAGGTTTTTGAGATTTTTATAACCAAATACATTTCAGTGTAACATATTAGCAGAAAGCATTAGTCTTT
GTACTTTGCTTACATTCCCAAAAGCTGACATTTTCACGATTCTTAAAAACACAAAGTTACACTTACTAAAATTAGGACATGTTTTCTCTT
TGAAATGAAGAATATAGTTTAAAAGCTTCCTCCTCCATAGGGACACATTTTCTCTAACCCTTAACTAAAGTGTAGGATTTTAAAATTAAA
TGTGAGGTAAAATAAGTTTATTTTTAATAGTATCTGTCAAGTTAATATCTGTCAACAGTTAATAATCATGTTATGTTAATTTTAACATGA
TTGCTGACTTGGATAATTCATTATTACCAGCAGTTATGAAGGAAATATTGCTAAAATGATCTGGGCCTACCATAAATAAATATCTCCTTT
TCTGAGCTCTAAGAATTATCAGAAACAGGAAAGAATTTAGAAAAACTTGAGAAAACCTAATCCAAAATAAAATTCACTTAAGTAGAACTA
TAAATAAATATCTAGAATCTGACTGGCTCATCATGACATCCTACTCATAACATAAATCAAAGGAGATGATTAATTTCCAGTTAGCTGGAA
GAAACTTTGGCTGTAGGTTTTTATTTTCTACAAGAATTCTGGTTTGAATTATTTTTGTAAGCAGGTACATTTTATAAAATGTAAGCCCTA
CTGTAAGGTTTAGCACTGGGTGTACATATTTATTAAAAATTTTTATTATAACAACTTTTATTAAAATGGCCTTTCTGAACACTTTATTTA
TTGATGTTGAAGTAAGGATTAGAAACATAGACTCCCAAGTTTTAAACACCTAAATGTGAATAACCCATATATACAACAAAGTTTCTGCCA
TCTAGCTTTTTGAAGTCTATGGGGGTCTTACTCAAGTACTAGTAATTTAACTTCATCATGAATGAACTATAATTTTTAAGTTATGCCCAT
TTATAACGTTGTTTATGACTACATTGTGAGTTAGAAACAAACTTAAAATTTGGGGTATAGAACCCCTCAACAGGTTAGTAATGCTGGAAT
TCTTGATGAGCAATAATGATAACCAGAGAGTGATTTCATTTACACTCATAGTAGTATAAAAAGAGATACATTTCCCTCTTAGGCCCCTGG
GAGAAGAGCAGCTTAGATTTCCCTACTGGCAAGGTTTTTAAAAATGAGGTAAATGCCGTATATGATCAATTACCTTAATTGGCCAAGAAA
ATGCTTCAGGTGTCTAGGGGTATCCTCTGCAACACTTGCAGAACAAAGGTCAATAAGATCCTTGCCTATGAATACCCCTCCCTTTTGCGC
TGTTAAATTTGCAATGAGAAGCAAATTTACAGTACCATAACTAATAAAGCAGGGTACAGATATAAACTACTGCATCTTTTCTATAAAACT
GTGATTAAGAATTCTACCTCTCCTGTATGGCTGTTACTGTACTGTACTCTCTGACTCCTTACCTAACAATGAATTTGTTACATAATCTTC
TACATGTATGATTTGTGCCACTGATCTTAAACCTATGATTCAGTAACTTCTTACCATATAAAAACGATAATTGCTTTATTTGGAAAAGAA
TTTAGGAATACTAAGGACAATTATTTTTATAGACAAAGTAAAAAGACAGATATTTAAGAGGCATAACCAAAAAAGCAAAACTTGTAAACA
GAGTAAAAATCTTTAATATTTCTAAAGACATACTGTTTATCTGCTTCATATGCTTTTTTTAATTTCACTATTCCATTTCTAAATTAAAGT
TATGCTAAATTGAGTAAGCTGTTTATCACTTAACAGCTCATTTTGTCTTTTTCAATATACAAATTTTAAAAATACTACAATATTTAACTA
AGGCCCAACCGATTTCCATAATGTAGCAGTTACCGTGTTCACCTCACACTAAGGCCTAGAGTTTGCTCTGATATGCATTTGGATGATTAA
TGTTATGCTGTTCTTTCATGTGAATGTCAAGACATGGAGGGTGTTTGTAATTTTATGGTAAAATTAATCCTTCTTACACATAATGGTGTC
TTAAAATTGACAAAAAATGAGCACTTACAATTGTATGTCTCCTCAAATGAAAATTCTTTATCTGAAATTTTAAAAGACATTGATTCCACA
TGTAAGGATTTTTCATCTGAAGTACAATAATGCACAATCAGTGTTGCTCAAACTGCTTTATACTTATAAACAGCCATCTTAAATAAGCAA
CGTATTGTGAGTACTGATATGTATATAATAAAAATTATCAAAGAAAATTAACTGCCAGTCATTTGTAAATGCTGTCTACTCCTGAAAGCC
TTCCTTCATCTCTATTTAGTTAATAATGTGCTCTCTCCTCCTGTTTTGAAACCCCATAGCTCTCTACACCTCTTATTGTACATCACTCTA
CTTTGCATTGGAGTTCTGTTTCTATATGTACTTATTCACCTGTTGCCTAAACATGCACTGTTCCTAAAAGGTACAGTTTTTGCTCAAAAT
ATATGAAAGGAAAGATAATCAGTTCTTAAAGTTTGGTATGCTAAATAAGCACCCAGGGAACTTACCTGCTCCACCTCACCCCAGAAATTG
ATTATTCAGGTCTGGAATATGGCTCAGGATTCTTAATTTTCAACCAACACAATATAGAATCCTGTCAGTTATCCTTGGATCATTTGCTAA
GTGATCTTGCAAAATCAAAACTCCTTTGAGACTATTTCATTTTCAGAAATATTTTAAAACTTGTTCAGAAACATCTTAAAACTTGTTAGC
ATATAGGAAAAGTACAATGCTTGGTGTAGGTAGGTTATTATTTGGTCATTTCCCTCAAACCATCCAGACAAGCCACTCTTCTACCACAAG
CTGGTAGAAATCCTTAGGCACCTTTCTGCTTCTGCACTGCTATCACTTTCAGGTGTCTAAGGCTTCTGGAAGGCTGTTGTCATAACCTGG
AGCCATACACCTAATGTACGTCTGGGGAAAGGACACCAATTAAAGAATCTAGAGCTAGGATGATGTTACATAAGACAGGGCACAATGGAG
ATGGACTCTGGATCCCTGCATCTGAAAGAAAAAGGCAAGAAAATGCAGGGCAGGGAAAATCCTGAAGGTCTTCACTGACCATGAATTAAA
ATCCTAATTGACAGTTTTACAAACAAAAACCCTCGTTTTAGTACTTGTGTTGTTTTTGTTTCTGTTTTAACAAGCTTAGATTTATTATTG
TGCCTTTTATGGAAGATGAGGAAGAAATAGGAAAGCAGTAAAATGAACAATGAGAATCTGTTACCCAAACTGATATAAACTCCCTCAGAA
AGAAAGATACTACTCCCTAATCCTGGAAGTGTTAAGTGGCAATAATGATCAAATGTTGTAAAGGGGATTGTTACTACAGCTAATATGAAA
TGGGAGGCTGGACTAAATCTAACCTTTCTACCCTTGATTTCAATTCTAAAAGGACACGTAATACCATTGCAGAAAGAAAAGACAGTTCCA
AATGATAAATTTTAGAGTTGTTTTGCTAGGATGCAAGAGAAATTGGATAAGTGGACCACTCATACGTTGCTGGTGAGATATGAAATAGTA
GAGCCACTGTGGAAAATATTCTTGGCAGTTTCTTATAAAACTAAACATACATTTAACATATAACTGGCATTTGTACTACTTGACAGTTAT
CCCTGAGAAGTTAAAACTTAACATTCACAAATGTTACATAGCACCTTCATTTATAATAGCCAAAACCCGGAAACAACCTGGATGTCCTTC
AAAAAGAGTGAATGGTTTAGTATGTCCACACCATGGAATACTAAATAGTAATATGAAGGAACAAACTACTGATACATGTAACAAATTGCA
TGGACCTCAAGGGAATTATGCTTGGGTGGTTTGGGGGGACAATCCTAAAGTTTTACACACTGTATGATTCTGTTTTTGTAACATTCTTAA
ATAATAAAGCTATAGAGATGGGAAACAAGATTCGTGGTTGCCAGGTCTTGGGACTGAAGGGAAGGAGAATGTGGCTATAAAGGGAGCCTT
GTGGTGGAAAAGTTCTGTAGTTTGATTGTGGTGATTACATAAATATACATGTGAAATGTTAGAAGTATTTATAGCTGAAACATATTAGTA
TGTTGGTATATACATATTTCTGACTAATTAATTTCGCCATGTTGCCCAGGCTGGTCTCGAACTCCTAAGCTCAAGTGATGTGCCCGCCTC
AACTTCCCAAGTGCTGAGATTACAGGCGTGAGCCACCATGTCCGGCCTGTTTTTTCCTATGCATGCATAATTACGATCAAGTTTAATTTG

>In-frame_ENST00000353233_ENST00000370282_TCGA-ET-A40S-01A_PRCC_chr1_156738031_+_TMED5_chr1_93625783_length(amino acids)=322AA_start in transcript=218_stop in transcript=1186
MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGF
PPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDVLDGAGLDIDFHLASPEGKTLVFE
QRKSDGVHTVETEVGDYMFCFDNTFSTISEKVIFFELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSGHIQTLL

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Fusion Gene PPI Analysis for PRCC-TMED5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRCC-TMED5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRCC-TMED5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRCCC4518356MiT family translocation renal cell carcinoma3ORPHANET